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2. Babesiosis

Babesiosis Babesiosis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Babesiosis Last reviewed: February 2019 Last updated: August 2018 Summary Transmitted to humans through the blood meal of Ixodes ticks, the same vector as for Lyme disease and human granulocytic anaplasmosis. Transfusion-related transmission is emerging as an important secondary mode. Usually asymptomatic or presents as a mild viral-type illness (...) in young and healthy people. May cause more serious disease or be fatal in asplenic or immunocompromised patients and in older people. Diagnosis is made by visualisation of parasites on a Giemsa-stained blood smear or by detection of babesial DNA in peripheral blood with PCR. Management includes observation and monitoring, oral or parenteral antimicrobials, and/or exchange transfusion. Definition Babesiosis is a tick-borne zoonotic disease typically characterised by fever, haemolysis

2018 BMJ Best Practice

3. Post-Babesiosis Warm Autoimmune Hemolytic Anemia. (PubMed)

Post-Babesiosis Warm Autoimmune Hemolytic Anemia. Background Babesiosis, a tickborne zoonotic disease caused by intraerythrocytic protozoa of the genus babesia, is characterized by nonimmune hemolytic anemia that resolves with antimicrobial treatment and clearance of parasitemia. The development of warm-antibody autoimmune hemolytic anemia (also known as warm autoimmune hemolytic anemia [WAHA]) in patients with babesiosis has not previously been well described. Methods After the observation (...) of sporadic cases of WAHA that occurred after treatment of patients for babesiosis, we conducted a retrospective cohort study of all the patients with babesiosis who were cared for at our center from January 2009 through June 2016. Data on covariates of interest were extracted from the medical records, including any hematologic complications that occurred within 3 months after the diagnosis and treatment of babesiosis. Results A total of 86 patients received a diagnosis of babesiosis during the 7.5-year

2017 NEJM

4. Congenital Babesiosis From Maternal Exposure: A Case Report. (PubMed)

Congenital Babesiosis From Maternal Exposure: A Case Report. Babesiosis is a disease caused by parasites that infect red blood cells; in infants it can be acquired from tick bites, blood transfusions, or congenitally via vertical transmission. It can present with thrombocytopenia, fevers, and parasitemia.A case of vertically transmitted babesiosis in an infant is described. Thrombocytopenia and parasitemia > 4% developed in this well-appearing infant. The diagnosis was made by history and blood (...) smear in both infant and mother, and the patient recovered fully with oral antibiotics. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Congenital babesiosis has been reported infrequently in the literature and is reviewed here. It is important to consider congenital tick-borne illness in endemic areas as a cause for febrile thrombocytopenia in neonates.Copyright © 2018 Elsevier Inc. All rights reserved.

2019 Journal of Emergency Medicine

5. LC-MS/MS analysis of the dog serum phosphoproteome reveals novel and conserved phosphorylation sites: Phosphoprotein patterns in babesiosis caused by Babesia canis, a case study. (PubMed)

LC-MS/MS analysis of the dog serum phosphoproteome reveals novel and conserved phosphorylation sites: Phosphoprotein patterns in babesiosis caused by Babesia canis, a case study. Phosphorylation is the most commonly studied protein post-translational modification (PTM) in biological systems due to its importance in controlling cell division, survival, growth, etc. Despite the thorough research in phosphoproteomics of cells and tissues there is little information on circulating phosphoproteins (...) . We compared serum from 10 healthy dogs and 10 dogs affected by B. canis-caused babesiosis with no organ dysfunctions by employing gel-free LC-MS/MS analysis of individual samples and tandem mass tag (TMT) label-based quantitative analyses of pools, both supported by phosphopeptide enrichment. Results showed a moderate number of phosphorylated proteins (50-55), with 89 phosphorylation sites not previously published for dogs although a number of them matched phosphorylation sites found in mammalian

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2018 PLoS ONE

6. Adjunctive treatment of clinically severe babesiosis with red blood cell exchange: a case series of nineteen patients. (PubMed)

