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Aspartate Aminotransferase

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121. Escherichia coli mutants deficient in the aspartate and aromatic amino acid aminotransferases. Full Text available with Trip Pro

Escherichia coli mutants deficient in the aspartate and aromatic amino acid aminotransferases. Two new mutations are described which, together, eliminate essentially all the aminotransferase activity required for de novo biosynthesis of tyrosine, phenylalanine, and aspartic acid in a K-12 strain of Escherichia coli. One mutation, designated tyrB, lies at about 80 min on the E. coli map and inactivates the "tyrosine-repressible" tyrosine/phenylalanine aminotransferase. The second mutation, aspC (...) , maps at about 20 min and inactivates a nonrespressible aspartate aminotransferase that also has activity on the aromatic amino acids. In ilvE- strains, which lack the branched-chain amino acid aminotransferase, the presence of either the tyrosine-repressible aminotransferase or the aspartate aminotransferase is sufficient for growth in the absence of exogenous tyrosine, phenylalanine, or aspartate; the tyrosine-repressible enzyme is also active in leucine biosynthesis. The ilvE gene product alone

1977 Journal of bacteriology

122. Mapping of the aspartate and aromatic amino acid aminotransferase genes tyrB and aspC. Full Text available with Trip Pro

Mapping of the aspartate and aromatic amino acid aminotransferase genes tyrB and aspC. Co-transduction experiments using P1-mediated reciprocal and three-factor crosses have been used to map two mutations affecting the aspartate and aromatic amino acid aminotransferases of Escherichia coli. tyrB-, which inactivates the tyrosine-repressible component of these activities is co-transducible with metA and malB; the gene order is metA-malB-tyrB. aspC-, which inactivates the nonrepressible (...) aminotransferase with high activity for aspartate, maps between and is co-transducible with serC and pyrD.

1977 Journal of bacteriology

123. Generation of aspartate aminotransferase multiple forms by deamidation. Full Text available with Trip Pro

Generation of aspartate aminotransferase multiple forms by deamidation. The development of aspartate aminotransferase subforms in vitro was followed by densitometry after thin-film isoelectric focusing. At the same time ammonia production was measured. Each reaction can be expressed in terms of a first-order process in which 2 mol of glutamine or asparagine/mol of dimer are deamidated with a half time of 22 days. The more negatively charged subforms developed in vitro were almost fully active

1979 Biochemical Journal

124. Evidence for the participation of aspartate aminotransferase in hepatic glucose synthesis in the suckling newborn rat. Full Text available with Trip Pro

Evidence for the participation of aspartate aminotransferase in hepatic glucose synthesis in the suckling newborn rat. Inhibition of liver aspartate aminotransferase by L-2-amino-4-methoxy-trans-3-butenoic acid in the suckling newborn rat causes a decrease in all gluconeogenic precursors from phosphoenolpyruvate to glucose and an accumulation of lactate but not of pyruvate. This suggests that the aspartate shuttle is operative and confirms the quantitative importance of lactate

1978 Biochemical Journal

125. Purification and general properties of aspartate aminotransferase of ox heart Full Text available with Trip Pro

Purification and general properties of aspartate aminotransferase of ox heart 1. A five-step procedure for preparing highly purified aspartate aminotransferase from ox heart is described. 2. The homogeneity of the pure enzyme was established by criteria such as ultracentrifugation and electrophoresis in starch gel and in polyacrylamide gel. 3. The pure enzyme has an isoelectric point of about pH5, and E(1%) (1cm.) 14.40 at 278mmu. 4. The molecular weight of the pure enzyme was determined

1966 Biochemical Journal

126. Amino acid composition and terminal residues of aspartate aminotransferase from ox heart Full Text available with Trip Pro

Amino acid composition and terminal residues of aspartate aminotransferase from ox heart 1. The amino acid composition of highly purified aspartate aminotransferase from ox heart was determined. 2. Alanine is the only N-terminal residue. 3. Leucine was identified as the only C-terminal residue. 4. No disulphide bridges are present in the enzyme molecule. 5. The thiol groups are not equally accessible, the accessibility being comparatively easier in the apoenzyme molecule.

