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Aspartate Aminotransferase

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81. Ryzodeg (insulin degludec (genetical recombination) / insulin aspart (genetical recombination))

Ryzodeg (insulin degludec (genetical recombination) / insulin aspart (genetical recombination)) This English version of the Japanese review report is intended to be a reference material to provide convenience for users. In the event of inconsistency between the Japanese original and this English translation, the former will prevail. The PMDA will not be responsible for any consequence resulting from the use of this English version. Report on the Deliberation Results December 3, 2012 Evaluation (...) and Licensing Division, Pharmaceutical and Food Safety Bureau Ministry of Health, Labour and Welfare [Brand name] (a) Ryzodeg FlexTouch (b) Ryzodeg Penfill [Non-proprietary name] Insulin Degludec (Genetical Recombination)/Insulin Aspart (Genetical Recombination) (JAN*) [Applicant] Novo Nordisk Pharma Ltd. [Date of application] March 9, 2012 [Results of deliberation] In the meeting held on November 30, 2012, the First Committee on New Drugs concluded that the product may be approved and that this result

2012 Pharmaceuticals and Medical Devices Agency, Japan

82. Prevalence and Predictors of Elevated Aspartate Aminotransferase-to-Platelet Ratio Index in Latin American Perinatally HIV-infected Children. (Full text)

Prevalence and Predictors of Elevated Aspartate Aminotransferase-to-Platelet Ratio Index in Latin American Perinatally HIV-infected Children. Chronic liver disease has emerged as an important problem in adults with longstanding HIV infection, but data are lacking for children. We characterized elevated aspartate aminotransferase-to-platelet ratio index (APRI), a marker of possible liver fibrosis, in perinatally HIV-infected children.The National Institute of Child Health and Human Development (...) was >1.5 in 32 (3.2%, 95% confidence interval: 2.2%-4.4%) including 2 of 4 participants with hepatitis B virus infection. Factors significantly associated with APRI > 1.5 (P < 0.01 compared with APRI ≤ 1.5) included country, younger age, past or current hepatitis B virus, higher alanine aminotransferase, lower total cholesterol, higher log10 current viral load, lower current CD4 count, lower nadir CD4 count, use of hepatotoxic nonantiretroviral (ARV) medications and no prior ARV use. Rates of APRI

2013 Pediatric Infectious Dsease Journal

83. Aspartate Aminotransferase-to-Platelet Ratio index (APRi) in infants with biliary atresia: Prognostic value at presentation. (PubMed)

Aspartate Aminotransferase-to-Platelet Ratio index (APRi) in infants with biliary atresia: Prognostic value at presentation. Biliary atresia (BA) is a progressive obliterative cholangiopathy leading to liver fibrosis and cirrhosis. The aspartate aminotransferase-to-platelet ratio index (APRi) has been used in other liver diseases and in older children with BA as a surrogate marker of liver fibrosis. The aim of this study was to calculate APRi at time of presentation and relate this to operative

2013 Journal of Pediatric Surgery

84. Aspartate aminotransferase

Aspartate aminotransferase AST Produced by In partnership with User Top Links Menu Search User Top Links Search AST Test Also Known As Aspartate aminotransferase Serum glutamic-oxaloacetic transaminase (SGOT) Formal Name Aspartate aminotransferase This article was last reviewed on 19 February 2018. This article was last modified on 27 November 2018. At a Glance Why Get Tested? To detect liver damage When To Get Tested? If your doctor thinks that you have symptoms of a Sample Required? A blood

2012 Lab Tests Online UK

85. Overexpression, purification, crystallization and structure determination of AspB, a putative aspartate aminotransferase from Mycobacterium tuberculosis (Full text)

Overexpression, purification, crystallization and structure determination of AspB, a putative aspartate aminotransferase from Mycobacterium tuberculosis A recombinant version of a putative aspartate aminotransferase, AspB (encoded by the ORF Rv3565), from Mycobacterium tuberculosis (Mtb) was overexpressed in M. smegmatis and purified to homogeneity using liquid chromatography. Crystals of AspB were grown in a condition consisting of 0.2 M ammonium phosphate monobasic, 0.1 M calcium chloride (...) dihydrate employing the hanging-drop vapour-diffusion method at 298 K. The crystals diffracted to a limit of 2.50 Å resolution and belonged to the orthorhombic space group P2₁2₁2₁, with unit-cell parameters a=93.27, b=98.19, c=198.70 Å. The structure of AspB was solved by the molecular-replacement method using a putative aminotransferase from Silicibacter pomeroyi (PDB entry 3h14) as the search model. The template shares 46% amino-acid sequence identity with Mtb AspB. The crystal asymmetric unit

