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Beau Lines

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101. Intestinal and Multivisceral Transplantation (Treatment)

, line infection, wound infection, pulmonary infection, urinary tract infection, and viral enteritis. Sepsis is not uncommon with acute rejection, and this should always be remembered when evaluating a septic patient. Approximately 40% of small bowel transplant recipients require further surgery during their original inpatient stay; additional surgery is usually the result of infectious complications. [ ] Furthermore, these complications are primarily responsible for the prolonged hospitalizations (...) of these patients; ISB recipients typically are hospitalized for 3 weeks to 3 months, and LSB recipients typically are hospitalized for 3-6 months. Following small bowel transplantation, typical pathogens are enteric organisms, fungal species, or staphylococci (associated with central venous line infections). Bacterial infection appears to be far more common if the colon is included in the allograft; thus, inclusion of the colon is not the recommended protocol in many centers. [ ] Empiric antibiotic selection

2014 eMedicine Surgery

102. Intestinal and Multivisceral Transplantation (Follow-up)

, line infection, wound infection, pulmonary infection, urinary tract infection, and viral enteritis. Sepsis is not uncommon with acute rejection, and this should always be remembered when evaluating a septic patient. Approximately 40% of small bowel transplant recipients require further surgery during their original inpatient stay; additional surgery is usually the result of infectious complications. [ ] Furthermore, these complications are primarily responsible for the prolonged hospitalizations (...) of these patients; ISB recipients typically are hospitalized for 3 weeks to 3 months, and LSB recipients typically are hospitalized for 3-6 months. Following small bowel transplantation, typical pathogens are enteric organisms, fungal species, or staphylococci (associated with central venous line infections). Bacterial infection appears to be far more common if the colon is included in the allograft; thus, inclusion of the colon is not the recommended protocol in many centers. [ ] Empiric antibiotic selection

2014 eMedicine Surgery

103. Short-Bowel Syndrome (Follow-up)

of intestine, the presence or absence of strictures or areas of stasis, bowel dilatation, and the intestinal transit time as described above. Various radiographic techniques, including contrast small-bowel follow-through and computed tomography (CT), are helpful in the decision. Transplant surgery is usually reserved for patients who are dependent on parenteral nutrition, who have run out of venous access, who have had several episodes of central line–related sepsis, or who have begun to manifest (...) . Gastroenterology . 1997 Nov. 113(5):1767-78. . Cavicchi M, Beau P, Crenn P, Degott C, Messing B. Prevalence of liver disease and contributing factors in patients receiving home parenteral nutrition for permanent intestinal failure. Ann Intern Med . 2000 Apr 4. 132 (7):525-32. . Klein S, Nealon WH. Hepatobiliary abnormalities associated with total parenteral nutrition. Semin Liver Dis . 1988 Aug. 8(3):237-46. . Quigley EM, Marsh MN, Shaffer JL, Markin RS. Hepatobiliary complications of total parenteral

2014 eMedicine Surgery

104. Intestinal and Multivisceral Transplantation (Overview)

diminished with the introduction of flexible, silastic, silicone rubber catheters; tunneled, cuffed catheters; and improved line care. [ , , ] Less common indications for intestinal transplantation include locally invasive desmoid tumors, premalignant conditions (Gardener syndrome), and fluid and electrolyte losses unmanageable with TPN. [ ] In summary, intestinal transplantation is a salvage procedure applied to patients who have either anatomic or functional diseases that preclude enteral tolerance (eg (...) of the central veins. Intestinal transplantation is considered when the patient has lost 2 or more common venous access sites, such as the subclavian or internal jugular veins, or when unconventional sites such as the right atrial, transhepatic, or direct inferior vena caval catheters are required. Patient history and previous records should reveal the number and type of organisms responsible for previous central venous line infections. Fungal infections requiring mechanical ventilation or vasopressor

2014 eMedicine Surgery

105. Non-Hodgkin Lymphoma (Diagnosis)

of a central line. In these individuals, consider biopsy performed under local anesthesia or immediate radiation therapy to the airway, provided that another site of disease is outside the radiation field (to allow for subsequent histologic confirmation of the diagnosis). Mediastinal tumors may cause compression of the great vessels ( ), with swelling of the neck, face, and upper extremities. Esophageal compression may lead to dysphagia. is sometimes observed and may be large enough to cause symptoms (...) cellular immunity. Anticancer Res . 1994 May-Jun. 14(3A):933-6. . van den Bosch CA. Is endemic Burkitt's lymphoma an alliance between three infections and a tumour promoter?. Lancet Oncol . 2004 Dec. 5(12):738-46. . Goldsby RE, Carroll WL. The molecular biology of pediatric lymphomas. J Pediatr Hematol Oncol . 1998 Jul-Aug. 20(4):282-96. . Lones MA, Sanger WG, Le Beau MM, Heerema NA, Sposto R, Perkins SL. Chromosome abnormalities may correlate with prognosis in Burkitt/Burkitt-like lymphomas

