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Base Excess

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1. Excess mortality following hip fracture in patients with diabetes according to age: a nationwide population-based cohort study of 154,047 hip fracture patients

Excess mortality following hip fracture in patients with diabetes according to age: a nationwide population-based cohort study of 154,047 hip fracture patients to test the hypothesis that excess mortality conferred by diabetes following hip fracture decreases with advancing age.a nationwide population-based cohort study including 154,047 patients who were admitted with a hip fracture in Denmark from 1996 to 2012. Information on hip fracture diagnosis, diabetes, other comorbidities (...) (1.02-1.16) for patients ≥90 years. There was a statistically significant interaction between diabetes and age (P < 0.001).diabetes is associated with excess mortality following hip fracture across all ages, but the excess mortality decreases with advancing age.© The Author(s) 2019. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.

2019 EvidenceUpdates

2. Excess Burden of Mental Illness and Hospitalization in Young-Onset Type 2 Diabetes: A Population-Based Cohort Study. (PubMed)

Excess Burden of Mental Illness and Hospitalization in Young-Onset Type 2 Diabetes: A Population-Based Cohort Study. Type 2 diabetes (T2D) increases hospitalization risk. Young-onset T2D (YOD) (defined as onset before age 40 years) is associated with excess morbidity and mortality, but its effect on hospitalizations is unknown.To determine hospitalization rates among persons with YOD and to examine the effect of age at onset on hospitalization risk.Prospective cohort study.Hong Kong.Adults aged (...) 20 to 75 years in population-based (2002 to 2014; n = 422 908) and registry-based (2000 to 2014; n = 20 886) T2D cohorts.All-cause and cause-specific hospitalization rates. Negative binomial regression models estimated effect of age at onset on hospitalization rate and cumulative bed-days from onset to age 75 years for YOD.Patients with YOD had the highest hospitalization rates by attained age. In the registry cohort, 36.8% of YOD bed-days before age 40 years were due to mental illness

2019 Annals of Internal Medicine

3. Carboplatin dose based on actual renal function: no excess of acute haematotoxicity in adjuvant treatment in seminoma stage I (PubMed)

Carboplatin dose based on actual renal function: no excess of acute haematotoxicity in adjuvant treatment in seminoma stage I The practice of carboplatin dosing is not concordant among different centres and oncologists. Some clinical guidelines recommend capping of the carboplatin dose at, for example, creatinine-clearance (Crea-Cl) of 125 mL/min because of concerns of excessive toxicity. Clinical data to support such recommendations are lacking, especially in patients with seminoma.This (...)  mL/min. No hAEs other than grade 1 occurred before day 10 and after day 24.Toxicity after single-dose carboplatin AUC 7 is generally mild. No excess of toxicity occurs in patients with high Crea-Cl above 125 mL/min, and therefore dose capping is not routinely necessary. In addition, this study provides a rationale for efficient use of healthcare services without compromising patients' safety.

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2018 ESMO open

4. Base excess is superior to lactate-levels in prediction of ICU mortality after cardiac surgery. (PubMed)

Base excess is superior to lactate-levels in prediction of ICU mortality after cardiac surgery. Cardiac surgery with the use of cardiopulmonary bypass is known to induce distinct metabolic changes. Respective changes in acid-base status including increased systemic lactate levels were previously related to clinical outcomes, but data remain controversial. Therefore, we aim to investigate the relevance of lactate and base excess (BE) levels on ICU-mortality in patients admitted to the ICU after

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2018 PLoS ONE

5. Excess mortality and cardiovascular disease in young adults with type 1 diabetes in relation to age at onset: a nationwide, register-based cohort study. (PubMed)

Excess mortality and cardiovascular disease in young adults with type 1 diabetes in relation to age at onset: a nationwide, register-based cohort study. People with type 1 diabetes are at elevated risk of mortality and cardiovascular disease, yet current guidelines do not consider age of onset as an important risk stratifier. We aimed to examine how age at diagnosis of type 1 diabetes relates to excess mortality and cardiovascular risk.We did a nationwide, register-based cohort study (...) of individuals with type 1 diabetes in the Swedish National Diabetes Register and matched controls from the general population. We included patients with at least one registration between Jan 1, 1998, and Dec 31, 2012. Using Cox regression, and with adjustment for diabetes duration, we estimated the excess risk of all-cause mortality, cardiovascular mortality, non-cardiovascular mortality, acute myocardial infarction, stroke, cardiovascular disease (a composite of acute myocardial infarction and stroke

