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Blood Products

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1. WHO public consultation on the draft proposal on principles for global consensus on the donation and management of blood, blood components and medical products of human origin

WHO public consultation on the draft proposal on principles for global consensus on the donation and management of blood, blood components and medical products of human origin WHO public consultation on the draft proposal on principles for global consensus on the donation and management of blood, blood components and medical products of human origin JavaScript is disabled for your browser. Some features of this site may not work without it. Toggle navigation Toggle navigation Search Browse (...) Statistics Related Links WHO public consultation on the draft proposal on principles for global consensus on the donation and management of blood, blood components and medical products of human origin View/ Open View Statistics Altmetrics Share Citation World Health Organization . (‎2017)‎. WHO public consultation on the draft proposal on principles for global consensus on the donation and management of blood, blood components and medical products of human origin. World Health Organization. . License: CC

2017 WHO

3. Blood Transfusion in Trauma: Timing and Product Ratio

Blood Transfusion in Trauma: Timing and Product Ratio Emergency Medicine > Journal Club > Archive > February 2018 Toggle navigation February 2018 Blood Transfusion in Trauma: Timing and Product Ratio Vignette It's an active early spring afternoon in the city, and you're pretty sure that just about everyone and their sister have been shot at, with most of the pour souls ending up in your TCC. As these things tend to go, The GSWs thus far are to the extremities or benign grazes (...) trauma patients receiving at least 3 units of blood product in the first 6 hours after ED admission ( ). A follow-up randomized controlled trial ( ) attempted to compare 1:1:1 (plasma:platelets:RBC) ratio to a 1:1:2 ratio among patients requiring the highest level trauma activation at any of 12 North American level 1 trauma centers who were predicted to require a massive transfusion. While the authors found no statistically significant difference in survival at 24 hours or 30 days, there was a trend

2018 Washington University Emergency Medicine Journal Club

4. Computerised decision support systems to promote appropriate use of blood products. (PubMed)

Computerised decision support systems to promote appropriate use of blood products. This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effect of computerised decision support systems (DSSs) on transfusion practice.

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2017 Cochrane

5. Increased Risk of Mortality with Female to Male Blood Product Transfusions

Increased Risk of Mortality with Female to Male Blood Product Transfusions "Increased Risk of Mortality with Female to Male Blood Product Transfus" by Haley Robinson and Kiersten Sperry < > > > > > Title Author Date of Graduation 8-10-2019 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies Rights . Abstract Background: Blood product transfusions are one of the most common procedures in the US. These transfusions are considered safe but there is still (...) of female blood products did increase mortality among male recipients. Four of the 5 studies did show an increase in mortality among male recipients of female blood product donation. One study found increased mortality among male recipients specifically receiving multiparous female blood products. Another study reported increased mortality among male recipients receiving more than 2 units of female plasma. One study found no increased risk to male recipients receiving female blood products. Conclusion

2019 Pacific University EBM Capstone Project

6. Blood manufacturing methods affect red blood cell product characteristics and immunomodulatory activity (PubMed)

Blood manufacturing methods affect red blood cell product characteristics and immunomodulatory activity Transfusion of red cell concentrates (RCCs) is associated with increased risk of adverse outcomes that may be affected by different blood manufacturing methods and the presence of extracellular vesicles (EVs). We investigated the effect of different manufacturing methods on hemolysis, residual cells, cell-derived EVs, and immunomodulatory effects on monocyte activity. Thirty-two RCC units (...) produced using whole blood filtration (WBF), red cell filtration (RCF), apheresis-derived (AD), and whole blood-derived (WBD) methods were examined (n = 8 per method). Residual platelet and white blood cells (WBCs) and the concentration, cell of origin, and characterization of EVs in RCC supernatants were assessed in fresh and stored supernatants. Immunomodulatory activity of RCC supernatants was assessed by quantifying monocyte cytokine production capacity in an in vitro transfusion model. RCF units

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2018 Blood advances

7. Comparison of Heart Rate Blood Pressure Product Versus Age-Predicted Maximum Heart Rate as Predictors of Cardiovascular Events During Exercise Stress Echocardiography

