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Base Excess

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41. Excess Productivity Costs of Systemic Lupus Erythematosus, Systemic Sclerosis, and Sjogren's Syndrome: A General Population-Based Study. Full Text available with Trip Pro

Excess Productivity Costs of Systemic Lupus Erythematosus, Systemic Sclerosis, and Sjogren's Syndrome: A General Population-Based Study. To determine excess productivity losses and costs of systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and Sjögren's syndrome (SS) at the population level.Administrative databases from the province of British Columbia, Canada, were used to establish population-based cohorts of SLE, SSc, and SS, and matched comparison cohorts were selected from (...) working-age patients were not employed at all, due to health (SLE = 36%, SSc = 32%, SS = 30%, and non-SARDs = 18%), and the majority of total productivity costs were from unpaid work loss (SLE = 73% of costs, SSc = 74%, SS = 60%, and non-SARDs = 47%). Adjusted excess costs from these unpaid production losses were $127, $100, and $82 per week, respectively, among SLE, SSc, and SS patients.In this population-based sample of prevalent SLE, SSc, and SS, lost productivity costs were substantial, mainly

2018 Arthritis care & research

42. Predictors of inappropriate and excessive use of reliever medications in asthma: a 16-year population-based study. Full Text available with Trip Pro

Predictors of inappropriate and excessive use of reliever medications in asthma: a 16-year population-based study. Understanding factors associated with the inappropriate or excessive use of short-acting beta agonists (SABA) can help develop better policies.We used British Columbian (BC)'s administrative health data (1997-2014) to create a retrospective cohort of asthma patients aged between 14 and 55 years. The primary and secondary outcomes were, respectively, inappropriate and excessive use (...) of SABA based on a previously validated definition. Exposures were categorised into groups comprising socio-demographic variables, indicators of type and quality of asthma care, and burden of comorbid conditions.343,520 individuals (56.3% female, average age 30.5) satisfied the asthma case definition, contributing 2.6 million person-years. 7.3% of person-years were categorised as inappropriate SABA use and 0.9% as excessive use. Several factors were associated with lower likelihood of inappropriate

2018 BMC pulmonary medicine

43. Quantitative study - other: Excess mortality associated with weekend hospital admissions may be due to patient-level differences, rather than reduced staffing or services

Quantitative study - other: Excess mortality associated with weekend hospital admissions may be due to patient-level differences, rather than reduced staffing or services Excess mortality associated with weekend hospital admissions may be due to patient-level differences, rather than reduced staffing or services | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time (...) . To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Excess mortality associated with weekend hospital admissions may be due

2018 Evidence-Based Nursing

44. Can venous base excess replace arterial base excess as a marker of early shock and a predictor of survival in trauma? Full Text available with Trip Pro

Can venous base excess replace arterial base excess as a marker of early shock and a predictor of survival in trauma? Arterial base excess is an established marker of shock and predictor of survival in trauma patients. However, venous blood is more quickly and easily obtained. This study aimed to determine if venous base excess could replace arterial base excess as a marker in trauma patients at presentation and if venous base excess is predictive of survival at 24 hours and one week.This (...) was a prospective study of 394 trauma patients presenting to the emergency department of a tertiary hospital over a 17-month period. Data on base excess at presentation, vital signs, shock index (SI), injury severity score (ISS), and mortality at 24 hours and one week was collected and analysed.Arterial and venous blood gas tests were performed on 260 and 134 patients, respectively. Patients were stratified into groups based on their SI and ISS for analysis. There was no statistical difference between mean

2016 Singapore medical journal

45. A telehealth lifestyle intervention to reduce excess gestational weight gain in pregnant women with overweight or obesity (GLOW): a randomised, parallel-group, controlled trial

]; mean between-group difference -0·07 kg per week, 95% CI -0·09 to -0·04). No between-group differences in perinatal complications were observed. Interpretation: Our evidence-based programme showed that health-care delivery systems could further adapt to meet the needs of their clinical settings to prevent excess GWG and improve healthy behaviours and markers of insulin resistance among women with overweight or obesity by using telehealth lifestyle interventions. Funding: US National Institutes (...) A telehealth lifestyle intervention to reduce excess gestational weight gain in pregnant women with overweight or obesity (GLOW): a randomised, parallel-group, controlled trial A Telehealth Lifestyle Intervention to Reduce Excess Gestational Weight Gain in Pregnant Women With Overweight or Obesity (GLOW): A Randomised, Parallel-Group, Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search

2020 EvidenceUpdates

46. Acute coronary syndrome in new-onset rheumatoid arthritis: a population-based nationwide cohort study of time trends in risks and excess risks (Abstract)

