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1. Estimating excess 1-year mortality associated with the COVID-19 pandemic according to underlying conditions and age: a population-based cohort study. Full Text available with Trip Pro

Estimating excess 1-year mortality associated with the COVID-19 pandemic according to underlying conditions and age: a population-based cohort study. The medical, societal, and economic impact of the coronavirus disease 2019 (COVID-19) pandemic has unknown effects on overall population mortality. Previous models of population mortality are based on death over days among infected people, nearly all of whom thus far have underlying conditions. Models have not incorporated information on high-risk (...) conditions or their longer-term baseline (pre-COVID-19) mortality. We estimated the excess number of deaths over 1 year under different COVID-19 incidence scenarios based on varying levels of transmission suppression and differing mortality impacts based on different relative risks for the disease.In this population-based cohort study, we used linked primary and secondary care electronic health records from England (Health Data Research UK-CALIBER). We report prevalence of underlying conditions defined

2020 Lancet

2. Excess mortality following hip fracture in patients with diabetes according to age: a nationwide population-based cohort study of 154,047 hip fracture patients (Abstract)

Excess mortality following hip fracture in patients with diabetes according to age: a nationwide population-based cohort study of 154,047 hip fracture patients to test the hypothesis that excess mortality conferred by diabetes following hip fracture decreases with advancing age.a nationwide population-based cohort study including 154,047 patients who were admitted with a hip fracture in Denmark from 1996 to 2012. Information on hip fracture diagnosis, diabetes, other comorbidities (...) (1.02-1.16) for patients ≥90 years. There was a statistically significant interaction between diabetes and age (P < 0.001).diabetes is associated with excess mortality following hip fracture across all ages, but the excess mortality decreases with advancing age.© The Author(s) 2019. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.

2019 EvidenceUpdates

3. Excess Burden of Mental Illness and Hospitalization in Young-Onset Type 2 Diabetes: A Population-Based Cohort Study. (Abstract)

Excess Burden of Mental Illness and Hospitalization in Young-Onset Type 2 Diabetes: A Population-Based Cohort Study. Type 2 diabetes (T2D) increases hospitalization risk. Young-onset T2D (YOD) (defined as onset before age 40 years) is associated with excess morbidity and mortality, but its effect on hospitalizations is unknown.To determine hospitalization rates among persons with YOD and to examine the effect of age at onset on hospitalization risk.Prospective cohort study.Hong Kong.Adults aged (...) 20 to 75 years in population-based (2002 to 2014; n = 422 908) and registry-based (2000 to 2014; n = 20 886) T2D cohorts.All-cause and cause-specific hospitalization rates. Negative binomial regression models estimated effect of age at onset on hospitalization rate and cumulative bed-days from onset to age 75 years for YOD.Patients with YOD had the highest hospitalization rates by attained age. In the registry cohort, 36.8% of YOD bed-days before age 40 years were due to mental illness

2019 Annals of Internal Medicine

4. Carboplatin dose based on actual renal function: no excess of acute haematotoxicity in adjuvant treatment in seminoma stage I Full Text available with Trip Pro

Carboplatin dose based on actual renal function: no excess of acute haematotoxicity in adjuvant treatment in seminoma stage I The practice of carboplatin dosing is not concordant among different centres and oncologists. Some clinical guidelines recommend capping of the carboplatin dose at, for example, creatinine-clearance (Crea-Cl) of 125 mL/min because of concerns of excessive toxicity. Clinical data to support such recommendations are lacking, especially in patients with seminoma.This (...)  mL/min. No hAEs other than grade 1 occurred before day 10 and after day 24.Toxicity after single-dose carboplatin AUC 7 is generally mild. No excess of toxicity occurs in patients with high Crea-Cl above 125 mL/min, and therefore dose capping is not routinely necessary. In addition, this study provides a rationale for efficient use of healthcare services without compromising patients' safety.

2018 ESMO open

5. COVID-10: Making Excess Death Comparisons

COVID-10: Making Excess Death Comparisons COVID-10: Making Excess Death Comparisons - CEBM CEBM The Centre for Evidence-Based Medicine develops, promotes and disseminates better evidence for healthcare. Navigate this website COVID-10: Making Excess Death Comparisons May 22, 2020 Jason Oke, Carl Heneghan A lot of has been made of the excess mortality in the current COVID outbreak. To estimate the excess mortality, a count of deaths from all causes relative to what would normally be expected (...) is required. The usual way to create excess mortality is to compare with the five-year average. Another way is to compare with a year where excess deaths occurred. In there were 50,100 excess winter deaths compared with the five year average of the preceding years in England and Wales. The difference in all-cause deaths between 2017/18 and the five-year average might not look like much, but they have a dramatic effect on the excess difference. Comparing the number of deaths in the last year to the five

