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Bilateral Peripheral Polyneuropathy in Diabetes

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1. Bilateral Peripheral Polyneuropathy in Diabetes

Bilateral Peripheral Polyneuropathy in Diabetes Bilateral Peripheral Polyneuropathy in Diabetes Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer (...) Administration 4 Bilateral Peripheral Polyneuropathy in Diabetes Bilateral Peripheral Polyneuropathy in Diabetes Aka: Bilateral Peripheral Polyneuropathy in Diabetes , Diabetic Distal Symmetric Polyneuropathy , Diabetic Distal Sensorimotor Polyneuropathy II. Epidemiology Most common Accounts for 26% of diabetic III. Symptoms Distal s, hyperesthesias or numbness Symptoms worse at night "Stocking & Glove" Related to longest axons affected first and atrophy may be noted Painful occurs in a subset of diabetic

2018 FP Notebook

2. Bilateral Peripheral Polyneuropathy in Diabetes

Bilateral Peripheral Polyneuropathy in Diabetes Bilateral Peripheral Polyneuropathy in Diabetes Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer (...) Administration 4 Bilateral Peripheral Polyneuropathy in Diabetes Bilateral Peripheral Polyneuropathy in Diabetes Aka: Bilateral Peripheral Polyneuropathy in Diabetes , Diabetic Distal Symmetric Polyneuropathy , Diabetic Distal Sensorimotor Polyneuropathy II. Epidemiology Most common Accounts for 26% of diabetic III. Symptoms Distal s, hyperesthesias or numbness Symptoms worse at night "Stocking & Glove" Related to longest axons affected first and atrophy may be noted Painful occurs in a subset of diabetic

2015 FP Notebook

3. Bilateral analgesic effects of abobotulinumtoxinA (Dysport<sup>®</sup> ) following unilateral administration in the rat. (PubMed)

effects of unilateral aboBoNT-A in several chronic pain models in Sprague-Dawley rats. Effects of aboBoNT-A on the paw withdrawal threshold in response to mechanical pressure was assessed in models of streptozotocin-induced diabetic polyneuropathy, chronic constriction injury (CCI)-associated mononeuropathy, and bilateral carrageenan-induced inflammatory pain.In diabetic polyneuropathy, aboBoNT-A (15, 20 U/kg) reversed hyperalgesia in the toxin-injected and non-injected paws. In unilateral CCI-exposed (...) Bilateral analgesic effects of abobotulinumtoxinA (Dysport® ) following unilateral administration in the rat. In addition to inhibition of muscle and glandular hyperactivity, botulinum neurotoxin (BoNT) type A also interferes with pain processing. Previously, in a rat model of paclitaxel-induced polyneuropathy, abobotulinumtoxinA (aboBoNT-A) elicited analgesic effects not only in the injected paw, but also in the contralateral, non-injected paw.Here, we assessed bilateral analgesic

2017 European Journal of Pain

4. Electrical Stimulation in Diabetic Peripheral Neuropathy

Completion Date : December 2015 Actual Study Completion Date : December 2015 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment No Intervention: Control Treated according to local protocol for diabetic peripheral neuropathy Experimental: NMES Treated with neuromuscular stimulation of both legs, for 10 weeks Device: NMES Application of NMES device bilaterally, once a day, 5 times a week, for 10 weeks Outcome Measures Go (...) for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion criteria 18+ years old Diabetes as defined by WHO diagnostic criteria on best medical therapy Diabetic peripheral polyneuropathy present, confirmed by nerve conduction testing Exclusion criteria Pregnancy Pacemaker Metal implants in the legs (below knee) Contacts and Locations Go to Information from the National Library of Medicine

2014 Clinical Trials

5. Spinal Cord Stimulation for Diabetic Polyneuropathy

of painful diabetic distal symmetric sensory/motor polyneuropathy using the LANSS (Leeds assessment of neuropathic symptoms and signs) pain scale score of 12 or greater and the TNS (total neuropathy score) score of 20 or greater. The subject has bilateral, moderate to severe pain from diabetic polyneuropathy for the previous 3 months. The subject has a VAS of > 4 at Baseline, on a stable analgesic regimen consisting of any one or combination of the following agents: anticonvulsants, antidepressants (...) provided by Abbott Medical Devices: Diabetes Polyneuropathy Spinal cord stimulation Additional relevant MeSH terms: Layout table for MeSH terms Polyneuropathies Diabetic Neuropathies Peripheral Nervous System Diseases Neuromuscular Diseases Nervous System Diseases Diabetes Complications Diabetes Mellitus Endocrine System Diseases