Acute coronary syndrome in new-onset rheumatoid arthritis: a population-based nationwide cohort study of time trends in risks and excess risks Acute coronary syndrome (ACS) and other cardiovascular diseases are the main drivers of the increased morbidity and preterm mortality in rheumatoid arthritis (RA). ACS in RA has been linked to inflammation and RA severity. During recent years and with new therapeutic options and treat-to-target strategies, increasing efforts have been made to reach RA (...) remission as soon as possible after diagnosis, and the average level of RA disease activity has declined. Whether this has resulted in declining excess risks for RA comorbidities remains unclear.We performed a nationwide population-based cohort study of patients with new-onset RA from 1997 to 2014, and matched general population comparators. In the Swedish healthcare system, all residents have equal access to healthcare services. Healthcare is monitored using high-quality population-based registers

2017 EvidenceUpdates

47. Gastrointestinal iron excretion and reversal of iron excess in a mouse model of inherited iron excess. Full Text available with Trip Pro

Gastrointestinal iron excretion and reversal of iron excess in a mouse model of inherited iron excess. The current paradigm in the field of mammalian iron biology states that body iron levels are determined by dietary iron absorption, not by iron excretion. Iron absorption is a highly regulated process influenced by iron levels and other factors. Iron excretion is believed to occur at a basal rate irrespective of iron levels and is associated with processes such as turnover of intestinal (...) epithelium, blood loss, and exfoliation of dead skin. Here we explore iron excretion in a mouse model of iron excess due to inherited transferrin deficiency. Iron excess in this model is attributed to impaired regulation of iron absorption leading to excessive dietary iron uptake. Pharmacologic correction of transferrin deficiency not only normalized iron absorption rates and halted progression of iron excess but also reversed body iron excess. Transferrin treatment did not alter the half-life of 59Fe

2018 Haematologica

48. Excess Antibiotic Treatment Duration and Adverse Events in Patients Hospitalized With Pneumonia: A Multihospital Cohort Study. (Abstract)

was the rate of excess antibiotic treatment duration (excess days per 30-day period). Excess days were calculated by subtracting each patient's shortest effective (expected) treatment duration (based on time to clinical stability, pathogen, and pneumonia classification [community-acquired vs. health care-associated]) from the actual duration. Negative binomial generalized estimating equations (GEEs) were used to calculate rate ratios to assess predictors of 30-day rates of excess duration. Patient outcomes (...) Excess Antibiotic Treatment Duration and Adverse Events in Patients Hospitalized With Pneumonia: A Multihospital Cohort Study. Randomized trials demonstrate no benefit from antibiotic treatment exceeding the shortest effective duration.To examine predictors and outcomes associated with excess duration of antibiotic treatment.Retrospective cohort study.43 hospitals in the Michigan Hospital Medicine Safety Consortium.6481 general care medical patients with pneumonia.The primary outcome

2019 Annals of Internal Medicine

49. Excess deaths associated with tigecycline after approval based on noninferiority trials

Excess deaths associated with tigecycline after approval based on noninferiority trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2012 DARE.

50. History, politics and vulnerability: explaining excess mortality

of the report. 33 5. Developing explanatory models for Scotland and Glasgow 5.1 Introduction The explanatory models that are presented here are based on the assessment of a large number of hypotheses that have been proposed as explanations, or partial explanations, for Scotland’s and Glasgow’s high levels of excess mortality, as well as others identified from a systematic review of similar ‘excesses’ observed in comparisons of other countries. In total, 40 proposed hypotheses were examined, individually (...) the divergence between Glasgow and the two English cities, and the relationship between deprivation and mortality in comparing Scotland with England & Wales, are what lie at the heart of this synthesis. 34 Figure 10: The context for Scottish excess mortality. The explanatory models presented below, therefore, are centred primarily around what the most likely effect modifiers are, with that judgement based in turn on existing knowledge, historical context and the assessment of over 40 suggested contributory

2016 Glasgow Centre for Population Health

51. Modified Lip Repositioning Surgery for the Management of Excessive Gingival Display Caused by Hyperactive Upper Lip Is a Viable Treatment Option

Modified Lip Repositioning Surgery for the Management of Excessive Gingival Display Caused by Hyperactive Upper Lip Is a Viable Treatment Option UTCAT3278, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Modified Lip Repositioning Surgery for the Management of Excessive Gingival Display Caused by Hyperactive Upper Lip Is a Viable Treatment Option Clinical Question Should lip repositioning surgery be part of our (...) armamentarium for the management of excessive gingival display? Clinical Bottom Line The modified lip repositioning surgery should be considered alone or as an adjunctive procedure for the management of “gummy smile.” This technique, although based on lower level evidence, has proven successful in cases with a hyperactive upper lip etiology in providing an esthetically satisfactory reduction of the gingival display while being minimally invasive and having limited complications. A thorough patient

2017 UTHSCSA Dental School CAT Library

52. Pre-pasted flash-free orthodontic brackets reduce bonding time and the need to remove excess adhesive compared to conventional orthodontic brackets and bonding techniques.

