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101. Excess Significance Bias in Repetitive Transcranial Magnetic Stimulation Literature for Neuropsychiatric Disorders. (PubMed)

Excess Significance Bias in Repetitive Transcranial Magnetic Stimulation Literature for Neuropsychiatric Disorders. Repetitive transcranial magnetic stimulation (rTMS) has been widely tested and promoted for use in multiple neuropsychiatric conditions, but as for many other medical devices, some gaps may exist in the literature and the evidence base for the clinical efficacy of rTMS remains under debate.We aimed to test for an excess number of statistically significant results in the literature (...) (110 for neurological disorders and 118 for psychiatric disorders) were assessed. For SMD = 0.3, the number of observed "positive" studies (n = 94) was larger than expected (n = 35). We found evidence for an excess of significant findings overall (p < 0.0001) and in 8/14 meta-analyses. Evidence for an excess of significant findings was also observed for SMD = 0.5 for neurological disorders. Of the 228 datasets, 0 (0%), 0 (0%), 3 (1%), and 53 (23%) had a power >0.80, respectively, for SMDs of 0.30

2019 Psychotherapy and Psychosomatics

102. Should Excess Topical Decongestant Use Raise a Red Flag? Rhinitis Medicamentosa and Opioid Use Disorder. (PubMed)

through December 2017. Cases, defined as patients who presented with excessive decongestant nasal spray usage based on history, were matched to control patients who presented with chronic rhinitis and did not report regular nasal decongestant usage. The charts were reviewed for patients that carried a problem of opioid abuse, identified using ICD-9 codes 304.XX or ICD-10 codes F11.XX. The primary outcome of this study was the odds of having an OUD. Secondary outcomes were assessed by summary (...) Should Excess Topical Decongestant Use Raise a Red Flag? Rhinitis Medicamentosa and Opioid Use Disorder. The objective of this study was to determine whether patients with rhinitis medicamentosa (RM) have an increased odds of having an opioid use disorder (OUD) and which characteristics may predict this association.The authors conducted a retrospective case control study of patients 18 years and older who presented to the otolaryngology clinic at an academic medical center from January 2013

2019 Rhinology and Laryngology

103. Excessive daytime sleepiness and topographic expansion of Lewy pathology. (PubMed)

Excessive daytime sleepiness and topographic expansion of Lewy pathology. While excessive daytime sleepiness (EDS) can predate the clinical diagnosis of Parkinson disease (PD), associations with underlying PD pathogenesis are unknown. Our objective is to determine if EDS is related to brain Lewy pathology (LP), a marker of PD pathogenesis, using clinical assessments of EDS with postmortem follow-up.Identification of LP was based on staining for α-synuclein in multiple brain regions in a sample

2019 Neurology

104. Excess heart age in adult outpatients in routine HIV care. (PubMed)

, at least 1-year of follow-up, and available covariate data. We calculated age and race/ethnicity-adjusted heart age and excess heart age (chronological age - heart age), using a Framingham risk score-based model.We analyzed data from 2467 men and 619 women (mean chronologic age 49.3 and 49.1 years, and 23.6% and 54.6% Non-Hispanic/Latino black, respectively). Adjusted excess heart age was 11.5 years (95% confidence interval, 11.1-12.0) among men and 13.1 years (12.0-14.1) among women. Excess heart age (...) Excess heart age in adult outpatients in routine HIV care. Cardiovascular disease (CVD) is a common cause of morbidity and mortality among persons living with HIV (PLWH). We used individual cardiovascular risk factor profiles to estimate heart age for PLWH in medical care in the United States.Cross-sectional analyses of HIV Outpatient Study (HOPS) data METHODS:: Included in this analysis were participants aged 30-74 years, without prior CVD, with at least two HOPS clinic visits during 2010-2017

2019 AIDS

105. Evaluating the feasibility of a web-based weight loss programme for naval service personnel with excess body weight. (Full text)

Evaluating the feasibility of a web-based weight loss programme for naval service personnel with excess body weight. Overweight and obesity are a major concern that may influence the operational capacity of the UK Naval Service (NS). This study was conducted to evaluate the feasibility of trialling and implementing a modified web-based weight loss programme for overweight and obese NS personnel.The feasibility of a web-based weight loss programme with minimal face to face support was evaluated (...) using a non-randomised design, based on the Reach, Efficacy, Adoption, and Implementation (RE-AIM) dimensions of a framework designed for analysing implementation of interventions in practice.It was estimated that 6% (n = 58) of eligible NS personnel at recruitment sites were reached, based on personnel's expressions of interest to take part in the study. The potential efficacy of the intervention was evaluated by analysing participants' change in weight (kg) in the two groups. Forty-three