1966 Biochemical Journal

127. Interaction of aspartate aminotransferase with amino acids Full Text available with Trip Pro

Interaction of aspartate aminotransferase with amino acids 1. The capacity of various amino acids to convert the pyridoxal form of aspartate aminotransferase into the pyridoxamine form has been investigated. 2. Glutamate has the highest converting capacity; aspartate, alpha-aminopimelate, alpha-aminoadipate and other amino acids follow. 3. The converting capacity of the various amino acids assayed is connected with their structural features. 4. A possible role of amino acids as secondary (...) substrates of aspartate aminotransferase is suggested.

1965 Biochemical Journal

128. Acylation of aspartate aminotransferase Full Text available with Trip Pro

Acylation of aspartate aminotransferase 1. Acetylation of aspartate aminotransferase from pig heart inhibits completely the enzymic activity when the coenzyme is in the amino form (pyridoxamine phosphate) or when the coenzyme has been removed, but not when the coenzyme is in the aldehyde form (pyridoxal phosphate). 2. The group the acylation of which is responsible for the inhibition has been identified with the in-amino group of a lysine residue at the coenzyme-binding site. Moreover

1967 Biochemical Journal

129. Aspartate aminotransferase. The effects of ionic concentration on kinetic constants of both isoenzymes Full Text available with Trip Pro

Aspartate aminotransferase. The effects of ionic concentration on kinetic constants of both isoenzymes 1. The Michaelis constants for both isoenzymes for both substrates depend strongly on ionic concentration, being approximately proportional to phosphate concentration over considerable ranges. This is probably an effect of anions only. 2. In the absence of added salt, K(m) (2-oxoglutarate) (anionic isoenzyme) is so small as to be indeterminate. 3. K(m) (l-aspartate) (anionic isoenzyme) passes

1968 Biochemical Journal

130. The interaction between α2-macroglobulin and cationic aspartate aminotransferase Full Text available with Trip Pro

The interaction between α2-macroglobulin and cationic aspartate aminotransferase On starch-gel or polyacrylamide-gel electrophoresis of human serum, a supernumerary zone of aspartate aminotransferase activity may be demonstrated, migrating with the slow alpha(2) protein zone. This appearance is due only to cationic aspartate aminotransferase, bound by alpha(2)-macroglobulin. The binding is strongly potentiated by dilute borate buffers.

1969 Biochemical Journal

131. The binding of pyridoxal 5-phosphate to aspartate aminotransferase of pig heart Full Text available with Trip Pro

The binding of pyridoxal 5-phosphate to aspartate aminotransferase of pig heart 13976516 1998 11 01 2018 12 01 0264-6021 88 1963 Jul The Biochemical journal Biochem. J. The binding of pyridoxal 5-phosphate to aspartate aminotransferase of pig heart. 172-5 SCARDI V V SCOTTO P P IACCARINO M M SCARANO E E eng Journal Article England Biochem J 2984726R 0264-6021 5V5IOJ8338 Pyridoxal Phosphate EC 2.6.1.1 Aspartate Aminotransferases OM Animals Aspartate Aminotransferases Heart Humans Myocardium (...) Pyridoxal Phosphate Sus scrofa Swine ASPARTATE AMINOTRANSFERASE MYOCARDIUM PYRIDOXAL PHOSPHATE 1963 7 1 1963 7 1 0 1 1963 7 1 0 0 ppublish 13976516 PMC1203869 J Biol Chem. 1951 Nov;193(1):45-52 14907688 J Biol Chem. 1959 Jan;234(1):51-7 13610891 Boll Soc Ital Biol Sper. 1960 Dec 31;36:1719-22 13747074 J Biol Chem. 1960 Mar;235:620-4 14407079 Biochem J. 1962 May;83:413-6 14497811