2014 eMedicine Pediatrics

106. Intestinal Transplantation (Diagnosis)

or overt liver failure secondary to IFALD Thrombosis of two or more central veins Two or more episodes per year of systemic sepsis secondary to line infections, or a single episode of fungal sepsis [ ] Frequent episodes of severe dehydration Additional indications for intestinal transplantation include the following: High risk of death Severe short bowel syndrome (gastrostomy, duodenostomy, residual small bowel [< 10 cm in infants, < 20 cm in adults]) Intestinal failure with frequent hospitalizations (...) , narcotic dependency, or pseudoobstruction Patient unwillingness to accept long-term parenteral nutrition The advent of ethanol lock therapy [ , ] has reduced the number of catheter-related infections dramatically. This may reduce the number of patients with recurrent infections necessitating intestinal transplant. Flushing lines with a 70% ethanol solution between feedings led to a decline in the number of catheter-related blood stream infections from 10.1 per 1000 catheter-feed days to 2.9

2014 eMedicine Pediatrics

107. Myelodysplastic Syndrome (Diagnosis)

marrow mimicking may be seen. Bone marrow cells display aberrant morphology and maturation (dysmyelopoiesis), resulting in ineffective blood cell production. MDS affects hematopoiesis at the stem cell level, as indicated by cytogenetic abnormalities, molecular mutations, and morphologic and physiologic abnormalities in maturation and differentiation of one or more of the hematopoietic cell lines. [ , , ] See the image below. Blood film (1000× magnification) demonstrating a vacuolated blast (...) published in 2008 and 2016. The 2016 WHO classification of MDS is as follows [ ] : MDS with single-lineage dysplasia (MDS-SLD) – 1 or 2 blood cytopenias; in bone marrow, dysplasia in ≥ 10% of one cell line, < 5% blasts MDS with multilineage dysplasia (MDS-MLD) – 1-3 blood cytopenias, < 1 × 10 9 /L monocytes; in bone marrow, dysplasia in ≥ 10% of cells in ≥ 2 hematopoietic lineages < 15% ring sideroblasts (or < 5% ring sideroblasts if SF3B1 mutation present) < 5% blasts MDS with ring sideroblasts (MDS-RS

2014 eMedicine.com

108. Intestinal and Multivisceral Transplantation (Diagnosis)

diminished with the introduction of flexible, silastic, silicone rubber catheters; tunneled, cuffed catheters; and improved line care. [ , , ] Less common indications for intestinal transplantation include locally invasive desmoid tumors, premalignant conditions (Gardener syndrome), and fluid and electrolyte losses unmanageable with TPN. [ ] In summary, intestinal transplantation is a salvage procedure applied to patients who have either anatomic or functional diseases that preclude enteral tolerance (eg (...) of the central veins. Intestinal transplantation is considered when the patient has lost 2 or more common venous access sites, such as the subclavian or internal jugular veins, or when unconventional sites such as the right atrial, transhepatic, or direct inferior vena caval catheters are required. Patient history and previous records should reveal the number and type of organisms responsible for previous central venous line infections. Fungal infections requiring mechanical ventilation or vasopressor

2014 eMedicine Surgery

109. Fingernail psoriasis reconsidered: A case-control study. (Abstract)

examination. The disease severity was measured by the NAPSI.Mean NAPSI score in patients and control subjects was 26.6 and 3.6, respectively. Most items included in the NAPSI were specific for nail psoriasis. Onycholysis and splinter hemorrhages were most frequently observed. Leukonychia was more frequent in control subjects. Longitudinal ridges and Beau lines are not included in the NAPSI but are significantly more frequently seen in patients than in control subjects.Limited sample size (...) was a limitation.The NAPSI was able to discriminate patients with fingernail psoriasis from healthy control subjects. Onycholysis and splinter hemorrhages were the most prevalent fingernail changes in psoriatic patients. Leukonychia was more frequently observed in control subjects, which raises the question of whether leukonychia should remain in the NAPSI. On the other hand, longitudinal ridges and Beau lines occurred more frequently in psoriasis but are not included in the NAPSI.Copyright © 2013 American Academy