Pre-pasted flash-free orthodontic brackets reduce bonding time and the need to remove excess adhesive compared to conventional orthodontic brackets and bonding techniques. UTCAT3290, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Pre-pasted flash-free orthodontic brackets reduce bonding time and the need to remove excess adhesive compared to conventional orthodontic brackets and bonding techniques. Clinical Question (...) Do pre-pasted flash-free adhesive orthodontic brackets reduce bonding time and the need to remove excess adhesive compared to conventional brackets in orthodontic patients? Clinical Bottom Line Pre-pasted flash-free orthodontic brackets reduce bonding time and the need to remove excess adhesive compared to conventional orthodontic brackets and bonding techniques. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level

2017 UTHSCSA Dental School CAT Library

53. Sleep problems in excessive technology use among adolescent: a systemic review and meta-analysis Full Text available with Trip Pro

Sleep problems in excessive technology use among adolescent: a systemic review and meta-analysis Sleep problems in excessive technology use among adolescent: a systemic review and meta-analysis | Sleep Science and Practice | Full Text Search Search all BMC articles Search Sleep problems in excessive technology use among adolescent: a systemic review and meta-analysis , , , , , , , & , volume 2 , Article number: 9 ( 2018 ) 9991 Accesses 7 Citations 18 Altmetric Abstract Background Inadequate (...) sleep quantity and quality is a public health concern with an array of detrimental health outcomes. Portable technological devices have become a ubiquitous part of adolescents’ lives and may affect their sleep duration and quality. The purpose of this study was to summarize published analyses of various technology uses and sleep outcomes and to examine whether there is an association between excessive technology use (ETU) and poor sleep outcomes in adolescents. Method We conduct a systematic review

2018 Sleep Science and Practice

54. Prevalence of weight excess in Brazilian children and adolescents: a systematic review Full Text available with Trip Pro

Prevalence of weight excess in Brazilian children and adolescents: a systematic review Prevalência de excesso de peso em crianças e adolescentes brasileiros: uma revisão sistemática | Revista Brasileira de Cineantropometria e Desempenho Humano Open Menu Buscar Buscar / / / Artigos de Revisão Wendell Arthur Lopes Universidade Estadual de Maringá Jane Maria Remor Universidade Estadual de Maringá João Carlos Locateli Universidade Estadual de Maringá Felipe Bandeira Lima Universidade Estadual de (...) a produção científica referente à prevalência de excesso de peso em crianças e adolescentes brasileiros. Realizou-se uma busca nas bases de dados MEDLINE/PubMed, WEB of Science, LILACS, Scielo e BVS.Foram analisados 61 estudos, sendo identificado 17% de sobrepeso e 11,6% de obesidade.As prevalências de excesso de peso (26,4% vs 23,5%), sobrepeso (17% vs 16%) e obesidade (11,9% vs 9,1%) foram maiores entre os meninos comparados as meninas, respectivamente. As crianças e os adolescentes da Região Sul

2018 Brazilian Journal of Kinanthropometry and Human Performance

55. Estimating the effect of healthcare-associated infections on excess length of hospital stay using inverse-probability weighted survival curves. Full Text available with Trip Pro

Estimating the effect of healthcare-associated infections on excess length of hospital stay using inverse-probability weighted survival curves. Studies estimating excess length of stay (LoS) attributable to nosocomial infections have failed to address time-varying confounding, likely leading to overestimation of their impact. We present a methodology based on inverse probability-weighted (IPW) survival curves to address this limitation.A case-study focusing on intensive care unit-acquired (...) bacteraemia using data from two general ICUs from two London teaching hospitals were used to illustrate the methodology. The area under the curve (AUC) of a conventional Kaplan Meier curve applied to the observed data was compared with that of an IPW Kaplan Meier curve applied after treating bacteraemia as censoring events. Weights were based on the daily probability of acquiring bacteraemia. The difference between the observed average LoS and the average LoS that would be observed if all bacteraemia

2020 Clinical Infectious Diseases

56. Classic and Nonclassic Apparent Mineralocorticoid Excess Syndrome. (Abstract)

Classic and Nonclassic Apparent Mineralocorticoid Excess Syndrome. Arterial hypertension (AHT) is one of the most frequent pathologies in the general population. Subtypes of essential hypertension characterized by low renin levels allowed the identification of 2 different clinical entities: aldosterone-mediated mineralocorticoid receptor (MR) activation and cortisol-mediated MR activation.This review is based upon a search of Pubmed and Google Scholar databases, up to August 2019, for all (...) publications relating to endocrine hypertension, apparent mineralocorticoid excess (AME) and cortisol (F) to cortisone (E) metabolism.The spectrum of cortisol-mediated MR activation includes the classic AME syndrome to milder (nonclassic) forms of AME, the latter with a much higher prevalence (7.1%) than classic AME but different phenotype and genotype. Nonclassic AME (NC-AME) is mainly related to partial 11βHSD2 deficiency associated with genetic variations and epigenetic modifications (first hit

