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1. Herbal cannabis and pharmaceutical cannabinoid treatment following motor vehicle accidents: A state of the science review

Herbal cannabis and pharmaceutical cannabinoid treatment following motor vehicle accidents: A state of the science review Herbal cannabis and pharmaceutical cannabinoid treatment following motor vehicle accidents: A state of the science review Final Report Carolyn J Green, PhD Ken L Bassett, MD, PhD Therapeutics Initiative University of British Columbia October 2018 Table of Contents 1.0 Developing a funding policy framework for ICBC insurance claims 1 1.1 Scientific medical knowledge (...) – randomized controlled trial RR – risk ratio being the probability of an event in an exposed group compared to the non exposed group THC – delta 9-tetrahydrocannabinol, the most psychoactive cannabiniod and the one responsible for the intoxication effects of herbal cannabis WHO – World Health Organization 1 Herbal cannabis and pharmaceutical cannabinoid treatment following motor vehicle accidents: A state of the science review 1.0 Developing a funding policy framework for ICBC insurance claims

2020 Therapeutics Letter

2. Trends in Automobile Travel, Motor Vehicle Fatalities, and Physical Activity: 2003-2015. Full Text available with Trip Pro

Trends in Automobile Travel, Motor Vehicle Fatalities, and Physical Activity: 2003-2015. Annual per-capita automobile travel declined by 600 miles from 2003 to 2014 with decreases greatest among young adults. This article tests whether the decline has been accompanied by public health co-benefits of increased physical activity and decreased motor vehicle fatalities.Minutes of auto travel and physical activity derived from active travel, sports, and exercise were obtained from the American Time (...) in total minutes of physical activity. Motor vehicle occupant fatalities per 100,000 population showed significant declines for all ages (Δ=-5.8, p<0.001) with the largest for young men (Δ= -15.3, p<0.001). Fatalities per million minutes of auto travel showed only modest declines across age groups and, for men aged 20-29 years, varied from 10.9 (95% CI=10.0, 11.7) in 2003 to 9.7 (95% CI=8.7, 10.8) in 2014.Reduced motor vehicle fatalities are a public health co-benefit of decreased driving, especially

2017 American journal of preventive medicine

3. Realistic driving simulation during generalized epileptiform discharges to identify electroencephalographic features related to motor vehicle safety: Feasibility and pilot study. Full Text available with Trip Pro

Realistic driving simulation during generalized epileptiform discharges to identify electroencephalographic features related to motor vehicle safety: Feasibility and pilot study. Generalized epileptiform discharges (GEDs) can occur during seizures or without obvious clinical accompaniment. Motor vehicle driving risk during apparently subclinical GEDs is uncertain. Our goals were to develop a feasible, realistic test to evaluate driving safety during GEDs, and to begin evaluating

2020 Epilepsia

4. A semi-nonparametric Poisson regression model for analyzing motor vehicle crash data. Full Text available with Trip Pro

A semi-nonparametric Poisson regression model for analyzing motor vehicle crash data. This paper develops a semi-nonparametric Poisson regression model to analyze motor vehicle crash frequency data collected from rural multilane highway segments in California, US. Motor vehicle crash frequency on rural highway is a topic of interest in the area of transportation safety due to higher driving speeds and the resultant severity level. Unlike the traditional Negative Binomial (NB) model, the semi

2018 PLoS ONE

5. Side impact motor vehicle crashes: driver, passenger, vehicle and crash characteristics for fatally and nonfatally-injured rear-seated adults Full Text available with Trip Pro

Side impact motor vehicle crashes: driver, passenger, vehicle and crash characteristics for fatally and nonfatally-injured rear-seated adults Most studies of rear-seated occupants have focused on or included pediatric occupants which may not translate to adults. This study examines passenger, driver, vehicle and crash characteristics for rear-seated adult occupants involved in side crashes.The National Automotive Sampling System General Estimates System (NASS/GES) for calendar years 2011-2014 (...) was used with accompanying weights to examine the occupant, vehicle and crash characteristics associated with injury in rear-seated adults (n = 395,504) involved in a side crash. A weighted subpopulation analysis includes occupants travelling in a vehicle with an IIHS safety rating (n = 39,208), which was used to control for vehicle safety. Statistical analysis used Chi-square tests and multilevel multivariable logistic regression. Unadjusted and adjusted odds ratios (ORs) are reported with 95