2013 Journal of American Academy of Dermatology

110. Unilateral Versus Bilateral Neuromodulation Tests in the Treatment of Refractory Idiopathic Overactive Bladder

for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: The patient must have given his/her informed and signed consent The patient must be insured or beneficiary of a health insurance plan The patient is available for 1 month of follow-up The patient understands and reads French The patient has symptoms of overactive bladder resistant to first-line treatments (physiotherapy, anticholinergics) The patient suffers from (...) : Laurent Wagner, MD +33.(0)4.66.68.33.00 Contact: Carey M Suehs, Ph D +33.(0)4.66.68.67.88 Locations Layout table for location information France Clinique Beau Soleil Recruiting Montpellier, France, 34070 Sub-Investigator: Antoine Faix, MD CHU de Nantes - Hôtel Dieu Recruiting Nantes Cedex 1, France, 44093 Sub-Investigator: Loïc Le Normand, MD CHU de Nîmes - Hôpital Universitaire Carémeau Recruiting Nîmes Cedex 09, France, 30029 Principal Investigator: Laurent Wagner, MD Sub-Investigator: Stéphane

2012 Clinical Trials

111. Uphold Mesh for the Surgical Treatment of Uterine-predominant Prolapse

Frame: 12 months ] Presence/absence: anatomical success as concerns apical (uterine) support, defined as point C <= stage 1 per POP-Q scoreing (ICS) Anterior vaginal wall anatomical success [ Time Frame: 12 months ] Presence/absence: anatomical success on anterior vaginal wall support, defined as point Ba < = stage 1 per POP-Q scoring (ICS) Change from baseline in PFDI-20 scores [ Time Frame: baseline to 12 lines ] Secondary Outcome Measures : Anterior vaginal wall anatomical success [ Time Frame: 6 (...) Croix Rousse Lyon Cedex 4, France, 69317 APHM - Hôpital de la Conception Marseille Cedex 5, France, 13385 Clinique Beau Soleil Montpellier, France, 34070 CHU de Montpellier - Hôpital Lapeyronie Montpellier, France, 34295 CHU de Nîmes - Hôpital Universitaire Carémeau Nîmes Cedex 09, France, 30029 CH Louis Giorgi Orange, France, 84106 CHU de Poitiers Poitiers, France, 86021 Hôpital Foch Suresnes, France, 92150 Sponsors and Collaborators Centre Hospitalier Universitaire de Nīmes Investigators Layout

2012 Clinical Trials

112. Skin Lesions in Dialysis - Part 5

is not well understood but is thought to be due to increased beta-melanocyte stimulating hormone in the nail bed. This does not improve with dialysis. Other changes are also seen in the nails of dialysis patients. Beau's lines are characterized by transverse deep depressions. Mee's lines have a single white band in the nail plate. Terry's nails present with the proximal 2/3 being wide and pale with the distal 1/3 narrow and red. (Image on the left shows Beau's Lines [ ], Image on the right show half

2013 Renal Fellow Network

114. Nail Deformities and Dystrophies

with lymphedema of limbs and/or chronic respiratory disorders. Yellow Nail Syndrome © Springer Science+Business Media Half-and-half nails (Lindsay nails) occur usually with ; the proximal half of the nail is white, and the distal half is pink or pigmented. Lindsay Nails (Half-and-Half Nails) © Springer Science+Business Media White nails occur with , although the distal third may remain pinker. Terry Nails © Springer Science+Business Media Beau Lines Due to Chemotherapy © Springer Science+Business Media Beau (...) Lines © Springer Science+Business Media Beau lines are horizontal grooves in the nail plate that occur when nail growth temporarily slows, which can occur after infection, trauma, or systemic illness. Onychomadesis similarly results from temporary growth arrest of the nail plate and differs from Beau lines in that the full thickness of the nail is involved, causing a proximal separation of the nail plate from the nail bed. It most frequently occurs several months after but can occur after other

2013 Merck Manual (19th Edition)

115. Nail disorders in children: diagnosis and management. (Abstract)

but are usually not the first clue to the diagnosis. Beau lines on several fingernails are very common in children after temperature crest. Tumors are rare in children. Radiographic examination allows confirmation of the diagnosis of subungual exostosis. Other cases should undergo biopsy. Single-digit longitudinal melanonychia in children is mostly due to nevi. Its management should be tailored on a case-by-case basis. Acute trauma should never be underestimated in children and hand surgeons should