2014 Acta crystallographica. Section F, Structural biology communications

86. Activities of citrate synthase, NAD+-linked and NADP+-linked isocitrate dehydrogenases, glutamate dehydrogenase, aspartate aminotransferase and alanine aminotransferase in nervous tissues from vertebrates and invertebrates. (Full text)

Activities of citrate synthase, NAD+-linked and NADP+-linked isocitrate dehydrogenases, glutamate dehydrogenase, aspartate aminotransferase and alanine aminotransferase in nervous tissues from vertebrates and invertebrates. 1. The activities of citrate synthase and NAD+-linked and NADP+-linked isocitrate dehydrogenases were measured in nervous tissue from different animals in an attempt to provide more information about the citric acid cycle in this tissue. In higher animals the activities (...) . This suggest that glycolysis can provide energy in excess of the aerobic capacity of the tissue. 2. The activities of glutamate dehydrogenase are high in most nervous tissues and the activities of aspartate aminotransferase are high in all nervous tissue investigated. However, the activities of alanine aminotransferase are low in all tissues except the ganglia of the waterbug and cockroach. In these insect tissues, anaerobic glycolysis may result in the formation of alanine rather than lactate.

1975 Biochemical Journal

87. Tissue fractionation studies. 17. Intracellular distribution of monoamine oxidase, aspartate aminotransferase, alanine aminotransferase, d-amino acid oxidase and catalase in rat-liver tissue (Full text)

Tissue fractionation studies. 17. Intracellular distribution of monoamine oxidase, aspartate aminotransferase, alanine aminotransferase, d-amino acid oxidase and catalase in rat-liver tissue 4378796 1966 01 17 2018 11 13 0264-6021 92 1 1964 Jul The Biochemical journal Biochem. J. Tissue fractionation studies. 17. Intracellular distribution of monoamine oxidase, aspartate aminotransferase, alanine aminotransferase, D-amino acid oxidase and catalase in rat-liver tissue. 179-84 Baudhuin P P (...) Beaufay H H Rahman-Li Y Y Sellinger O Z OZ Wattiaux R R Jacques P P De Duve C C eng Journal Article England Biochem J 2984726R 0264-6021 EC 1.11.1.6 Catalase EC 1.4.3.3 D-Amino-Acid Oxidase EC 1.4.3.4 Monoamine Oxidase EC 2.6.1.1 Aspartate Aminotransferases EC 2.6.1.2 Alanine Transaminase IM Alanine Transaminase metabolism Animals Aspartate Aminotransferases metabolism Catalase metabolism Chemistry Techniques, Analytical D-Amino-Acid Oxidase metabolism In Vitro Techniques Liver enzymology Microsomes

1964 Biochemical Journal

88. The activities of proline dehydrogenase, glutamate dehydrogenase, aspartate-oxoglutarate aminotransferase and alanine-oxoglutarate aminotransferase in some insect flight muscles. (Full text)

The activities of proline dehydrogenase, glutamate dehydrogenase, aspartate-oxoglutarate aminotransferase and alanine-oxoglutarate aminotransferase in some insect flight muscles. 5451904 1970 10 07 2018 11 13 0264-6021 117 5 1970 May The Biochemical journal Biochem. J. The activities of proline dehydrogenase, glutamate dehydrogenase, aspartate-oxoglutarate aminotransferase and alanine-oxoglutarate aminotransferase in some insect flight muscles. 1019-21 Crabtree B B Newsholme E A EA eng Journal (...) Article England Biochem J 2984726R 0264-6021 9DLQ4CIU6V Proline EC 1.4.- Amino Acid Oxidoreductases EC 1.4.1.2 Glutamate Dehydrogenase EC 2.6.1.1 Aspartate Aminotransferases EC 2.6.1.2 Alanine Transaminase IM Alanine Transaminase analysis Amino Acid Oxidoreductases analysis Animals Aspartate Aminotransferases analysis Bees enzymology Glutamate Dehydrogenase analysis Insecta enzymology Muscles enzymology Proline 1970 5 1 1970 5 1 0 1 1970 5 1 0 0 ppublish 5451904 PMC1179065 Annu Rev Entomol. 1961;6:103

1970 Biochemical Journal

89. Clinicopathological features of choledocholithiasis patients with high aminotransferase levels without cholangitis: Prospective comparative study. (Full text)