2016 Injury epidemiology

6. Factors Associated With Unrestrained Young Passengers in Motor Vehicle Crashes. Full Text available with Trip Pro

Factors Associated With Unrestrained Young Passengers in Motor Vehicle Crashes. : media-1vid110.1542/5984244682001PEDS-VA_2018-2507Video Abstract BACKGROUND AND OBJECTIVE: Unrestrained child passengers are at significant risk of crash-related injury. Previous researchers using nationally representative crash data from 1992 to 1993 found an association between driver and passenger safety-belt use. Our objective in this study is to investigate factors associated with young, unrestrained (...) passengers in fatal and nonfatal motor vehicle crashes using updated national crash data.We analyzed 2011-2015 Fatality Analysis Reporting System and National Automotive Sampling System data and included vehicles with a young passenger (≤19 years old) in a crash. Driver and passenger characteristics were compared by using bivariate analyses separately for fatal and nonfatal crashes. Logistic regression analyses were performed on a combined data set to predict passenger restraint use.In unadjusted

2019 Pediatrics

7. Association Between Emergency Medical Service Response Time and Motor Vehicle Crash Mortality in the United States. Full Text available with Trip Pro

Association Between Emergency Medical Service Response Time and Motor Vehicle Crash Mortality in the United States. Motor vehicle crashes (MVCs) are a leading public health concern. Emergency medical service (EMS) response time is a modifiable, system-level factor with the potential to influence trauma patient survival. The relationship between EMS response time and MVC mortality is unknown.To measure the association between EMS response times and MVC mortality at the population level across US (...) in the Fatality Analysis Reporting System of the National Highway Traffic Safety Administration.During the study period, 2 214 480 ambulance responses to MVCs were identified (median, 229 responses per county [interquartile range (IQR), 73-697 responses per county]) in 2268 US counties. The median county response time was 9 minutes (IQR, 7-11) minutes. Longer response times were significantly associated with higher rates of MVC mortality (≥12 vs <7 minutes; mortality rate ratio, 1.46; 95% CI, 1.32-1.61) after

2019 JAMA surgery

8. Preventive effects of car safety seat use on clinical outcomes in infants and young children with road traffic injuries: A 7-year observational study. (Abstract)

Preventive effects of car safety seat use on clinical outcomes in infants and young children with road traffic injuries: A 7-year observational study. Road traffic injury (RTI) is one of the major mechanisms of injury leading to high disability and case-fatality in infants and children. Proper car safety seat use can reduce fatal outcomes in pediatric patients with RTI; however, the use rate is still low. This study aimed to measure the preventive effects of car safety seat use on clinical (...) outcomes among infants and young children injured from RTI.A multicenter cross-sectional study was conducted using the Emergency Department-based Injury In-depth Surveillance (EDIIS) registry from 23 EDs between Jan 2010 and Dec 2016. All pediatric patients who were under 6 years of age and who sustained RTI in a vehicle with fewer than 10-seats were eligible. Primary and secondary endpoints were intracranial injury and mortality. We calculated the adjusted odds ratio (AOR) of the car safety seat

2018 Injury

9. The Canadian Society of Breast Imaging (CSBI) and the Canadian Association of Radiology (CAR) Guidelines for Breast Imaging during the COVID-19 Pandemic

Continuous Positive Airway Pressure (CPAP), Bi-level Positive Airway Pressure (BiPAP), high flow nasal oxygenotherapy, and patients with a tracheostomy, there is no procedure in breast imaging at risk for aerosol generation. Refer to CAR/CAIR and CAR/CSTR guidelines for further details (7, 8). h. Given the potential for limited availability of PPE and recognizing that selective use of high priority breast imaging will be performed, the safety of staff is paramount. A minimum of two surgical masks (...) The Canadian Society of Breast Imaging (CSBI) and the Canadian Association of Radiology (CAR) Guidelines for Breast Imaging during the COVID-19 Pandemic Approved by CSBI and CAR Board of Directors – April 2, 2020 – version 1 Page 1 of 4 The Canadian Society of Breast Imaging (CSBI) and the Canadian Association of Radiology (CAR) Guidelines for Breast Imaging during the COVID-19 Pandemic April 2, 2020 Universal precautions should be taken to protect health care workers from infection or disease

2020 Canadian Association of Radiologists

10. Management of Obstructive Sleep Apnea in Commercial Motor Vehicle Operators: Recommendations of the AASM Sleep and Transportation Safety Awareness Task Force Full Text available with Trip Pro

Management of Obstructive Sleep Apnea in Commercial Motor Vehicle Operators: Recommendations of the AASM Sleep and Transportation Safety Awareness Task Force The American Academy of Sleep Medicine Sleep and Transportation Safety Awareness Task Force responded to the Federal Motor Carrier Safety Administration and Federal Railroad Administration Advance Notice of Proposed Rulemaking and request for public comments regarding the evaluation of safety-sensitive personnel for moderate-to-severe (...) obstructive sleep apnea (OSA). The following document represents this response. The most salient points provided in our comments are that (1) moderate-to-severe OSA is common among commercial motor vehicle operators (CMVOs) and contributes to an increased risk of crashes; (2) objective screening methods are available and preferred for identifying at-risk drivers, with the most commonly used indicator being body mass index; (3) treatment in the form of continuous positive airway pressure (CPAP