Adjunctive treatment of clinically severe babesiosis with red blood cell exchange: a case series of nineteen patients. Infection with the protozoan parasite Babesia, the causative agent of babesiosis, can result in asymptomatic to life-threatening illness. Severe cases of babesiosis are characterized by high levels of parasitemia (>4%-10%) and commonly treated with adjunctive red blood cell exchange (RCE) in addition to antimicrobial therapy. The efficacy of RCE in this context is unknown.Blood (...) bank records were examined for requests for RCE during a 10-year period from 2007 to 2017. Relevant clinical and laboratory variables were extracted from medical records from presentation to 35 days after RCE and analyzed in univariate and multivariate models.Nineteen cases of babesiosis were identified in which RCE was performed. The median age of patients was 77 years, 74% of whom were male. A total of 37% of patients were asplenic. RCE was performed on average 1.3 days after presentation

2019 Transfusion

7. Human babesiosis: Indication of a molecular mimicry between thrombospondin domains from a novel Babesia microti BmP53 protein and host platelets molecules. (PubMed)

Human babesiosis: Indication of a molecular mimicry between thrombospondin domains from a novel Babesia microti BmP53 protein and host platelets molecules. Human babesiosis is caused by the apicomplexan parasite Babesia microti, which is of major public health concern in the United States and elsewhere, resulting in malaise and fatigue, followed by a fever and hemolytic anemia. In this paper we focus on the characterization of a novel B. microti thrombospondin domain (TSP1)-containing protein

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2017 PLoS ONE

8. Human Babesiosis Caused by a Babesia crassa-like Pathogen: A Case Series. (PubMed)

Human Babesiosis Caused by a Babesia crassa-like Pathogen: A Case Series. Human babesiosis is an emerging health problem in China.Babesia were identified in ticks, sheep, and humans in northeastern China using polymerase chain reaction (PCR) followed by genetic sequencing. We enrolled residents who experienced a viral-like illness after recent tick bite or were healthy residents. We defined a case using the definition for babesiosis developed by the US Centers for Disease Control

2018 Clinical Infectious Diseases

9. Analysis of antigen-antibody cross-reactivity among lineages and sublineages of Babesia microti parasites using human babesiosis specimens. (PubMed)

Analysis of antigen-antibody cross-reactivity among lineages and sublineages of Babesia microti parasites using human babesiosis specimens. Human babesiosis is caused mainly by Babesia microti and has recently become a public health concern due to an increase in transfusion-transmitted infection. Thus, the development of an antibody detection method with high specificity and sensitivity is a priority. Seroreactivity against B. microti has been reported to be highly specific not only to B

2018 Transfusion

10. Transfusion-transmitted and community-acquired babesiosis in New York, 2004 to 2015. (PubMed)

Transfusion-transmitted and community-acquired babesiosis in New York, 2004 to 2015. Babesiosis is a potentially life-threatening zoonotic infection most frequently caused by the intraerythrocytic parasite Babesia microti. The pathogen is usually tickborne, but may also be transfusion or vertically transmitted. Healthy persons, including blood donors, may be asymptomatic and unaware they are infected. Immunocompromised patients are at increased risk for symptomatic disease.All reported (...) community-acquired babesiosis cases in New York from 2004 to 2015 were evaluated, enumerated, and characterized. All potential transfusion-transmitted babesiosis (TTB) cases reported through one or more of three public health surveillance systems were investigated to determine the likelihood of transfusion transmission. In addition, host-seeking ticks were actively collected in public parks and other likely sites of human exposure to B. microti.From 2004 to 2015, a total of 3799 cases of babesiosis were

2018 Transfusion

11. A Walk in the Park: A Case of Babesiosis in the South Bronx (PubMed)

A Walk in the Park: A Case of Babesiosis in the South Bronx Babesiosis, mainly endemic within the Northeastern and upper Midwestern regions of the United States, is a zoonotic disease that invades and lyses red blood cells, which can result in hemolytic anemia. Its decreased incidence in comparison to Lyme disease is often attributed to the greater asymptomatic infection proportion and insufficient physician awareness or suspicion of this disease. Here we describe a case of undifferentiated (...) febrile illness with hemolytic anemia that yielded the diagnosis of babesiosis.