2011 American journal of clinical dermatology

116. Kawasaki disease Full Text available with Trip Pro

the original on 2011-11-20 . Retrieved 2010-04-16 . CS1 maint: Archived copy as title ( ) Wang S, Best BM, Burns JC (June 2009). . . 28 (6): 538–9. : . . . Michie C, Kinsler V, Tulloh R, Davidson S (October 2000). . . 83 (4): 353–5. : . . . ^ López Neyra A, Alvarez-Coca González J, Pérez Suárez E, Martínez Pérez J, Rubio Villanueva JL (December 2007). "Líneas de Beau y enfermedad de Kawasaki" [Beau's lines and Kawasaki disease]. Anales de Pediatría (in Spanish). 67 (6): 610–1. : . . González Pascual E

2012 Wikipedia

117. Mastocytosis Full Text available with Trip Pro

to inactivation of pancreatic enzymes by increased acid) Hepatosplenomegaly Pathophysiology [ ] are located in , including the , the linings of the stomach and intestine, and other sites. They play an important role in the immune defence against bacteria and parasites. By releasing chemical "alarms" such as , mast cells attract other key players of the to areas of the body where they are needed. [ ] Mast cells seem to have other roles as well. Because they gather together around , mast cells may play a part (...) A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, Bloomfield CD, Cazzola M, Vardiman JW (May 2016). "The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia". Blood . 127 (20): 2391–405. : . . Hermine O, Lortholary O, Leventhal PS, et al. (2008). Soyer HP, ed. . PLOS One . 3 (5): e2266. : . . . Moura DS, Sultan S, Georgin-Lavialle S, Pillet N, Montestruc F, Gineste P, Barete S, Damaj G, Moussy A, Lortholary O, Hermine O (2011). . PLOS One . 6 (10): e26375

2012 Wikipedia

118. Acute megakaryoblastic leukemia

) behind these cases of secondary AMKL are unknown although an in at positions q21 and q26, i.e. inv(3)(q21q26), is often seen in these secondary cases of adult-AMKL. Rare cases of adult-AMKL also have . These tumors are malignancies of , i.e. primitive cells that give rise to and cells. In adult-AMKL, mediastinal germ cell tumors that are associated with adult-AMKL are not seminomas (i.e. do not originate from the sperm cell line) and occur before or concomitantly with but not after the diagnosis AMKL (...) , immunochemical evidence that these blast cells bear platelet line-specific markers, and occurrence of the genetic aberrations in these blast cells that have been associated with the disease. Treatment [ ] Adult-AMKL has remained poorly responsive to the treatment regiments used in DS-AMKL and non-DS-AMKL. These treatments have given complete remission rates of 43-50%. Prognosis [ ] The prognosis of adult-AMKL in patients treated for the disease is far below that of other forms of AMKL. Their median overall

2012 Wikipedia

119. Acute myeloid leukemia

or , , , Treatment , , Prognosis ~27% (US) Frequency 1 million (2015) Deaths 147,100 (2015) Acute myeloid leukemia ( AML ) is a of the line of , characterized by the rapid growth of abnormal cells that build up in the and and interfere with . Symptoms may include feeling tired, , easy bruising and bleeding, and increased risk of . Occasionally, spread may occur to the brain, skin, or gums. As an , AML progresses rapidly and is typically fatal within weeks or months if left untreated. include , previous (...) and/or the activation of proto-oncogenes. Treatment [ ] First-line treatment of AML consists primarily of , and is divided into two phases: induction and postremission (or consolidation) therapy. The goal of induction therapy is to achieve a complete remission by reducing the number of leukemic cells to an undetectable level; the goal of consolidation therapy is to eliminate any residual undetectable disease and achieve a cure. Hematopoietic stem cell transplantation is usually considered if induction chemotherapy

2012 Wikipedia

120. Acute lymphoblastic leukemia

, or cranial nerve palsies (CNS involvement) Frequent or unexplained and Weight loss and/or loss of appetite Excessive and unexplained bruising Bone pain, joint pain (caused by the spread of "blast" cells to the surface of the bone or into the joint from the marrow cavity) Breathlessness Enlarged lymph nodes, liver and/or spleen Pitting edema (swelling) in the lower limbs and/or abdomen Petechiae, which are tiny red spots or lines in the skin due to low levels Testicular enlargement Mediastinal mass Cause (...) electromagnetic radiation from power lines has also been associated with a slightly increased risk of ALL. This result is questioned as no causal mechanism linking electromagnetic radiation with cancer is known. High birth weight (greater than 4000g or 8.8lbs) is also associated with a small increased risk. The mechanism connecting high birth weight to ALL is also not known. Evidence suggests that can develop in individuals treated with certain types of chemotherapy, such as and . Delayed infection hypothesis

2012 Wikipedia

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