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that starts in blood-forming tissue, such as the bone marrow, and causes large numbers of abnormal blood cells ^ World Cancer Report 2014 . World Health Organization. 2014. pp. Chapter 5.13. . Vardiman, JW; Thiele, J; Arber, DA; Brunning, RD; Borowitz, MJ; Porwit, A; Harris, NL; Le Beau, MM; Hellström-Lindberg, E; Tefferi, A; Bloomfield, CD (30 Jul 2009). "The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes (...) , Thiele J, Borowitz MJ, Le Beau MM, Bloomfield CD, Cazzola M, Vardiman JW (2016). "The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia". Blood . 127 (20): 2391–405. : . . Bhatnagar N, Nizery L, Tunstall O, Vyas P, Roberts I (October 2016). . Current Hematologic Malignancy Reports . 11 (5): 333–41. : . . . Crispino JD, Horwitz MS (April 2017). . Blood . 129 (15): 2103–2110. : . . . Seewald L, Taub JW, Maloney KW, McCabe ER (September 2012). "Acute
CML in patients who were either resistant to or intolerant of imatinib. A second new TK inhibitor, , was also approved by the FDA for the same indication. In 2010, nilotinib and dasatinib were also approved for first-line therapy, making three drugs in this class available for treatment of newly diagnosed CML. In 2012, joined the class of novel agents in the inhibition of the BCR-ABL protein and was approved in South Korea for patients resistant to or intolerant of imatinib. received US FDA and EU (...) (7): 1441–6. : . . Sokal JE, Baccarani M, Russo D, Tura S (Jan 1988). "Staging and prognosis in chronic myelogenous leukemia". Seminars in Hematology . 25 (1): 49–61. . Vardiman JW, Harris NL, Brunning RD (Oct 2002). "The World Health Organization (WHO) classification of the myeloid neoplasms". Blood . 100 (7): 2292–302. : . . Arber, Daniel A.; Orazi, Attilio; Hasserjian, Robert; Thiele, Jürgen; Borowitz, Michael J.; Beau, Michelle M. Le; Bloomfield, Clara D.; Cazzola, Mario; Vardiman, James W
Seasonal onychomadesis in an elderly gentleman A 79-year-old man with a history of dementia and hypertension initially presented with a ten year history of Beau'slines and seasonal nail shedding of his fingernails only. He denied any exposure to heavy metals, unusual activities or food. He stated that the seasonal nail shedding had been occurring for the last 5-10 years. On examination, six out of ten fingernails had been affected. He had significant toenail dystrophy. Fungal cultures and PAS
: June 22, 2009 Last Update Posted : September 14, 2011 Sponsor: Institut Paoli-Calmettes Information provided by (Responsible Party): Institut Paoli-Calmettes Study Details Study Description Go to Brief Summary: Taxotere® can induce nails changes like dyschromia, hematoma, lines of Beau-Reil (signing the stop of the epithelial proliferation), abscess, or pain. In this context, this randomized, monocentric phase III trial evaluates the cryotherapy, using frozen glove, in the prevention of nails
Unilateral trachyonychia in a patient with reflex sympathetic dystrophy. Reflex sympathetic dystrophy (RSD) is a poorly understood neurovascular disorder characterized by pain, altered sensation, motor disturbance, soft tissue changes, vasomotor changes, and autonomic changes that occurs after trauma to an extremity. Unilateral leukonychia, Beau'slines, nailfold swelling, and nail clubbing have been an observed sequela of RSD. We present a case of a unilateral atypical trachyonychia occurring
nail disorders nail disorders - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search nail disorders Congenital: paronychia congenita nail patellar syndrome Acquired: infections - acute and chronic paronychia, pseudomonas, tinea inflammatory - psoriasis, eczema, lichen planus, alopecia areata, Darier's disease systemic disease - clubbing, koilonychia, Beau'slines, yellow nail syndrome, "half-and-half" nails Links: General
likely to get a more serious infection during an outbreak of scarlet fever. Parents should be warned to watch out for cellulitis, high fever and arthritis. [ ] Minor late sequelae: Beau'slines on nails Telogen hair loss Prognosis Scarlet fever follows a benign course in the vast majority of cases. Any morbidity is likely to arise from suppurative complications, most often in untreated patients. Historical Second in the historical order of classic exanthems identified: Rubeola (measles). Scarlet (...) generalised it may appear more prominent in skin creases, with confluent or lines (capillary fragility). This sign, seen particularly in the axillae and groin, is Pastia's sign and the lines are known as "Pastia's lines". The skin may start to peel (desquamation) even during the febrile stage. This peeling, which often produces flakes of skin on the face, continues for several weeks. It also affects the tips of the fingers, the toes, axilla, groin and ears. It is a valuable sign if the patient has