Comparison of Heart Rate Blood Pressure Product Versus Age-Predicted Maximum Heart Rate as Predictors of Cardiovascular Events During Exercise Stress Echocardiography Exercise stress echocardiograms (ESEs) are a functional cardiovascular (CV) test typically used for the investigation of coronary artery disease. ESEs are often terminated at a predetermined age-predicted maximum heart rate (APMHR) to facilitate timely acquisition of ultrasound images at peak exercise. Although an APMHR of 85 (...) % is often used, this has not been validated as a suitable termination end point. Heart rate blood pressure product (HRBPP) as an established measure of myocardial work may provide a more reliable assessment of cardiac workload. The aim of this study was to assess maximal HRBPP (MHRBPP) and APMHR as markers of cardiac workload during ESE, using CV events at mean follow-up as the outcome variable. After exclusions, 712 patients being investigated for ischemic heart disease, performed an ESE to volitional

2019 EvidenceUpdates

8. Meta-analysis Comparing Autologous Blood-Derived Products (Including Platelet-Rich Plasma) Injection Versus Placebo in Patients With Achilles Tendinopathy

Meta-analysis Comparing Autologous Blood-Derived Products (Including Platelet-Rich Plasma) Injection Versus Placebo in Patients With Achilles Tendinopathy To compare the effectiveness of autologous blood-derived products (ABP) injection with that of placebo (sham injection, no injection, or physiotherapy alone) in patients with Achilles tendinopathy.Electronic databases, including PubMed, Scopus, EMBASE, and Cochrane Library were searched up to June 2017. All published or unpublished randomized

2018 EvidenceUpdates

9. Consumption of chokeberry (Aronia mitschurinii) products modestly lowered blood pressure and reduced low-grade inflammation in patients with mildly elevated blood pressure. (PubMed)

Consumption of chokeberry (Aronia mitschurinii) products modestly lowered blood pressure and reduced low-grade inflammation in patients with mildly elevated blood pressure. Previous studies suggest that consumption of chokeberries may improve cardiovascular disease risk factor profiles. We hypothesized that chokeberries (Aronia mitschurinii) have beneficial effects on blood pressure, low-grade inflammation, serum lipids, serum glucose, and platelet aggregation in patients with untreated mild (...) and IL-5 (-4.5 pg/mL [P = .084] and -0.06 pg/mL [P = .059], respectively). No changes in serum lipids, lipoproteins, glucose, and in vitro platelet aggregation were noted with the chokeberry intervention. These findings suggest that inclusion of chokeberry products in the diet of participants with mildly elevated blood pressure has minor beneficial effects on cardiovascular health.Copyright © 2016 Elsevier Inc. All rights reserved.

2018 Nutrition research (New York, N.Y.)

10. Relations between dairy product intake and blood pressure: the INTERnational study on MAcro/micronutrients and blood Pressure. (PubMed)

Relations between dairy product intake and blood pressure: the INTERnational study on MAcro/micronutrients and blood Pressure. Epidemiologic evidence suggests that low-fat dairy consumption may lower risk of hypertension. Dairy products may be distinctly linked to health, because of differences in nutritional composition, but little is known about specific nutrients that contribute to the dairy-blood pressure (BP) association, nor to underlying kidney function.We examined cross-sectional (...) associations to BP of dairy product intakes, total and by type, from the INTERnational study on MAcro/micronutrients and blood Pressure (INTERMAP) including 2694 participants aged 40-59 years from the UK and the USA. Eight BP, four 24-h dietary recalls and two 24-h urine samples were collected during four visits. Linear regression models adjusted for lifestyle/dietary factors to estimate BP differences per 2SD higher intakes of total-and-individual-types of dairy were calculated.Multivariable linear

2018 Journal of Hypertension

11. Accurate costs of blood transfusion: a microcosting of administering blood products in the United Kingdom National Health Service. (PubMed)

Accurate costs of blood transfusion: a microcosting of administering blood products in the United Kingdom National Health Service. In an environment of limited health care resources, it is crucial for health care systems which provide blood transfusion to have accurate and comprehensive information on the costs of transfusion, incorporating not only the costs of blood products, but also their administration. Unfortunately, in many countries accurate costs for administering blood (...) are not available. Our study aimed to generate comprehensive estimates of the costs of administering transfusions for the UK National Health Service.A detailed microcosting study was used to cost two key inputs into transfusion: transfusion laboratory and nursing inputs. For each input, data collection forms were developed to capture staff time, equipment, and consumables associated with each step in the transfusion process. Costing results were combined with costs of blood product wastage to calculate the cost

