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Beau Lines

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21. Epilepsy in Pregnancy

be an opportunity to screen for structural abnormalities. The fetal anomaly scan at 18 +0 –20 +6 weeks of gestation can identify major cardiac defects in addition to neural tube defects. All WWE should be offered a detailed ultrasound in line with the National Health Service Fetal Anomaly Screening Programme standards. How should women taking AEDs be monitored to avoid worsening of seizures? For WWE taking AEDs, is dose escalation better than expectant management? Based on current evidence, routine monitoring (...) should be offered a detailed ultrasound in line with the National Health Service Fetal Anomaly Screening Programme standards. Biochemical screening with maternal serum alphafetoprotein when combined with ultrasonography increases the detection rate for neural tube defects to 94–100%, 56 thereby offering the opportunity to detect these abnormalities in early gestation for WWE. No studies have assessed the role of routine fetal echocardiography in detecting congenital heart disease in babies of WWE

2016 Royal College of Obstetricians and Gynaecologists

22. Screening and Management of Late and Long-term Consequences of Myeloma and its Treatment

University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK Summary A growing population of long-term survivors of myeloma is now accumulating the ‘late effects’ not only of myeloma itself, but also of several lines of treatment given throughout the course of the disease. It is thus important to recognise the cumulative burden of the disease and treatment-related toxicity in both the stable and active phases of myeloma, some of which is unlikely to be detected by routine monitor- ing. We (...) ’ (http://www.cancer.gov/d ictionary). With the improved outcomes for a range of cancers, increasing attention is merited for late disease and treatment effects and their impact on patient experience (Denlinger et al, 2014). Late effects are increasingly relevant to myeloma patients, given that they can often live for over a decade post-diagnosis, have repeated lines of complex therapies and have long-term disease control in the absence of cure. Late effects in myeloma Life expectancy for myeloma

2017 British Committee for Standards in Haematology

23. Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association

of the palms and soles and firm and sometimes painful induration of the hands or feet often occur in the acute phase. Desquamation of the fingers and toes usually begins in the periungual region within 2 to 3 weeks after the onset of fever and may extend to involve the palms and soles. At 1 to 2 months after fever onset, deep transverse grooves across the nails (Beau’s lines) may be noted. Rash An erythematous rash usually appears within 5 days of fever onset. Most commonly, this is a diffuse maculopapular (...) and Pathogenesis Despite 4 decades of investigation, the cause of KD remains unknown. Current understanding of the immune response suggests response to a classic antigen that is protective against future exposure in most patients. An impressive list of candidate pathogens has been tested and discarded. One line of investigation suggests infection with a novel RNA virus that enters through the upper respiratory tract. , Intracytoplasmic inclusion bodies in bronchial epithelial cells and multiple other cell

2017 American Heart Association

24. Midostaurin for the indication of Acute Myeloid Leukaemia

therapy. De- pending on line of the induction and consolidation therapy (i.e., first induction, sec- ond induction etc.), variations might occur and mitoxantrone might be added during the second induction or third consolidation. MeSH terms: midostaurin (MeSH Unique ID: C059539) Comparison ? standard induction and consolidation chemotherapy (see above). Eligible patients might receive SCT. ? induction and consolidation chemotherapy, except daunorubicin 90 mg/m 2 /day (instead of 60 mg/m 2 /day) is used

2017 EUnetHTA

26. Initial Diagnostic Workup of Acute Leukemia

have been described and included in the most recent revision of the WHO Classi?cation of Tumours of Haematopoietic and Lymphoid Tissues 8 ; the most well-known of which include AML with germline CEBPA mutation, 46,47 myeloid or lymphoid neoplasms with germline RUNX1 mutation, 48,51 myeloid or lymphoid neoplasms with germ- line ANKRD26 mutation, 52,53 and myeloid neoplasms with GATA2 mutation, 54,58 among others. In addition, AL arising in patients with a background of inherited bone marrow (BM

2016 College of American Pathologists

27. Childhood Cancer Genomics (PDQ®): Health Professional Version

, and they appear to induce resistance to mercaptopurine and thioguanine.[ ] Another gene that is found mutated only at relapse is PRSP1 , a gene involved purine biosynthesis.[ ] Mutations were observed in 13.0% of a Chinese cohort and 2.7% of a German cohort, and were observed in patients with on-treatment relapses. The PRSP1 mutations observed in relapsed cases induce resistance to thiopurines in leukemia cell lines. CREBBP mutations are also enriched at relapse and appear to be associated with increased

