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Beau Lines

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101. Alopecia Areata (Diagnosis)

and the patches coalesce Ophiasis - Hair loss is localized to the sides and lower back of the scalp Sisaipho (ophiasis spelled backwards) - Hair loss spares the sides and back of the head Alopecia totalis - 100% hair loss on the scalp Alopecia universalis - Complete loss of hair on all hair-bearing areas Nail involvement, predominantly of the fingernails, is found in 6.8-49.4% of patients, most commonly in severe cases. Pitting is the most common; other reported abnormalities have included trachyonychia, Beau (...) lines, onychorrhexis, onychomadesis, koilonychias, leukonychia, and red lunulae See for more detail. Diagnosis Diagnosis usually can be made on clinical grounds. A scalp biopsy seldom is needed, but it can be helpful when the clinical diagnosis is less certain. See for more detail. Management Treatment is not mandatory, because the condition is benign, and spontaneous remissions and recurrences are common. Treatment can be topical or systemic. [ ] Corticosteroids Intralesional corticosteroid therapy

2014 eMedicine.com

102. Cutaneous Manifestations of HIV Disease (Diagnosis)

related to HIV-1 infection. [ ] Beau lines, telogen effluvium, and pallor of the nail beds are the general effects of the chronic illness. Elongation of the eyelashes and softening and straightening of the scalp hair may be observed in HIV disease, and proximal subungual onychomycosis is also usually a sign of HIV disease. The frequency of onychomycosis may be higher in men than in women. Generalized alopecia can occur in patients with HIV who are treated with indinavir, an antiretroviral protease

2014 eMedicine.com

103. Acute Lymphoblastic Leukemia (Diagnosis)

survival. Leuk Res . 2017 May. 56:44-51. . [Guideline] NCCN Clinical Practice Guidelines in Oncology: Acute Lymphoblastic Leukemia. National Comprehensive Cancer Network. Available at . Version 5.2017 — October 27, 2017; Accessed: January 16, 2018. Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood . 2016 May 19. 127 (20):2391-405. . Roberts KG, Li Y, Payne-Turner D (...) of a phase II study of imatinib mesylate with hyper-CVAD for the front-line treatment of adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. Haematologica . 2015 May. 100 (5):653-61. . Ludwig WD, Rieder H, Bartram CR, Heinze B, Schwartz S, Gassmann W, et al. Immunophenotypic and genotypic features, clinical characteristics, and treatment outcome of adult pro-B acute lymphoblastic leukemia: results of the German multicenter trials GMALL 03/87 and 04/89. Blood . 1998 Sep 15

2014 eMedicine.com

104. Acute Myelogenous Leukemia (Diagnosis)

Organization classification of myeloid neoplasms and acute leukemia now includes a subtype "Myeloid neoplasms with germ line predisposition". [ ] Thus, to properly classify patients with AML, these genes must be included in nextgen panels. Some hereditary cancer syndromes, such as Li-Fraumeni syndrome, can manifest as leukemia. However, cases of leukemia are less common than the solid tumors that generally characterize these syndromes. Environmental exposures Several studies demonstrate a relationship (...) the and the , as well as and . Previous References Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood . 2016 May 19. 127 (20):2391-405. . . Smith MT, Skibola CF, Allan JM, Morgan GJ. Causal models of leukaemia and lymphoma. IARC Sci Publ . 2004. 373-92. . Ghiaur G, Wroblewski M, Loges S. Acute Myelogenous Leukemia and its Microenvironment: A Molecular Conversation. Semin Hematol

