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Beau Lines

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41. Acute and Chronic Heart Failure

12.3 Invasive monitoring . . . . . . . . . . . . . . . . . . . . . . . .1831 12.3.1 Intra-arterial line . . . . . . . . . . . . . . . . . . . . . . .1831 12.3.2 Pulmonary artery catheterization . . . . . . . . . . . .1831 12.4 Monitoring after stabilization . . . . . . . . . . . . . . . . . .1831 12.5 Other in-patient assessments . . . . . . . . . . . . . . . . .1831 12.6 Readiness for discharge . . . . . . . . . . . . . . . . . . . . .1831 12.7 Special patient populations (...) of the indication for mineralocorticoid (aldosterone) receptor antagonists (MRAs); (ii) a new indication for the sinus node inhibitor ivabradine; (iii) an expanded indication for cardiac resynchronization therapy (CRT); (iv) new information on the role of coronary revascularization in HF; (v) recognition of the growing use of ventricular assist devices; and (vi) the emergence of transcatheter valve interventions. There are also changes to the structure and format of the guide- lines. Therapeutic recommendations

2012 European Society of Cardiology

42. Nail psoriasis – what a rheumatologist should know about (PubMed)

was searched using the key words 'nail psoriasis' and 'psoriatic arthritis'. Psoriasis involving the nail matrix shows up as changes such as pitting, Beau lines, leukonychia, red spots in the lunula, or nail plate crumbling. Nail bed psoriasis manifests as onycholysis, oil drops (or salmon patches), dyschromia, splinter hemorrhages, or subungual hyperkeratosis. Nail psoriasis and psoriatic lesions in the gluteal cleft and on the scalp usually accompany PsA, especially in adult men.

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2017 Reumatologia

43. Laboratory Diagnosis of Malaria

. vivax infection, the species cannot be determined (v) quantification is not possible (vi) operator misunderstanding or misinterpretation of test line patterns may lead to apparent discrepancy between RDT and blood film results (vii) rarely, a prozone effect may occur with HRP2 based RDTs (Luchavez et al , ). Currently available RDTs cannot specifically identify P. knowlesi . HRP2‐based test lines detect only P. falciparum . Plasmodium lactate dehydrogenase (pLDH) and aldolase‐based test lines may (...) detect P. knowlesi as ‘malaria parasites’ but cannot identify the species. A hospital study in Malaysia detected 74% of PCR‐confirmed P. knowlesi using a pan‐pLDH RDT test line and a pan‐aldolase RDT test line detected 23%. The authors commented that neither the pLDH‐ nor aldolase‐based RDT they tested demonstrated sufficiently high overall sensitivity for P. knowlesi (Barber et al , ). The World Health Organization has produced detailed performance assessment of commercially available RDTs (see

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2013 British Committee for Standards in Haematology

44. Diagnosis and management of myelofibrosis

for a median of 6 months after discontinuation of therapy (Faoro et al , ). JAK inhibitors JAK inhibitors may have a future role in the management of splenomegaly (see ‘Novel Therapies’ section) and are the only therapies to have been evaluated in the context of randomized clinical trials. Recommendations: medical management of splenomegaly First Line: Hydroxycarbamide (in the absence of cytopenias). Thalidomide and prednisolone (in presence of cytopenias) – consider lenalidomide (if anaemic with platelet (...) count >100 × 10 9 /l). Second Line: Consideration should be given to the use of JAK inhibitors either as part of a clinical trial, or via patient access protocols. These agents are now approved in the USA for first line therapy which is appropriate following approval (Evidence level 1, Grade A). Surgical management The place of splenectomy in the management of myelofibrosis is well established (Barosi et al , ; Tefferi et al , ). Routine splenectomy is inappropriate and the procedure should

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2012 British Committee for Standards in Haematology

45. Idiopathic Sporadic Onychomadesis of Toenails (PubMed)

Idiopathic Sporadic Onychomadesis of Toenails Onychomadesis is a clinical sign of nail plate separation due to transient or permanent arrest of nail matrix activities. Onychomadesis can be considered as a severe form of Beau's line. This condition usually occurs after trauma, causal diseases, or medications, yet it rarely occurs as an idiopathic condition. We report a case of a 38-year-old Thai female who developed recurrence onychomadesis in several toenails in the absence of predisposing

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2016 Case reports in dermatological medicine

46. Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies Treatment (PDQ®): Health Professional Version

abnormalities in presence of persistent cytopenias of undetermined origin should be considered to support a presumptive diagnosis of MDS when morphological characteristics are not observed. f The diagnostic criteria for childhood MDS (refractory cytopenia of childhood [RCC]-provisional entry) include: 1) persistent cytopenia of 1–3 cell lines with <5% bone marrow blasts, <2% peripheral blood blasts, and no ringed sideroblasts and 2) dysplastic changes in 1–3 lineages should be present. Table 4. Definitions

2015 PDQ - NCI's Comprehensive Cancer Database

48. The 10 Ps of Marijuana Legalization

of heavy users. There are also concerns that a for-profit industry and its lobbyists will fight against regulation and taxation. Thus, serious thought should be given to whether marijuana should be supplied by profit-maximizing firms. Besides home production and cooperatives, other options include limiting the market to nonprofit organizations or “for-benefit corporations,” which typically focus on the triple-bottom line of people, planet, and profits. Jurisdictions could also limit supply to a state (...) in Washington, D.C., and collectives being implemented in Uruguay highlight some of the other non-commercial approaches. While these 10 Ps are not the only choices confronting jurisdictions considering changes in marijuana policy, they cover many of the critical decisions that will determine whether removing prohibition is a good idea. May they serve as fodder for debate and as an outline for jurisdictions seeking guidance if they decide to legalize. Beau Kilmer is the co-director of the RAND Drug Policy

2015 The RAND blog

49. Unprecedented Changes in Marijuana Policy

that the increase in marijuana use resulting from legal availability and lower prices will increase dependence and other negative health consequences, such as contributing to a rise in individuals experiencing psychotic symptoms. Opponents also fear that marijuana will be marketed in the same manner as alcohol and that there will be a new industry with lobbyists who would fight against regulation and taxation (or, for that matter, that existing tobacco companies might enter this line of business) The remainder (...) of this commentary is available on . Beau Kilmer is co-director of the RAND Drug Policy Research Center and co-author of " ," (Oxford University Press, 2012). This commentary originally appeared in Britannica Book of the Year on April 21, 2015. Commentary gives RAND researchers a platform to convey insights based on their professional expertise and often on their peer-reviewed research and analysis. Codirector, RAND Drug Policy Research Center; Interim Director, RAND San Francisco Bay Area; Senior Policy

2015 The RAND blog

52. Pilot Study of Efficacy of Nail Gel in Finger Nail Surface Abnormality

: Mahidol University Information provided by (Responsible Party): Mahidol University Study Details Study Description Go to Brief Summary: Nail surface abnormalities is any conditions that affect the nail matrix or nail bed which cause nail plates grow defectively. Common nail surface abnormalities are pitting nails, longitudinal ridging, and transverse ridging/Beau's line. Aging nails usually have nail surface abnormalities as well. Nail gels are artificial nails used widely for aesthetic purposes

2015 Clinical Trials

53. Nail findings in hand-foot-and-mouth disease. (PubMed)

Nail findings in hand-foot-and-mouth disease. Hand-foot-and-mouth disease (HFMD) is a common self-limited viral illness seen in the United States and around the world. Its classic features are easily recognizable; however, nail changes are not well known or characterized. This case demonstrates onychomadesis and Beau lines in a child following clinical diagnosis of hand-foot-and-mouth disease. In this setting, nail dystrophies should be reassuring to pediatricians and families.

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2015 Pediatric Infectious Dsease Journal

54. Skin Lesions in Dialysis - Part 5

is not well understood but is thought to be due to increased beta-melanocyte stimulating hormone in the nail bed. This does not improve with dialysis. Other changes are also seen in the nails of dialysis patients. Beau's lines are characterized by transverse deep depressions. Mee's lines have a single white band in the nail plate. Terry's nails present with the proximal 2/3 being wide and pale with the distal 1/3 narrow and red. (Image on the left shows Beau's Lines [ ], Image on the right show half

2013 Renal Fellow Network

55. Onychomadesis: Literature Review. (PubMed)

using the same terms. In total 56 articles have been published, including our previously reported series of idiopathic onychomadesis. Articles pertaining only to Beau's lines and not true onychomadesis were excluded. Onychomadesis has been associated with autoimmune disease, other major medical illness, neonatal illness, medication and infection. © 2014 British Association of Dermatologists.

