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Blackwater Fever

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1. Blackwater fever in Ugandan children with severe anemia is associated with poor post-discharge outcomes. A prospective cohort study. (PubMed)

Blackwater fever in Ugandan children with severe anemia is associated with poor post-discharge outcomes. A prospective cohort study. Blackwater fever (BWF), one of the complications of severe malaria, has recently re-emerged as a cause of severe anemia (SA) in African children. However, post-discharge morbidity in children with BWF has hitherto not been described.This was a descriptive cohort study in which children, aged 0-5 years, admitted to Jinja Regional Referral Hospital with acute

2019 Clinical Infectious Diseases

2. A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether-lumefantrine treatment. (PubMed)

A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether-lumefantrine treatment. Blackwater fever is a complication of malaria infection consisting of a syndrome of febrile intra-vascular haemolysis with severe anaemia and intermittent passage of dark-red to black colour urine. Despite numerous reports and studies of this condition, its pathogenesis remains incompletely understood.This report describes a case of classic blackwater fever (...) in a returning traveller, without prior history of malaria infection nor usage of anti-malarial prophylaxis, treated with two courses of oral artemether-lumefantrine combination therapy. Unusual persistence of submicroscopic Plasmodium falciparum parasitaemia was detected by PCR for 18 days after initiation of treatment.To the authors' knowledge this is the first reported occurrence of a case of blackwater fever associated with prolonged submicroscopic parasitaemia. This unusual case challenges the current

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2018 Malaria journal

3. Blackwater fever in a non-immune patient with Plasmodium falciparum malaria after intravenous artesunate. (PubMed)

Blackwater fever in a non-immune patient with Plasmodium falciparum malaria after intravenous artesunate. Blackwater fever was typically reported after quinine administration, although it is poor recognized in patients receiving artesunate. This case describes a blackwater fever in a non-immune patient after artesunate for severe malaria. It highlights the importance of monitoring haemolytic parameters in severe malaria to avoid renal impairment or severe anaemia.© International Society

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2018 Journal of Travel Medicine

4. The Multifactorial Epidemiology of Blackwater Fever. (PubMed)

The Multifactorial Epidemiology of Blackwater Fever. Blackwater fever is a massive hemolytic event usually occurring in the context of repeated falciparum malaria infections and intermittent quinine use. Its etiology is poorly understood, and it is rarely seen today. Historical epidemiological observations from the 20th century demonstrated variable patterns in prisoners in Andaman Islands, refugees in Macedonia, canal workers in Panama, expatriates in Rhodesia, and Second World War soldiers (...) . Rates of blackwater fever per 1,000 malaria cases varied over two orders of magnitude. Islands, such as the Andaman Islands and New Guinea, had lower blackwater fever rates than continental areas. During the Second World War, blackwater fever rates in British soldiers in West Africa and Australian soldiers in New Guinea differed by a factor of 40 despite similar treatment regimens and falciparum malaria transmission risks. Blackwater fever is a complex interaction between host erythrocyte

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2017 American Journal of Tropical Medicine & Hygiene

5. High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda. (PubMed)

High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda. In the Fluid Expansion as a Supportive Treatment (FEAST) trial, an unexpectedly high proportion of participants from eastern Uganda presented with blackwater fever (BWF).We describe the prevalence and outcome of BWF among trial participants and compare the prevalence of 3 malaria-protective red blood cell polymorphisms in BWF cases vs both trial (non-BWF) and population

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2017 Clinical Infectious Diseases

6. Blackwater Fever

Blackwater Fever Blackwater Fever Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Blackwater Fever Blackwater Fever Aka: Blackwater (...) Fever , Malarial Hemoglobinuria From Related Chapters II. Pathophysiology Complication of III. Symptoms Sudden onset of symptoms Chills, irregular fever ( , ) IV. Signs Enlarged tender liver l s V. Labs Blood smear with l s Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Blackwater Fever." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology

2018 FP Notebook

7. Blackwater fever in an uncomplicated Plasmodium falciparum patient treated with dihydroartemisinin-piperaquine. (PubMed)