2014 eMedicine.com

105. Non-Hodgkin Lymphoma (Overview)

of a central line. In these individuals, consider biopsy performed under local anesthesia or immediate radiation therapy to the airway, provided that another site of disease is outside the radiation field (to allow for subsequent histologic confirmation of the diagnosis). Mediastinal tumors may cause compression of the great vessels ( ), with swelling of the neck, face, and upper extremities. Esophageal compression may lead to dysphagia. is sometimes observed and may be large enough to cause symptoms (...) cellular immunity. Anticancer Res . 1994 May-Jun. 14(3A):933-6. . van den Bosch CA. Is endemic Burkitt's lymphoma an alliance between three infections and a tumour promoter?. Lancet Oncol . 2004 Dec. 5(12):738-46. . Goldsby RE, Carroll WL. The molecular biology of pediatric lymphomas. J Pediatr Hematol Oncol . 1998 Jul-Aug. 20(4):282-96. . Lones MA, Sanger WG, Le Beau MM, Heerema NA, Sposto R, Perkins SL. Chromosome abnormalities may correlate with prognosis in Burkitt/Burkitt-like lymphomas

2014 eMedicine Pediatrics

106. Intestinal Transplantation (Follow-up)

one third of cases, this results in a remission of the PTLD. If improvement is not evident after 2 weeks, all immunosuppression should be discontinued and serious consideration should be given to additional therapeutic measures, including chemotherapy using R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) or adoptive immunotherapy. [ ] Radiotherapy is considered a second-line intervention against PTLD in both pediatric and adult patients. [ ] If necessary (...) , et al. 51Cr-EDTA: a marker of early intestinal rejection in the rat. J Surg Res . 1989 May. 46(5):507-14. . Buchman AL, Iyer K, Fryer J. Parenteral nutrition-associated liver disease and the role for isolated intestine and intestine/liver transplantation. Hepatology . 2006 Jan. 43(1):9-19. . Cavicchi M, Beau P, Crenn P, Degott C, Messing B. Prevalence of liver disease and contributing factors in patients receiving home parenteral nutrition for permanent intestinal failure. Ann Intern Med . 2000

2014 eMedicine Pediatrics

107. Non-Hodgkin Lymphoma (Treatment)

and antimetabolites. Current survival rates for patients with advanced disease are 65-75% for T-cell lymphoblastic lymphomas and 80-90% for those with B-cell lymphomas. Antibiotics If present, fever simply may reflect the underlying malignancy. However, consider beginning empiric, broad-spectrum antibiotic coverage until sepsis or focal infection (eg, due to bowel perforation) is excluded. Central venous access For most patients, a is necessary to manage chemotherapy. If feasible, multiple procedures (eg, line (...) the SFOP described surprising efficacy for monotherapy with vinblastine for relapsing anaplastic LCL, even in patients who previously underwent myeloablative therapy with autologous bone marrow transplantation. [ ] The role of vinblastine in front-line therapy for anaplastic LCL was examined in a Children's Oncology Group protocol (A5941), which compared the standard APO regimen with an experimental therapy that included vinblastine. Myelosuppression was more significant than anticipated and the trial

2014 eMedicine Pediatrics

108. Intestinal Transplantation (Overview)

or overt liver failure secondary to IFALD Thrombosis of two or more central veins Two or more episodes per year of systemic sepsis secondary to line infections, or a single episode of fungal sepsis [ ] Frequent episodes of severe dehydration Additional indications for intestinal transplantation include the following: High risk of death Severe short bowel syndrome (gastrostomy, duodenostomy, residual small bowel [< 10 cm in infants, < 20 cm in adults]) Intestinal failure with frequent hospitalizations (...) , narcotic dependency, or pseudoobstruction Patient unwillingness to accept long-term parenteral nutrition The advent of ethanol lock therapy [ , ] has reduced the number of catheter-related infections dramatically. This may reduce the number of patients with recurrent infections necessitating intestinal transplant. Flushing lines with a 70% ethanol solution between feedings led to a decline in the number of catheter-related blood stream infections from 10.1 per 1000 catheter-feed days to 2.9