2014 British Journal of Dermatology

56. Leukemia, Adult Acute Myeloid

) criteria, the classification of AML is solely based upon morphology as determined by the degree of differentiation along different cell lines and the extent of cell maturation.[ , ] Under the WHO classification, the category “acute myeloid leukemia not otherwise categorized” is morphology-based and reflects the FAB classification with a few significant modifications.[ , ] The most significant difference between the WHO and FAB classifications is the WHO recommendation that the requisite blast (...) dysplasia” as one of the following: AML evolving from an MDS. AML following an MDS. AML with multilineage dysplasia is characterized by 20% or more blasts in the blood or bone marrow and dysplasia in two or more myeloid cell lines, generally including megakaryocytes.[ ] To make the diagnosis, dysplasia must be present in 50% or more of the cells of at least two lineages and must be present in a pretreatment bone marrow specimen.[ , ] AML with multilineage dysplasia may occur de novo or following MDS

2012 PDQ - NCI's Comprehensive Cancer Database

57. Myeloid Leukemia, Childhood Acute/Other Childhood Myeloid Malignancies

MDS (refractory cytopenia of childhood [RCC]-provisional entry) include: 1) persistent cytopenia of 1–3 cell lines with <5% bone marrow blasts, <2% peripheral blood blasts, and no ringed sideroblasts and 2) dysplastic changes in 1–3 lineages should be present. MDS with single lineage dysplasia Unilineage dysplasia: ≥10% in one myeloid lineage 1–2 cytopenias b <5% blasts Blasts <1% c <15% ring sideroblasts MDS with ring sideroblasts (MDS-RS) Erythroid dysplasia only <5% blasts No blasts ≥15% ring

2012 PDQ - NCI's Comprehensive Cancer Database

58. Intestinal and Multivisceral Transplantation (Diagnosis)

diminished with the introduction of flexible, silastic, silicone rubber catheters; tunneled, cuffed catheters; and improved line care. [ , , ] Less common indications for intestinal transplantation include locally invasive desmoid tumors, premalignant conditions (Gardener syndrome), and fluid and electrolyte losses unmanageable with TPN. [ ] In summary, intestinal transplantation is a salvage procedure applied to patients who have either anatomic or functional diseases that preclude enteral tolerance (eg (...) of the central veins. Intestinal transplantation is considered when the patient has lost 2 or more common venous access sites, such as the subclavian or internal jugular veins, or when unconventional sites such as the right atrial, transhepatic, or direct inferior vena caval catheters are required. Patient history and previous records should reveal the number and type of organisms responsible for previous central venous line infections. Fungal infections requiring mechanical ventilation or vasopressor

2014 eMedicine Surgery

59. Intestinal and Multivisceral Transplantation (Follow-up)

, line infection, wound infection, pulmonary infection, urinary tract infection, and viral enteritis. Sepsis is not uncommon with acute rejection, and this should always be remembered when evaluating a septic patient. Approximately 40% of small bowel transplant recipients require further surgery during their original inpatient stay; additional surgery is usually the result of infectious complications. [ ] Furthermore, these complications are primarily responsible for the prolonged hospitalizations (...) of these patients; ISB recipients typically are hospitalized for 3 weeks to 3 months, and LSB recipients typically are hospitalized for 3-6 months. Following small bowel transplantation, typical pathogens are enteric organisms, fungal species, or staphylococci (associated with central venous line infections). Bacterial infection appears to be far more common if the colon is included in the allograft; thus, inclusion of the colon is not the recommended protocol in many centers. [ ] Empiric antibiotic selection

2014 eMedicine Surgery

60. Myelodysplastic Syndrome (Diagnosis)

marrow mimicking may be seen. Bone marrow cells display aberrant morphology and maturation (dysmyelopoiesis), resulting in ineffective blood cell production. MDS affects hematopoiesis at the stem cell level, as indicated by cytogenetic abnormalities, molecular mutations, and morphologic and physiologic abnormalities in maturation and differentiation of one or more of the hematopoietic cell lines. [ , , ] See the image below. Blood film (1000× magnification) demonstrating a vacuolated blast (...) published in 2008 and 2016. The 2016 WHO classification of MDS is as follows [ ] : MDS with single-lineage dysplasia (MDS-SLD) – 1 or 2 blood cytopenias; in bone marrow, dysplasia in ≥ 10% of one cell line, < 5% blasts MDS with multilineage dysplasia (MDS-MLD) – 1-3 blood cytopenias, < 1 × 10 9 /L monocytes; in bone marrow, dysplasia in ≥ 10% of cells in ≥ 2 hematopoietic lineages < 15% ring sideroblasts (or < 5% ring sideroblasts if SF3B1 mutation present) < 5% blasts MDS with ring sideroblasts (MDS-RS

2014 eMedicine.com

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