1963 Biochemical Journal

132. Dissociation of the prosthetic group of aspartate aminotransferase. Full Text available with Trip Pro

Dissociation of the prosthetic group of aspartate aminotransferase. 5726192 1969 02 04 2018 11 13 0264-6021 110 2 1968 Nov The Biochemical journal Biochem. J. Dissociation of the prosthetic group of aspartate aminotransferase. 18P-19P Dixon H B HB Severin E S ES eng Journal Article England Biochem J 2984726R 0264-6021 0 Glutamates EC 2.6.1.1 Aspartate Aminotransferases IM Animals Aspartate Aminotransferases Chemical Phenomena Chemistry Chromatography, Gel Glutamates Swine 1968 11 1 1968 11 1 0

1968 Biochemical Journal

133. Regeneration of aspartate aminotransferase from its apoenzyme. Full Text available with Trip Pro

Regeneration of aspartate aminotransferase from its apoenzyme. 5726194 1969 02 04 2018 11 13 0264-6021 110 2 1968 Nov The Biochemical journal Biochem. J. Regeneration of aspartate aminotransferase from its apoenzyme. 19P Severin E S ES Dixon H B HB eng Journal Article England Biochem J 2984726R 0264-6021 0 Coenzymes 0 Phosphates EC 2.6.1.1 Aspartate Aminotransferases IM Animals Aspartate Aminotransferases Chemical Phenomena Chemistry Coenzymes Phosphates analysis Swine 1968 11 1 1968 11 1 0 1

1968 Biochemical Journal

134. The influence of chloride and other univalent inorganic anions on the visible-absorption spectrum of aspartate aminotransferase Full Text available with Trip Pro

The influence of chloride and other univalent inorganic anions on the visible-absorption spectrum of aspartate aminotransferase 1. The influence of Cl(-), Br(-), NO(3) (-) and F(-) ions on the visible-absorption spectrum of deionized aspartate aminotransferase was investigated. 2. Except for F(-), these anions caused an increase of the extinction at 430mmu with a concomitant decrease of that at 362mmu. 3. The affinity constants for Cl(-) and NO(3) (-) ions were calculated by a procedure based

1968 Biochemical Journal

135. The Association between Fruit and Vegetable Intake and Liver Enzymes (Aspartate and Alanine Transaminases) in Tehran, Iran Full Text available with Trip Pro

function enzymes.This cross-sectional study was conducted on 265 Tehrani healthy adults. Fruit and vegetable intake was assessed by a 147-items semi-quantitative food frequency questionnaire. Serum glucose, lipids, liver enzymes (alanine aminotransferase (ALT), aspartate aminotransferase (AST)), hs-Crp and body composition were measured in a fasting state.The mean age (± SD) of the participants was 35 ± 8.78. In the higher quartiles of vegetable intake, low-density lipoprotein (LDL) serum and total (...) The Association between Fruit and Vegetable Intake and Liver Enzymes (Aspartate and Alanine Transaminases) in Tehran, Iran Intake of fiber and antioxidants and following hypocaloric diets has beneficial effects on reduction of the liver enzymes. Fruits and vegetables are low in calorie and rich in fiber and antioxidants. There are few studies about special dietary effects on liver function. The aim of this study was to evaluate the association between fruit and vegetables intake and liver

2017 Ethiopian journal of health sciences

136. Correlations of Complete Blood Count with Alanine and Aspartate Transaminase in Chinese Subjects and Prediction Based on Back-Propagation Artificial Neural Network (BP-ANN) Full Text available with Trip Pro

Correlations of Complete Blood Count with Alanine and Aspartate Transaminase in Chinese Subjects and Prediction Based on Back-Propagation Artificial Neural Network (BP-ANN) BACKGROUND The complete blood count (CBC) is the most common examination used to monitor overall health in clinical practice. Whether there is a relationship between CBC indexes and alanine transaminase (ALT) and aspartate aminotransferase (AST) has been unclear. MATERIAL AND METHODS In this study, 572 normal-weight and 346