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2018 Clinical Practice and Cases in Emergency Medicine

12. Development of an Indirect ELISA Based on a Recombinant Chimeric Protein for the Detection of Antibodies against Bovine Babesiosis (PubMed)

Development of an Indirect ELISA Based on a Recombinant Chimeric Protein for the Detection of Antibodies against Bovine Babesiosis The current method for Babesia spp. serodiagnosis based on a crude merozoite antigen is a complex and time-consuming procedure. An indirect enzyme-linked immunosorbent assay (iELISA) based on a recombinant multi-antigen of Babesia bovis (rMABbO) was developed for detection of antibodies in bovines suspected of infection with this parasite. The multi-antigen (...) analysis, showing a sensitivity of 95.9% and a specificity of 94.3%. The rMABbo-iELISA was further tested in a blind trial using an additional set of 263 field bovine sera from enzootic and tick-free regions of Argentina. Results showed a good agreement with the gold standard test with a Cohen's kappa value of 0.76. Finally, the prevalence of bovine babesiosis in different tick enzootic regions of Argentina was analyzed where seropositivity values among 68-80% were obtained. A certain level of cross

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2018 Veterinary Sciences

13. Human Babesiosis Caused by Babesia duncani Has Widespread Distribution across Canada (PubMed)

Human Babesiosis Caused by Babesia duncani Has Widespread Distribution across Canada Human babesiosis caused by Babesia duncani is an emerging infectious disease in Canada. This malaria-like illness is brought about by a protozoan parasite infecting red blood cells. Currently, controversy surrounds which tick species are vectors of B. duncani. Since the availability of a serological or molecular test in Canada for B. duncani has been limited, we conducted a seven-year surveillance study (2011 (...) babesiosis may be asymptomatic, but as this parasitemia progresses, symptoms range from mild to fatal. Donors of blood, plasma, living tissues, and organs may unknowingly be infected with this piroplasm and are contributing to the spread of this zoonosis. Our data show that greater awareness of human babesiosis is needed in Canada, and the imminent threat to the security of the Canadian blood supply warrants further investigation. Based on our epidemiological findings, human babesiosis should

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2018 Healthcare

14. The first concurrent diagnosis of acute symptomatic Babesiosis and chronic myeloid leukemia in a healthy young adult (PubMed)

The first concurrent diagnosis of acute symptomatic Babesiosis and chronic myeloid leukemia in a healthy young adult 29963524 2018 11 14 2287-979X 53 2 2018 Jun Blood research Blood Res The first concurrent diagnosis of acute symptomatic Babesiosis and chronic myeloid leukemia in a healthy young adult. 163-166 10.5045/br.2018.53.2.163 Xie Yan Y Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH, USA. Visconte Valeria V Department of Translational Hematology and Oncology Research

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2018 Blood research

15. Fatal human babesiosis caused by Babesia divergens in an asplenic host (PubMed)

Fatal human babesiosis caused by Babesia divergens in an asplenic host We report a fatal case of human babesiosis caused by bovine pathogen Babesia divergens in Russia. Falciparum malaria was falsely diagnosed due to the presence of small ring forms in the blood smear. Laboratory diagnosis can distinguish between babesiosis and malaria according to the examination of stained blood smears.

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2018 IDCases

16. Canine babesiosis treatment rates in South African veterinary clinics between 2011 and 2016 (PubMed)

Canine babesiosis treatment rates in South African veterinary clinics between 2011 and 2016 South African veterinarians report the perception of a multi-year decline in the number of dogs presenting with clinical babesiosis, a common and serious disease of dogs in the country. This study tested this observation through analysis of veterinary hospital medical records from 2011 through 2016.Medical records were collected from 44 participating South African veterinary hospitals. The collected (...) medical records were searched to enumerate the number of Babesia-specific medication treatments administered to dogs at all participating hospitals. A healthcare use rate was calculated for canine babesiosis treatment for each calendar year from 2011 to 2016. The healthcare use rate numerator was the total number of canine babesiosis treatments and the denominator was the total dog visits to all participating veterinary practices over the same period.There were 2.6 million dog visits to 44