2020 Oxford COVID-19 Evidence Service

6. Excess mortality and cardiovascular disease in young adults with type 1 diabetes in relation to age at onset: a nationwide, register-based cohort study. Full Text available with Trip Pro

Excess mortality and cardiovascular disease in young adults with type 1 diabetes in relation to age at onset: a nationwide, register-based cohort study. People with type 1 diabetes are at elevated risk of mortality and cardiovascular disease, yet current guidelines do not consider age of onset as an important risk stratifier. We aimed to examine how age at diagnosis of type 1 diabetes relates to excess mortality and cardiovascular risk.We did a nationwide, register-based cohort study (...) of individuals with type 1 diabetes in the Swedish National Diabetes Register and matched controls from the general population. We included patients with at least one registration between Jan 1, 1998, and Dec 31, 2012. Using Cox regression, and with adjustment for diabetes duration, we estimated the excess risk of all-cause mortality, cardiovascular mortality, non-cardiovascular mortality, acute myocardial infarction, stroke, cardiovascular disease (a composite of acute myocardial infarction and stroke

2018 Lancet

7. Development of an Instrument to Assess Parents' Excessive Web-Based Searches for Information Pertaining to Their Children's Health: The "Children's Health Internet Research, Parental Inventory" (CHIRPI). Full Text available with Trip Pro

Development of an Instrument to Assess Parents' Excessive Web-Based Searches for Information Pertaining to Their Children's Health: The "Children's Health Internet Research, Parental Inventory" (CHIRPI). People often search the internet to obtain health-related information not only for themselves but also for family members and, in particular, their children. However, for a minority of parents, such searches may become excessive and distressing. Little is known about excessive web-based (...) are excellent. Correlations with mSHAI and CSS-15 indicate its validity. CHIRPI appears to be differentially sensitive to excessive searches owing to parents perceiving their child's health to be vulnerable rather than to higher informational needs of parents with chronically ill children. Therefore, it may help to identify parents who search excessively for web-based health information. CHIRPI (and, in particular, the Distress subscale) seems to capture a pattern of factors related to anxious health

2020 Journal of medical Internet research

8. Targeting excessive worry with internet-based extinction therapy: a randomised controlled trial with mediation analysis and economical evaluation. Full Text available with Trip Pro

Targeting excessive worry with internet-based extinction therapy: a randomised controlled trial with mediation analysis and economical evaluation. Excessive worry is a common phenomenon. Our research group has previously developed an online intervention for excessive worry based on operant principles of extinction (IbET; internet-based extinction therapy) and tested it against a waiting-list. The aim of this study was to evaluate IbET against an active control comparator (CTRL).A 10-week (...) parallel participant blind randomised controlled trial with health-economical evaluation and mediation analyses. Participants (N = 311) were randomised (ratio 4.5:4.5:1) to IbET, to CTRL (an internet-based stress-management training program) or to waiting-list. The nation-wide trial included self-referred adults with excessive worry. The primary outcome was change in worry assessed with the Penn State Worry Questionnaire from baseline to 10 weeks.IbET had greater reductions in worry compared to CTRL

2020 Psychological Medicine

9. Quantifying the excess risk of infant mortality based on race/ethnicity at the county level to inform Michigan's home visiting outreach plans. Full Text available with Trip Pro

Quantifying the excess risk of infant mortality based on race/ethnicity at the county level to inform Michigan's home visiting outreach plans. Michigan's infant mortality rate is consistently higher than the national rate, with persistent and significant racial/ethnic disparities. In Michigan, nine counties account for more than 80% of all infant deaths. A home visiting program serving low-income, first-time mothers in high-risk communities is one strategy to reduce infant mortality (...) . The objective of this study was to quantify the risk of infant mortality based on race/ethnicity within Michigan's highest-risk counties to guide outreach for home visiting services in these counties.To maximize the efficiency of limited resources and to identify women at highest risk, we used decomposition to develop risk-based, county-specific estimates of excess infant deaths in nine Michigan counties using data from the 2007 to 2009 Michigan resident infant death file linked to the live birth/file.The

2018 PLoS ONE

10. Base excess is superior to lactate-levels in prediction of ICU mortality after cardiac surgery. Full Text available with Trip Pro

Base excess is superior to lactate-levels in prediction of ICU mortality after cardiac surgery. Cardiac surgery with the use of cardiopulmonary bypass is known to induce distinct metabolic changes. Respective changes in acid-base status including increased systemic lactate levels were previously related to clinical outcomes, but data remain controversial. Therefore, we aim to investigate the relevance of lactate and base excess (BE) levels on ICU-mortality in patients admitted to the ICU after

2018 PLoS ONE

11. Correction: Excess mortality and hospitalizations in transitional-age youths with a long-term disease: A national population-based cohort study. Full Text available with Trip Pro

Correction: Excess mortality and hospitalizations in transitional-age youths with a long-term disease: A national population-based cohort study. [This corrects the article DOI: 10.1371/journal.pone.0193729.].