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2018 Lancet

6. Correction: Excess mortality and hospitalizations in transitional-age youths with a long-term disease: A national population-based cohort study. (PubMed)

Correction: Excess mortality and hospitalizations in transitional-age youths with a long-term disease: A national population-based cohort study. [This corrects the article DOI: 10.1371/journal.pone.0193729.].

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2018 PLoS ONE

7. Excess mortality and hospitalizations in transitional-age youths with a long-term disease: A national population-based cohort study. (PubMed)

Excess mortality and hospitalizations in transitional-age youths with a long-term disease: A national population-based cohort study. The number of adolescents with a severe chronic disease has increased in high-income countries due to improvements in the prognosis of childhood-onset chronic conditions. The transition from childhood to adulthood is a critical period that may be associated with increased mortality and morbidity. We aimed to estimate the prevalence of adolescents with a long-term (...) disease (LTD) in France and assess their mortality and hospitalization risks relative to the general population.We extracted a population-based cohort from the French national health insurance database that included 61,119 subjects who reached 14 years of age between 2005 and 2014. LTDs are diagnosed by patients' physicians and then confirmed and registered by a physician of the national health insurance system. We assessed mortality and hospitalizations using data of patients who were between 14

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2018 PLoS ONE

8. Excess mortality and life expectancy of individuals with type 1 diabetes: a rapid review

REPORTING ON LIFE EXPECTANCY 15 3.2.1. Literature search 15 3.2.2. The Scottish registry-based cohort study by Livingstone et al. 15 3.2.3. The Swedish registry-based cohort study by Petrie et al 16 2 Excess mortality and life expectancy of individuals with type 1 diabetes KCE Report 314 3.2.4. The Australian registry-based cohort study by Huo et al.. 16 3.2.5. Consistency of the evidence in the Scottish, Swedish and Australian cohort studies 17 3.2.6. The Taiwanese longitudinal cohort study based (...) 3.3.7. A Norwegian retrospective cohort study 29 3.3.8. A Norwegian registry-based study 29 3.3.9. An Australian cohort study 30 3.3.10. An Australian registry-based study 30 3.3.11. A recent narrative overview on type 1 diabetes. 30 4. DISCUSSION AND CONCLUSION 31 4.1. EXCESS MORTALITY AND PARAMETERS THAT MODIFY THIS RISK 31 4.2. AGE AT ONSET 32 4.3. DISEASE DURATION, CURRENT AGE 32 4.4. GENDER 33 4.5. LEVEL OF OVERALL GLYCAEMIC (METABOLIC) CONTROL 33 4.6. RISK FACTORS FOR ACUTE LIFE-THREATENING

2019 Belgian Health Care Knowledge Centre

9. Base excess in predicting the prognosis of patients with paraquat poisoning: A meta-analysis. (PubMed)

Base excess in predicting the prognosis of patients with paraquat poisoning: A meta-analysis. Although the prognostic significance of base excess (BE) in patients with paraquat (PQ) poisoning has been investigated for several years, the results remain controversial. Thus, we performed for the first time a comprehensive meta-analysis to explore the value of BE in predicting the prognosis of patients with PQ poisoning.We searched PubMed, EMBase, Web of Science, ScienceDirect, Cochrane Library

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2019 Medicine

10. On the use of flexible excess hazard regression models for describing long-term breast cancer survival: a case-study using population-based cancer registry data. (PubMed)

On the use of flexible excess hazard regression models for describing long-term breast cancer survival: a case-study using population-based cancer registry data. Breast cancer prognosis has dramatically improved over 40 years. There is, however, no proof of population 'cure'. This research aimed to examine the pattern of long-term excess mortality due to breast cancer and evaluate its determinants in the context of cancer registry data.We used data from the Geneva Cancer Registry to identify (...) women younger than 75 years diagnosed with invasive, localised and operated breast cancer between 1995 and 2002. Flexible modelling of excess mortality hazard, including time-dependent (TD) regression parameters, was used to estimate mortality related to breast cancer. We derived a single "final" model using a backward selection procedure and evaluated its stability through sensitivity analyses using a bootstrap technique.We analysed data from 1574 breast cancer women including 351 deaths (22.3