2014 eMedicine Pediatrics

109. Intestinal Transplantation (Treatment)

one third of cases, this results in a remission of the PTLD. If improvement is not evident after 2 weeks, all immunosuppression should be discontinued and serious consideration should be given to additional therapeutic measures, including chemotherapy using R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) or adoptive immunotherapy. [ ] Radiotherapy is considered a second-line intervention against PTLD in both pediatric and adult patients. [ ] If necessary (...) , et al. 51Cr-EDTA: a marker of early intestinal rejection in the rat. J Surg Res . 1989 May. 46(5):507-14. . Buchman AL, Iyer K, Fryer J. Parenteral nutrition-associated liver disease and the role for isolated intestine and intestine/liver transplantation. Hepatology . 2006 Jan. 43(1):9-19. . Cavicchi M, Beau P, Crenn P, Degott C, Messing B. Prevalence of liver disease and contributing factors in patients receiving home parenteral nutrition for permanent intestinal failure. Ann Intern Med . 2000

2014 eMedicine Pediatrics

110. Intestinal and Multivisceral Transplantation (Treatment)

, line infection, wound infection, pulmonary infection, urinary tract infection, and viral enteritis. Sepsis is not uncommon with acute rejection, and this should always be remembered when evaluating a septic patient. Approximately 40% of small bowel transplant recipients require further surgery during their original inpatient stay; additional surgery is usually the result of infectious complications. [ ] Furthermore, these complications are primarily responsible for the prolonged hospitalizations (...) of these patients; ISB recipients typically are hospitalized for 3 weeks to 3 months, and LSB recipients typically are hospitalized for 3-6 months. Following small bowel transplantation, typical pathogens are enteric organisms, fungal species, or staphylococci (associated with central venous line infections). Bacterial infection appears to be far more common if the colon is included in the allograft; thus, inclusion of the colon is not the recommended protocol in many centers. [ ] Empiric antibiotic selection

2014 eMedicine Surgery

111. Non-Hodgkin Lymphoma (Diagnosis)

of a central line. In these individuals, consider biopsy performed under local anesthesia or immediate radiation therapy to the airway, provided that another site of disease is outside the radiation field (to allow for subsequent histologic confirmation of the diagnosis). Mediastinal tumors may cause compression of the great vessels ( ), with swelling of the neck, face, and upper extremities. Esophageal compression may lead to dysphagia. is sometimes observed and may be large enough to cause symptoms (...) cellular immunity. Anticancer Res . 1994 May-Jun. 14(3A):933-6. . van den Bosch CA. Is endemic Burkitt's lymphoma an alliance between three infections and a tumour promoter?. Lancet Oncol . 2004 Dec. 5(12):738-46. . Goldsby RE, Carroll WL. The molecular biology of pediatric lymphomas. J Pediatr Hematol Oncol . 1998 Jul-Aug. 20(4):282-96. . Lones MA, Sanger WG, Le Beau MM, Heerema NA, Sposto R, Perkins SL. Chromosome abnormalities may correlate with prognosis in Burkitt/Burkitt-like lymphomas

2014 eMedicine Pediatrics

112. Non-Hodgkin Lymphoma (Follow-up)

and antimetabolites. Current survival rates for patients with advanced disease are 65-75% for T-cell lymphoblastic lymphomas and 80-90% for those with B-cell lymphomas. Antibiotics If present, fever simply may reflect the underlying malignancy. However, consider beginning empiric, broad-spectrum antibiotic coverage until sepsis or focal infection (eg, due to bowel perforation) is excluded. Central venous access For most patients, a is necessary to manage chemotherapy. If feasible, multiple procedures (eg, line (...) the SFOP described surprising efficacy for monotherapy with vinblastine for relapsing anaplastic LCL, even in patients who previously underwent myeloablative therapy with autologous bone marrow transplantation. [ ] The role of vinblastine in front-line therapy for anaplastic LCL was examined in a Children's Oncology Group protocol (A5941), which compared the standard APO regimen with an experimental therapy that included vinblastine. Myelosuppression was more significant than anticipated and the trial

