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141. Dose escalation to 84 Gy with concurrent chemotherapy in stage III NSCLC appears excessively toxic: Results from a prematurely terminated randomized phase II trial. (PubMed)

Dose escalation to 84 Gy with concurrent chemotherapy in stage III NSCLC appears excessively toxic: Results from a prematurely terminated randomized phase II trial. Concurrent chemoradiotherapy is the mainstay treatment for NSCLC stage III disease. To investigate whether radiation dose escalation based on individual normal tissue constraints can improve outcome, the Swedish lung cancer study group launched this randomized phase II trial.NSCLC patients with stage III disease, good performance (...) status (0-1) and adequate lung function (FEV1 > 1.0 L and CO diffusion capacity > 40%) received three cycles of cisplatin (75 mg/m2 day 1) and vinorelbine (25 mg/m2 day 1 and 8) every third week. Radiotherapy started concurrently with the second cycle, with either 2 Gy daily, 5 days a week, to 68 Gy (A) or escalated therapy (B) based on constraints to the spinal cord, esophagus and lungs up to 84 Gy by adding an extra fraction of 2 Gy per week.A pre-planned safety analysis revealed excessive toxicity

2018 Lung Cancer

142. Persistence of excess mortality following individual non-hip fractures: A relative survival analysis. (PubMed)

Persistence of excess mortality following individual non-hip fractures: A relative survival analysis. Little is known about long-term excess mortality following fragility nonhip fractures.The study aimed to determine which fracture was associated with excess mortality and for how long the postfracture excess mortality persisted.This nationwide registry-based follow-up study included all individuals in Denmark aged 50+ years who first experienced fragility fractures in 2001 and were followed up (...) for up to 10 years for their mortality risk.The contribution of fracture to mortality at precise postfracture time intervals was examined using relative survival analysis, accounting for time-related mortality changes in the background population.There were 21,123 women (aged 72 ± 13 years) and 9481 men (aged 67 ± 12 years) with an incident fragility fracture in 2001, followed by 10,668 and 4745 deaths, respectively. Excess mortality was observed following all proximal and lower leg fractures

2018 Journal of Clinical Endocrinology and Metabolism

143. Excess risk of hospitalisation for heart failure among people with type 2 diabetes. (Full text)

Excess risk of hospitalisation for heart failure among people with type 2 diabetes. Type 2 diabetes is an established risk factor for heart failure, but age-specific data are sparse. We aimed to determine excess risk of heart failure, based on age, glycaemic control and kidney function in comparison with age- and sex-matched control individuals from the general population.Individuals with type 2 diabetes registered in the Swedish National Diabetes Registry 1998-2012 (n = 266,305) were compared (...) group, men and women with type 2 diabetes who were younger than 55 years of age had HRs for hospitalisation for heart failure of 2.07 (95% CI 1.73, 2.48) and 4.59 (95% CI 3.50, 6.02), respectively, using analyses adjusted for socioeconomic variables and associated conditions. Younger age, poorer glycaemic control and deteriorating renal function were all associated with increased excess risk of heart failure in those with type 2 diabetes compared with the control group. However, people with diabetes

2018 Diabetologia PubMed

144. Excessive umbilical cord coiling confers risk of elevated nocturnal blood pressure and severe/early-onset preeclampsia. (PubMed)

Excessive umbilical cord coiling confers risk of elevated nocturnal blood pressure and severe/early-onset preeclampsia. The associations between umbilical cord coiling, feto-placental vascular resistance and maternal blood pressure (BP) are not well understood.We retrospectively analyzed 502 pregnant women suspected of hypertensive disorders in the third trimester from a hospital-based cohort, who underwent ambulatory BP monitoring and umbilical artery Doppler velocimetry examinations within 14 (...) -onset (odds ratio 2.43, 95% confidence interval: 1.18-4.97) preeclampsia after adjusting for covariates. Further mediation analysis showed that elevated high UAPIMOM (≥1.30) could explain 11.4% of the umbilical cord hypercoiling → high night-time DBP association.Therefore, this retrospective study identifies excessive umbilical cord coiling, and its interaction with increased feto-placental vascular resistance, as novel risk factors for nocturnal BP elevation and preeclampsia.

2018 Journal of Hypertension

145. Polypharmacy in older patients with chronic diseases: a cross-sectional analysis of factors associated with excessive polypharmacy. (Full text)

Polypharmacy in older patients with chronic diseases: a cross-sectional analysis of factors associated with excessive polypharmacy. Polypharmacy is common in older people and associated with potential harms. The aim of this study was to analyse the characteristics of an older multimorbid population with polypharmacy and to identify factors contributing to excessive polypharmacy in these patients.This cross-sectional analysis is based on the PRIMA-eDS trial, a large randomised controlled (...) , and smoking apparently do not seem to be related to excessive polypharmacy. Physicians should especially pay attention to their frail, obese patients who have multiple diagnoses and a decreased health-related quality of life, to check carefully whether all the drugs prescribed are evidence-based, safe, and do not interact in an unfavourable way.This trial has been registered with Current Controlled Trials Ltd. on 31 July 2014 (ISRCTN10137559).

