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Aspartate Aminotransferase

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41. Preoperative aspartate aminotransferase-to-platelet ratio index (APRI) is a predictor on postoperative outcomes of hepatocellular carcinoma. Full Text available with Trip Pro

Preoperative aspartate aminotransferase-to-platelet ratio index (APRI) is a predictor on postoperative outcomes of hepatocellular carcinoma. Preoperative aspartate aminotransferase-to-platelet ratio index (APRI) has been identified as a biochemical marker for histological fibrogenesis and fibrosis in cirrhosis and prognosis of hepatocellular carcinoma (HCC). Whether preoperative APRI can predict postoperative short-term outcomes has not been studied. The purpose of this study was to investigate

2016 Medicine

42. Downregulated endogenous sulfur dioxide/aspartate aminotransferase pathway is involved in angiotensin II-stimulated cardiomyocyte autophagy and myocardial hypertrophy in mice. (Abstract)

Downregulated endogenous sulfur dioxide/aspartate aminotransferase pathway is involved in angiotensin II-stimulated cardiomyocyte autophagy and myocardial hypertrophy in mice. The study was designed to investigate if endogenous sulfur dioxide (SO2) was involved in cardiomyocyte autophagy and myocardial hypertrophy stimulated by angiotensin II (Ang II).Thirty-two C57 mice were randomly divided into control, SO2, Ang II and Ang II+SO2 groups. Human myocardial cell line H9c2 was divided into four (...) groups including control, SO2, Ang II and Ang II+SO2 groups. Blood pressure and myocardial hypertrophy of the mice were measured two weeks after Ang II administration. LC3 II/I ratio, and Beclin1, Atg4B and p62 expressions were determined both in vivo and in vitro. Autophagosome was observed in H9c2 cells with confocal microscope. Endogenous SO2 generation and aspartate aminotransferase (AAT) expression were measured.In animal studies, hypertension and myocardial hypertrophy developed two weeks after

2016 International journal of cardiology

43. A novel and accurate predictor of survival for patients with hepatocellular carcinoma after surgical resection: the neutrophil to lymphocyte ratio (NLR) combined with the aspartate aminotransferase/platelet count ratio index (APRI). Full Text available with Trip Pro

A novel and accurate predictor of survival for patients with hepatocellular carcinoma after surgical resection: the neutrophil to lymphocyte ratio (NLR) combined with the aspartate aminotransferase/platelet count ratio index (APRI). The occurrence and development of hepatocellular carcinoma (HCC) depends largely on such non-tumor factors as inflammatory condition, immune state, viral infection and liver fibrosis. Various inflammation-based prognostic scores have been associated with survival (...) in patients with HCC, such as the neutrophil/lymphocyte ratio (NLR), the platelet/lymphocyte ratio (PLR) and the prognostic nutritional index (PNI). The aspartate aminotransferase/platelet count ratio index (APRI) is thought to be a biomarker of liver fibrosis and cirrhosis. This study aims to evaluate the ability of these indices to predict survival in HCC patients after curative hepatectomy, and probe the increased prognostic accuracy of APRI combined with established inflammation-based prognostic

2016 BMC Cancer

44. Preoperative Aspartate Aminotransferase to White Blood Cell Count Ratio Predicting Postoperative Outcomes of Hepatocellular Carcinoma. Full Text available with Trip Pro

Preoperative Aspartate Aminotransferase to White Blood Cell Count Ratio Predicting Postoperative Outcomes of Hepatocellular Carcinoma. Effective biomarkers for predicting prognosis of hepatocellular carcinoma (HCC) patients after hepatectomy is urgently needed. The purpose of this study is to evaluate the value of the preoperative peripheral aspartate aminotransferase to white blood cell count ratio (AWR) for the prognostication of patients with HCC.Clinical data of 396 HCC patients who (...) underwent radical hepatectomy were retrospectively analyzed. The patients were divided into the low-AWR group (AWR ≤5.2) and the high-AWR group (AWR >5.2); univariate analysis, Kaplan-Meier method analysis, and the multivariate analysis by Cox regression were conducted, respectively.The results showed that AWR was associated with alpha-fetoprotein (AFP), tumor size, Barcelona clinic liver cancer (BCLC) stage, portal vein tumor thrombus (PVTT), and alanine aminotransferase (ALT) in HCC. AWR > 5.2, AFP