2017 Medical science monitor : international medical journal of experimental and clinical research

137. Research Study Comparing a New Medicine "Fast-acting Insulin Aspart" to Another Already Available Medicine "NovoRapid"/"NovoLog" in People With Type 2 Diabetes

] Measured in appropriate SI unit Change from baseline in aspartate aminotransferase (AST) [ Time Frame: Week 0, week 16 ] Measured in appropriate SI unit Change from baseline in albumin [ Time Frame: Week 0, week 16 ] Measured in appropriate SI unit Change from baseline in alkaline phosphatase [ Time Frame: Week 0, week 16 ] Measured in appropriate SI unit Change from baseline in creatinine [ Time Frame: Week 0, week 16 ] Measured in appropriate SI unit Change from baseline in potassium [ Time Frame (...) Research Study Comparing a New Medicine "Fast-acting Insulin Aspart" to Another Already Available Medicine "NovoRapid"/"NovoLog" in People With Type 2 Diabetes Research Study Comparing a New Medicine "Fast-acting Insulin Aspart" to Another Already Available Medicine "NovoRapid"/"NovoLog" in People With Type 2 Diabetes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study

2017 Clinical Trials

138. A 38 Week Trial Comparing Effect and Safety of Insulin Degludec/Insulin Aspart vs. Insulin Glargine Plus Insulin Aspart in Subjects With Type 2 Diabetes Treated With Basal Insulin With or Without Oral Antidiabetic Treatment in Need of Treatment Intensific

A 38 Week Trial Comparing Effect and Safety of Insulin Degludec/Insulin Aspart vs. Insulin Glargine Plus Insulin Aspart in Subjects With Type 2 Diabetes Treated With Basal Insulin With or Without Oral Antidiabetic Treatment in Need of Treatment Intensific A 38 Week Trial Comparing Effect and Safety of Insulin Degludec/Insulin Aspart vs. Insulin Glargine Plus Insulin Aspart in Subjects With Type 2 Diabetes Treated With Basal Insulin With or Without Oral Antidiabetic Treatment in Need (...) of Treatment Intensification - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A 38 Week Trial Comparing Effect and Safety of Insulin Degludec/Insulin Aspart vs. Insulin Glargine Plus Insulin Aspart in Subjects With Type

2016 Clinical Trials

139. A Study to Compare Insulin Intensification of Biphasic Insulin Aspart 30 and Insulin Analogues (Insulin Glargine and Insulin Aspart) in Insulin naïve Type 2 Diabetic Patients

A Study to Compare Insulin Intensification of Biphasic Insulin Aspart 30 and Insulin Analogues (Insulin Glargine and Insulin Aspart) in Insulin naïve Type 2 Diabetic Patients A Study to Compare Insulin Intensification of Biphasic Insulin Aspart 30 and Insulin Analogues (Insulin Glargine and Insulin Aspart) in Insulin naïve Type 2 Diabetic Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information (...) . Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study to Compare Insulin Intensification of Biphasic Insulin Aspart 30 and Insulin Analogues (Insulin Glargine and Insulin Aspart) in Insulin naïve Type 2 Diabetic Patients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does

2015 Clinical Trials

140. Salivary lactate dehydrogenase and aminotransferases in diabetic patients. Full Text available with Trip Pro

Salivary lactate dehydrogenase and aminotransferases in diabetic patients. Diabetes mellitus (DM) is a group of metabolic diseases resulting from impaired insulin secretion and/or action. DM is characterized by hyperglycemia that can lead to the dysfunction or damage of organs, including the salivary glands.The aim of this study was to compare the levels of salivary lactate dehydrogenase (LDH), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in diabetic patients.The study

2016 Medicine

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