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Beau Lines

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41. Acute and Chronic Heart Failure

12.3 Invasive monitoring . . . . . . . . . . . . . . . . . . . . . . . .1831 12.3.1 Intra-arterial line . . . . . . . . . . . . . . . . . . . . . . .1831 12.3.2 Pulmonary artery catheterization . . . . . . . . . . . .1831 12.4 Monitoring after stabilization . . . . . . . . . . . . . . . . . .1831 12.5 Other in-patient assessments . . . . . . . . . . . . . . . . .1831 12.6 Readiness for discharge . . . . . . . . . . . . . . . . . . . . .1831 12.7 Special patient populations (...) of the indication for mineralocorticoid (aldosterone) receptor antagonists (MRAs); (ii) a new indication for the sinus node inhibitor ivabradine; (iii) an expanded indication for cardiac resynchronization therapy (CRT); (iv) new information on the role of coronary revascularization in HF; (v) recognition of the growing use of ventricular assist devices; and (vi) the emergence of transcatheter valve interventions. There are also changes to the structure and format of the guide- lines. Therapeutic recommendations

2012 European Society of Cardiology

42. Suicide Prevention Interventions and Referral/Follow-up Services

report when possible; however, when describing results from primary studies, we use terminology as reported in the original articles in order to describe outcomes consistent with the primary studies. 9 Suicide Prevention Interventions and Referral/Follow-up Services: A Systematic Review Evidence-based Synthesis Program Figure 1. Suicide Prevention Analytical Model Population-level interventions Help seeking resources (e.g., crisis • lines) Public education (e.g., PSAs on • suicide awareness

2012 Veterans Affairs Evidence-based Synthesis Program Reports

43. Involvement of Nail Apparatus in Pemphigus Vulgaris in Ethnic Poles Is Infrequent Full Text available with Trip Pro

apparatus changes included, by order of frequency, paronychia, nail discoloration, onychorrhexis, Beau lines, periungual hemorrhages, onychomadesis, cross-ridging, onycholysis, and trachyonychia. The average time between the onset, as recalled by patients, and the diagnosis of pemphigus vulgaris with direct immunofluorescence was not statistically different in PV patients with and without nail apparatus lesions. In this article the molecular and immunological rationale for of periungual involvement

2018 Frontiers in medicine

44. ASPEN Clinical Guidelines: Support of Pediatric Patients with Intestinal Failure at Risk of Parenteral Nutrition - Associated Liver Disease

. After the author response to the initial reviews, the guideline was reviewed and approved by the A.S.P.E.N. Board of Directors and their legal consultant. Results Four questions were developed to be addressed by this guide- line. The questions and recommendations are summarized in Table 1. For the current Clinical Guideline, the following terms were used to search PubMed and CINAHL until May 2013: intestinal failure, short bowel syndrome, clinical outcomes, lipid, bloodstream infection, team (...) et al, 2012 54 Retrospective case series HPN patients, N = 4 Report case series of catheter complications after use of 70% ethanol lock 3 times weekly Thrombosis in line when ethanol withdrawn at 413 days (n = 1), at 168 days (n = 1), at 9 days (n = 1), and CVC occlusion at 3 days (n = 1). The occlusion cleared after stopping ethanol lock. Wales et al, 2011 55 Retrospective case series HPN patients with at least 1 previous CLABSI. N = 10 Median age 44 months (range, 31–129 months) Body weight: 5

2014 American Society for Parenteral and Enteral Nutrition

46. Laboratory Diagnosis of Malaria

. vivax infection, the species cannot be determined (v) quantification is not possible (vi) operator misunderstanding or misinterpretation of test line patterns may lead to apparent discrepancy between RDT and blood film results (vii) rarely, a prozone effect may occur with HRP2 based RDTs (Luchavez et al , ). Currently available RDTs cannot specifically identify P. knowlesi . HRP2‐based test lines detect only P. falciparum . Plasmodium lactate dehydrogenase (pLDH) and aldolase‐based test lines may (...) detect P. knowlesi as ‘malaria parasites’ but cannot identify the species. A hospital study in Malaysia detected 74% of PCR‐confirmed P. knowlesi using a pan‐pLDH RDT test line and a pan‐aldolase RDT test line detected 23%. The authors commented that neither the pLDH‐ nor aldolase‐based RDT they tested demonstrated sufficiently high overall sensitivity for P. knowlesi (Barber et al , ). The World Health Organization has produced detailed performance assessment of commercially available RDTs (see

