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61. Palliative care - oral: Scenario: Halitosis, excessive salivation and altered taste

[ ; ]. Correction of the underlying cause is usually not possible in advanced cancer, but secondary care irradiation of the salivary glands corrects the problem [ ]. The information on drugs that some experts may use to control excessive salivation is based on expert opinion [ ; ]. Alteration in taste Stress the importance of good oral hygiene. See . Treat dry mouth if present. See . Treat oral candidiasis. See . Withdraw treatment with drugs that may induce or increase symptoms (for examples, see Table 1 (...) Palliative care - oral: Scenario: Halitosis, excessive salivation and altered taste Scenario: Halitosis, excessive salivation and altered taste | Management | Palliative care - oral | CKS | NICE Search CKS… Menu Scenario: Halitosis, excessive salivation and altered taste Palliative care - oral: Scenario: Halitosis, excessive salivation and altered taste Last revised in October 2018 Scenario: Halitosis, excessive salivation and altered taste From age 16 years onwards. Halitosis due to an oral

2019 NICE Clinical Knowledge Summaries

62. Hyperhidrosis: How should I assess a person with excessive sweating?

Hyperhidrosis: How should I assess a person with excessive sweating? Assessment | Diagnosis | Hyperhidrosis | CKS | NICE Search CKS… Menu Assessment Hyperhidrosis: How should I assess a person with excessive sweating? Last revised in May 2018 How should I assess a person with excessive sweating? Assess the person to help determine if hyperhidrosis is primary (idiopathic), or secondary to an . Ask about: The , distribution, and symmetry of excessive sweating — focal (likely primary (...) which may cause sweating, and any alcohol or drug misuse or withdrawal. The of symptoms on quality of life, and associated anxiety which may exacerbate symptoms. Any family history of excessive sweating or possible underlying cause(s). Any known which may cause sweating. Examine the person to assess: The location(s) and distribution of visible excessive sweating. Body weight and body mass index (BMI). See the CKS topic on for more information. For any . For any other signs suggesting an underlying

2019 NICE Clinical Knowledge Summaries

63. Base Excess

Base Excess Base Excess Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Base Excess Base Excess Aka: Base Excess , Base Deficit II (...) . Calculation Base Excess = (Actual_pH - Predicted_pH) * 67 Calculate predicted pH based on (see ) III. Interpretation: Normal Range: -2 to +2 meq/L IV. Interpretation: General Positive (Base Excess) Negative (Base Deficit) V. Interpretation: Neonatology Severe Acidosis (Base Excess < -10) Calculate Total Body Bicarbonate deficit Deficit = (Base Deficit) x (Weight in kg) x 0.3 Administer 25% of bicarbonate deficit (~1 meq/kg) Images: Related links to external sites (from Bing) These images are a random

2018 FP Notebook

64. Base excess in predicting the prognosis of patients with paraquat poisoning: a meta-analysis

Base excess in predicting the prognosis of patients with paraquat poisoning: a meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address (...) : Timing and effect measures Timing and effect measures Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Context and rationale Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Example: Screening will be performed in two phases, namely initial screening based on title and abstract, followed by full-text

2018 PROSPERO

65. Impact of Parental Socioeconomic Status on Excess Mortality in a Population-Based Cohort of Subjects With Childhood-Onset Type 1 Diabetes Full Text available with Trip Pro

Impact of Parental Socioeconomic Status on Excess Mortality in a Population-Based Cohort of Subjects With Childhood-Onset Type 1 Diabetes The aim of this study was to analyze the possible impact of parental and individual socioeconomic status (SES) on all-cause mortality in a population-based cohort of patients with childhood-onset type 1 diabetes.Subjects recorded in the Swedish Childhood Diabetes Registry (SCDR) from 1 January 1978 to 31 December 2008 were included (n = 14,647). The SCDR

2015 EvidenceUpdates

66. Excess Mortality in Patients With Type 1 Diabetes Without Albuminuria-Separating the Contribution of Early and Late Risks Full Text available with Trip Pro

Excess Mortality in Patients With Type 1 Diabetes Without Albuminuria-Separating the Contribution of Early and Late Risks The current study investigated whether the risk of mortality in patients with type 1 diabetes without any signs of albuminuria is different than in the general population and matched control subjects without diabetes.We studied a nationwide, population-based Finnish register of 10,737 patients diagnosed with type 1 diabetes during 1980-2005 and followed for 10 years (...) ). However, it was higher compared with that of control subjects without diabetes (1.33 [1.06-1.66], P = 0.01). Excess mortality was largely due to acute diabetes complications and ischemic heart disease, which remained more than fourfold higher (mortality rate ratio 4.34 [2.49-7.57]) in adults with type 1 diabetes than in control subjects without diabetes, despite the absence of albuminuria. By contrast, deaths due to alcohol and drugs were reduced in adults with type 1 diabetes (P = 0.007), especially