2018 BMC Family Practice PubMed

146. The effect of excess iodine intake from iodized salt and/or groundwater iodine on thyroid function in non-pregnant and pregnant women, infants and children: a multicenter study in East Africa. (PubMed)

previously reporting iodine excess in children, urinary iodine concentration (UIC), thyrotropin, total thyroxine, and thyroglobulin (Tg) were measured in school-age children (SAC), women of reproductive age, pregnant (PW) and lactating women, and breast-feeding and weaning infants. In a national study in Djibouti, UIC was measured in SAC and PW. At all sites, daily iodine intake was estimated based on UIC, and iodine concentration was measured in household salt and drinking water.The total sample size (...) The effect of excess iodine intake from iodized salt and/or groundwater iodine on thyroid function in non-pregnant and pregnant women, infants and children: a multicenter study in East Africa. Acute excess iodine intake can damage the thyroid, but the effects of chronic excess iodine intake are uncertain. Few data exist for pregnant and lactating women and infants exposed to excessive iodine intake.This was a multicenter cross-sectional study. At study sites in rural Kenya and urban Tanzania

2018 Thyroid

147. Visual acuity loss associated with excessive “dry macula” in exudative age-related macular degeneration (Full text)

Visual acuity loss associated with excessive “dry macula” in exudative age-related macular degeneration To investigate the correlation between visual acuity and central macular thickness (CMT) and choroidal thickness (CCT) in patients with wet age-related macular degeneration (AMD).In this retrospective analysis, 14 eyes that received >10 ranibizumab injections (based on pro re nata [PRN] regimen) and maintained initial visual acuity gain were analyzed. The following 5 parameters were

2018 Clinical ophthalmology (Auckland, N.Z.) PubMed

148. Persistence of TBT and copper in excess on leisure boat hulls around the Baltic Sea (Full text)

Persistence of TBT and copper in excess on leisure boat hulls around the Baltic Sea A handheld XRF-analyzer specially calibrated for measurements of metals on plastic boat hulls has been used on leisure boats in Denmark (DK), Finland (FI), and Germany (DE). The results on tin and copper are presented as μg metal/cm2. Tin is a proxy for the occurrence of organotin compounds on the boat. Two or three sites were visited in each country and between 25 and 90 boats were measured at each site. Every (...) data from different parts of Sweden, i.e., boats in fresh water, brackish water, and salt water. The results show that tin with mean values > 50 μg Sn/cm2 is still found on 42, 24, and 23% of the boats in DK, FI, and DE, respectively. The corresponding percentages based on median values are 38, 22, and 18% for DK, FI, and DE, respectively. The variation among boats is high with a maximum mean value of 2000 μg Sn/cm2. As comparison, one layer of an old TBT antifouling paint Hempels Hard racing

2018 Environmental science and pollution research international PubMed

149. Excessive risk of second primary cancers in young‐onset colorectal cancer survivors (Full text)

Excessive risk of second primary cancers in young‐onset colorectal cancer survivors With an increasing trend of patients with young-onset colorectal cancer (CRC), risks of second primary cancers (SPCs) among them become a concerning issue. We aimed to define the detailed risk and site-distributed patterns of SPCs in young CRC individuals (age ≤50). A population-based cohort were identified from the Surveillance, Epidemiology, and End Results database between 1973 and 2013. Standardized (...) incidence ratios (SIRs) and absolute excess risk (AER) were calculated to assess the risk for SPCs compared with the general population. A total of 44,106 patients, including 3245 (7.4%) the young and 40,861 (92.6%) the old, developed 50,679 secondary malignancies subsequently. With increased age, the risk of secondary cancers gradually decreased. A significant 44% excess risk of SPCs was observed in the young (SIR = 1.44, AER = 34.23), while a slightly increased risk was noted in the old (SIR = 1.02

2018 Cancer medicine PubMed

150. A quantitative meta-analysis of fMRI studies investigating emotional processing in excessive worriers: Application of activation likelihood estimation analysis. (PubMed)