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2018 PDQ - NCI's Comprehensive Cancer Database

29. Pediatric nail consultation in an academic center in Belgium: a 10-year retrospective study. (PubMed)

Fabiola Children's University Hospital. The data was synthesized from information obtained through medical records as well as from photographs taken during consultation. Follow-up was completed by phone interview.Three hundred and one patients were included. The majority of nail abnormalities involved the toenails (57.6%). The most common clinical signs were, in descending order, Beau's lines, pachyonychia, subungual hyperkeratosis and onycholysis. The most frequent diagnoses were fever-related Beau's (...) lines or onychomadesis (9.7%), trachyonychia (8.4%), longitudinal melanonychia (8.1%) and congenital malalignment of the great toenail (8.1%). The main diagnoses by age group were: congenital hypertrophy of the lateral nail folds (21.4%) [0 to 2 years old]; fever-related Beau's lines or onychomadesis (21%) [2 to 6 years old]; trachyonychia (22%) [6 to 12 years old]; juvenile ingrown nail (21.4%) [12 to 18 years old]. Management included clinical observation for 119 patients and specific advices

2019 Journal of the European Academy of Dermatology and Venereology

30. Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies Treatment (PDQ®): Health Professional Version

abnormalities in presence of persistent cytopenias of undetermined origin should be considered to support a presumptive diagnosis of MDS when morphological characteristics are not observed. f The diagnostic criteria for childhood MDS (refractory cytopenia of childhood [RCC]-provisional entry) include: 1) persistent cytopenia of 1–3 cell lines with <5% bone marrow blasts, <2% peripheral blood blasts, and no ringed sideroblasts and 2) dysplastic changes in 1–3 lineages should be present. Table 4. Definitions

2017 PDQ - NCI's Comprehensive Cancer Database

31. Management of AML in Pregnancy

treatment. According to the UK Teratology Information Service (UKTIS), the first choice antiemetic drugs are the antihistamines, cyclizine and promethazine (UKTIS ). Prochlorperazine and metoclopromide are considered second line agents because they may be associated with maternal dystonic reactions (UKTIS ). Ondansetron can be used in cases where first and second line antiemetic therapies have been unsuccessful (Einarson et al , ). Antibiotics Patients usually suffer severe neutropenia either (...) , M.J. , Porwit, A. , Harris, N.L. , Le Beau, M.M. , Hellström‐Lindberg, E. , Tefferi, A. & Bloomfield, C.D. ( 2009 ) The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukaemia: rationale and important changes . Blood , 114 , 937 – 951 . Wagner, V.M. , Hill, J.S. , Weaver, D. & Baehner, R.L. ( 1980 ) Congenital abnormalities in baby born to cytarabine treated mother . Lancet , 316 , 98 – 99 . Weisz, B. , Meirow, D. , Schiff, E. & Lishner, M

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2015 British Committee for Standards in Haematology

32. Laboratory diagnosis of non-immune hereditary red cell membrane disorders

are composed of linear repeats (i.e. homologous triple helical segments). Each repeat is about 106 amino acids in length and is organized into a triple helix. The arrangement is that helix 2 and 3 in one repeat lock into helix 1 of the next repeat. The self‐association site (circle with dotted line) comprises the N‐terminus of α chain (mainly the αI domain, M r 80 kDa) and the C‐terminus of the β chain. Mutations in Spα LELY allele affect repeats α18 and α21. Mutations in the α‐spectrin and β‐spectrin

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2015 British Committee for Standards in Haematology

33. Liver Transplantation, evaluation of the pediatric patient

symptoms, including those associated with PALF, and preclude the need for LT. LT is an accepta- ble therapeutic option for patients with FAOD who present with fulminant liver failure, but fail medical and dietary intervention. 308 Recommendations: 68. Management of FAOD with diet and intrave- nous glucose should be the ?rst line of therapy. (2-B) 69. Patients with FAOD should be considered for LT evaluation if they experience recurrent episodes of PALF or have failed medical therapy. (2-B) HEPATOLOGY

2014 American Association for the Study of Liver Diseases

34. ASPEN Clinical Guidelines: Support of Pediatric Patients with Intestinal Failure at Risk of Parenteral Nutrition - Associated Liver Disease