2011 Clinical Trials

6. Symmetric Peripheral Neuropathy

Neuropathy Symmetric Peripheral Neuropathy Aka: Symmetric Peripheral Neuropathy , Polyneuropathy From Related Chapters II. Causes: Proximal or distal sensorimotor Neuropathy (Type 1) Acute Inflammatory Demyelinating Polyneuropathy Chronic Inflammatory Demyelinating Polyneuropathy Primary Myelinopathy Malignancy HIV or Buckthorn III. Causes: Distal sensorimotor Polyneuropathy or DSPN (Type 2) (Diabetic DSPN) induced ( ic DSPN) HIV or Malignancy (paraneoplastic syndrome) Charcot-Marie- Toxins Acrylamide (...) Peripheral Neuropathy." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Polyneuropathy (C0152025) Definition (CHV) a nerve disease where many peripheral nerves are affected Definition (CHV) a nerve disease where many peripheral nerves are affected Definition (MSH) Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory

2018 FP Notebook

7. Evaluation of distal symmetric polyneuropathy: role of autonomic testing, nerve biopsy, and skin biopsy

-product 9.5; PN = peripheral neuropathy; PRT = blood pressure recovery time; QAE = quantitative autonomic examination; QSART = quantitative sudomotor axon reflex test; QSS = Quality Standards Subcommittee; QST = quantitative sensory testing; SFSN = small fiber sensory polyneuropathy; TST = thermoregulatory sweat testing. Polyneuropathy is a relatively common neurologic disorder. The overall prevalence is approximately 2,400 (2.4%) per 100,000 population, but in individuals older than 55 years (...) to the evaluation of DSP, and subcommittees were formed to address each of these questions. DESCRIPTION OF THE ANALYTIC PROCESS The literature search included OVID MEDLINE (1966 to March 2007), OVID Excerpta Medica (EMBASE; 1980 to March 2007), and OVID Current Contents (2000 to March 2007). The search included articles on humans only and in all languages. The search terms selected were peripheral neuropathy, polyneuropathy, and distal symmetric polyneuropathy. These terms were cross-referenced with the terms

2009 American Academy of Neurology

8. Spatio-Temporal Gait Parameters and Gait Symmetry In Diabetic Lower Extremity Burn Injury.

relevant MeSH terms: Layout table for MeSH terms Wounds and Injuries Polyneuropathies Burns Diabetic Neuropathies Foot Injuries Peripheral Nervous System Diseases Neuromuscular Diseases Nervous System Diseases Diabetes Complications Diabetes Mellitus Endocrine System Diseases Leg Injuries (...) Erdogan University Training and Research Hospital Collaborators: Hacettepe University Ankara Training and Research Hospital Information provided by (Responsible Party): Melek Merve ERDEM, Recep Tayyip Erdogan University Training and Research Hospital Study Details Study Description Go to Brief Summary: This study evaluated the spatio-temporal gait parameters and gait symmetry in individuals with lower extremity burn injury due to diabetic polyneuropathy. Study group consisted of 14 subjects

2018 Clinical Trials

9. Trazodone/Gabapentin Fixed Dose Combination Products in Painful Diabetic Neuropathy

personal data processing) and available to sign and date the written informed consent. Exclusion Criteria: Known hypersensitivity to trazodone or gabapentin or any excipients of the test drugs. Any other form of non-diabetic distal symmetric polyneuropathy or any other pain condition that can impair the study endpoint (e.g. painful conditions where the intensity of pain is significantly more severe than the diabetic peripheral neuropathic pain). Concomitant treatment with medications for pain (...) in a randomized controlled clinical trial. Diabetic peripheral neuropathic pain represents an important therapeutic challenge as its pathophysiology is not yet fully understood and pain relief is still unsatisfactory. The pharmacological treatments, with exception to those targeted to the glycemic control, are symptomatic and their use is limited by not universal efficacy, side effects or by the development of tolerance. A wide variety of drugs, used both alone and in combination, has shown to significantly

2018 Clinical Trials

10. Omnitram Safety and Efficacy in the Treatment of Diabetic Neuropathy

. Condition or disease Intervention/treatment Phase Diabetic Neuropathies Neuropathic Pain Pain, Chronic Drug: Omnitram Oral Tablet Drug: Placebo Oral Tablet Phase 2 Detailed Description: A multi-centered, randomized, double-blind, placebo-controlled, two-period cross-over study to compare the safety and efficacy of Omnitram (30 mg to 120 mg daily) and placebo in patients with painful diabetic polyneuropathy. For subjects receiving treatment for neuropathic pain prior to study enrollment, their treatment (...) ) Sharing Statement: Plan to Share IPD: No Layout table for additional information Studies a U.S. FDA-regulated Drug Product: Yes Studies a U.S. FDA-regulated Device Product: No Keywords provided by Syntrix Biosystems, Inc.: Analgesia Additional relevant MeSH terms: Layout table for MeSH terms Neuralgia Diabetic Neuropathies Chronic Pain Peripheral Nervous System Diseases Neuromuscular Diseases Nervous System Diseases Pain Neurologic Manifestations Signs and Symptoms Diabetes Complications Diabetes