2014 eMedicine Pediatrics

113. Intestinal Transplantation (Diagnosis)

or overt liver failure secondary to IFALD Thrombosis of two or more central veins Two or more episodes per year of systemic sepsis secondary to line infections, or a single episode of fungal sepsis [ ] Frequent episodes of severe dehydration Additional indications for intestinal transplantation include the following: High risk of death Severe short bowel syndrome (gastrostomy, duodenostomy, residual small bowel [< 10 cm in infants, < 20 cm in adults]) Intestinal failure with frequent hospitalizations (...) , narcotic dependency, or pseudoobstruction Patient unwillingness to accept long-term parenteral nutrition The advent of ethanol lock therapy [ , ] has reduced the number of catheter-related infections dramatically. This may reduce the number of patients with recurrent infections necessitating intestinal transplant. Flushing lines with a 70% ethanol solution between feedings led to a decline in the number of catheter-related blood stream infections from 10.1 per 1000 catheter-feed days to 2.9

2014 eMedicine Pediatrics

114. Short-Bowel Syndrome (Treatment)

of intestine, the presence or absence of strictures or areas of stasis, bowel dilatation, and the intestinal transit time as described above. Various radiographic techniques, including contrast small-bowel follow-through and computed tomography (CT), are helpful in the decision. Transplant surgery is usually reserved for patients who are dependent on parenteral nutrition, who have run out of venous access, who have had several episodes of central line–related sepsis, or who have begun to manifest (...) . Gastroenterology . 1997 Nov. 113(5):1767-78. . Cavicchi M, Beau P, Crenn P, Degott C, Messing B. Prevalence of liver disease and contributing factors in patients receiving home parenteral nutrition for permanent intestinal failure. Ann Intern Med . 2000 Apr 4. 132 (7):525-32. . Klein S, Nealon WH. Hepatobiliary abnormalities associated with total parenteral nutrition. Semin Liver Dis . 1988 Aug. 8(3):237-46. . Quigley EM, Marsh MN, Shaffer JL, Markin RS. Hepatobiliary complications of total parenteral

2014 eMedicine Surgery

115. Short-Bowel Syndrome (Follow-up)

of intestine, the presence or absence of strictures or areas of stasis, bowel dilatation, and the intestinal transit time as described above. Various radiographic techniques, including contrast small-bowel follow-through and computed tomography (CT), are helpful in the decision. Transplant surgery is usually reserved for patients who are dependent on parenteral nutrition, who have run out of venous access, who have had several episodes of central line–related sepsis, or who have begun to manifest (...) . Gastroenterology . 1997 Nov. 113(5):1767-78. . Cavicchi M, Beau P, Crenn P, Degott C, Messing B. Prevalence of liver disease and contributing factors in patients receiving home parenteral nutrition for permanent intestinal failure. Ann Intern Med . 2000 Apr 4. 132 (7):525-32. . Klein S, Nealon WH. Hepatobiliary abnormalities associated with total parenteral nutrition. Semin Liver Dis . 1988 Aug. 8(3):237-46. . Quigley EM, Marsh MN, Shaffer JL, Markin RS. Hepatobiliary complications of total parenteral

2014 eMedicine Surgery

116. Intestinal and Multivisceral Transplantation (Follow-up)

, line infection, wound infection, pulmonary infection, urinary tract infection, and viral enteritis. Sepsis is not uncommon with acute rejection, and this should always be remembered when evaluating a septic patient. Approximately 40% of small bowel transplant recipients require further surgery during their original inpatient stay; additional surgery is usually the result of infectious complications. [ ] Furthermore, these complications are primarily responsible for the prolonged hospitalizations (...) of these patients; ISB recipients typically are hospitalized for 3 weeks to 3 months, and LSB recipients typically are hospitalized for 3-6 months. Following small bowel transplantation, typical pathogens are enteric organisms, fungal species, or staphylococci (associated with central venous line infections). Bacterial infection appears to be far more common if the colon is included in the allograft; thus, inclusion of the colon is not the recommended protocol in many centers. [ ] Empiric antibiotic selection