evidence, UK and European Guidelines. You may find one of our more useful. In this article In This Article Nail Disorders and Abnormalities In this article Nail disorders and abnormalities are common. Appearances may be difficult to diagnose with certainty. Care must be taken to ensure correct diagnosis and therefore treatment. Abnormal-looking nails [ , ] The following are common nail abnormalities, with possible causes. Beau'slines Transverse ridges are usually transient and due to a temporary (...) disturbance of nail growth - eg, severe illness, trauma or infection. Beau'slines occur in ALL nails, due a general cause preventing nail growth. Other causes of transverse ridges include psoriasis, paronychia and eczema. Longitudinal ridging Causes include lichen planus, rheumatoid arthritis, myxoid cysts and peripheral arterial disease. Pitted nails Causes include alopecia areata, psoriasis and eczema. Clubbing An increase in the soft tissue of the distal part of the fingers or toes; common causes
with HIV disease. Cutaneous vasculitis has been reported. Photosensitivity is more prominent. Photo-induced lichenoid drug reactions may be seen, especially on dark skin. Hair and nails [ ] Diffuse alopecia or alopecia areata may be inflammatory and permanent. Generalised alopecia can occur after treatment with indinavir, an antiretroviral agent. [ ] Elongation of the eyelashes and softening and straightening of the scalp hair may be seen. Beau'slines, telogen effluvium and pallor of the nail beds may
. Diarrhea, generalized alopecia and Beau-Reil lines on the nails are frequent manifestations. Paronychia, conjunctivitis, blepharitis and erythematous oral mucous membranes are also sometimes observed. Other features associated with severe and chronic zinc deficiency include failure to thrive, mental slowness, photophobia, hypogeusia, anemia, poor wound healing, hypogonadism in males, and delayed puberty. Etiology AE is due to a mutation in the SLC39A4 gene (8q24.3) that encodes a zinc transporter
A nail psoriasis severity index. The Psoriasis Area and Severity Index does not take the severity of nail involvement into account.To devise a system of scoring for nail psoriasis.A system of scoring for nail psoriasis was devised that takes into account the site of the pathology, i.e. (i) the matrix, (ii) the subungual tissues distal to the lunula, or (iii) the whole nail unit.The proposed scoring system evaluates several signs of nail psoriasis separately, each on a 1-3 scale: pitting, Beau's (...) lines, subungual hyperkeratosis and onycholysis.Using this classification it will be possible to assess and grade nail pathology simply and accurately.
in five, conjunctival haemorrhage in 15, maculopapular eruptions in the intertriginous areas in eight, acral desquamation in 11, and herpesvirus infection in three. The histopathological findings of the maculopapular eruptions showed moderate to marked perivascular infiltration with endothelial swelling. Examination of 21 patients at 3 months after their exposure to arsenic revealed ungual changes including Mee's or Beau'slines in 17 cases, periungual pigmentation in nine, and acral desquamation
Taxane-induced nail changes: incidence, clinical presentation and outcome. The clinical characteristics of nail changes in seven patients receiving taxane-containing chemotherapy are described. They include nail pigmentation, subungual hematoma, Beau'slines and onycholysis and subungual suppuration. The incidence of such changes (ranging from 0% to 44%) is reviewed from a Medline search of the literature.
Case report showed Muehrcke's nails, not Beau'slines 12521984 2003 01 24 2018 11 13 1756-1833 326 7380 2003 Jan 11 BMJ (Clinical research ed.) BMJ Case report showed Muehrcke's nails, not Beau'slines. 105 Möhrenschlager Matthias M Abeck Dietrich D Ring Johannes J eng Letter England BMJ 8900488 0959-8138 AIM IM Antineoplastic Combined Chemotherapy Protocols therapeutic use Diagnosis, Differential Female Humans Lymphoma, Non-Hodgkin drug therapy Nail Diseases chemically induced diagnosis 2003 1
Amelogenesis imperfecta, sensorineural hearing loss, and Beau'slines: a second case report of Heimler's syndrome 10636745 2000 01 07 2008 11 20 0022-2593 36 12 1999 Dec Journal of medical genetics J. Med. Genet. Amelogenesis imperfecta, sensorineural hearing loss, and Beau'slines, a second case report of Heimler's syndrome. 941-3 Tischkowitz M M Clenaghan C C Davies S S Hunter L L Potts J J Verhoef S S eng Case Reports Letter England J Med Genet 2985087R 0022-2593 IM Amelogenesis Imperfecta