2018 Clinical Trials

11. MKSAP: 57-year-old man with type 2 diabetes mellitus

MKSAP: 57-year-old man with type 2 diabetes mellitus Treatment options for diabetic polyneuropathy MKSAP: 57-year-old man with type 2 diabetes mellitus | | August 11, 2018 4 Shares Test your medicine knowledge with the , in partnership with the . A 57-year-old man with a 15-year history of type 2 diabetes mellitus is evaluated for bilateral burning sensation in his feet for the last 6 to 12 months. The sensation worsens at night. His HbA1c levels have remained less than 7.0% for the last 2 (...) symmetric polyneuropathy is a bilateral “stocking-glove” distribution. Damage to the small nerve fibers can result in pain, numbness, burning, and tingling. It can also impair light touch and temperature sensation. Damage to the large nerve fibers leads to abnormal vibration sensation and proprioception. Diminished or loss of ankle reflexes is commonly seen early with diabetic polyneuropathy. Motor weakness can occur as the polyneuropathy progresses. Several classes of drugs are frequently used

2018 KevinMD blog

12. Trazodone in Painful Diabetic Neuropathy

or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years to 75 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Male and female patient of any ethnic origin between 18 and 75 years of age (limits included). Patient with painful diabetic symmetric polyneuropathy manifesting with distally distributed (...) - releasing system (IUS) in combination with male condom, bilateral tubal occlusion, vasectomised partner, sexual abstinence. Legally capable to give their consent to participate in the study and available to sign and date the written informed consent. Exclusion Criteria: Known hypersensitivity to trazodone or gabapentin or their excipients. Other forms of neuropathic pain or non-neuropathic pain (included but not limited to peripheral arterial disease, radiculopathy, mononeuropathy, proximal motor

2017 Clinical Trials

13. Light-emitting-diode in Diabetic Subjects

throughout the tibialis anterior muscle and bilateral sural triceps. Device: Infrared Light-emitting diode device The phototherapy will be applied for 3 days followed by a infrared LED blanket of 25x40 cm2, with equidistant distribution - 1 cm between them, with total energy per area of 180 J, bilaterally on the anterior tibial and triceps sural muscles, bilaterally. The intervention of these muscular groups is made possible by the distal involvement of diabetic polyneuropathy. All LEDs will be checked (...) Light-emitting diode device The phototherapy will be applied for 3 days followed by a infrared and Red LED blanket of 25x40 cm2, with equidistant distribution - 1 cm between them, with total energy per area of 180 J, bilaterally on the anterior tibial and triceps sural muscles, bilaterally. The intervention of these muscular groups is made possible by the distal involvement of diabetic polyneuropathy. All LEDs will be checked at the beginning of the project in the Laboratory of Photophysics

2017 Clinical Trials

14. Safety and Efficacy of EMA401 in Patients With Painful Diabetic Neuropathy (PDN)

. FDA-regulated Device Product: No Keywords provided by Novartis ( Novartis Pharmaceuticals ): Painful diabetic neuropathy Neuropathic pain Angiotensin II type 2 receptor antagonist Additional relevant MeSH terms: Layout table for MeSH terms Peripheral Nervous System Diseases Pain Diabetic Neuropathies Neuromuscular Diseases Nervous System Diseases Neurologic Manifestations Signs and Symptoms Diabetes Complications Diabetes Mellitus Endocrine System Diseases Angiotensin II Type 2 Receptor Blockers (...) Safety and Efficacy of EMA401 in Patients With Painful Diabetic Neuropathy (PDN) Safety and Efficacy of EMA401 in Patients With Painful Diabetic Neuropathy (PDN) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2017 Clinical Trials

15. Painful and Prolonged Muscle Cramps following Insulin Injections in a Patient with Type 2 Diabetes Mellitus: Revisiting the 1992 Duke Case (PubMed)

with a combined electromyography-nerve conduction study which indicated extensive diabetic axonal polyneuropathy. By contrast, lower extremity segmental arterial pressures were negative for peripheral vasculo-occlusive disease, ruling out vascular insufficiency as a possible etiology of the cramps. We then measured the levels of serum electrolytes right-before and 30 min right-after injecting the patient with his insulin. Potassium dropped by about 16% from its initial level, compared to a drop of only around (...) Painful and Prolonged Muscle Cramps following Insulin Injections in a Patient with Type 2 Diabetes Mellitus: Revisiting the 1992 Duke Case A 56-year-old middle-eastern male with a long-standing history of poorly controlled type 2 diabetes mellitus presented to us complaining of severely painful bilateral upper and lower extremity cramps occurring shortly after his rapid-acting insulin analog injection(s). The cramps had started 6 months ago and have been occurring intermittently in non

