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141. Exploring the excess mortality due to depressive symptoms in a community-based sample: The role of Alzheimer's Disease. Full Text available with Trip Pro

Exploring the excess mortality due to depressive symptoms in a community-based sample: The role of Alzheimer's Disease. Depression has been associated with increased risk of death. However, there is lack of studies exploring such relationship in the context of dementia. Given the high prevalence of both depression and Alzheimer's Disease (AD), investigating their temporal association with mortality is of public health relevance.Longitudinal data from the WHICAP study were analyzed (1958

2016 Journal of Affective Disorders

142. Excess mortality rate associated with hepatitis C virus infection: a community-based cohort study in rural Egypt. (Abstract)

Excess mortality rate associated with hepatitis C virus infection: a community-based cohort study in rural Egypt. >80% of people chronically infected with hepatitis C virus (HCV) live in resource-limited countries, yet the excess mortality associated with HCV infection in these settings is poorly documented.Individuals were recruited from three villages in rural Egypt in 1997-2003 and their vital status was determined in 2008-2009. Mortality rates across the cohorts were compared according

2016 Journal of Hepatology

143. Acidosis-Induced Hypochloremic Alkalosis in Diabetic Ketoacidosis Confirmed by The Modified Base Excess Method. Full Text available with Trip Pro

Acidosis-Induced Hypochloremic Alkalosis in Diabetic Ketoacidosis Confirmed by The Modified Base Excess Method. Diabetic ketoacidosis (DKA) is associated with a metabolic alkalosis, which is thought to be due to vomiting. However, alkalosis can occur in DKA without vomiting. We retrospectively reviewed the acid-base disturbances in DKA admissions without vomiting.We included admissions of the patients with blood glucose and beta-hydroxybutyrate (βOHB) levels > 250 mg/dL and > 1.0 mmol/L (...) , respectively. Admissions without vomiting were classified into a group with a βOHB > 3.0 mmol/L (DKA group) and a group with βOHB of 1.0-3.0 mmol/L (pre-DKA group). The acid-base status was analyzed by the modified base excess (BE) method. BE effects were calculated by changes in sodium (BE free water, [BEFW]), and chloride (BECl). Positive and negative values for each parameter suggested alkalosis and acidosis, respectively.Forty-five included admissions were divided into DKA (n = 34) and pre-DKA (n =11

2016 Journal of Clinical Endocrinology and Metabolism

144. Adjusting for overdispersion in piecewise exponential regression models to estimate excess mortality rate in population-based research. Full Text available with Trip Pro

Adjusting for overdispersion in piecewise exponential regression models to estimate excess mortality rate in population-based research. In population-based cancer research, piecewise exponential regression models are used to derive adjusted estimates of excess mortality due to cancer using the Poisson generalized linear modelling framework. However, the assumption that the conditional mean and variance of the rate parameter given the set of covariates x i are equal is strong and may fail (...) to account for overdispersion given the variability of the rate parameter (the variance exceeds the mean). Using an empirical example, we aimed to describe simple methods to test and correct for overdispersion.We used a regression-based score test for overdispersion under the relative survival framework and proposed different approaches to correct for overdispersion including a quasi-likelihood, robust standard errors estimation, negative binomial regression and flexible piecewise modelling.All piecewise

2016 BMC medical research methodology

145. Web-Based Behavioral Intervention Increases Maternal Exercise but Does Not Prevent Excessive Gestational Weight Gain in Previously Sedentary Women. (Abstract)

Web-Based Behavioral Intervention Increases Maternal Exercise but Does Not Prevent Excessive Gestational Weight Gain in Previously Sedentary Women. Innovative methods are warranted to optimize prenatal outcomes. This study's objective was to determine if a web-based behavioral intervention (BI) can prevent excessive gestational weight gain (GWG) by increasing physical activity (PA).Participants were randomized to usual care (UC; n = 21) or BI (n = 24) between 10 to 14 weeks gestation. GWG, PA (...) -minute PA bouts: 61.3 ± 21.9; 30-minute PA bouts: 39.6 ± 14.8, both P < .05). BI energy intake at mid-pregnancy significantly increased from baseline (336 ± 127 kcals, P = .04) and was significantly greater than UC (2,503 ± 703 vs. 1,894 ± 594, P = .005).Sedentary pregnant women should increase PA but may need additional dietary counseling to prevent excessive GWG.