Clinicopathological features of choledocholithiasis patients with high aminotransferase levels without cholangitis: Prospective comparative study. Common bile duct (CBD) stones are generally associated with greater elevations of alkaline phosphatase and gamma-glutamyl transpeptidase levels than aspartate aminotransferase and alanine aminotransferase levels. However, some patients with CBD stones show markedly increased aminotransferase levels, sometimes leading to the misdiagnosis of liver (...) disease. Therefore, the aim of this study was to investigate the clinicopathologic features of patients with CBD stones and high aminotransferase levels.This prospective cohort study included 882 patients diagnosed with CBD stones using endoscopic retrograde cholangiopancreatography (ERCP). Among these patients, 38 (4.3%) exhibited aminotransferase levels above 400 IU/L without cholangitis (gallstone hepatitis [GSH] group), and 116 (13.2%) exhibited normal aminotransferase levels (control group). We

2017 Medicine Controlled trial quality: uncertain

90. The past and present of serum aminotransferases and the future of liver injury biomarkers (Full text)

The past and present of serum aminotransferases and the future of liver injury biomarkers Laboratory testing is important in the diagnosis and monitoring of liver injury and disease. Current liver tests include plasma markers of injury (e.g. aminotransferases, γ-glutamyl transferase, and alkaline phosphatase), markers of function (e.g. prothrombin time, bilirubin), viral hepatitis serologies, and markers of proliferation (e.g. α-fetoprotein). Among the injury markers, the alanine and aspartate (...) aminotransferases (ALT and AST, respectively) are the most commonly used. However, interpretation of ALT and AST plasma levels can be complicated. Furthermore, both have poor prognostic utility in acute liver injury and liver failure. New biomarkers of liver injury are rapidly being developed, and the US Food and Drug Administration the European Medicines Agency have recently expressed support for use of some of these biomarkers in drug trials. The purpose of this paper is to review the history of liver

2016 EXCLI journal

91. Non-ALT biomarkers for markedly abnormal liver histology among Chinese persistently normal alanine aminotransferase-chronic hepatitis B patients (Full text)

Non-ALT biomarkers for markedly abnormal liver histology among Chinese persistently normal alanine aminotransferase-chronic hepatitis B patients To determine incidence and clinical biomarkers of marked necroinflammation and fibrosis characteristics among chronic hepatitis B (CHB) patients with persistently normal alanine aminotransferase (PNALT).Liver biopsy was performed on 115 CHB patients with PNALT. Necroinflammation and fibrosis were graded by the Knodell histologic activity index (...) and the Ishak fibrosis score, respectively. Correlations between the available clinical parameters and necroinflammation and fibrosis were analysed.Marked necroinflammation (Knodell activity index ≥ 7) and fibrosis (Ishak fibrosis score ≥ 3) were found in 36.5% and 15.5% of CHB patients with PNALT, respectively. Following a univariate logistic regression analysis, multiple logistic regression analysis indicated that aspartate transaminase (AST) (AUROC = 0.852, cut-off value = 22.5 U/L) serves

2017 World Journal of Gastroenterology

92. Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis (Full text)

Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis The alanine:glyoxylate aminotransferase (AGT), a hepatocyte-specific pyridoxal-5'-phosphate (PLP) dependent enzyme, transaminates L-alanine and glyoxylate to glycine and pyruvate, thus detoxifying glyoxylate and preventing pathological oxalate precipitation in tissues. In the widely accepted catalytic mechanism of the aminotransferase family (...) , the lysine binding to PLP acts as a catalyst in the stepwise 1,3-proton transfer, interconverting the external aldimine to ketimine. This step requires protonation by a conserved aspartate of the pyridine nitrogen of PLP to enhance its ability to stabilize the carbanionic intermediate. The aspartate residue is also responsible for a significant geometrical distortion of the internal aldimine, crucial for catalysis. We present the structure of human AGT in which complete X-ray photoreduction of the Schiff

2017 Scientific reports

93. Exacerbations of oral lichen planus and elevated levels of aminotransferases. (PubMed)

Exacerbations of oral lichen planus and elevated levels of aminotransferases. Liver enzymes appear to be involved in oral lichen planus (OLP), but it is not known whether the elevation develops concomitantly with exacerbations of disease. We compared the levels of serum hepatic aspartate (AST) and alanine (ALT) aminotransferases as markers of OLP exacerbation in patients with chronic hepatitis C from those with chronic liver disorders, seronegative for hepatitis C virus (HCV).We studied 71 (...) patients with OLP, (48 HCV seropositive and 23 HCV seronegative with chronic liver diseases) measuring AST and ALT. Association of HCV infection status with serum aminotransferase levels in relation to several types of OLP, exacerbations, and clinical score was studied by means of logistic and linear regression (correcting for age and sex).Of 476 patients screened, 71 were eligible for the study. Patients in the HCV seropositive group had more elevation of AST and ALT levels (mean level, 51.0 U/l

2017 International Journal of Dermatology

94. Prediction of hepatocellular carcinoma development by aminotransferase to platelet ratio index in primary biliary cholangitis (Full text)