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2017 Frontiers in endocrinology

16. Efficacy of Bilateral Stimulation With Task-oriented Training in Improving Lower Limb Motor Functions in Patients With Stroke

receptive dysphasia Have significant lower limb peripheral neuropathy (e.g. diabetic polyneuropathy) Are involved in drug studies or other clinical trials. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02152813 Locations Layout table for location (...) Efficacy of Bilateral Stimulation With Task-oriented Training in Improving Lower Limb Motor Functions in Patients With Stroke Efficacy of Bilateral Stimulation With Task-oriented Training in Improving Lower Limb Motor Functions in Patients With Stroke - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2014 Clinical Trials

17. Polyneuropathy (PubMed)

Polyneuropathy Polyneuropathy is characterized by simultaneous bilateral symmetrical involvement of peripheral nerves. Clinical features in fully-developed cases are paresthesias, irregular 'glove and stocking' cutaneous sensory loss, loss of deep sensations, weakness of distal muscles of extremities, and absent deep tendon reflexes. The most common forms of neuropathy encountered in practice are -- alcohol-induced, Guillain-Barre syndrome, and that secondary to diabetes mellitus. Since PN has

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1974 Canadian Family Physician

18. Polyneuropathy

are deficient. Vasa nervorum involvement (eg, caused by vasculitis or infections) can begin as multiple mononeuropathies, which, when many nerves are affected bilaterally, can look like polyneuropathy. Abnormalities tend to be asymmetric early in the disorder and rarely affect the proximal one third of the limb or trunk muscles. Cranial nerve involvement is rare, except in diabetes, which commonly affects the 3rd cranial (oculomotor) nerve. Later, if nerve lesions coalesce, symptoms and signs may appear (...) to do a 4-Minute Neurologic Exam SOCIAL MEDIA Add to Any Platform Loading , MDCM, Weill Cornell Medical College Click here for Patient Education NOTE: This is the Professional Version. CONSUMERS: Topic Resources A polyneuropathy is a diffuse that is not confined to the distribution of a single nerve or a single limb and typically is relatively symmetrical bilaterally. Electrodiagnostic tests should always be done to classify the nerve structures involved, distribution, and severity of the disorder

2013 Merck Manual (19th Edition)

19. The Efficacy and Safety of Clonidine Hydrochloride Topical Gel, vs Clonidine Hydrochloride Gel Comparator to Treat Painful Diabetic Neuropathy

Disorders that Masquerade as Painful Diabetic Neuropathy. Subject has other sustained pain with intensity at or greater than the bilateral neuropathic pain in the feet. Subject is using an implanted medical device (e.g., spinal cord stimulator, intrathecal pump, or peripheral nerve stimulator) for treatment of pain. Subject is hypotensive with a resting diastolic blood pressure <60 mm Hg or a systolic blood pressure <90 mm Hg at the Screening or Day 1 Visit. The subject has recent history (within (...) , alcoholism, pernicious anemia, hepatitis, malignancy, chronic inflammatory demyelinating polyneuropathy [CIDP], human immunodeficiency virus [HIV], medication-induced neuropathy, vitamin B12 deficiency). Subject has a significant neurological disorder or condition that might confound assessment of painful diabetic neuropathy (e.g., stroke with distal neurological deficit, mononeuritis multiplex, lumbar radiculopathy). Subject has a confounding disorder as determined by the Algorithm for Excluding

2015 Clinical Trials

20. Evaluation of Corneal Confocal Microscopy for the Identification and Prediction of Neuropathy in Type 1 Diabetes

for future research in this field. Condition or disease Intervention/treatment Diabetic Polyneuropathy Diabetes Mellitus Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Complications Other: Exposure: Corneal nerve fibre morphology by the CCM Procedure Detailed Description: The diffuse injury to peripheral nerves (diabetic neuropathy) is exceptionally common in type 1 diabetes, but there is a lack of an objective surrogate marker to identify early subclinical stages when treatments might (...) relevant MeSH terms: Layout table for MeSH terms Diabetes Mellitus Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetic Neuropathies Polyneuropathies Diabetes Complications Glucose Metabolism Disorders Metabolic Diseases Endocrine System Diseases Autoimmune Diseases Immune System Diseases Peripheral Nervous System Diseases Neuromuscular Diseases Nervous System Diseases

2015 Clinical Trials

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