2017 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

11. Cycling injury risk in London: A case-control study exploring the impact of cycle volumes, motor vehicle volumes, and road characteristics including speed limits Full Text available with Trip Pro

modelled cyclist flow data alongside datasets covering some characteristics of the London route network. A multilevel binary logistic regression model is used to investigate factors associated with injury risk, comparing injury sites with control sites selected using the modelled flow data. Findings provide support for 'safety in numbers': for each increase of a natural logarithmic unit (2.71828) in cycling flows, an 18% decrease in injury odds was found. Conversely, increased motor traffic volume (...) Cycling injury risk in London: A case-control study exploring the impact of cycle volumes, motor vehicle volumes, and road characteristics including speed limits Cycling injury risk is an important topic, but few studies explore cycling risk in relation to exposure. This is largely because of a lack of exposure data, in other words how much cycling is done at different locations. This paper helps to fill this gap. It reports a case-control study of cycling injuries in London in 2013-2014, using

2018 Accident; analysis and prevention

12. General cognitive impairment as a risk factor for motor vehicle collision involvement: a prospective population-based study Full Text available with Trip Pro

on the Mini Mental State Exam (MMSE). Decline was defined as those with a 1-year change in MMSE scores in the lowest quartile (largest decrease). Motor vehicle collision involvement was obtained from the Alabama Department of Public Safety. Poisson regression was used to calculate crude and adjusted rate ratios (RR). There were 278 crashes during the follow-up period. Rates of crash involvement were higher for those with cognitive impairment (crude RR=2.33) compared to those without impairment at baseline (...) General cognitive impairment as a risk factor for motor vehicle collision involvement: a prospective population-based study This study examined whether cognitive impairment and decline as assessed by a brief mental status screening test is associated with future crash risk in a cohort of older drivers. A three-year prospective study was conducted in a population-based sample of 2000 licensed drivers aged 70 years and older. At the baseline visit, cognitive impairment was defined as <24

2018 Geriatrics (Basel, Switzerland)

13. Association Between Vestibular Vertigo and Motor Vehicle Accidents: Data From the 2016 National Health Interview Survey. (Abstract)

Association Between Vestibular Vertigo and Motor Vehicle Accidents: Data From the 2016 National Health Interview Survey. Recent evidence has shown that individuals with vestibular impairment have higher rates of self-reported driving difficulty compared with individuals without vestibular impairment. However, it is unknown whether individuals with vestibular impairment are more likely to be involved in motor vehicle accidents. We used data from the 2016 National Health Interview Survey of U.S (...) . adults to evaluate whether individuals with vestibular vertigo are more likely to experience motor vehicle accidents relative to individuals without vestibular vertigo. In multivariate analysis, vestibular vertigo was associated with an over threefold increased odds of motor vehicle accidents (odds ratio, 3.5; 95% confidence interval, 1.7-7.3). This study supports an association between vestibular dysfunction and driving impairment, and provides a relative risk of motor vehicle accidents associated

2018 Ear and hearing

14. Epidemiology of Pedestrian-Motor Vehicle Fatalities and Injuries, 2006-2015. (Abstract)

Epidemiology of Pedestrian-Motor Vehicle Fatalities and Injuries, 2006-2015. Pedestrian road safety remains a public health priority. The objective of this study is to describe trends in fatalities and injuries after pedestrian-motor vehicle collisions in the U.S. and identify associated risk factors for pedestrian fatalities.This is a cross-sectional study of U.S. pedestrian-motor vehicle collisions from 2006 to 2015 (performed in 2017). Pedestrian fatality and injury data were obtained from (...) the National Highway Traffic Safety Administration's Fatality Analysis Reporting System and National Automotive Sampling System General Estimates System. Frequencies of fatalities, injuries, and associated characteristics were calculated. Multivariable logistic regression was performed for risk of fatality, controlling for demographic and crash-related factors.There were 47,789 pedestrian fatalities and 674,414 injuries during the 10-year study period. Fatality rates were highest among the elderly aged 85

2018 American journal of preventive medicine

15. Hip dislocations and concurrent injuries in motor vehicle collisions. (Abstract)

Hip dislocations and concurrent injuries in motor vehicle collisions. Motor Vehicle Collisions (MVC) can cause high energy hip dislocations associated with serious injury profiles impacting triage. Changes in safety and regulation of restraint devices have likely lowered serious injuries from what was previously reported in the 1990s. This study aims to describe modern-day injury profile of patients with traumatic hip dislocations, with special attention to aortic injury.Retrospective review

2018 Injury

16. Fetal closed head injuries following maternal motor vehicle accident: A clinicopathologic case report. Full Text available with Trip Pro