2016 Journal of physical activity & health

146. The relative association of obstructive sleep apnea, obesity, and excessive daytime sleepiness with incident depression: A longitudinal, population-based study. Full Text available with Trip Pro

The relative association of obstructive sleep apnea, obesity, and excessive daytime sleepiness with incident depression: A longitudinal, population-based study. It is postulated that obstructive sleep apnea (OSA) is a risk factor for the development of depression. However, obesity and excessive daytime sleepiness (EDS) are associated with both OSA and depression. The goal of this study was to examine the relative contribution of OSA, obesity and EDS to incident depression.A representative

2016 International Journal of Obesity

147. Excessive Sleep and Lack of Sleep Are Associated With Slips and Falls in the Adult Korean Population: A Population-Based Cross-Sectional Study. Full Text available with Trip Pro

Excessive Sleep and Lack of Sleep Are Associated With Slips and Falls in the Adult Korean Population: A Population-Based Cross-Sectional Study. Few studies have evaluated the impacts of excessive sleep duration on falls. This study investigated the associations between sleep duration and falls among Korean adults in a wide range of age groups while adjusting for numerous confounding factors. Data collected from study participants ranging in age from 19 to 109 years old were analyzed from

2016 Medicine

148. Combining motivational and volitional approaches to reducing excessive alcohol consumption in pre-drinkers: a theory-based intervention protocol. Full Text available with Trip Pro

Combining motivational and volitional approaches to reducing excessive alcohol consumption in pre-drinkers: a theory-based intervention protocol. Pre-drinking refers to the consumption of alcohol at home or a private residence prior to attending a subsequent social event. We present the study protocol of an online theory-based intervention to reduce pre-drinking and related harm in pre-drinking undergraduates, using behavior change techniques targeting the motivational and volitional phases (...) of behaviour.A fully randomized 2 (autonomy support: present vs. absent) x 2 (implementation intention: present vs. absent) between-participants design will be used to ascertain the effectiveness of the intervention in reducing pre-drinking alcohol consumption and alcohol-related harm. Participants will complete a range of theory-based measures prior to being allocated to one of the four experimental conditions. Four weeks later, participants will complete a follow-up questionnaire comprised of theoretical

2016 BMC Public Health Controlled trial quality: uncertain

149. Excess cost burden of diabetes in Southern India: a clinic-based, comparative cost-of-illness study Full Text available with Trip Pro

Excess cost burden of diabetes in Southern India: a clinic-based, comparative cost-of-illness study There are few data on excess direct and indirect costs of diabetes in India and limited data on rural costs of diabetes. We aimed to further explore these aspects of diabetes burdens using a clinic-based, comparative cost-of-illness study.Persons with diabetes (n = 606) were recruited from government, private, and rural clinics and compared to persons without diabetes matched for age, sex (...) , and socioeconomic status (n = 356). We used interviewer-administered questionnaires to estimate direct costs (outpatient, inpatient, medication, laboratory, and procedures) and indirect costs [absence from (absenteeism) or low productivity at (presenteeism) work]. Excess costs were calculated as the difference between costs reported by persons with and without diabetes and compared across settings. Regression analyses were used to separately identify factors associated with total direct and indirect

2016 Global Health, Epidemiology and Genomics

150. Excessive daytime sleepiness is associated with an exacerbation of migraine: A population-based study Full Text available with Trip Pro

Excessive daytime sleepiness is associated with an exacerbation of migraine: A population-based study Previous studies have shown that migraine and sleep disturbances are closely associated. Excessive daytime sleepiness (EDS) is a common symptom of various types of sleep disturbance. Findings from clinic-based studies suggest that a high percentage of migraineurs experience EDS. However, the prevalence and clinical impact of EDS among migraineurs at the population level have rarely been (...) to migraineurs without EDS.Approximately 20 % of migraineurs had EDS in this population-based sample. Excessive daytime sleepiness was associated with an exacerbation of some migraine symptoms.