2017 Pilot and feasibility studies PubMed

106. Dataset on electro-optically tunable smart-supercapacitors based on oxygen-excess nanograin tungsten oxide thin film (Full text)

Dataset on electro-optically tunable smart-supercapacitors based on oxygen-excess nanograin tungsten oxide thin film The dataset presented here is related to the research article entitled "Highly Efficient Electro-optically Tunable Smart-supercapacitors Using an Oxygen-excess Nanograin Tungsten Oxide Thin Film" (Akbar et al., 2017) [9] where we have presented a nanograin WO3 film as a bifunctional electrode for smart supercapacitor devices. In this article we provide additional information

2017 Data in brief PubMed

107. Exploring socio-cultural explanations of Glasgow?s ?excess? mortality

. These are important considerations to take into account when supporting continuing placed-based regeneration efforts. The data here comes from the experiences of nine communities across three cities but is also applicable more broadly. Through these experiences we reveal how the creation and use of social connections are adaptations to the particular socioeconomic histories and current circumstances of communities. Background: Explaining Glasgow’s ‘excess’ mortality Although there is a well-established link (...) ’. This is the hypothesis that elements of socio-cultural difference such as psychological outlook, family life, social mobility and the expression and enactment of social capital are candidate explanations for explaining the ‘excess’ mortality of Glasgow and the wider region. We designed this study to explore cultural aspects of life within and between the three cities. Five socio-cultural components, or dimensions, were used to stimulate discussion based on pre-existing hypotheses for how Glasgow’s culture may

2015 Glasgow Centre for Population Health

108. Excessive use of WeChat, social interaction and locus of control among college students in China. (Full text)

Excessive use of WeChat, social interaction and locus of control among college students in China. In China, the number of college students using mobile phone based messaging and social networking applications like WeChat is increasing rapidly. However, there has been minimal research into the addictive nature of these applications and the psychological characteristics associate with their excessive use. There is also no published scale available for assessing excessive use of WeChat and similar (...) applications. In the current study, we collected data from 1,245 college students in China (715 females) and developed the WeChat Excessive Use Scale (WEUS). We then assessed the relationship between excessive use of WeChat and excessive use of a social networking application-Weibo, problematic use of mobile phones, external locus of control, and social interaction skills. Our 10-item scale featured three factors, namely- "mood modification," "salience" and ''conflict"- critical factors in assessing

2017 PLoS ONE PubMed

109. Health and social care spending cuts linked to 120,000 excess deaths in England

Health and social care spending cuts linked to 120,000 excess deaths in England Health and social care spending cuts linked to 120,000 excess deaths in England | BMJ Open by Over 60s and care home residents most at risk; changes in nurse numbers may be key of its kind, published in the online journal . The critical factor in these figures may be changes in nurse numbers, say the researchers, who warn that there could be an additional toll of up to 100 deaths every day from now (...) with those that would be expected, based on trends before spending cuts came into play, and taking account of national and economic factors, such as unemployment rates and pensions. They categorised their findings by age, place of death, and the local government area in which the death occurred, and used these to estimate future death rates up to 2020. Finally, they looked at the health and social care funds that would be needed in addition to those already budgeted by the government as of 2016 to close

2017 BMJ Open Blog

110. Drugs to curb excess stomach acid may be linked to heightened risk of death

Drugs to curb excess stomach acid may be linked to heightened risk of death Drugs to curb excess stomach acid may be linked to heightened risk of death | BMJ Open by May be time to restrict use of widely available proton pump inhibitors, say researchers published in the online journal . Given how widely available these drugs are, and the accumulating evidence pointing to links with a range of potentially serious side effects, it may be time to restrict the indications for use and duration (...) on the end of chromosomes and perform a role similar to the plastic tips on the end of shoelaces. The researchers base their findings on national US data obtained from a network of integrated healthcare systems involving more than 6 million people whose health was tracked for an average of almost six years—until 2013 or death, whichever came first. They carried out three comparative analyses: those taking PPIs with those taking another type of drug used to dampen down acid production called histamine H2

2017 BMJ Open Blog

111. Excess atherosclerosis in systemic lupus erythematosus,-A matter of renal involvement: Case control study of 281 SLE patients and 281 individually matched population controls. (Full text)