2014 eMedicine Surgery

117. Fingernail psoriasis reconsidered: A case-control study. (Abstract)

examination. The disease severity was measured by the NAPSI.Mean NAPSI score in patients and control subjects was 26.6 and 3.6, respectively. Most items included in the NAPSI were specific for nail psoriasis. Onycholysis and splinter hemorrhages were most frequently observed. Leukonychia was more frequent in control subjects. Longitudinal ridges and Beau lines are not included in the NAPSI but are significantly more frequently seen in patients than in control subjects.Limited sample size (...) was a limitation.The NAPSI was able to discriminate patients with fingernail psoriasis from healthy control subjects. Onycholysis and splinter hemorrhages were the most prevalent fingernail changes in psoriatic patients. Leukonychia was more frequently observed in control subjects, which raises the question of whether leukonychia should remain in the NAPSI. On the other hand, longitudinal ridges and Beau lines occurred more frequently in psoriasis but are not included in the NAPSI.Copyright © 2013 American Academy

2013 Journal of American Academy of Dermatology

118. Uphold Mesh for the Surgical Treatment of Uterine-predominant Prolapse

Frame: 12 months ] Presence/absence: anatomical success as concerns apical (uterine) support, defined as point C <= stage 1 per POP-Q scoreing (ICS) Anterior vaginal wall anatomical success [ Time Frame: 12 months ] Presence/absence: anatomical success on anterior vaginal wall support, defined as point Ba < = stage 1 per POP-Q scoring (ICS) Change from baseline in PFDI-20 scores [ Time Frame: baseline to 12 lines ] Secondary Outcome Measures : Anterior vaginal wall anatomical success [ Time Frame: 6 (...) Croix Rousse Lyon Cedex 4, France, 69317 APHM - Hôpital de la Conception Marseille Cedex 5, France, 13385 Clinique Beau Soleil Montpellier, France, 34070 CHU de Montpellier - Hôpital Lapeyronie Montpellier, France, 34295 CHU de Nîmes - Hôpital Universitaire Carémeau Nîmes Cedex 09, France, 30029 CH Louis Giorgi Orange, France, 84106 CHU de Poitiers Poitiers, France, 86021 Hôpital Foch Suresnes, France, 92150 Sponsors and Collaborators Centre Hospitalier Universitaire de Nīmes Investigators Layout

2012 Clinical Trials

119. Unilateral Versus Bilateral Neuromodulation Tests in the Treatment of Refractory Idiopathic Overactive Bladder

for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: The patient must have given his/her informed and signed consent The patient must be insured or beneficiary of a health insurance plan The patient is available for 1 month of follow-up The patient understands and reads French The patient has symptoms of overactive bladder resistant to first-line treatments (physiotherapy, anticholinergics) The patient suffers from (...) : Laurent Wagner, MD +33.(0)4.66.68.33.00 Contact: Carey M Suehs, Ph D +33.(0)4.66.68.67.88 Locations Layout table for location information France Clinique Beau Soleil Recruiting Montpellier, France, 34070 Sub-Investigator: Antoine Faix, MD CHU de Nantes - Hôtel Dieu Recruiting Nantes Cedex 1, France, 44093 Sub-Investigator: Loïc Le Normand, MD CHU de Nîmes - Hôpital Universitaire Carémeau Recruiting Nîmes Cedex 09, France, 30029 Principal Investigator: Laurent Wagner, MD Sub-Investigator: Stéphane

2012 Clinical Trials

120. Skin Lesions in Dialysis - Part 5

is not well understood but is thought to be due to increased beta-melanocyte stimulating hormone in the nail bed. This does not improve with dialysis. Other changes are also seen in the nails of dialysis patients. Beau's lines are characterized by transverse deep depressions. Mee's lines have a single white band in the nail plate. Terry's nails present with the proximal 2/3 being wide and pale with the distal 1/3 narrow and red. (Image on the left shows Beau's Lines [ ], Image on the right show half

2013 Renal Fellow Network

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