2016 The journal of headache and pain

151. Human heart failure biomarker immunosensor based on excessively tilted fiber gratings Full Text available with Trip Pro

Human heart failure biomarker immunosensor based on excessively tilted fiber gratings A label-free immunosensor platform based on excessively tilted fiber gratings (Ex-TFGs) was developed for highly specific and fast detection of human N-terminal pro-B-type natriuretic peptide (NT-proBNP), which is considered a powerful biomarker for prognosis and risk stratification of heart failure (HF). High-purity anti-NT-proBNP monoclonal antibodies (MAbs) prepared in our laboratory were immobilized

2016 Biomedical optics express

152. Comparison of Toxicities to Vibrio fischeri and Fish Based on Discrimination of Excess Toxicity from Baseline Level Full Text available with Trip Pro

Comparison of Toxicities to Vibrio fischeri and Fish Based on Discrimination of Excess Toxicity from Baseline Level Investigations on the relationship of toxicities between species play an important role in the understanding of toxic mechanisms to environmental organisms. In this paper, the toxicity data of 949 chemicals to fish and 1470 chemicals to V. fischeri were used to investigate the modes of action (MOAs) between species. The results show that although there is a positive interspecies (...) correlation, the relationship is poor. Analysis on the excess toxicity calculated from toxic ratios (TR) shows that many chemicals have close toxicities and share the same MOAs between the two species. Linear relationships between the toxicities and octanol/water partition coefficient (log KOW) for baseline and less inert compounds indicate that the internal critical concentrations (CBRs) approach a constant both to fish and V. fischeri for neutral hydrophobic compounds. These compounds share the same

2016 PloS one

153. Challenges of Integrating an Evidence-based Intervention in Health Departments to Prevent Excessive Gestational Weight Gain among Low-income Women Full Text available with Trip Pro

Challenges of Integrating an Evidence-based Intervention in Health Departments to Prevent Excessive Gestational Weight Gain among Low-income Women To examine health departments' (HD) capacity to adapt and implement an intervention to prevent excessive gestational weight gain.Seventy-seven stakeholders (nurses, nutritionists, social workers, health educators, health directors, and multilingual service providers) in nine HDs participated. A descriptive mixed methods approach was used to collect (...) data at workshops held onsite to introduce the evidence-based intervention (EBI) and discuss its adaptation.A survey was administered to assess the intervention's fit with the HDs context. Generalized logit mixed models were used to analyze the survey data. The discussions of adaptation were audiotaped and thematically analyzed to identify factors influencing implementation.The majority of stakeholders desired to participate in the training portion of the EBI, but they were reluctant to adopt

2016 Public health nursing (Boston, Mass.)

154. A School-Based Intervention to Reduce Excess Weight in Overweight and Obese Primary School Students. (Abstract)

A School-Based Intervention to Reduce Excess Weight in Overweight and Obese Primary School Students. This study evaluated the effect of an intervention for reducing excess weight gain in primary school-age children in Tehran.A cluster-randomized controlled trial was conducted in 12 primary schools in Tehran. Three hundred thirty-four pupils, 167 in the intervention and 167 in the comparison group, determined to be overweight or obese based on World Health Organization standards, were recruited

2016 Biological research for nursing Controlled trial quality: uncertain

155. A Comparison between Two Dilute Citrate Solutions (15 vs. 18 mmol/l) in Continuous Renal Replacement Therapy: The Base Excess and Renal Substitution Solution Study. (Abstract)

A Comparison between Two Dilute Citrate Solutions (15 vs. 18 mmol/l) in Continuous Renal Replacement Therapy: The Base Excess and Renal Substitution Solution Study. The study aimed to compare the changes in biochemistry occurring in patients undergoing continuous renal replacement therapy (CRRT) using 2 trisodium citrate solutions, Baxter hemofiltration fluid containing 18 mmol/l (C18) and Baxter NamSol, a custom manufactured solution containing 15 mmol/l (C15), both delivered as regional (...) base excess and serum bicarbonate concentration, all being higher in the C18 group (p < 0.01). By day 5, the PaCO2 had also risen in the C18 group (p = 0.03).The C15 solution provided equivalent filter life to the C18 solution but without significant hypernatremia and metabolic alkalosis.© 2016 S. Karger AG, Basel.