2018 EvidenceUpdates

67. Excess of de novo variants in genes involved in chromatin remodelling in patients with marfanoid habitus and intellectual disability. (Abstract)

on a combination of trio-based (33 subjects) or single probands (31 subjects), of which 61 were sporadic.We identified eight genes with de novo variants (DNVs) in at least two unrelated individuals (ARID1B, ATP1A1, DLG4, EHMT1, NFIX, NSD1, NUP205 and ZEB2). Using simulation models, we showed that five genes (DLG4, NFIX, EHMT1, ZEB2 and ATP1A1) met conservative Bonferroni genomewide significance for an excess of the observed de novo point variants. Overall, at least one pathogenic or likely pathogenic variant (...) Excess of de novo variants in genes involved in chromatin remodelling in patients with marfanoid habitus and intellectual disability. Marfanoid habitus (MH) combined with intellectual disability (ID) (MHID) is a clinically and genetically heterogeneous presentation. The combination of array CGH and targeted sequencing of genes responsible for Marfan or Lujan-Fryns syndrome explain no more than 20% of subjects.To further decipher the genetic basis of MHID, we performed exome sequencing

2020 Journal of Medical Genetics

68. Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation. Full Text available with Trip Pro

Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation. The cause of fatty liver is multifactorial, including genetic and environmental factors. Currently, only a few genetic variants explain the heritability of the disease. QTL analysis of mouse strains enables the identification of genes causing complex human diseases. In a backcross of New Zealand obese (NZO) and C57BL/6J (B6) mice we identified the QTL Ltg/NZO on chromosome 18, which associates with increased (...) liver triglycerides.Recombinant congenic mice carrying 5.3 Mbp of Ltg/NZO were fed a high-fat diet and characterized for liver fat. Bioinformatic analysis, mRNA profiles and electrophoretic mobility shift assays were performed to identify genes responsible for the Ltg/NZO phenotype. Candidate genes were manipulated in vivo by injection of specific microRNAs in B6 mice. Pulldown coupled with mass-spectrometry-based proteomics and immunoprecipitation were performed to identify interaction partners

2020 Journal of Hepatology

69. Excess of singleton loss-of-function variants in Parkinson's disease contributes to genetic risk. Full Text available with Trip Pro

Excess of singleton loss-of-function variants in Parkinson's disease contributes to genetic risk. Parkinson's disease (PD) is a neurodegenerative disorder with complex genetic architecture. Besides rare mutations in high-risk genes related to monogenic familial forms of PD, multiple variants associated with sporadic PD were discovered via association studies.We studied the whole-exome sequencing data of 340 PD cases and 146 ethnically matched controls from the Parkinson's Progression Markers (...) Initiative (PPMI) and performed burden analysis for different rare variant classes. Disease prediction models were built based on clinical, non-clinical and genetic features, including both common and rare variants, and two machine learning methods.We observed a significant exome-wide burden of singleton loss-of-function variants (corrected p=0.037). Overall, no exome-wide burden of rare amino acid changing variants was detected. Finally, we built a disease prediction model combining singleton loss

2020 Journal of Medical Genetics

70. History, politics and vulnerability: explaining excess mortality

of the report. 33 5. Developing explanatory models for Scotland and Glasgow 5.1 Introduction The explanatory models that are presented here are based on the assessment of a large number of hypotheses that have been proposed as explanations, or partial explanations, for Scotland’s and Glasgow’s high levels of excess mortality, as well as others identified from a systematic review of similar ‘excesses’ observed in comparisons of other countries. In total, 40 proposed hypotheses were examined, individually (...) the divergence between Glasgow and the two English cities, and the relationship between deprivation and mortality in comparing Scotland with England & Wales, are what lie at the heart of this synthesis. 34 Figure 10: The context for Scottish excess mortality. The explanatory models presented below, therefore, are centred primarily around what the most likely effect modifiers are, with that judgement based in turn on existing knowledge, historical context and the assessment of over 40 suggested contributory

2016 Glasgow Centre for Population Health

71. Exploring socio-cultural explanations of Glasgow?s ?excess? mortality

. These are important considerations to take into account when supporting continuing placed-based regeneration efforts. The data here comes from the experiences of nine communities across three cities but is also applicable more broadly. Through these experiences we reveal how the creation and use of social connections are adaptations to the particular socioeconomic histories and current circumstances of communities. Background: Explaining Glasgow’s ‘excess’ mortality Although there is a well-established link (...) ’. This is the hypothesis that elements of socio-cultural difference such as psychological outlook, family life, social mobility and the expression and enactment of social capital are candidate explanations for explaining the ‘excess’ mortality of Glasgow and the wider region. We designed this study to explore cultural aspects of life within and between the three cities. Five socio-cultural components, or dimensions, were used to stimulate discussion based on pre-existing hypotheses for how Glasgow’s culture may