Blackwater fever in an uncomplicated Plasmodium falciparum patient treated with dihydroartemisinin-piperaquine. The mechanism of massive intravascular haemolysis occurring during the treatment of malaria infection resulting in haemoglobinuria, commonly known as blackwater fever (BWF), remains unknown. BWF is most often seen in those with severe malaria treated with amino-alcohol drugs, including quinine, mefloquine and halofantrine. The potential for drugs containing artemisinins, chloroquine

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2014 Malaria journal

8. Blackwater fever in Congolese children: a report of clinical, laboratory features and risk factors. (PubMed)

Blackwater fever in Congolese children: a report of clinical, laboratory features and risk factors. Blackwater fever (BWF) is one of the severe forms of malaria. This complication was first described among non-immune European expatriates in the malaria endemic areas. Recently, resurgence of this form of malaria has been reported among the indigenous populations. The objective of this study was to investigate the risk factors among BWF patients.A case-control study was conducted between in four

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2013 Malaria journal

9. African Hæmoglobinuric Fever, Commonly Called Blackwater Fever (PubMed)

African Hæmoglobinuric Fever, Commonly Called Blackwater Fever 20758062 2011 03 29 2011 03 29 0007-1447 2 1969 1898 Sep 24 British medical journal Br Med J African Haemoglobinuric Fever, Commonly Called Blackwater Fever. 882-5 Connolly R M RM eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1898 9 24 0 0 1898 9 24 0 1 ppublish 20758062 PMC2434286

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1898 British medical journal

10. A PRELIMINARY NOTE ON THE USE OF VITEX PEDUNCULARIS IN MALARIAL FEVER AND IN BLACKWATER FEVER (PubMed)

A PRELIMINARY NOTE ON THE USE OF VITEX PEDUNCULARIS IN MALARIAL FEVER AND IN BLACKWATER FEVER 20770160 2011 03 31 2011 03 31 0007-1447 1 3136 1921 Feb 05 British medical journal Br Med J A PRELIMINARY NOTE ON THE USE OF VITEX PEDUNCULARIS IN MALARIAL FEVER AND IN BLACKWATER FEVER. 186-8 Vaughan J C JC eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1921 2 5 0 0 1921 2 5 0 1 ppublish 20770160 PMC2414465

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1921 British medical journal

11. Blackwater Fever

Blackwater Fever Blackwater Fever Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Blackwater Fever Blackwater Fever Aka: Blackwater (...) Fever , Malarial Hemoglobinuria From Related Chapters II. Pathophysiology Complication of III. Symptoms Sudden onset of symptoms Chills, irregular fever ( , ) IV. Signs Enlarged tender liver l s V. Labs Blood smear with l s Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Blackwater Fever." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology

2015 FP Notebook

12. Proguanil and Blackwater Fever (PubMed)

Proguanil and Blackwater Fever 18224799 2008 01 28 2018 12 01 0007-1447 1 4598 1949 Feb 19 British medical journal Br Med J Proguanil and blackwater fever. 324 BEST A M AM eng Journal Article England Br Med J 0372673 0007-1447 S61K3P7B2V Proguanil OM Blackwater Fever therapy Humans Proguanil 4916:587c1 BLACKWATER FEVER/therapy PROGUANIL 1949 2 19 0 0 2008 2 13 9 0 1949 2 19 0 0 ppublish 18224799 PMC2049378

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1949 British medical journal

13. Blackwater Fever in West Africa (PubMed)

Blackwater Fever in West Africa 20785946 2011 04 04 2018 11 13 0007-1447 1 4392 1945 Mar 10 British medical journal Br Med J Blackwater Fever in West Africa. 325-7 Skipper E W EW Haine G L GL eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1945 3 10 0 0 1945 3 10 0 1 ppublish 20785946 PMC2056957 Proc R Soc Med. 1939 Aug;32(10):1278-80 19992069

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1945 British medical journal

14. Hemoglobinuria (Blackwater Fever) in Monkeys: A Consideration of the Disease in Man (PubMed)

Hemoglobinuria (Blackwater Fever) in Monkeys: A Consideration of the Disease in Man 18113078 2007 12 27 2018 12 01 0002-9440 25 2 1949 Mar The American journal of pathology Am. J. Pathol. Hemoglobinuria, blackwater fever, in monkeys; a consideration of the disease in man. 195-209 RIGDON R H RH eng Journal Article United States Am J Pathol 0370502 0002-9440 OM Animals Blackwater Fever pathology Haplorhini Hemoglobinuria Humans Male 4916:782u BLACKWATER FEVER/pathology 1949 3 1 0 0 2008 1 17 9 0