A quantitative meta-analysis of fMRI studies investigating emotional processing in excessive worriers: Application of activation likelihood estimation analysis. Excessive worry is a highly impairing cognitive activity which features a range of psychological disorders. Investigations of its disturbed underlying neural mechanisms have presented largely heterogeneous results. This quantitative neuroimaging meta-analysis aims to identify consistent functional disturbances in emotional processing (...) associated with excessive worry across previously published studies.We used the activation likelihood estimation (ALE) method to test for significant convergence across findings of 16 neuroimaging experiments reporting functional aberrations during emotional processing between individuals experiencing high versus normal levels of worry.Results demonstrated convergent aberrations in high compared to normal worriers mainly in a left-hemispheric cluster comprising parts of the middle frontal gyrus, inferior

2018 Journal of Affective Disorders

151. Excessive gingival display treated with 2-piece segmental Le Fort I osteotomy: A case report. (PubMed)

Excessive gingival display treated with 2-piece segmental Le Fort I osteotomy: A case report. The demand for orthognathic surgery has increased worldwide. Women with jaw deformity tend to have a worse quality of life than men owing to the deformity's negative effects on body image, low self-esteem, lack of self-confidence, and dissatisfaction with life. Therefore, they wish for more reliable treatment options.A woman aged 25 years and 9 months sought treatment for a convex profile and excessive (...) gingival display caused by a skeletal Class II jaw-base relationship. Gingival exposure was up to 6.5 millimeters at full smile. She chose orthognathic surgery, and the authors performed a 2-piece segmental Le Fort I osteotomy and bilateral sagittal split ramus osteotomy. After active orthodontic treatment, the protrusive profile was improved, and an acceptable occlusion and an attractive smile were achieved.It is hoped that 2-piece segmental Le Fort I osteotomy becomes a common treatment option

2018 Journal of the American Dental Association

152. Responding to excessive alcohol consumption in third-level (REACT): a study protocol. (Full text)

(Responding to Excessive Alcohol Consumption in Third-level) Programme.This evaluation will provide the evidence base for programme development, implementation and improvement. Stage one involved defining the multi-component intervention. This was developed following a systematic review of existing literature and a Delphi-consensus workshop involving university students, staff and relevant stakeholders. Following this, the programme is being implemented across the Higher Education sector in Ireland (...) Responding to excessive alcohol consumption in third-level (REACT): a study protocol. Problem alcohol use is an ongoing, worldwide phenomenon of considerable concern. Throughout the past 20 years, national policies have noted the importance of students when tackling alcohol consumption. Considering alcohol is a multifaceted issue, a multi-component response is required to combat its excessive use. This protocol sets out the approach used for developing, implementing and evaluating the REACT

2018 BMC health services research PubMed

153. The effectiveness of an online intervention in preventing excessive gestational weight gain: the e-moms roc randomized controlled trial. (Full text)

, the effectiveness of a self-directed, integrated online and mobile phone behavioral intervention in preventing excessive GWG.This effectiveness trial was a double-blind, three-arm trial with a parallel group design. Two arms received the same e-health intervention during pregnancy with the third arm serving as the placebo control. The intervention was based on a previously efficacious non-digital intervention that was adapted to electronic format. It included three behavior change tools: a weight gain tracker (...) The effectiveness of an online intervention in preventing excessive gestational weight gain: the e-moms roc randomized controlled trial. Excessive gestational weight gain (GWG) is common and contributes to the development of obesity in women and their offspring. Electronic or e-health interventions have the potential to reach large groups of women and prevent excessive GWG, but their effectiveness has not been demonstrated. The purpose of this study was to evaluate, in a real-world setting

2018 BMC Pregnancy and Childbirth PubMed

154. A Randomized Controlled Trial of an Intensive Nutrition Intervention Versus Standard Nutrition Care to Avoid Excess Weight Gain After Kidney Transplantation: The INTENT Trial. (Full text)

A Randomized Controlled Trial of an Intensive Nutrition Intervention Versus Standard Nutrition Care to Avoid Excess Weight Gain After Kidney Transplantation: The INTENT Trial. Excessive weight gain is common after kidney transplantation and increases cardiovascular risk. The aim of this randomized controlled trial was to determine whether an intensive nutrition and exercise intervention delivered alongside routine post-transplant care would reduce post-transplant weight gain.Single-blind (...) ) or to standard nutrition care (guideline based; 4 dietitian visits).The primary outcome was weight at 6 months after transplant adjusted for baseline weight, obesity, and gender, analyzed using analysis of covariance. The secondary outcomes included body composition, biochemistry, quality of life, and physical function.Thirty-seven participants were randomized to the intensive intervention (n = 19) or to standard care (n = 18); one intensive group participant withdrew before baseline. Weight increased

2018 Journal of Renal Nutrition PubMed

155. Androgen Excess- Polycystic Ovary Syndrome Society: position statement on depression, anxiety, quality of life, and eating disorders in polycystic ovary syndrome. (PubMed)