2016 Blood purification Controlled trial quality: uncertain

156. Incidence and excess mortality of hip fracture in young adults: a nationwide population-based cohort study. Full Text available with Trip Pro

Incidence and excess mortality of hip fracture in young adults: a nationwide population-based cohort study. This study assessed the incidence and excess mortality of hip fractures among inpatients aged 20-40 years in a nationwide population database in Taiwan.Subjects were selected from Taiwan's National Health Insurance Research Database for the period 2001-2008 and were followed up until the end of 2010. A total of 4,523 subjects were admitted for the first time with primary diagnosis of hip

2016 BMC Musculoskeletal Disorders

157. Will the Need-Based Planning of Health Human Resources Currently Undertaken in Several Countries Lead to Excess Supply and Inefficiency? A Comment on Basu and Pak. (Abstract)

Will the Need-Based Planning of Health Human Resources Currently Undertaken in Several Countries Lead to Excess Supply and Inefficiency? A Comment on Basu and Pak. Basu and Pak (2014) argue that need-based workforce planning models would not maximize social welfare, and use of need-based models would result in inefficiency. They propose that planning be based on service utilization to incorporate preferences or other socioeconomic factors. We show that the analysis is based on inappropriate (...) considerations of the nature of healthcare demand, a misrepresentation of need-based approaches and misunderstanding publicly funded healthcare system objectives. We explain how current levels of utilization emerge from workload and income interests of providers that underlie utilization-based models and are incompatible with public goals of maximizing health gains. Copyright © 2016 John Wiley & Sons, Ltd.Copyright © 2016 John Wiley & Sons, Ltd.

2016 Health economics

158. Measuring baseline level of excessive alcohol intake in pregnancy in the West of Scotland

in Pregnancy. Alcohol Research & Health. 28:38-43. 6 7 APPENDIX Box 1: Deriving a “Best Guess” estimate of the prevalence of heavy drinking in the most deprived regions of Glasgow, using two approaches: (1) Based on smoking figures alone: in the three most deprived regions of Glasgow smoking during pregnancy is approximately 60-80% higher than the Scottish average (source: GCPH profiles). If we assume that heavy drinking during pregnancy has a similar excess then we might expect the prevalence of heavy (...) (based on the sex patterning in alcohol related GP consultations [ongoing work, DeS]), giving an estimated excess of alcohol related deaths in these neighbourhoods of around 60-80% compared to the Scottish estimates. The excess of heavy drinking during pregnancy is likely to be lower still, based on that seen with smoking figures (2a, above). Reflecting this, the estimated excess in heavy drinking of 60-80% can be reduced by a further 5-20% giving an estimated excess of heavy drinking during

2012 Glasgow Centre for Population Health

159. Predictors for Development of Excessive Daytime Sleepiness in Women: A Population-Based 10-Year Follow-Up Full Text available with Trip Pro

Predictors for Development of Excessive Daytime Sleepiness in Women: A Population-Based 10-Year Follow-Up To analyze predictors of excessive daytime sleepiness (EDS) and to analyze how changes within risk factors over time predict incident EDS in women.Population-based prospective study.General population of the City of Uppsala, Sweden.From a random, general population sample of 7,051 women from the Sleep and HEalth in women ("SHE") cohort, 4,322 women without EDS at baseline were followed up (...) for predicting incident excessive daytime sleepiness (EDS) and, in addition, somatic disease, obesity, and snoring predicted EDS. It is important not only to treat these conditions but also to inform women of the importance of a healthy lifestyle in order to prevent and reduce EDS in women.© 2015 Associated Professional Sleep Societies, LLC.

2015 Sleep

160. Adoption and maintenance of gym-based strength training in the community setting in adults with excess weight or type 2 diabetes: a randomized controlled trial. Full Text available with Trip Pro

Adoption and maintenance of gym-based strength training in the community setting in adults with excess weight or type 2 diabetes: a randomized controlled trial. Participant adoption and maintenance is a major challenge in strength training (ST) programs in the community-setting. In adults who were overweight or with type 2 diabetes (T2DM), the aim of this study was to compare the effectiveness of a standard ST program (SST) to an enhanced program (EST) on the adoption and maintenance of ST (...) 1.5-45.5). No significant between-group differences were observed for maintenance of ST in either pooled or stratified analyses. In those with T2DM, there was a significant reduction in HbA1c in the EST compared to SST group during the adoption phase (net difference, -0.13 % [-0.26 to -0.01]), which persisted after 12-months (-0.17 % [-0.3 to -0.05]).A behaviorally-focused community-based EST intervention was more effective than a SST program for the adoption of ST in adults with excess weight

2015 The international journal of behavioral nutrition and physical activity Controlled trial quality: uncertain

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