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Beau Lines

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21. SCAI consensus guidelines for device selection in femoral?popliteal arterial interventions

free of restenosis (mean follow‐up of 22 months) . Stent thrombosis resulting in acute limb ischemia occurs more frequently following covered stent‐grafts compared to BMS; covered stent oversizing, loss of collaterals and edge restenosis have been implicated as the contributing factors to stent graft failure . The concerns regarding stent thrombosis and acute limb ischemia as the failure mode for covered stents have resulted in limited utilization of these devices as first‐line definitive therapy

2018 Society for Cardiovascular Angiography and Interventions

23. Diagnosis and management of polycythaemia vera Full Text available with Trip Pro

extrapolated from the evidence in ET (Cortelazzo et al , ) and HC has been used in the management of PV. A recent retrospective study of PV demonstrated that patients treated with HC experienced significantly fewer vascular complications (11%) than patients treated with venesection only, with a survival advantage for patients treated with HC when adjusted for variables supporting the use of this agent in first‐line treatment (Enblom‐Larsson et al , ). Side effects HC is generally well tolerated (...) with higher risk (Santoro et al , ). HC is recommended as a first line cytoreductive treatment option for all patients for whom this is required. The risk benefit profiles need to be discussed with patients. HC is not safe in pregnancy and it is recommended that it be stopped 3 months prior to intended conception. Adequate contraception should be used by patients receiving this medication. Hydroxycarbamide intolerance and resistance There has been an attempt to define the criteria to suggest failure of HC

2018 British Committee for Standards in Haematology

24. Screening and Management of Late and Long-term Consequences of Myeloma and its Treatment

University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK Summary A growing population of long-term survivors of myeloma is now accumulating the ‘late effects’ not only of myeloma itself, but also of several lines of treatment given throughout the course of the disease. It is thus important to recognise the cumulative burden of the disease and treatment-related toxicity in both the stable and active phases of myeloma, some of which is unlikely to be detected by routine monitor- ing. We (...) ’ (http://www.cancer.gov/d ictionary). With the improved outcomes for a range of cancers, increasing attention is merited for late disease and treatment effects and their impact on patient experience (Denlinger et al, 2014). Late effects are increasingly relevant to myeloma patients, given that they can often live for over a decade post-diagnosis, have repeated lines of complex therapies and have long-term disease control in the absence of cure. Late effects in myeloma Life expectancy for myeloma

2017 British Committee for Standards in Haematology

26. Guidelines for the prevention and control of carbapenem-resistant Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosa in health care facilities

, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted and dashed lines on maps represent approximate border lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by WHO in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished

2017 World Health Organisation Guidelines

27. Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association Full Text available with Trip Pro

of the palms and soles and firm and sometimes painful induration of the hands or feet often occur in the acute phase. Desquamation of the fingers and toes usually begins in the periungual region within 2 to 3 weeks after the onset of fever and may extend to involve the palms and soles. At 1 to 2 months after fever onset, deep transverse grooves across the nails (Beau’s lines) may be noted. Rash An erythematous rash usually appears within 5 days of fever onset. Most commonly, this is a diffuse maculopapular (...) and Pathogenesis Despite 4 decades of investigation, the cause of KD remains unknown. Current understanding of the immune response suggests response to a classic antigen that is protective against future exposure in most patients. An impressive list of candidate pathogens has been tested and discarded. One line of investigation suggests infection with a novel RNA virus that enters through the upper respiratory tract. , Intracytoplasmic inclusion bodies in bronchial epithelial cells and multiple other cell

2017 American Heart Association

28. Midostaurin for the indication of Acute Myeloid Leukaemia

therapy. De- pending on line of the induction and consolidation therapy (i.e., first induction, sec- ond induction etc.), variations might occur and mitoxantrone might be added during the second induction or third consolidation. MeSH terms: midostaurin (MeSH Unique ID: C059539) Comparison ? standard induction and consolidation chemotherapy (see above). Eligible patients might receive SCT. ? induction and consolidation chemotherapy, except daunorubicin 90 mg/m 2 /day (instead of 60 mg/m 2 /day) is used