Fetal closed head injuries following maternal motor vehicle accident: A clinicopathologic case report. The clinicopathologic appearance of fetal closed head injury (FCHI) due to a maternal motor vehicle accident has not been fully investigated because of its extreme rarity.A 22-year-old woman at 31 weeks of gestation was riding in the front passenger seat of a car, and another rightward-turning car struck the right side of her vehicle.Uterine injury with placental abruption was strongly (...) despite intensive care. Autopsy showed severe brain softening, subarachnoid hemorrhage with cerebral and cerebellar contusion, and bilateral thalamic hemorrhage. No hypoxic/ischemic changes of the thoracoabdominal organs were evident at autopsy.This was a clear case of FCHI by both shear and tensile forces. Multiple factors including the structural vulnerability of the fetal brain, the head posture of the fetus, the crash location and direction of force on the vehicle, and the employment of safety

2018 Medicine

17. Evaluating the "cushion effect" among children in frontal motor vehicle crashes. (Abstract)

percentile was not significantly associated with MAIS 2+ abdominal injury on multivariable logistic regression (adjusted Odds Ratio, 0.86; 95% CI, 0.72-1.03; p=0.10).The "cushion effect" was not apparent among pediatric frontal motor vehicle crash victims in this study. Future work is needed to investigate other analytic morphomic measures. By understanding how body composition relates to injury patterns, there is a unique opportunity to improve vehicle safety design.Prognosis Study, Level III.Copyright (...) Evaluating the "cushion effect" among children in frontal motor vehicle crashes. The "Cushion Effect," the phenomenon in which obesity protects against abdominal injury in adults in motor vehicle accidents, has not been evaluated among pediatric patients. This work evaluates the association between subcutaneous fat cross-sectional area, quantified using analytic morphomic techniques and abdominal injury.This retrospective study includes 119 patients aged 1 to 18years involved in frontal impact

2018 Journal of Pediatric Surgery

18. Psychological distress following a motor vehicle crash: preliminary results of a randomised controlled trial investigating brief psychological interventions Full Text available with Trip Pro

Psychological distress following a motor vehicle crash: preliminary results of a randomised controlled trial investigating brief psychological interventions The preliminary results of a randomised controlled trial are presented. The aim of the trial is to determine the efficacy, feasibility and acceptability of email-delivered psychological interventions with telephone support, for adults injured in a motor vehicle crash engaged in seeking compensation. The primary intention (...) not depressed, time plus telephone support is most likely sufficient enough to assist them to recover. The trial will continue with further recruitment to only the CBT and control groups, over longer follow-up periods.Australian and New Zealand Clinical Trials Registry: Preventing psychological distress following a motor vehicle accident; ACTRN12615000326594 . Registered on 9 April 2015.

2018 Trials Controlled trial quality: uncertain

19. Revving the CAR - Combination strategies to enhance CAR T cell effectiveness. (Abstract)

of resistance to CAR T cells, including cell-intrinsic mechanisms and the immunosuppressive tumor microenvironment. In this review, we discuss current experimental strategies that combine small molecules and monoclonal antibodies with CAR T cells to overcome these resistance mechanisms. We describe the biological rationale, pre-clinical data and clinical trials in progress that test the efficacy and safety of these combinations.Copyright © 2020. Published by Elsevier Ltd. (...) Revving the CAR - Combination strategies to enhance CAR T cell effectiveness. Chimeric antigen receptor (CAR) T cell therapy is currently approved for treatment of refractory B-cell malignancies. Response rates in these diseases are impressive by historical standards, but most patients do not have a durable response and there remains room for improvement. To date, CAR T cell activity has been even more limited in solid malignancies. These limitations are thought to be due to several pathways

2020 Blood reviews

20. First-in-man clinical trial of CAR NK-92 cells: safety test of CD33-CAR NK-92 cells in patients with relapsed and refractory acute myeloid leukemia Full Text available with Trip Pro

First-in-man clinical trial of CAR NK-92 cells: safety test of CD33-CAR NK-92 cells in patients with relapsed and refractory acute myeloid leukemia CAR T cells have shown clinical efficacy for acute lymphoblastic leukemia, but this therapy has not been effective for acute myeloid leukemia (AML), and other treatment options are needed. Theoretically, CAR-NK cells have a more favorable toxicity profile compared to CAR T cells, especially in avoiding adverse effects such as cytokine release (...) syndrome. However, the clinical evidence for this has not yet been reported. In the current study, we tested the safety of CD33-CAR NK cells in patients with relapsed and refractory AML. At doses up to 5 × 109 (5 billion) cells per patient, no significant adverse effects were observed. CAR NK-92 cells can be produced at much lower cost compared to CAR T cells, and we believe after being optimized, they will be widely accessible for the treatment of cancer.

2018 American journal of cancer research

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