2018 PLoS ONE

12. Excess mortality and hospitalizations in transitional-age youths with a long-term disease: A national population-based cohort study. Full Text available with Trip Pro

Excess mortality and hospitalizations in transitional-age youths with a long-term disease: A national population-based cohort study. The number of adolescents with a severe chronic disease has increased in high-income countries due to improvements in the prognosis of childhood-onset chronic conditions. The transition from childhood to adulthood is a critical period that may be associated with increased mortality and morbidity. We aimed to estimate the prevalence of adolescents with a long-term (...) disease (LTD) in France and assess their mortality and hospitalization risks relative to the general population.We extracted a population-based cohort from the French national health insurance database that included 61,119 subjects who reached 14 years of age between 2005 and 2014. LTDs are diagnosed by patients' physicians and then confirmed and registered by a physician of the national health insurance system. We assessed mortality and hospitalizations using data of patients who were between 14

2018 PLoS ONE

13. Excess mortality and life expectancy of individuals with type 1 diabetes: a rapid review

REPORTING ON LIFE EXPECTANCY 15 3.2.1. Literature search 15 3.2.2. The Scottish registry-based cohort study by Livingstone et al. 15 3.2.3. The Swedish registry-based cohort study by Petrie et al 16 2 Excess mortality and life expectancy of individuals with type 1 diabetes KCE Report 314 3.2.4. The Australian registry-based cohort study by Huo et al.. 16 3.2.5. Consistency of the evidence in the Scottish, Swedish and Australian cohort studies 17 3.2.6. The Taiwanese longitudinal cohort study based (...) 3.3.7. A Norwegian retrospective cohort study 29 3.3.8. A Norwegian registry-based study 29 3.3.9. An Australian cohort study 30 3.3.10. An Australian registry-based study 30 3.3.11. A recent narrative overview on type 1 diabetes. 30 4. DISCUSSION AND CONCLUSION 31 4.1. EXCESS MORTALITY AND PARAMETERS THAT MODIFY THIS RISK 31 4.2. AGE AT ONSET 32 4.3. DISEASE DURATION, CURRENT AGE 32 4.4. GENDER 33 4.5. LEVEL OF OVERALL GLYCAEMIC (METABOLIC) CONTROL 33 4.6. RISK FACTORS FOR ACUTE LIFE-THREATENING

2019 Belgian Health Care Knowledge Centre

14. What is the excess cost/use of health and social resources related to alcohol?

What is the excess cost/use of health and social resources related to alcohol? Knowledge & Library Services (KLS) Evidence Briefing What is the excess cost/use of health and social resources related to alcohol? Dr Caroline De Brún 19 th July 2018 What is the excess cost/use of resources related to alcohol? KLS Evidence Briefing 19/07/18 Question This briefing summarises the evidence about the excess costs/use of health and social resources related to alcohol, and includes research published (...) require additional support than those without the condition. • People who drink excessively are at greater risk of costly conditions such as injury, hypertension, and psychiatric conditions. • People who have family members who are dependent on alcohol or drugs (AODD) encounter health issues, such as substance use disorders, depression, and trauma, and therefore are also likely to require access to health care services. • Decision-makers do not always account for the health and social service

2018 Public Health England - Evidence Briefings

15. Mindfulness-based group intervention in adolescents at-risk for excess weight gain: A randomized controlled pilot study. (Abstract)

Mindfulness-based group intervention in adolescents at-risk for excess weight gain: A randomized controlled pilot study. To assess feasibility/acceptability of a mindfulness-based approach to excess weight prevention in adolescents at-risk for excess weight gain. To pilot test efficacy of a mindfulness-based intervention for improving food reward sensitivity, stress-eating, executive function (EF), and BMI/adiposity.A pilot randomized controlled trial was conducted with 12-17y adolescents (...) at-risk for excess weight gain based on above-average weight (body mass index [BMI]≥70%ile) or parental history of obesity (BMI≥30 kg/m2). Adolescents were randomized to a mindfulness-based (n = 29) or health education control group (n = 25) that met for six weekly one-hour sessions. Feasibility/acceptability were determined from attendance and acceptability survey ratings. At baseline, six-week and six-month follow-up, adolescents' perceived stress was measured with the Perceived Stress Scale, food