2018 Transfusion

12. A Difference in Bleeding and Use of Blood and Blood Products in Patients who Were Preoperatively on Aspirin or Dual Antiplatelet Therapy Before Coronary Artery Bypass Grafting (PubMed)

A Difference in Bleeding and Use of Blood and Blood Products in Patients who Were Preoperatively on Aspirin or Dual Antiplatelet Therapy Before Coronary Artery Bypass Grafting Postoperative bleeding in patients who underwent elective coronary artery bypass surgery (CABG) may increase due to preoperative anticoagulant therapy indicative of their disease - acute coronary syndrome or implanted coronary artery stent. Increased bleeding in many cases requires the use of blood and blood derivatives (...) that there is no significant difference between the observed groups (p>0.05). Also, our study did not show a statistically significant difference between arrhythmia onset, the length of mechanical ventilation, use of protamineand tranexamic acid. Reoperation due to postoperative bleeding was recorded in 2 cases in the DAPT group as well as 2 lethal cases.In our study, we could not demonstrate less postoperative bleeding and use of blood and blood products in a group of patients who were preoperatively treated with aspirin

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2018 Medical Archives

13. Multicomponent exercise decreases blood pressure, heart rate and double product in normotensive and hypertensive older patients with high blood pressure. (PubMed)

Multicomponent exercise decreases blood pressure, heart rate and double product in normotensive and hypertensive older patients with high blood pressure. The present study aimed to investigate the effects of a 6-month multicomponent exercise program on blood pressure, heart rate, and double product of uncontrolled and controlled normotensive and hypertensive older patients.The study included 183 subjects, 97 normotensives, of which 53 were controlled normotensives (CNS), and 44 uncontrolled (...) with the changes observed in blood pressure.In conclusion, the data of the present study indicate that a 6-month multicomponent exercise program may lead to significant reductions in blood pressure, heart rate, and double product of normotensive and hypertensive patients with high blood pressure values.Copyright © 2018 Instituto Nacional de Cardiología Ignacio Chávez. Publicado por Masson Doyma México S.A. All rights reserved.

2018 Archivos de cardiologia de Mexico

14. Estimated injury-associated blood loss versus availability of emergency blood products at a district-level public hospital in Cape Town, South Africa (PubMed)

Estimated injury-associated blood loss versus availability of emergency blood products at a district-level public hospital in Cape Town, South Africa International guidance suggests that injury-associated haemorrhagic shock should be resuscitated using blood products. However, in low- and middle-income countries resuscitation emphasises the use of crystalloids - mainly due to poor access to blood products. This study aimed to estimate the amount of blood loss from serious injury in relation (...) to available emergency blood products at a secondary-level, public Cape Town hospital.This retrospective, cross-sectional study included all injured patients cared for in the resuscitation area of Khayelitsha Hospital's emergency centre over a fourteen-week period. Injuries were coded using the Abbreviated Injury Scale, which was then used to estimate blood loss for each patient using an algorithm from the Trauma Audit Research Network. Descriptive statistics were used to describe blood volume lost

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2018 African Journal of Emergency Medicine

15. Pentoxifylline alone or in combination with gentamicin or vancomycin inhibits live microbe-induced pro-inflammatory cytokine production in human cord blood and cord blood monocytes <i>in vitro</i>. (PubMed)

Pentoxifylline alone or in combination with gentamicin or vancomycin inhibits live microbe-induced pro-inflammatory cytokine production in human cord blood and cord blood monocytes in vitro. Neonatal sepsis and its accompanying inflammatory response contribute to substantial morbidity and mortality. Pentoxifylline (PTX), a phosphodiesterase inhibitor which suppresses transcription and production of proinflammatory cytokines, is a candidate adjunctive therapy for newborn sepsis. We (...) hypothesized that PTX decreases live microbe-induced inflammatory cytokine production in newborn blood. Cord blood was stimulated with live microorganisms commonly encountered in newborn sepsis (Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis, or Candida albicans) and simultaneously treated with antimicrobial agents (gentamicin, vancomycin, or amphotericin B) and/or clinically relevant concentrations of PTX. Microbial colony counts were enumerated by plating, supernatant cytokines were