2015 Glasgow Centre for Population Health

72. Predicting excess cost for older inpatients with clinical complexity: A retrospective cohort study examining cognition, comorbidities and complications. Full Text available with Trip Pro

Predicting excess cost for older inpatients with clinical complexity: A retrospective cohort study examining cognition, comorbidities and complications. Hospital-acquired complications increase length of stay and contribute to poorer patient outcomes. Older adults are known to be at risk for four key hospital-acquired complications (pressure injuries, pneumonia, urinary tract infections and delirium). These complications have been identified as sensitive to nursing characteristics (...) of length-of-stay costs. Explanatory variables included patient age, sex, comorbidities, admission severity, dementia status, surgical status and four complications. Extra costs were based on above-average length-of-stay for each patient's Diagnosis Related Group from hospital discharge data.For adults over 50 who have length of stay longer than average for their diagnostic condition, comorbid dementia predicts an extra cost of A$874, (US$1,247); any one of four key complications predicts A$812 (US

2018 PLoS ONE

73. Parents’ perceptions of reasons for excess weight loss in obese children: a peer researcher approach Full Text available with Trip Pro

this excess weight loss is achieved. Interviews were conducted by peer researchers, transcribed verbatim and analysed thematically by both peer- and university-based investigators.The peer researchers felt confident to conduct interviews after three training sessions. Recruitment of interviewees was challenging, resulting in only four volunteers (all mothers) over a 5-month period; thus peer researchers were only able to conduct one interview each. All interviews were considered good quality in comparison (...) Parents’ perceptions of reasons for excess weight loss in obese children: a peer researcher approach This study reports on the process of conducting participatory research by training peer researchers to conduct interviews and analyse data collected with parents of overweight children. The methodology was chosen as a means of (a) encouraging participation among a hard-to-engage group (i.e., parents of overweight children), and (b) generating novel insights and challenging academic/health

2017 Research involvement and engagement

74. Development of a Primary Care Guide for Implementing Evidence-Based Screening and Counseling for Unhealthy Alcohol Use With Epic-Based Electronic Health Record Tools: A Pilot Dissemination Project

Development of a Primary Care Guide for Implementing Evidence-Based Screening and Counseling for Unhealthy Alcohol Use With Epic-Based Electronic Health Record Tools: A Pilot Dissemination Project Methods Research Report Development of a Primary Care Guide for Implementing Evidence-Based Screening and Counseling for Unhealthy Alcohol Use With Epic- Based Electronic Health Record Tools: A Pilot Dissemination Project Methods Research Report Development of a Primary Care Guide for Implementing (...) Evidence-Based Screening and Counseling for Unhealthy Alcohol Use With Epic- Based Electronic Health Record Tools: A Pilot Dissemination Project Prepared for: Agency for Healthcare Research and Quality U.S. Department of Health and Human Services 5600 Fishers Lane Rockville, MD 20857 www.ahrq.gov Contract No. 290-2015-00011-I, Task Order 1 Prepared by: RTI International–University of North Carolina Evidence-based Practice Center Research Triangle Park, NC Investigators: Colleen Barclay, M.P.H. Meera

2018 Effective Health Care Program (AHRQ)

75. Serum Iodine Is Correlated with Iodine Intake and Thyroid Function in School-Age Children from a Sufficient-to-Excessive Iodine Intake Area. Full Text available with Trip Pro

Serum Iodine Is Correlated with Iodine Intake and Thyroid Function in School-Age Children from a Sufficient-to-Excessive Iodine Intake Area. An alternative feasible and convenient method of assessing iodine intake is needed.The aim of this study was to examine the utility of serum iodine for assessing iodine intake in children.One blood sample and 2 repeated 24-h urine samples (1-mo interval) were collected from school-age children in Shandong, China. Serum free triiodothyronine (FT3), free (...) thyroxine (FT4), thyroid-stimulating hormone (TSH), thyroglobulin (Tg), total iodine (StI), and non-protein-bound iodine (SnbI) concentrations and urine iodine (UIC) and creatinine (UCr) concentrations were measured. Iodine intake was estimated based on two 24-h urine iodine excretions (24-h UIE). Associations between serum iodine and other factors were analyzed using the Spearman rank correlation test. Receiver operating characteristic (ROC) curves were used to illustrate diagnostic ability of StI