2017 EUnetHTA

29. No Clinical Difference in the Osseointegration of Zirconia Dental Implants Compared to Titanium Dental Implants at 1 Year

to traditional titanium implants? Clinical Bottom Line Based on 1-year survival rates, zirconia implants have the potential to be an alternative to titanium implants; however, further studies are needed to establish how their long-term survival rates compare to titanium, as well as to establish the risk for technical/hardware and biological complications. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1 (...) mcneillb@livemail.uthscsa.edu Author Beau McNeill Co-author(s) Co-author(s) e-mail Faculty mentor/Co-author Jeffrey L. Hicks, BS, DDS Faculty mentor/Co-author e-mail HicksJ@uthscsa.edu Basic Science Rationale (Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?) None available Comments and Evidence-Based Updates on the CAT (FOR PRACTICING

2017 UTHSCSA Dental School CAT Library

30. Acute lymphoblastic leukemia

positive ALL: 4.1.1. No TKI has been clearly shown to be superior upfront. As most studies have assessed high does imatinib (600 – 800mg) we recommend that it be used first line 4.1.1.1. Patients with intolerance to, or not achieving an adequate response to, imatinib should be switched to a second generation TKI such as dasatinib 4.1.1.2. Ponatinib should be used in patients with a T315I mutation 4.1.1.3. For patients with CNS diseae at diagnosis dasatinib should be used upfront. 4.1.2. Ph/BCR-ABL

2016 CPG Infobase

31. Epilepsy in Pregnancy

be an opportunity to screen for structural abnormalities. The fetal anomaly scan at 18 +0 –20 +6 weeks of gestation can identify major cardiac defects in addition to neural tube defects. All WWE should be offered a detailed ultrasound in line with the National Health Service Fetal Anomaly Screening Programme standards. How should women taking AEDs be monitored to avoid worsening of seizures? For WWE taking AEDs, is dose escalation better than expectant management? Based on current evidence, routine monitoring (...) should be offered a detailed ultrasound in line with the National Health Service Fetal Anomaly Screening Programme standards. Biochemical screening with maternal serum alphafetoprotein when combined with ultrasonography increases the detection rate for neural tube defects to 94–100%, 56 thereby offering the opportunity to detect these abnormalities in early gestation for WWE. No studies have assessed the role of routine fetal echocardiography in detecting congenital heart disease in babies of WWE

2016 Royal College of Obstetricians and Gynaecologists

33. Carpal tunnel syndrome and associated nail changes: Review and examples from the author's practice. (Abstract)

accompanied by a variety of nail changes including koilonychia, longitudinal fissuring, Beau's lines, onychomadesis, melanonychia, nail thickening, hyperkeratosis, and ischemic ulcerations with paronychia. Furthermore, when these changes are limited to the second and third fingernails, they should prompt the diagnosis of CTS. Once suspected, diagnostic evaluation is not difficult and surgical management can resolve cutaneous findings and prevent irreversible changes such as acro-osteolysis.Copyright ©

2020 Journal of American Academy of Dermatology

34. Childhood Cancer Genomics (PDQ®): Health Professional Version

, a gene involved in purine biosynthesis.[ ] Mutations were observed in 13.0% of a Chinese cohort and 2.7% of a German cohort, and were observed in patients with on-treatment relapses. The PRSP1 mutations observed in relapsed cases induce resistance to thiopurines in leukemia cell lines. CREBBP mutations are also enriched at relapse and appear to be associated with increased resistance to glucocorticoids.[ , ] With increased understanding of the genomics of relapse, it may be possible to tailor upfront

2018 PDQ - NCI's Comprehensive Cancer Database

35. Initial Diagnostic Workup of Acute Leukemia

have been described and included in the most recent revision of the WHO Classi?cation of Tumours of Haematopoietic and Lymphoid Tissues 8 ; the most well-known of which include AML with germline CEBPA mutation, 46,47 myeloid or lymphoid neoplasms with germline RUNX1 mutation, 48,51 myeloid or lymphoid neoplasms with germ- line ANKRD26 mutation, 52,53 and myeloid neoplasms with GATA2 mutation, 54,58 among others. In addition, AL arising in patients with a background of inherited bone marrow (BM