Androgen Excess- Polycystic Ovary Syndrome Society: position statement on depression, anxiety, quality of life, and eating disorders in polycystic ovary syndrome. To formulate clinical consensus recommendations for screening depression, anxiety, health-related quality of life (HRQoL), and disordered eating symptoms in women with polycystic ovary syndrome (PCOS) and review prevalence based on phenotypes and ethnicity, changes over time, etiology, and impact of treatment.Systematic reviews

2018 Fertility and Sterility

156. Excess medical comorbidity and mortality across the lifespan in schizophrenia.: A nationwide Danish register study. (PubMed)

Excess medical comorbidity and mortality across the lifespan in schizophrenia.: A nationwide Danish register study. People with severe mental illness have greater risk of un-detected and inadequately treated medical disorders, adding up to the risk of premature death. This study investigated how chronic medical comorbidity evolved across the lifespan in schizophrenia and the associated impact on mortality.A register-based retrospective nested case-control study was conducted, identifying

2018 Schizophrenia Research

157. Excess body weight in the city of São Paulo: panorama from 2003 to 2015, associated factors and projection for the next years. (Full text)

Excess body weight in the city of São Paulo: panorama from 2003 to 2015, associated factors and projection for the next years. Excess body weight (EBW: overweight and obesity) has high and rising prevalence in Brazil. Up-to-date information about the distribution and changes in the prevalence of EBW and their associated factors are essential to determine target groups and to identify priority actions. The aim of this study was to investigate the associated factors and to determine (...) the prevalence of overweight and obesity in the adolescent and adult population of the city of São Paulo in the years of 2003, 2008, and 2015, as well as to estimate the prediction for the next years.Individuals aged 12 years and older from three editions of the Health Survey of São Paulo (ISA-Capital), a cross-sectional population-based survey, carried out in 2003 (n = 2144), 2008 (n = 2599), and 2015 (n = 3939), had their socioeconomic, anthropometric, and lifestyle data collected at households

2018 BMC Public Health PubMed

158. Excess Mortality in Patients With Type 1 Diabetes Without Albuminuria-Separating the Contribution of Early and Late Risks. (PubMed)

Excess Mortality in Patients With Type 1 Diabetes Without Albuminuria-Separating the Contribution of Early and Late Risks. The current study investigated whether the risk of mortality in patients with type 1 diabetes without any signs of albuminuria is different than in the general population and matched control subjects without diabetes.We studied a nationwide, population-based Finnish register of 10,737 patients diagnosed with type 1 diabetes during 1980-2005 and followed for 10 years (...) ). However, it was higher compared with that of control subjects without diabetes (1.33 [1.06-1.66], P = 0.01). Excess mortality was largely due to acute diabetes complications and ischemic heart disease, which remained more than fourfold higher (mortality rate ratio 4.34 [2.49-7.57]) in adults with type 1 diabetes than in control subjects without diabetes, despite the absence of albuminuria. By contrast, deaths due to alcohol and drugs were reduced in adults with type 1 diabetes (P = 0.007), especially

2018 Diabetes Care

159. Cohort study: Excess weight gain in the first 18?months of life is associated with later childhood overweight, obesity and greater arterial wall thickness

Cohort study: Excess weight gain in the first 18?months of life is associated with later childhood overweight, obesity and greater arterial wall thickness Excess weight gain in the first 18 months of life is associated with later childhood overweight, obesity and greater arterial wall thickness | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how (...) we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Excess weight gain in the first 18 months of life is associated with later childhood overweight

2014 Evidence-Based Nursing

160. Exploring potential reasons for Glasgow's 'excess' mortality: results of a three-city survey of Glasgow, Liverpool and Manchester

Exploring potential reasons for Glasgow's 'excess' mortality: results of a three-city survey of Glasgow, Liverpool and Manchester Exploring potential reasons for Glasgow’s ‘excess’ mortality: Results of a three-city survey of Glasgow, Liverpool and Manchester David Walsh, Gerry McCartney, Sarah McCullough, Marjon van der Pol, Duncan Buchanan, Russell Jones A report by the Glasgow Centre for Population Health, NHS Health Scotland and the University of Aberdeen www.gcph.co.uk Exploring potential (...) reasons for Glasgow’s ‘excess’ mortality: Results of a three-city survey of Glasgow, Liverpool and Manchester June 2013 June 2013 12195 GCPH Brochure Cover A4_V2.indd 1-3 12/06/2013 12:01Exploring potential reasons for Glasgow’s ‘excess’ mortality Results of a three-city survey of Glasgow, Liverpool and Manchester 2 David Walsh is a Public Health Programme Manager at the Glasgow Centre for Population Health (GCPH); Gerry McCartney is a consultant in Public Health and Head of the Public Health

2013 Health Economics Research Unit

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