2019 Appetite Controlled trial quality: uncertain

16. On the use of flexible excess hazard regression models for describing long-term breast cancer survival: a case-study using population-based cancer registry data. Full Text available with Trip Pro

On the use of flexible excess hazard regression models for describing long-term breast cancer survival: a case-study using population-based cancer registry data. Breast cancer prognosis has dramatically improved over 40 years. There is, however, no proof of population 'cure'. This research aimed to examine the pattern of long-term excess mortality due to breast cancer and evaluate its determinants in the context of cancer registry data.We used data from the Geneva Cancer Registry to identify (...) women younger than 75 years diagnosed with invasive, localised and operated breast cancer between 1995 and 2002. Flexible modelling of excess mortality hazard, including time-dependent (TD) regression parameters, was used to estimate mortality related to breast cancer. We derived a single "final" model using a backward selection procedure and evaluated its stability through sensitivity analyses using a bootstrap technique.We analysed data from 1574 breast cancer women including 351 deaths (22.3

2019 BMC Cancer

17. Acute coronary syndrome in new-onset rheumatoid arthritis: a population-based nationwide cohort study of time trends in risks and excess risks (Abstract)

Acute coronary syndrome in new-onset rheumatoid arthritis: a population-based nationwide cohort study of time trends in risks and excess risks Acute coronary syndrome (ACS) and other cardiovascular diseases are the main drivers of the increased morbidity and preterm mortality in rheumatoid arthritis (RA). ACS in RA has been linked to inflammation and RA severity. During recent years and with new therapeutic options and treat-to-target strategies, increasing efforts have been made to reach RA (...) remission as soon as possible after diagnosis, and the average level of RA disease activity has declined. Whether this has resulted in declining excess risks for RA comorbidities remains unclear.We performed a nationwide population-based cohort study of patients with new-onset RA from 1997 to 2014, and matched general population comparators. In the Swedish healthcare system, all residents have equal access to healthcare services. Healthcare is monitored using high-quality population-based registers

2017 EvidenceUpdates

18. Excess deaths associated with tigecycline after approval based on noninferiority trials

Excess deaths associated with tigecycline after approval based on noninferiority trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2012 DARE.

19. Excess mortality related to circulatory system diseases and diabetes mellitus among Italian AIDS patients vs. non-AIDS population: a population-based cohort study using the multiple causes-of-death approach. Full Text available with Trip Pro

Excess mortality related to circulatory system diseases and diabetes mellitus among Italian AIDS patients vs. non-AIDS population: a population-based cohort study using the multiple causes-of-death approach. Chronic diseases, chiefly cancers and circulatory system diseases (CSDs), have become the leading non-AIDS-related causes of death among HIV-infected people, as in the general population. After our previous report of an excess mortality for several non-AIDS-defining cancers, we now aim (...) to assess whether people with AIDS (PWA) experience also an increased mortality for CSDs and diabetes mellitus (DM), as compared to the non-AIDS general population (non-PWA).A nationwide, population-based, retrospective cohort study was conducted including 5285 Italians, aged 15-74 years, who were diagnosed with AIDS between 2006 and 2011. Multiple cause-of-death (MCoD) data, i.e. all conditions reported in death certificates, were retrieved through record-linkage with the National Register of Causes

2018 BMC Infectious Diseases

20. Combating Excessive Eating: A Role for Four Evidence-Based Remedies. Full Text available with Trip Pro

Combating Excessive Eating: A Role for Four Evidence-Based Remedies. The aim of this study is to review the control of energy balance and outline some causes of and remedies for excessive energy intake.A narrative review was conducted.There is negative feedback control of energy intake and body weight, but, nonetheless, energy intake is only loosely coupled with energy expenditure. Consequently, we are vulnerable to eating in excess of energy requirements. In this context, energy density (...) effect of products because fullness is not inherently rewarding. Low-calorie sweeteners provide a means to reduce energy density while largely preserving food or beverage reward value. Consistent with this, consumption of low-calorie sweeteners compared with consumption of sugars has been found to reduce energy intake and body weight.Understanding what causes excessive eating also provides insights into how to combat this problem.© 2018 The Obesity Society.

2018 Obesity

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