2020 Journal of Clinical Endocrinology and Metabolism

57. Long Noncoding RNA HUPCOS Promotes Follicular Fluid Androgen Excess in PCOS Patients via Aromatase Inhibition. (Abstract)

Long Noncoding RNA HUPCOS Promotes Follicular Fluid Androgen Excess in PCOS Patients via Aromatase Inhibition. Androgen excess is a key feature of polycystic ovary syndrome (PCOS), but the underlying molecular mechanism remains unclear.To determine the role and mechanism of novel long noncoding RNA (lncRNA) highly up-regulated in PCOS (HUPCOS) in the androgen excess of PCOS patients.The lncRNA expression profile in granulosa cells derived from PCOS and non-PCOS women were analyzed by using (...) microarray assay. Human granulosa cell line KGN was used for mechanism investigation.This was a university-based study.Thirty-eight PCOS and 38 control patients were recruited: 8 PCOS and 8 control samples used for microarray discovery, the remaining 30 PCOS cases and 30 controls for quantitative RT-PCR validation.The aberrant expression lncRNA profile of PCOS patients was measured using microarray. The relationship of HUPCOS and follicular fluid testosterone was measured. Aromatase expression were

2020 Journal of Clinical Endocrinology and Metabolism

58. Glucocorticoid Excess in Patients with Pheochromocytoma Compared with Paraganglioma and Other Forms of Hypertension. Full Text available with Trip Pro

Glucocorticoid Excess in Patients with Pheochromocytoma Compared with Paraganglioma and Other Forms of Hypertension. Catecholamines and adrenocortical steroids are important regulators of blood pressure. Bidirectional relationships between adrenal steroids and catecholamines have been established but whether this is relevant to patients with pheochromocytoma is unclear.This study addresses the hypothesis that patients with pheochromocytoma and paraganglioma (PPGL) have altered steroid (...) production compared with patients with primary hypertension.Multicenter cross-sectional study.Twelve European referral centers.Subjects included 182 patients with pheochromocytoma, 36 with paraganglioma and 270 patients with primary hypertension. Patients with primary aldosteronism (n = 461) and Cushing syndrome (n = 124) were included for additional comparisons.In patients with PPGLs, surgical resection of tumors.Differences in mass spectrometry-based profiles of 15 adrenal steroids between groups

2020 Journal of Clinical Endocrinology and Metabolism

59. Excess Out-of-Hospital Mortality and Declining Oxygen Saturation: The Sentinel Role of Emergency Medical Services Data in the COVID-19 Crisis in Tijuana, Mexico. Full Text available with Trip Pro

Excess Out-of-Hospital Mortality and Declining Oxygen Saturation: The Sentinel Role of Emergency Medical Services Data in the COVID-19 Crisis in Tijuana, Mexico. Emergency medical services (EMS) may serve as a key source of real-time data about the evolving health of coronavirus disease 2019 (COVID-19)-affected populations, especially in low- and middle-income countries with less rapid and reliable vital statistics registration systems. Although official COVID-19 statistics in Mexico report (...) almost exclusively inhospital mortality events, excess out-of-hospital mortality has been identified in other countries, including 1 EMS study in Italy that showed a 58% increase. Additionally, EMS and hospital reports from several countries have suggested that silent hypoxemia-low Spo2 in the absence of dyspnea-is associated with COVID-19. It is unclear, however, how these phenomena can be generalized to low- and middle-income countries. We assess how EMS data can be used in a sentinel capacity

2020 Annals of Emergency Medicine

60. Ultra-Processed Foods and Excess Heart Age Among U.S. Adults. (Abstract)

Ultra-Processed Foods and Excess Heart Age Among U.S. Adults. A high percentage of total calories from ultra-processed foods has been associated with several cardiovascular disease risk factors. No study has examined the association between ultra-processed foods and heart age. This study examines the association between ultra-processed foods and excess heart age (difference between estimated heart age and chronological age) among U.S. adults.The National Health and Nutrition Examination Survey (...) (2009-2016) data for participants aged 30-74 years without cardiovascular disease or stroke (n=12,640) was used. Ultra-processed food was assigned based on NOVA classification of food processing, with ultra-processed food being the highest level. This study estimated the usual percentage of calories from ultra-processed foods and used sex-specific Framingham heart age algorithms to calculate heart age. The multivariable linear or logistic regression was used to examine the association between ultra

2020 American journal of preventive medicine

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