Excess atherosclerosis in systemic lupus erythematosus,-A matter of renal involvement: Case control study of 281 SLE patients and 281 individually matched population controls. Systemic lupus erythematosus (SLE), is a heterogeneous disease which predominantly affects young females (90%). SLE is associated with a shorter life expectancy than in the general population. Standardized mortality ratios (SMR) of 2.4 have been reported, which is comparable to diabetes. In modern societies cardiovascular (...) disease (CVD) is the major cause of premature mortality. Accelerated atherosclerosis is generally assumed to be the underlying cause for SLE related CVD. However, previous studies diverge regarding whether atherosclerosis is more common in SLE than in controls. With this in mind and based on own clinical experience we hypothesized that accelerated atherosclerosis is not a general feature of SLE, but prevails in SLE subgroups.281 SLE patients and 281 individually age and sex matched population controls

2017 PLoS ONE PubMed

112. A review of the evidence base for modelling the costs of overweight, obesity and diet-related illness for Scotland, and critical appraisal of the cost-effectiveness evidence base for population wide interventions to reduce overweight, obesity and diet-rel

A review of the evidence base for modelling the costs of overweight, obesity and diet-related illness for Scotland, and critical appraisal of the cost-effectiveness evidence base for population wide interventions to reduce overweight, obesity and diet-rel 1 A review of the evidence base for modelling the costs of overweight, obesity and diet-related illness for Scotland, and critical appraisal of the cost-effectiveness evidence base for population wide interventions to reduce overweight (...) of methods 10 1.4 Structure of the report 10 2 Evidence base relating to the costs of overweight, obesity and diet-related illness 11 2.1 Overview of cost of illness methods 11 Figure 1 Overview of costs 12 2.2 Literature search 14 Figure 2 PRISMA (Preferred Reporting Items for Systematic Reviews and Meta- Analyses) flow chart of cost of illness studies 16 Included 16 Eligibility 16 Screening 16 Identification 16 2.3 Results and critical appraisal 17 2.4 Summary and conclusions 22 3 Cost-effectiveness

2017 Health Economics Research Unit

113. Effect of dietary counseling on preventing excessive weight gain during pregnancy. (PubMed)

Effect of dietary counseling on preventing excessive weight gain during pregnancy. Excessive gestational weight gain (EGWG) is associated with short- and long-term health problems among mothers and their offspring. The aim of this study was to assess the effect of dietary counseling on EGWG.Randomized controlled intervention trial.The study was conducted at the antenatal care (ANC) clinic, Center for Social and Preventive Medicine, Pediatrics Hospital, Cairo University, during the period from (...) July 2015 to April 2016. A total of 200 primigravidae aged between 20 and 30 years were included and randomized into intervention and control groups. Based on data analysis from phase 1, nutritional practices of the studied participants were identified and tailored nutrition counseling sessions designed. Follow-up of the studied participants throughout ANC visits was done to enforce the healthy dietary intake and encourage weight gain according to the recommendations to avoid EGWG.The intervention

2018 Public health

114. A randomized controlled trial to prevent excessive gestational weight gain and promote postpartum weight loss in overweight and obese women: Health In Pregnancy and Postpartum (HIPP). (PubMed)

A randomized controlled trial to prevent excessive gestational weight gain and promote postpartum weight loss in overweight and obese women: Health In Pregnancy and Postpartum (HIPP). Interventions to prevent excessive gestational weight gain and promote postpartum weight loss have yielded modest results, particularly in overweight and obese women.To examine the impact of a theory-based lifestyle intervention on gestational weight gain, postpartum weight loss, and related maternal and child (...) self-monitoring and increasing physical activity and healthy dietary behavior practices, guided by Social Cognitive Theory. Standard care participants receive monthly mailings and a matched number of podcasts on non-weight related topics. All intervention activities last from ≤18weeks gestation to 6months after delivery. Gestational weight gain is the primary outcome. Secondary outcomes are meeting gestational weight gain guidelines (inadequate, adequate, excessive), weekly rate of gestational

2018 Contemporary clinical trials

115. Sensitivity and Specificity of 50% Excess Weight Loss (50%EWL) and Twelve Other Bariatric Criteria for Weight Loss Success. (PubMed)