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2019 BMC Cancer

11. Acute coronary syndrome in new-onset rheumatoid arthritis: a population-based nationwide cohort study of time trends in risks and excess risks

Acute coronary syndrome in new-onset rheumatoid arthritis: a population-based nationwide cohort study of time trends in risks and excess risks Acute coronary syndrome (ACS) and other cardiovascular diseases are the main drivers of the increased morbidity and preterm mortality in rheumatoid arthritis (RA). ACS in RA has been linked to inflammation and RA severity. During recent years and with new therapeutic options and treat-to-target strategies, increasing efforts have been made to reach RA (...) remission as soon as possible after diagnosis, and the average level of RA disease activity has declined. Whether this has resulted in declining excess risks for RA comorbidities remains unclear.We performed a nationwide population-based cohort study of patients with new-onset RA from 1997 to 2014, and matched general population comparators. In the Swedish healthcare system, all residents have equal access to healthcare services. Healthcare is monitored using high-quality population-based registers

2017 EvidenceUpdates

12. Mindfulness-based group intervention in adolescents at-risk for excess weight gain: A randomized controlled pilot study. (PubMed)

Mindfulness-based group intervention in adolescents at-risk for excess weight gain: A randomized controlled pilot study. To assess feasibility/acceptability of a mindfulness-based approach to excess weight prevention in adolescents at-risk for excess weight gain. To pilot test efficacy of a mindfulness-based intervention for improving food reward sensitivity, stress-eating, executive function (EF), and BMI/adiposity.A pilot randomized controlled trial was conducted with 12-17y adolescents (...) at-risk for excess weight gain based on above-average weight (body mass index [BMI]≥70%ile) or parental history of obesity (BMI≥30 kg/m2). Adolescents were randomized to a mindfulness-based (n = 29) or health education control group (n = 25) that met for six weekly one-hour sessions. Feasibility/acceptability were determined from attendance and acceptability survey ratings. At baseline, six-week and six-month follow-up, adolescents' perceived stress was measured with the Perceived Stress Scale, food

2019 Appetite Controlled trial quality: uncertain

13. Excess deaths associated with tigecycline after approval based on noninferiority trials

Excess deaths associated with tigecycline after approval based on noninferiority trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2012 DARE.

14. Base excess in predicting the prognosis of patients with paraquat poisoning: a meta-analysis

Base excess in predicting the prognosis of patients with paraquat poisoning: a meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address (...) : Timing and effect measures Timing and effect measures Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Context and rationale Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Example: Screening will be performed in two phases, namely initial screening based on title and abstract, followed by full-text

2018 PROSPERO

15. Effectiveness of school-based nutrition education interventions to prevent and reduce excessive weight gain in children and adolescents: a systematic review

Effectiveness of school-based nutrition education interventions to prevent and reduce excessive weight gain in children and adolescents: a systematic review Effectiveness of school-based nutrition education interventions to prevent and reduce excessive weight gain in children and adolescents: a systematic review Effectiveness of school-based nutrition education interventions to prevent and reduce excessive weight gain in children and adolescents: a systematic review Silveira JA, Taddei JA (...) for research. Funding Fundacao de Amparao a Pesquisa de Sao Paulo (FAPESP), Brazil. One reviewer received a scholarship from Cordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES). Bibliographic details Silveira JA, Taddei JA, Guerra PH, Nobre MR. Effectiveness of school-based nutrition education interventions to prevent and reduce excessive weight gain in children and adolescents: a systematic review. Jornal de Pediatria 2011; 87(5): 382-392 PubMedID DOI Original Paper URL Indexing Status

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2012 DARE.