Prediction of hepatocellular carcinoma development by aminotransferase to platelet ratio index in primary biliary cholangitis To investigate the usefulness of aspartate aminotransferase to platelet ratio index (APRI) in predicting hepatocellular carcinoma (HCC) risk in primary biliary cholangitis (PBC).We identified PBC patients between 2000 and 2015 by searching the electronic medical database of a tertiary center. The hazard ratio (HR) of HCC with different risk factors was determined by Cox

2017 World Journal of Gastroenterology

95. Gender difference in the association between aminotransferase levels and hypertension in a Chinese elderly population. (Full text)

aminotransferase (ALT) and aspartate aminotransferase (AST) levels were measured on fasting morning serum samples using the Kinetic method. Hypertension was defined as systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg and/or receiving treatment for hypertension. Multiple logistic regression was used to estimate the association between gender-specific aminotransferase levels and hypertension.Increased serum ALT but not AST level was positively associated with hypertension. After (...) Gender difference in the association between aminotransferase levels and hypertension in a Chinese elderly population. Few epidemiological studies have examined the association between serum aminotransferase levels and hypertension, and have yielded inconsistent results.A cross-sectional study was performed in a Chinese rural elderly population. A total of 2174 participants with normal range of aminotransferase levels and without excessive drinking were included in the present study. Alanine

2017 Medicine

96. HIV Monoinfection Is Associated With Increased Aspartate Aminotransferase-to-Platelet Ratio Index, a Surrogate Marker for Hepatic Fibrosis. (Full text)

HIV Monoinfection Is Associated With Increased Aspartate Aminotransferase-to-Platelet Ratio Index, a Surrogate Marker for Hepatic Fibrosis. Although liver disease commonly causes morbidity and mortality among human immunodeficiency virus (HIV)-infected individuals, data are limited on its prevalence in HIV monoinfection. We used the aspartate aminotransferase-to-platelet ratio index (APRI) as a surrogate marker of hepatic fibrosis to characterize liver disease in the Multicenter AIDS Cohort

2012 Journal of Infectious Diseases

97. Diagnostic accuracy of the aspartate aminotransferase-to-platelet ratio index for the prediction of hepatitis B-related fibrosis: a leading meta-analysis. (Full text)

Diagnostic accuracy of the aspartate aminotransferase-to-platelet ratio index for the prediction of hepatitis B-related fibrosis: a leading meta-analysis. The aspartate aminotransferase-to-platelet ratio index (APRI), a tool with limited expense and widespread availability, is a promising noninvasive alternative to liver biopsy for detecting hepatic fibrosis. The objective of this study was to systematically review the performance of the APRI in predicting significant fibrosis and cirrhosis

2012 BMC gastroenterology

98. Perioperative Serum Aspartate Aminotransferase Level as a Predictor of Survival After Coronary Artery Bypass Grafting. (PubMed)

Perioperative Serum Aspartate Aminotransferase Level as a Predictor of Survival After Coronary Artery Bypass Grafting. Elevated cardiac enzymes after coronary artery bypass grafting (CABG) surgery have been identified as a risk factor for worse postoperative outcome. Cardiac enzymes play an important role in the diagnosis of perioperative myocardial infarction. This study aims to investigate the predictive value of aspartate aminotransferase (AST) with respect to early and late mortality after

2012 Annals of Thoracic Surgery

99. Upper limit of normal serum alanine and aspartate aminotransferase levels in Korea. (PubMed)

Upper limit of normal serum alanine and aspartate aminotransferase levels in Korea.  The widely accepted range of upper limits of normal (ULN) alanine aminotransferase (ALT) levels (ULN < 40 U/L) was recently challenged by several reports. Both ALT and aspartate aminotransferase (AST) are commonly used as surrogate markers of liver disease, but almost all studies of aminotransferase activity were conducted on ALT. We investigated not only ULN of ALT but also AST activity and to identify factors

2013 Journal of gastroenterology and hepatology

100. Aspartate Aminotransferase

Aspartate Aminotransferase Aspartate Aminotransferase Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Aspartate Aminotransferase (...) Aspartate Aminotransferase Aka: Aspartate Aminotransferase , Serum Glutamic Oxaloacetic Transaminase , Glutamic oxaloacetic transaminase , Serum AST , AST , SGOT II. Definition Serum transaminase marker of hepatocyte injury Less specific than ALT (present outside liver) III. Normal Level: <35 U/L IV. Increased See Sensitive marker for hepatocellular marker Same causes as (ALT) AST is less specific then ALT (present outside liver) Heart, lung, , brain, , muscle s and s disease causes of increased AST See

2015 FP Notebook

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