. After the author response to the initial reviews, the guideline was reviewed and approved by the A.S.P.E.N. Board of Directors and their legal consultant. Results Four questions were developed to be addressed by this guide- line. The questions and recommendations are summarized in Table 1. For the current Clinical Guideline, the following terms were used to search PubMed and CINAHL until May 2013: intestinal failure, short bowel syndrome, clinical outcomes, lipid, bloodstream infection, team (...) et al, 2012 54 Retrospective case series HPN patients, N = 4 Report case series of catheter complications after use of 70% ethanol lock 3 times weekly Thrombosis in line when ethanol withdrawn at 413 days (n = 1), at 168 days (n = 1), at 9 days (n = 1), and CVC occlusion at 3 days (n = 1). The occlusion cleared after stopping ethanol lock. Wales et al, 2011 55 Retrospective case series HPN patients with at least 1 previous CLABSI. N = 10 Median age 44 months (range, 31–129 months) Body weight: 5

2014 American Society for Parenteral and Enteral Nutrition

35. Cardiac Pacing and Cardiac Resynchronization Therapy

professionals involved with the medical care of patients with this path- ology. Selected experts in the ?eld undertook a comprehensive review ofthepublishedevidencefordiagnosis,managementand/orprevention of a given condition, according to ESC Committee for Practice Guide- lines (CPG) policy. A critical evaluation of diagnostic and therapeutic procedures was performed, including assessment of the risk–bene?t ratio. Estimates of expected health outcomes for larger populations were included, where data exist

2013 European Society of Cardiology

37. Involvement of Nail Apparatus in Pemphigus Vulgaris in Ethnic Poles Is Infrequent (PubMed)

apparatus changes included, by order of frequency, paronychia, nail discoloration, onychorrhexis, Beau lines, periungual hemorrhages, onychomadesis, cross-ridging, onycholysis, and trachyonychia. The average time between the onset, as recalled by patients, and the diagnosis of pemphigus vulgaris with direct immunofluorescence was not statistically different in PV patients with and without nail apparatus lesions. In this article the molecular and immunological rationale for of periungual involvement

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2018 Frontiers in medicine

38. Childhood Cancer Genomics (PDQ®): Health Professional Version

, and they appear to induce resistance to mercaptopurine and thioguanine.[ ] Another gene that is found mutated only at relapse is PRSP1 , a gene involved purine biosynthesis.[ ] Mutations were observed in 13.0% of a Chinese cohort and 2.7% of a German cohort, and were observed in patients with on-treatment relapses. The PRSP1 mutations observed in relapsed cases induce resistance to thiopurines in leukemia cell lines. CREBBP mutations are also enriched at relapse and appear to be associated with increased

Full Text available with Trip Pro

2016 PDQ - NCI's Comprehensive Cancer Database

39. Adult Acute Myeloid Leukemia Treatment (PDQ®): Health Professional Version

morphology, cytogenetics, molecular genetics, and immunologic markers in an attempt to construct a classification that is universally applicable and prognostically valid.[ ] In the older French-American-British (FAB) criteria, the classification of AML is solely based upon morphology as determined by the degree of differentiation along different cell lines and the extent of cell maturation.[ , ] Under the WHO classification, the category “acute myeloid leukemia not otherwise categorized” is morphology (...) With Multilineage Dysplasia In the WHO classification, refractory anemia with excess blasts in transformation (RAEB-t) is no longer considered a distinct clinical entity and is instead included within the broader category “AML with multilineage dysplasia” as one of the following: AML evolving from an MDS. AML following an MDS. AML with multilineage dysplasia is characterized by 20% or more blasts in the blood or bone marrow and dysplasia in two or more myeloid cell lines, generally including megakaryocytes

2016 PDQ - NCI's Comprehensive Cancer Database

40. Suicide Prevention Interventions and Referral/Follow-up Services

report when possible; however, when describing results from primary studies, we use terminology as reported in the original articles in order to describe outcomes consistent with the primary studies. 9 Suicide Prevention Interventions and Referral/Follow-up Services: A Systematic Review Evidence-based Synthesis Program Figure 1. Suicide Prevention Analytical Model Population-level interventions Help seeking resources (e.g., crisis • lines) Public education (e.g., PSAs on • suicide awareness

2012 Veterans Affairs Evidence-based Synthesis Program Reports

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