Sensitivity and Specificity of 50% Excess Weight Loss (50%EWL) and Twelve Other Bariatric Criteria for Weight Loss Success. Criteria for bariatric weight loss success are numerous. Most of them are arbitrary. None of them is evidence-based. Our objective was to determine their sensitivity and specificity.Thirteen common bariatric weight loss criteria were compared to a benchmark reflecting the gold standard in bariatric surgery. We used an elaborate baseline BMI-independent weight loss (...) percentile chart, based on retrospective data after laparoscopic Roux-en-Y gastric bypass (LRYGB), performed between 2007 and 2017. Percentile curves p31.6 (patients' expectation), p25 (interquartile range), p15.9 (1 standard deviation (SD) below median), and p10.9 (surgeons' goal) were used as possible cutoff for success to determine true or false positive and negative results beyond 1 year.We operated 4497 primary LRYGB patients, with mean follow-up 22 (± 1 SD 19; range 0-109) months, 3031 patients

2018 Obesity Surgery

116. Secular trends in excess mortality of late-life depression. (PubMed)

Secular trends in excess mortality of late-life depression. Late-life depression is associated with premature mortality, however, little is known whether excess mortality rates of depression have changed over time. This study aims to identify and explain secular trends in excess mortality of major depressive disorder (MDD) and subthreshold depression (SUBD).Cohort-sequential-longitudinal study of 4084 community-dwelling older adults in the Netherlands based on data from the Longitudinal Aging (...) Equations was used to investigate the association between the interaction 'Depression × Time' and 5-year mortality, and to find explanatory factors for the trend.A downward trend in excess mortality of MDD was found (OR = .92, 95%-CI:.85-.99, P = .04), adjusted for age and sex, which could not be explained by education, health and lifestyle factors, nor antidepressants use. Sex differences in the trend were not found (P = .77). No trend in excess mortality of SUBD was found (OR = 1.01, 95%-CI: .97-1.04

2018 Journal of Affective Disorders

117. Avoiding excessive pregnancy weight gain to obtain better pregnancy outcomes in Taiwan. (Full text)

Avoiding excessive pregnancy weight gain to obtain better pregnancy outcomes in Taiwan. Pregnancy weight gain may be associated with adverse pregnancy outcomes. The article aims to explore the relationship between weight change and pregnancy outcome in the Taiwanese pregnant women.The retrospective cohort study enrolled women with vertex singleton pregnancy at University-associated Hospital between 2011 and 2014. Pregnancy weight change was separated into 3 groups, based on the Institute

2018 Medicine PubMed

118. The Excess Opioid Disposal Study

Experimental: one acetaminophen 650 mg three times/day ibuprofen 600 mg three times/day opioid dose based on use in hospital day prior to discharge Behavioral: phone contact patients will be called prior to their outpatient appointment Outcome Measures Go to Primary Outcome Measures : opioid disposal rate [ Time Frame: 1 year ] % of patients that dispose of excess opioids in an FDA compliant manner Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate (...) The Excess Opioid Disposal Study The Excess Opioid Disposal Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Excess Opioid Disposal Study The safety and scientific validity of this study

2018 Clinical Trials

119. Excess mortality in Finnish diabetic subjects due to alcohol, accidents and suicide: a nationwide study (PubMed)

Excess mortality in Finnish diabetic subjects due to alcohol, accidents and suicide: a nationwide study To characterize the burden of external causes of death attributable to alcohol-related causes, accidents and suicide among diabetic patients in a large national cohort.The population included diabetic individuals who had purchased and received reimbursement for at least one insulin prescription and/or one oral antidiabetic drug prescription between January 1997 and December 2010, and a non (...) -diabetic reference population matched by sex, age and area. All new insulin users in this period were included, as well as 50% of new oral drug (OAD) users as a random sample. The data were collected by means of linkage from national registries. We analyzed the cohort data using Poisson regression models separately for each end-point and by gender (mortality rate ratio (MRR)). We subjected the case-cohort data to conditional logistic regression analysis based on exposure information within 1 year

2018 European Journal of Endocrinology

120. "Differential mortality and the excess rates of hip fracture associated with type 2 diabetes: accounting for competing risks in fracture prediction matters". (PubMed)

"Differential mortality and the excess rates of hip fracture associated with type 2 diabetes: accounting for competing risks in fracture prediction matters". Type 2 diabetes (T2DM) is associated with a reduced life expectancy. The latest published evidence suggests an increased risk of fractures among T2DM patients. We conducted a population-based cohort study to determine the impact of mortality as a competing risk in the study of the association between T2DM and hip fracture rates

2018 Journal of Bone and Mineral Research

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