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2018 Parasites & vectors

17. The MEP pathway in Babesia orientalis apicoplast, a potential target for anti-babesiosis drug development (PubMed)

The MEP pathway in Babesia orientalis apicoplast, a potential target for anti-babesiosis drug development The apicomplexan parasite Babesia orientalis, the causative agent of water buffalo babesiosis in China, is widespread in central and south China, resulting in a huge economic loss annually. Currently, there is no effective vaccine or drug against this disease. Babesia bovis and Plasmodium falciparum were reported to possess an apicoplast which contains the methylerythritol phosphate (MEP (...) be a potential drug target for controlling and curing babesiosis. Considering the high price and instability of fosmidomycin, further studies should focus on the screening of stable and cheap drugs.

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2018 Parasites & vectors

18. Notes from the Field: Reference Laboratory Investigation of Patients with Clinically Diagnosed Lyme Disease and Babesiosis — Indiana, 2016 (PubMed)

Notes from the Field: Reference Laboratory Investigation of Patients with Clinically Diagnosed Lyme Disease and Babesiosis — Indiana, 2016 30335739 2018 12 17 2018 12 17 1545-861X 67 41 2018 Oct 19 MMWR. Morbidity and mortality weekly report MMWR Morb. Mortal. Wkly. Rep. Notes from the Field: Reference Laboratory Investigation of Patients with Clinically Diagnosed Lyme Disease and Babesiosis - Indiana, 2016. 1160-1161 10.15585/mmwr.mm6741a6 Brown Jennifer A JA Allman Rex R Herwaldt Barbara L (...) BL Gray Elizabeth E Rivera Hilda N HN Qvarnstrom Yvonne Y Kwit Natalie N Schriefer Martin E ME Hinckley Alison A Pontones Pamela P eng Journal Article 2018 10 19 United States MMWR Morb Mortal Wkly Rep 7802429 0149-2195 IM Adult Aged Babesiosis diagnosis Child Clinical Laboratory Techniques Female Humans Indiana Laboratories Lyme Disease diagnosis Male Middle Aged All authors have completed and submitted the ICMJE form for disclosure of potential conflicts of interest. No potential conflicts

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2018 Morbidity and Mortality Weekly Report

19. Misdiagnosis of Babesiosis as Malaria, Equatorial Guinea, 2014. (PubMed)

Misdiagnosis of Babesiosis as Malaria, Equatorial Guinea, 2014. We report a case of babesiosis, caused by Babesia microti, in a missionary who worked in Equatorial Guinea but also visited rural Spain. The initial diagnosis, based on clinical features and microscopy, was malaria. The patient's recovery was delayed until she received appropriate treatment for babesiosis.

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2018 Emerging Infectious Diseases

20. Molecular evidence for the transovarial passage of Babesia gibsoni in Haemaphysalis hystricis (Acari: Ixodidae) ticks from Taiwan: a novel vector for canine babesiosis (PubMed)

Molecular evidence for the transovarial passage of Babesia gibsoni in Haemaphysalis hystricis (Acari: Ixodidae) ticks from Taiwan: a novel vector for canine babesiosis Babesia gibsoni is the predominant tick-borne protozoan blood parasite affecting dogs throughout the Oriental region. Babesia gibsoni is transmitted by Haemaphysalis longicornis, whereas a similar role has been suggested for Rhipicephalus sanguineus. Haemaphysalis longicornis does not occur in Taiwan, but R. sanguineus is widely (...) distributed on dogs. However, clinical cases of babesiosis are mainly restricted to the northern part of the island. The discrepancy between tick distribution and clinical cases stimulated us to investigate the tick species distribution on dogs in northern Taiwan, with the aim to identify the local vector for canine babesiosis.Ticks were collected from stray dogs or free ranging pet dogs in northern Taiwan between 2015 and 2017 and, after identification, were tested for the presence of tick-borne Babesia

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2018 Parasites & vectors

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