2016 College of American Pathologists

36. Laboratory diagnosis of non-immune hereditary red cell membrane disorders

are composed of linear repeats (i.e. homologous triple helical segments). Each repeat is about 106 amino acids in length and is organized into a triple helix. The arrangement is that helix 2 and 3 in one repeat lock into helix 1 of the next repeat. The self‐association site (circle with dotted line) comprises the N‐terminus of α chain (mainly the αI domain, M r 80 kDa) and the C‐terminus of the β chain. Mutations in Spα LELY allele affect repeats α18 and α21. Mutations in the α‐spectrin and β‐spectrin

2015 British Committee for Standards in Haematology

37. Management of AML in Pregnancy

treatment. According to the UK Teratology Information Service (UKTIS), the first choice antiemetic drugs are the antihistamines, cyclizine and promethazine (UKTIS ). Prochlorperazine and metoclopromide are considered second line agents because they may be associated with maternal dystonic reactions (UKTIS ). Ondansetron can be used in cases where first and second line antiemetic therapies have been unsuccessful (Einarson et al , ). Antibiotics Patients usually suffer severe neutropenia either (...) , M.J. , Porwit, A. , Harris, N.L. , Le Beau, M.M. , Hellström‐Lindberg, E. , Tefferi, A. & Bloomfield, C.D. ( 2009 ) The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukaemia: rationale and important changes . Blood , 114 , 937 – 951 . Wagner, V.M. , Hill, J.S. , Weaver, D. & Baehner, R.L. ( 1980 ) Congenital abnormalities in baby born to cytarabine treated mother . Lancet , 316 , 98 – 99 . Weisz, B. , Meirow, D. , Schiff, E. & Lishner, M

2015 British Committee for Standards in Haematology

38. Pediatric nail consultation in an academic center in Belgium: a 10-year retrospective study. (Abstract)

Fabiola Children's University Hospital. The data was synthesized from information obtained through medical records as well as from photographs taken during consultation. Follow-up was completed by phone interview.Three hundred and one patients were included. The majority of nail abnormalities involved the toenails (57.6%). The most common clinical signs were, in descending order, Beau's lines, pachyonychia, subungual hyperkeratosis and onycholysis. The most frequent diagnoses were fever-related Beau's (...) lines or onychomadesis (9.7%), trachyonychia (8.4%), longitudinal melanonychia (8.1%) and congenital malalignment of the great toenail (8.1%). The main diagnoses by age group were: congenital hypertrophy of the lateral nail folds (21.4%) [0 to 2 years old]; fever-related Beau's lines or onychomadesis (21%) [2 to 6 years old]; trachyonychia (22%) [6 to 12 years old]; juvenile ingrown nail (21.4%) [12 to 18 years old]. Management included clinical observation for 119 patients and specific advices

2019 Journal of the European Academy of Dermatology and Venereology

39. Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies Treatment (PDQ®): Health Professional Version

diagnosis of MDS when morphological characteristics are not observed. f The diagnostic criteria for childhood MDS (refractory cytopenia of childhood [RCC]-provisional entry) include: 1) persistent cytopenia of 1–3 cell lines with <5% bone marrow blasts, <2% peripheral blood blasts, and no ringed sideroblasts and 2) dysplastic changes in 1–3 lineages should be present. Table 4. Definitions for Minimal Diagnostic Criteria for Childhood Myelodysplastic Syndrome (MDS) (Provisional Entity: Refractory

2017 PDQ - NCI's Comprehensive Cancer Database

40. Cardiac Pacing and Cardiac Resynchronization Therapy

professionals involved with the medical care of patients with this path- ology. Selected experts in the ?eld undertook a comprehensive review ofthepublishedevidencefordiagnosis,managementand/orprevention of a given condition, according to ESC Committee for Practice Guide- lines (CPG) policy. A critical evaluation of diagnostic and therapeutic procedures was performed, including assessment of the risk–bene?t ratio. Estimates of expected health outcomes for larger populations were included, where data exist

2013 European Society of Cardiology

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