16. CO Preferential Photo-Oxidation in Excess of Hydrogen in Dark and Simulated Solar Light Irradiation over AuCu-Based Catalysts on SBA-15 Mesoporous Silica-Titania (PubMed)

CO Preferential Photo-Oxidation in Excess of Hydrogen in Dark and Simulated Solar Light Irradiation over AuCu-Based Catalysts on SBA-15 Mesoporous Silica-Titania In this work, SBA-15 silica and silica-titania have been used as supports for photocatalysts based on AuCu alloy (Au:Cu = 1) to be used in the preferential oxidation of CO (CO-PROX) in excess of hydrogen at room temperature and atmospheric pressure both in the dark and under simulated solar light irradiation. To study their textural

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2018 Materials

17. Hand-Held Refractometer-Based Measurement and Excess Permittivity Analysis Method for Detection of Diesel Oils Adulterated by Kerosene in Field Conditions (PubMed)

Hand-Held Refractometer-Based Measurement and Excess Permittivity Analysis Method for Detection of Diesel Oils Adulterated by Kerosene in Field Conditions Adulteration of fuels is a major problem, especially in developing and third world countries. One such case is the adulteration of diesel oil by kerosene. This problem contributes to air pollution, which leads to other far-reaching adverse effects, such as climate change. The objective of this study was to develop a relatively easy (...) measurement method based on an inexpensive, handheld Abbe refractometer for the detection of adulteration and estimation of the ascending order of the amount of kerosene present in adulterated samples in field conditions. We achieved this by increasing the volume of pure diesel sample in the adulterated diesel oil, and measuring the trend of refractive index change, and next, exploiting the true and ideal permittivities of the binary mixture. The permittivity can be obtained with the aid of the measured

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2018 Sensors (Basel, Switzerland)

18. Curbing excess gestational weight gain in primary care: using a point-of-care tool based on behavior change theory (PubMed)

Curbing excess gestational weight gain in primary care: using a point-of-care tool based on behavior change theory Excess gestational weight gain (GWG) is a risk factor for several adverse outcomes for mothers and their offspring. In Nova Scotia, Canada, approximately 60% of women experience excess GWG. Outside the pregnancy arena, a patient-centered approach has been shown to promote increased patient adherence to clinician recommendations, and increased intentions for, and attempts

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2018 International journal of women's health Controlled trial quality: uncertain

19. The Family Check-Up 4 Health (FCU4Health): Applying Implementation Science Frameworks to the Process of Adapting an Evidence-Based Parenting Program for Prevention of Pediatric Obesity and Excess Weight Gain in Primary Care (PubMed)

The Family Check-Up 4 Health (FCU4Health): Applying Implementation Science Frameworks to the Process of Adapting an Evidence-Based Parenting Program for Prevention of Pediatric Obesity and Excess Weight Gain in Primary Care Implementation experts have recently argued for a process of "scaling out" evidence-based interventions, programs, and practices (EBPs) to improve reach to new populations and new service delivery systems. A process of planned adaptation is typically required to integrate (...) EBPs into new service delivery systems and address the needs of targeted populations while simultaneously maintaining fidelity to core components. This process-oriented paper describes the application of an implementation science framework and coding system to the adaptation of the Family Check-Up (FCU), for a new clinical target and service delivery system-prevention of obesity and excess weight game in primary care. The original FCU has demonstrated both short- and long-term effects on obesity

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2018 Frontiers in public health

20. Ghanaians Might Be at Risk of Excess Dietary Intake of Potassium Based on Food Supply Data (PubMed)

Ghanaians Might Be at Risk of Excess Dietary Intake of Potassium Based on Food Supply Data The World Health Organization (WHO) has highlighted the beneficial role of adequate intake of potassium (K) in combating the global burden of noncommunicable diseases (NCDs), mainly hypertension and cardiovascular diseases. Diets are the main source of K supply to humans and can contribute to both K deficiency (hypokalemia) and excess (hyperkalemia). While global attention is currently devoted to K (...) trends in food and K supply. The average food supply in the FBS for 2010 and 2011 was used in assessing the risk of inadequate or excess dietary intake of K. The K content of the food items was obtained from food composition databases. Based on 2010-2011 average data, the K supply per capita per day was approximately 9,086 mg, about 2.6-fold larger than the WHO-recommended level (3,510 mg). The assessment suggests a potentially large risk of excess dietary K supply at both individual and population

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2018 Journal of nutrition and metabolism

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