2016 Medicine

45. Prevalence of and progression to abnormal noninvasive markers of liver disease (aspartate aminotransferase-to-platelet ratio index and Fibrosis-4) among US HIV-infected youth. Full Text available with Trip Pro

Prevalence of and progression to abnormal noninvasive markers of liver disease (aspartate aminotransferase-to-platelet ratio index and Fibrosis-4) among US HIV-infected youth. To longitudinally characterize noninvasive markers of liver disease in HIV-infected youth.HIV infection, without viral hepatitis coinfection, may contribute to liver disease. Noninvasive markers of liver disease [FIB-4 (Fibrosis-4) and APRI (aspartate aminotransferase-to-platelet ratio index)] have been evaluated

2016 AIDS

46. Influence of Preoperative Serum Aspartate Aminotransferase (AST) Level on the Prognosis of Patients with Non-Small Cell Lung Cancer Full Text available with Trip Pro

Influence of Preoperative Serum Aspartate Aminotransferase (AST) Level on the Prognosis of Patients with Non-Small Cell Lung Cancer The purpose of this work is to analyze preoperative serum aspartate aminotransferase (AST) levels and their effect on the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical operation. These analyses were performed retrospectively in patients with NSCLC followed by surgery; participants were recruited between January 2004 and January 2008

2016 International journal of molecular sciences

47. Prognostic significance of preoperative aspartate aminotransferase to neutrophil ratio index in patients with hepatocellular carcinoma after hepatic resection Full Text available with Trip Pro

Prognostic significance of preoperative aspartate aminotransferase to neutrophil ratio index in patients with hepatocellular carcinoma after hepatic resection Various inflammation-based prognostic scores have been associated with poor survival in patients with hepatocellular carcinoma (HCC), and neutrophils display important roles. However, few studies have illuminated the relationship between preoperative aspartate aminotransferase (AST) to neutrophil ratio index (ANRI) and poor prognosis

2016 Oncotarget

48. Aspartate aminotransferase to platelet ratio index and sustained virologic response are associated with progression from hepatitis C associated liver cirrhosis to hepatocellular carcinoma after treatment with pegylated interferon plus ribavirin Full Text available with Trip Pro

Aspartate aminotransferase to platelet ratio index and sustained virologic response are associated with progression from hepatitis C associated liver cirrhosis to hepatocellular carcinoma after treatment with pegylated interferon plus ribavirin The aim of this study was to evaluate the clinically significant predictors of hepatocellular carcinoma (HCC) development among hepatitis C virus (HCV) cirrhotic patients receiving combination therapy.One hundred and five compensated cirrhosis patients (...) ). Fifteen (14.3%) patients developed HCC during follow-up period. Thirteen of them had high baseline aspartate aminotransferase to platelet ratio index (APRI) (ie, an APRI >2.0). Multivariate analysis showed that those without sustained virologic response (SVR) (hazard ratio [HR] 5.795; 95% confidence interval [CI] 1.370-24.5; P=0.017) and high APRI (HR 5.548; 95% CI 1.191-25.86; P=0.029) had a significantly higher risk of HCC occurrence. The cumulative incidence of HCC was significantly higher (P=0.009

2016 Clinical interventions in aging

49. Prediction of the Risk of Hepatocellular Carcinoma in Chronic Hepatitis C Patients after Sustained Virological Response by Aspartate Aminotransferase to Platelet Ratio Index Full Text available with Trip Pro

Prediction of the Risk of Hepatocellular Carcinoma in Chronic Hepatitis C Patients after Sustained Virological Response by Aspartate Aminotransferase to Platelet Ratio Index Following sustained virological response (SVR) for chronic hepatitis C (CHC) infection, patients with advanced fibrosis require regular monitoring for hepatocellular carcinoma (HCC). The aspartate aminotransferase to platelet ratio index (APRI) is a simple noninvasive surrogate marker known to reflect fibrosis.We