2018 Antimicrobial Agents and Chemotherapy

16. High production of pro-inflammatory cytokines by maternal blood mononuclear cells is associated with reduced maternal malaria but increased cord blood infection. (PubMed)

High production of pro-inflammatory cytokines by maternal blood mononuclear cells is associated with reduced maternal malaria but increased cord blood infection. Increased susceptibility to malaria during pregnancy is not completely understood. Cellular immune responses mediate both pathology and immunity but the effector responses involved in these processes have not been fully characterized. Maternal and fetal cytokine and chemokine responses to malaria at delivery, and their association (...) -1β were associated with a reduced risk of P. falciparum infection in pregnant women (p < 0.049). Pro-inflammatory cytokines IL-6, IL-1β and TNF strongly correlated among themselves (ρ > 0.5, p < 0.001). Higher production of IL-1β was significantly associated with congenital malaria (p < 0.046) and excessive TNF was associated with peripheral infection and placental lesions (p < 0.044).Complex network of immuno-pathological cytokine mechanisms in the placental and utero environments showed

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2018 Malaria journal

17. The Thirty Minute Rule for the Return of Blood Products to the Blood Bank: Clinical Evidence and Guidelines

The Thirty Minute Rule for the Return of Blood Products to the Blood Bank: Clinical Evidence and Guidelines Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time (...) for the Return of Blood Products to the Blood Bank: Clinical Evidence and Guidelines DATE: 23 March 2012 RESEARCH QUESTIONS 1. What is the clinical evidence regarding the safe timeframe for returning blood products to refrigeration or ideal storage temperature once they have been removed from the blood bank? 2. What are the evidence-based guidelines regarding the safe timeframe for returning blood products to refrigeration or ideal storage temperature once they have been removed from the blood bank? KEY

2012 Canadian Agency for Drugs and Technologies in Health - Rapid Review

18. Transfusion of Cell Saver Salvaged Blood in Neonates and Infants Undergoing Open Heart Surgery Significantly Reduces RBC and Coagulant Product Transfusions and Donor Exposures: Results of a Prospective, Randomized, Clinical Trial

Transfusion of Cell Saver Salvaged Blood in Neonates and Infants Undergoing Open Heart Surgery Significantly Reduces RBC and Coagulant Product Transfusions and Donor Exposures: Results of a Prospective, Randomized, Clinical Trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2014 PedsCCM Evidence-Based Journal Club

19. Intravenous Infusion Pumps for Transfusion of Blood Products

Intravenous Infusion Pumps for Transfusion of Blood Products TITLE: Intravenous Infusion Pumps for Transfusion of Blood Products: Clinical Effectiveness and Guidelines DATE: 14 July 2014 RESEARCH QUESTIONS 1. What is the clinical effectiveness of intravenous infusion pumps for transfusion of blood products? 2. What are the guidelines for the use of intravenous infusion pumps for transfusion of blood products? KEY MESSAGE One evidence-based guideline was identified regarding the use (...) of intravenous infusion pumps for transfusion of blood products. METHODS A limited literature search was conducted on key resources including PubMed, The Cochrane Library (2014, Issue 6), University of York Centre for Reviews and Dissemination (CRD) databases, Canadian and major international health technology agencies, as well as a focused Internet search. No filters were applied to limit the retrieval by study type. The search was limited to English language documents published between Jan 1, 2010 and Jun

2014 Canadian Agency for Drugs and Technologies in Health - Rapid Review

20. Risk of massive blood product requirement in cardiac surgery: A large retrospective study from 2 heart centers. (PubMed)

Risk of massive blood product requirement in cardiac surgery: A large retrospective study from 2 heart centers. Cardiac surgery under cardiopulmonary bypass (CPB) accounts for most consumption of red blood cells (RBCs). Identifying risk factors for massive red blood cell transfusion (MRT) in cardiac surgery may help to reduce this consumption.We retrospectively analyzed 8238 patients who underwent valve surgery and/or coronary artery bypass grafting (CABG) under CPB at 2 major heart centers

2019 Medicine

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