2013 British Committee for Standards in Haematology

47. Diagnosis and management of myelofibrosis

for a median of 6 months after discontinuation of therapy (Faoro et al , ). JAK inhibitors JAK inhibitors may have a future role in the management of splenomegaly (see ‘Novel Therapies’ section) and are the only therapies to have been evaluated in the context of randomized clinical trials. Recommendations: medical management of splenomegaly First Line: Hydroxycarbamide (in the absence of cytopenias). Thalidomide and prednisolone (in presence of cytopenias) – consider lenalidomide (if anaemic with platelet (...) count >100 × 10 9 /l). Second Line: Consideration should be given to the use of JAK inhibitors either as part of a clinical trial, or via patient access protocols. These agents are now approved in the USA for first line therapy which is appropriate following approval (Evidence level 1, Grade A). Surgical management The place of splenectomy in the management of myelofibrosis is well established (Barosi et al , ; Tefferi et al , ). Routine splenectomy is inappropriate and the procedure should

2012 British Committee for Standards in Haematology

48. Nail psoriasis – what a rheumatologist should know about Full Text available with Trip Pro

was searched using the key words 'nail psoriasis' and 'psoriatic arthritis'. Psoriasis involving the nail matrix shows up as changes such as pitting, Beau lines, leukonychia, red spots in the lunula, or nail plate crumbling. Nail bed psoriasis manifests as onycholysis, oil drops (or salmon patches), dyschromia, splinter hemorrhages, or subungual hyperkeratosis. Nail psoriasis and psoriatic lesions in the gluteal cleft and on the scalp usually accompany PsA, especially in adult men.

2017 Reumatologia

49. Childhood Cancer Genomics (PDQ®): Health Professional Version

, a gene involved in purine biosynthesis.[ ] Mutations were observed in 13.0% of a Chinese cohort and 2.7% of a German cohort, and were observed in patients with on-treatment relapses. The PRSP1 mutations observed in relapsed cases induce resistance to thiopurines in leukemia cell lines. CREBBP mutations are also enriched at relapse and appear to be associated with increased resistance to glucocorticoids.[ , ] With increased understanding of the genomics of relapse, it may be possible to tailor upfront

2016 PDQ - NCI's Comprehensive Cancer Database

50. Adult Acute Myeloid Leukemia Treatment (PDQ®): Health Professional Version

morphology, cytogenetics, molecular genetics, and immunologic markers in an attempt to construct a classification that is universally applicable and prognostically valid.[ ] In the older French-American-British (FAB) criteria, the classification of AML is solely based upon morphology as determined by the degree of differentiation along different cell lines and the extent of cell maturation.[ , ] Under the WHO classification, the category “acute myeloid leukemia not otherwise categorized” is morphology (...) With Multilineage Dysplasia In the WHO classification, refractory anemia with excess blasts in transformation (RAEB-t) is no longer considered a distinct clinical entity and is instead included within the broader category “AML with multilineage dysplasia” as one of the following: AML evolving from an MDS. AML following an MDS. AML with multilineage dysplasia is characterized by 20% or more blasts in the blood or bone marrow and dysplasia in two or more myeloid cell lines, generally including megakaryocytes

2016 PDQ - NCI's Comprehensive Cancer Database

51. Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies Treatment (PDQ®): Health Professional Version

be considered to support a presumptive diagnosis of MDS when morphological characteristics are not observed. f The diagnostic criteria for childhood MDS (refractory cytopenia of childhood [RCC]-provisional entry) include: 1) persistent cytopenia of 1–3 cell lines with <5% bone marrow blasts, <2% peripheral blood blasts, and no ringed sideroblasts and 2) dysplastic changes in 1–3 lineages should be present. Table 4. Definitions for Minimal Diagnostic Criteria for Childhood Myelodysplastic Syndrome (MDS

2015 PDQ - NCI's Comprehensive Cancer Database

52. Idiopathic Sporadic Onychomadesis of Toenails Full Text available with Trip Pro

Idiopathic Sporadic Onychomadesis of Toenails Onychomadesis is a clinical sign of nail plate separation due to transient or permanent arrest of nail matrix activities. Onychomadesis can be considered as a severe form of Beau's line. This condition usually occurs after trauma, causal diseases, or medications, yet it rarely occurs as an idiopathic condition. We report a case of a 38-year-old Thai female who developed recurrence onychomadesis in several toenails in the absence of predisposing

