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285 results for

Baclofen Withdrawal

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281. Neonatal convulsions after withdrawal of baclofen Full Text available with Trip Pro

Neonatal convulsions after withdrawal of baclofen 11451783 2001 08 16 2018 11 13 0959-8138 323 7304 2001 Jul 14 BMJ (Clinical research ed.) BMJ Drug points: Neonatal convulsions after withdrawal of baclofen. 85 Ratnayaka B D BD Department of Neonatal Medicine, City Hospital, Nottingham NG5 1PB. Dhaliwal H H Watkin S S eng Case Reports Journal Article England BMJ 8900488 0959-8138 0 GABA Agonists 0 Muscle Relaxants, Central H789N3FKE8 Baclofen AIM IM Baclofen adverse effects Female GABA Agonists

2001 BMJ : British Medical Journal

282. Withdrawal of baclofen may cause acute confusion in elderly patients Full Text available with Trip Pro

Withdrawal of baclofen may cause acute confusion in elderly patients 11597980 2001 12 05 2018 11 13 0959-8138 323 7317 2001 Oct 13 BMJ (Clinical research ed.) BMJ Withdrawal of baclofen may cause acute confusion in elderly patients. 870 O'Rourke F F Steinberg R R Ghosh P P Khan S S eng Case Reports Letter England BMJ 8900488 0959-8138 0 GABA Agonists 0 Muscle Relaxants, Central H789N3FKE8 Baclofen AIM IM Acute Disease Aged Aged, 80 and over Baclofen adverse effects Confusion chemically induced (...) GABA Agonists adverse effects Humans Male Muscle Relaxants, Central adverse effects Substance Withdrawal Syndrome 2001 10 13 10 0 2002 1 5 10 1 2001 10 13 10 0 ppublish 11597980 PMC1121408 Arch Phys Med Rehabil. 1999 Dec;80(12):1600-4 10597813 BMJ. 2001 Jul 14;323(7304):85 11451783 Anesth Analg. 1998 Sep;87(3):562-3 9728828 Anesth Analg. 1995 May;80(5):1054-6 7726408 Arch Neurol. 1981 Sep;38(9):588-9 6791618

2001 BMJ : British Medical Journal

283. Baclofen versus clonidine in the treatment of opiates withdrawal, side-effects aspect: a double-blind randomized controlled trial. (Abstract)

Baclofen versus clonidine in the treatment of opiates withdrawal, side-effects aspect: a double-blind randomized controlled trial. Baclofen is known for the alleviation of signs and symptoms of spasticity. Reports from our previous study have suggested that it may be at least as effective as clonidine in the management of physical symptoms of opiate withdrawal syndromes and superior to clonidine in the management of mental symptoms. We now report on a randomized double-blind comparison (...) between two treat7ments in terms of retention in treatment (dropout) and overall side-effect. Nevertheless, significantly more problems relating to hypotension were encountered with subjects on clonidine.We conclude that, the low incidence of hypotension with baclofen suggests that the drug may be suitable for outpatient ambulatory treatment of withdrawal from opiates.

2001 Journal of clinical pharmacy and therapeutics Controlled trial quality: uncertain

284. Double-blind randomized controlled trial of baclofen vs. clonidine in the treatment of opiates withdrawal. (Abstract)

Double-blind randomized controlled trial of baclofen vs. clonidine in the treatment of opiates withdrawal. A variety of detoxification methods have been utilized for the treatment of opiate withdrawal syndrome, of which alpha-adrenergic agonists have attracted considerable attention over the last two decades. However, accumulating evidence in rats shows the efficacy of the GABAB receptor agonist, baclofen, in reducing alcohol intake and self-administration of cocaine.To examine the ability (...) of baclofen, in the management of opiate withdrawal.A total of 62 opiate addicts randomly assigned to treatment with baclofen or clonidine during a 14-day, double-blind clinical trial. All patients met the DSM IV criteria for opioid dependence. Maximum daily doses were 40 mg for baclofen and 0.8 mg for clonidine given three times a day in divided doses. The severity of the opiate withdrawal syndrome was measured on days 0, 1, 2, 3, 4, 7 and 14 using the Short Opiate Withdrawal Scale (SOWS).Baclofen

2000 Journal of clinical pharmacy and therapeutics Controlled trial quality: uncertain

285. Intrathecal baclofen withdrawal mimicking sepsis. (Abstract)

Intrathecal baclofen withdrawal mimicking sepsis. Baclofen (Lioresal) is a drug of choice to treat spasticity and is increasingly being administered intrathecally via an implantable pump in cases refractory to oral therapy. Emergency physicians will likely treat patients with baclofen withdrawal or overdose as this treatment becomes more widespread. The syndrome of baclofen withdrawal presents with altered mental status, fever, tachycardia, hypertension or hypotension, seizures, and rebound (...) spasticity, and may be fatal if not treated appropriately. Baclofen withdrawal may mimic other diseases including sepsis, meningitis, autonomic dysreflexia, malignant hyperthermia, or neuroleptic malignant syndrome. Treatment consists of supportive care, reinstitution of baclofen, benzodiazepines, and diagnosis and eventual repair of intrathecal pump and catheter malfunction.

2003 Journal of Emergency Medicine

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