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1949 The American journal of pathology

15. Blackwater Fever (PubMed)

Blackwater Fever 14848575 2004 02 15 2018 12 01 0007-1447 2 4726 1951 Aug 04 British medical journal Br Med J BLACKWATER fever. 281-3 eng Journal Article England Br Med J 0372673 0007-1447 OM Blackwater Fever Humans 5120:81744 1951 8 4 1951 8 4 0 1 1951 8 4 0 0 ppublish 14848575 PMC2069635 Ann Trop Med Parasitol. 1949 Oct;43(2):213-24 15393593

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1951 British medical journal

16. Blackwater Fever Treated with Cortisone (PubMed)

Blackwater Fever Treated with Cortisone 13032514 2003 05 01 2018 12 01 0007-1447 1 4814 1953 Apr 11 British medical journal Br Med J Blackwater fever treated with cortisone. 819-20 LINLEY-ADAMS J C JC eng Journal Article England Br Med J 0372673 0007-1447 V27W9254FZ Cortisone OM Blackwater Fever Cortisone therapeutic use Humans Malaria complications 5324:2654:169:384 CORTISONE/therapeutic use MALARIA/complications 1953 4 11 1953 4 11 0 1 1953 4 11 0 0 ppublish 13032514 PMC2016000 Bull Johns

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1953 British medical journal

17. Blackwater Fever in African Children (PubMed)

Blackwater Fever in African Children 14830853 2004 02 15 2018 12 01 0007-1447 1 4715 1951 May 19 British medical journal Br Med J Blackwater fever in African children. 1117-9 JELLIFFE D B DB eng Journal Article England Br Med J 0372673 0007-1447 OM African Continental Ancestry Group Blackwater Fever Child Humans Malaria 5120:63358:7:74:105 BLACKWATER FEVER MALARIA NEGROES 1951 5 19 1951 5 19 0 1 1951 5 19 0 0 ppublish 14830853 PMC2068909 Ann Trop Med Parasitol. 1949 Oct;43(2):213-24 15393593

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1951 British medical journal

18. Proguanil and Blackwater Fever (PubMed)

Proguanil and Blackwater Fever 13019138 2003 05 01 2018 12 01 0007-1447 1 4810 1953 Mar 14 British medical journal Br Med J Proguanil and blackwater fever. 598-600 SINGH I I eng Journal Article England Br Med J 0372673 0007-1447 S61K3P7B2V Proguanil OM Blackwater Fever Humans Malaria therapy Proguanil toxicity 5323:44041:118:324 CHLOROGUANIDE/toxicity MALARIA/therapy 1953 3 14 1953 3 14 0 1 1953 3 14 0 0 ppublish 13019138 PMC2015565

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1953 British medical journal

19. The Artificial Kidney in Malaria and Blackwater Fever (PubMed)

The Artificial Kidney in Malaria and Blackwater Fever 14450615 1998 11 01 2018 12 01 0007-1447 1 5289 1962 May 19 British medical journal Br Med J The artificial kidney in malaria and blackwater fever. 1367-72 JACKSON R C RC WOODRUFF A W AW eng Journal Article England Br Med J 0372673 0007-1447 OM Acute Kidney Injury therapy Blackwater Fever Humans Kidney Kidneys, Artificial Malaria complications ACUTE RENAL FAILURE/therapy KIDNEY, ARTIFICIAL MALARIA/complications 1962 5 19 1962 5 19 0 1 1962 5

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1962 British medical journal

20. More blackwater fever. (PubMed)

More blackwater fever. 5797772 1969 09 09 2018 11 13 0007-1447 3 5667 1969 Aug 16 British medical journal Br Med J More blackwater fever. 372 eng Journal Article England Br Med J 0372673 0007-1447 AIM IM Africa, Central Humans Malaria drug therapy epidemiology United Kingdom 1969 8 16 1969 8 16 0 1 1969 8 16 0 0 ppublish 5797772 PMC1984111 Am J Med. 1968 Dec;45(6):899-903 4881129 Br Med J. 1969 Jun 28;2(5660):781-5 4891335 Br Med J. 1962 May 19;1(5289):1367-72 14450615

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1969 British medical journal

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