2016 Case reports in dermatological medicine

53. Pilot Study of Efficacy of Nail Gel in Finger Nail Surface Abnormality

: Mahidol University Information provided by (Responsible Party): Mahidol University Study Details Study Description Go to Brief Summary: Nail surface abnormalities is any conditions that affect the nail matrix or nail bed which cause nail plates grow defectively. Common nail surface abnormalities are pitting nails, longitudinal ridging, and transverse ridging/Beau's line. Aging nails usually have nail surface abnormalities as well. Nail gels are artificial nails used widely for aesthetic purposes

2015 Clinical Trials

54. Nail findings in hand-foot-and-mouth disease. (Abstract)

Nail findings in hand-foot-and-mouth disease. Hand-foot-and-mouth disease (HFMD) is a common self-limited viral illness seen in the United States and around the world. Its classic features are easily recognizable; however, nail changes are not well known or characterized. This case demonstrates onychomadesis and Beau lines in a child following clinical diagnosis of hand-foot-and-mouth disease. In this setting, nail dystrophies should be reassuring to pediatricians and families.

2015 Pediatric Infectious Dsease Journal

55. Leukemia, Adult Acute Myeloid

) criteria, the classification of AML is solely based upon morphology as determined by the degree of differentiation along different cell lines and the extent of cell maturation.[ , ] Under the WHO classification, the category “acute myeloid leukemia not otherwise categorized” is morphology-based and reflects the FAB classification with a few significant modifications.[ , ] The most significant difference between the WHO and FAB classifications is the WHO recommendation that the requisite blast (...) dysplasia” as one of the following: AML evolving from an MDS. AML following an MDS. AML with multilineage dysplasia is characterized by 20% or more blasts in the blood or bone marrow and dysplasia in two or more myeloid cell lines, generally including megakaryocytes.[ ] To make the diagnosis, dysplasia must be present in 50% or more of the cells of at least two lineages and must be present in a pretreatment bone marrow specimen.[ , ] AML with multilineage dysplasia may occur de novo or following MDS

2012 PDQ - NCI's Comprehensive Cancer Database

56. Myeloid Leukemia, Childhood Acute/Other Childhood Myeloid Malignancies

MDS (refractory cytopenia of childhood [RCC]-provisional entry) include: 1) persistent cytopenia of 1–3 cell lines with <5% bone marrow blasts, <2% peripheral blood blasts, and no ringed sideroblasts and 2) dysplastic changes in 1–3 lineages should be present. MDS with single lineage dysplasia Unilineage dysplasia: ≥10% in one myeloid lineage 1–2 cytopenias b <5% blasts Blasts <1% c <15% ring sideroblasts MDS with ring sideroblasts (MDS-RS) Erythroid dysplasia only <5% blasts No blasts ≥15% ring

2012 PDQ - NCI's Comprehensive Cancer Database

59. Unprecedented Changes in Marijuana Policy

that the increase in marijuana use resulting from legal availability and lower prices will increase dependence and other negative health consequences, such as contributing to a rise in individuals experiencing psychotic symptoms. Opponents also fear that marijuana will be marketed in the same manner as alcohol and that there will be a new industry with lobbyists who would fight against regulation and taxation (or, for that matter, that existing tobacco companies might enter this line of business) The remainder (...) of this commentary is available on . Beau Kilmer is co-director of the RAND Drug Policy Research Center and co-author of " ," (Oxford University Press, 2012). This commentary originally appeared in Britannica Book of the Year on April 21, 2015. Commentary gives RAND researchers a platform to convey insights based on their professional expertise and often on their peer-reviewed research and analysis. Codirector, RAND Drug Policy Research Center; Interim Director, RAND San Francisco Bay Area; Senior Policy

2015 The RAND blog

60. The 10 Ps of Marijuana Legalization

of heavy users. There are also concerns that a for-profit industry and its lobbyists will fight against regulation and taxation. Thus, serious thought should be given to whether marijuana should be supplied by profit-maximizing firms. Besides home production and cooperatives, other options include limiting the market to nonprofit organizations or “for-benefit corporations,” which typically focus on the triple-bottom line of people, planet, and profits. Jurisdictions could also limit supply to a state (...) in Washington, D.C., and collectives being implemented in Uruguay highlight some of the other non-commercial approaches. While these 10 Ps are not the only choices confronting jurisdictions considering changes in marijuana policy, they cover many of the critical decisions that will determine whether removing prohibition is a good idea. May they serve as fodder for debate and as an outline for jurisdictions seeking guidance if they decide to legalize. Beau Kilmer is the co-director of the RAND Drug Policy

2015 The RAND blog

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