2019 Journal of Nutrition

76. Predicting hazardous drinking in late adolescence/young adulthood from early and excessive adolescent drinking - a longitudinal cross-national study of Norwegian and Australian adolescents. Full Text available with Trip Pro

, ambiguous definitions of the concept, and an assumption that early onset is independent of cultural norms and national alcohol policies. This study addresses these limitations by examining whether EOD, independent of early onset of excessive drinking (EOE), prospectively predicts hazardous drinking in late adolescence/young adulthood in Norway and Australia, two countries with different drinking cultures.Data were drawn from two population-based longitudinal studies; the Norwegian Tracking Opportunities (...) Predicting hazardous drinking in late adolescence/young adulthood from early and excessive adolescent drinking - a longitudinal cross-national study of Norwegian and Australian adolescents. Research has consistently shown that early onset of drinking (EOD) is associated with alcohol-related problems in adulthood. However, recent reviews have identified several limitations in the early onset literature, including the use of retrospective reports, insufficient control for potential confounders

2019 BMC Public Health

77. Breast cancer histologic subtypes show excess familial clustering. (Abstract)

Breast cancer histologic subtypes show excess familial clustering. The inherited predisposition to developing specific histologic subtypes of invasive breast carcinoma has been incompletely investigated. By using a large, population-based database, the authors sought to investigate familial clustering of breast cancer by histologic subtype.By using the Utah Population Database, which links genealogy records to the National Cancer Institute's statewide Surveillance, Epidemiology, and End Results (...) histologic subtypes other than invasive ductal carcinoma (including inflammatory [n = 178], lobular [n = 1688], and mucinous [n = 542]). Statistically significant excess distant relatedness was identified for the mucinous subtype (P = .011) as well as for inflammatory breast cancers (P = .024). The RR for breast cancer of any histology in second-degree relatives was significantly increased for patients with inflammatory (RR, 1.32; 95% CI, 1.02-1.68; P = .03), lobular (RR, 1.36; 95% CI, 1.25-1.47; P

2019 Cancer

78. Excess weight loss is a vital strategy for controlling hypertension among multi-ethnic population in northwest China: A cross-sectional analysis. Full Text available with Trip Pro

Excess weight loss is a vital strategy for controlling hypertension among multi-ethnic population in northwest China: A cross-sectional analysis. Hypertension is a common global health problem including China. This study aimed to assess the prevalence and awareness of hypertension, and evaluate risk factors associated with hypertension among multi-ethnic population in northwest China using a random sampling cross-sectional data.A cross-sectional survey was conducted between 2014 and 2015 (...) as part of a nationwide survey using stratified four-stage random sampling in Xinjiang. Hypertension was defined as mean systolic blood pressure (SBP) and/or diastolic blood pressure (DBP) ≥140/90 mm Hg and/or taking anti-hypertensive medication. In addition, the prevalence of hypertension (SBP ≥ 130 or DBP ≥ 80 mm Hg) was also estimated according to the 2017 American College of Cardiology (ACC)/American Heart Association (AHA) High Blood Pressure Guideline. Awareness of hypertension was based on self

2019 Medicine

79. Effectiveness of a behavioural intervention involving regular weighing and feedback by community midwives within routine antenatal care to prevent excessive gestational weight gain: POPS2 randomised controlled trial. Full Text available with Trip Pro

Effectiveness of a behavioural intervention involving regular weighing and feedback by community midwives within routine antenatal care to prevent excessive gestational weight gain: POPS2 randomised controlled trial. To assess the effectiveness of a brief behavioural intervention based on routine antenatal weighing to prevent excessive gestational weight gain (defined by US Institute of Medicine).Randomised controlled trial.Antenatal clinic in England.Women between 10+0 and 14+6 weeks gestation (...) weight gain, depression, anxiety and physical activity.Six hundred and fifty-six women from four maternity centres were recruited: 329 women were randomised to the intervention group and 327 to UC. We found no evidence that the intervention decreased excessive gestational weight gain. At 38 weeks gestation, the proportions gaining excessive gestational weight were 27.6% (81/305) versus 28.9% (90/311) (adjusted OR 0.84, 95% CI: 0.53 to 1.33) in the intervention and UC group, respectively. There were

2019 BMJ open

80. Excessive daytime sleepiness and topographic expansion of Lewy pathology. (Abstract)

Excessive daytime sleepiness and topographic expansion of Lewy pathology. While excessive daytime sleepiness (EDS) can predate the clinical diagnosis of Parkinson disease (PD), associations with underlying PD pathogenesis are unknown. Our objective is to determine if EDS is related to brain Lewy pathology (LP), a marker of PD pathogenesis, using clinical assessments of EDS with postmortem follow-up.Identification of LP was based on staining for α-synuclein in multiple brain regions in a sample

2019 Neurology

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