2016 Gut and liver

50. Postoperative aspartate aminotransferase to platelet ratio index change predicts prognosis for hepatocellular carcinoma. Full Text available with Trip Pro

Postoperative aspartate aminotransferase to platelet ratio index change predicts prognosis for hepatocellular carcinoma. An elevated preoperative aspartate aminotransferase (AST) to platelet ratio index (APRI) is reported to be a prognostic factor for patients with hepatocellular carcinoma (HCC) after treatment. However, delta APRI (ΔAPRI), which represents the change from preoperative to postoperative APRI, has received little attention. The present study was designed to evaluate

2016 Medicine

51. Lowering the upper limit of serum alanine aminotransferase levels may reveal significant liver disease in the elderly. Full Text available with Trip Pro

) were reviewed for a diagnosis of chronic liver disease; aspartate aminotransferase/platelet ratio index, FIB-4 and alanine aminotransferase/aspartate aminotransferase ratio were used to evaluate liver fibrosis. The prevalence of significant liver disease, by diagnoses and fibrosis scores was compared between subjects with alanine aminotransferase levels in the delta range (men, 42-45 IU/L; women, 26-34 IU/L) and in the newly suggested normal range (men, 15-42 IU/L; women, 10-26 IU/L). The cohort (...) Lowering the upper limit of serum alanine aminotransferase levels may reveal significant liver disease in the elderly. This study sought to determine the prevalence of significant liver disease in those subjects with serum alanine aminotransferase levels in the range between the current and the newly suggested upper limit of normal (termed the delta range). The files of the previous study subjects (who underwent at least one alanine aminotransferase measurement in 2002 and followed to 2012

2019 PLoS ONE

52. Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose: a Response Full Text available with Trip Pro

Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose: a Response 26567032 2017 12 07 2018 12 02 1937-6995 12 2 2016 06 Journal of medical toxicology : official journal of the American College of Medical Toxicology J Med Toxicol Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose: a Response. 218 10.1007/s13181-015-0514-8 Levine Michael M Section of Medical (...) of Medical Toxicology, Banner Good Samaritan Medical Center, Phoenix, AZ, USA. eng Letter Comment United States J Med Toxicol 101284598 1556-9039 0 Analgesics, Non-Narcotic 362O9ITL9D Acetaminophen EC 2.6.1.1 Aspartate Aminotransferases WYQ7N0BPYC Acetylcysteine IM J Med Toxicol. 2016 Mar;12 (1):100-6 26341088 J Med Toxicol. 2016 Jun;12 (2):217 26574022 Acetaminophen Acetylcysteine Analgesics, Non-Narcotic Aspartate Aminotransferases Chemical and Drug Induced Liver Injury Drug Overdose Humans Prothrombin

2015 Journal of Medical Toxicology

53. In Response to: “Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose.” Full Text available with Trip Pro

In Response to: “Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose.” 26574022 2017 12 07 2018 12 02 1937-6995 12 2 2016 06 Journal of medical toxicology : official journal of the American College of Medical Toxicology J Med Toxicol In Response to: "Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose.". 217 10.1007/s13181-015-0513-9 Fernandez Denise D 0000 (...) -0002-5883-0387 Ronald O. Perelman Department of Emergency Medicine, New York School of Medicine, New York, NY, USA. denfernandez@gmail.com. Nelson Lewis S LS Ronald O. Perelman Department of Emergency Medicine, New York School of Medicine, New York, NY, USA. eng Letter Comment United States J Med Toxicol 101284598 1556-9039 0 Analgesics, Non-Narcotic 362O9ITL9D Acetaminophen EC 2.6.1.1 Aspartate Aminotransferases WYQ7N0BPYC Acetylcysteine IM J Med Toxicol. 2016 Mar;12 (1):100-6 26341088 J Med

2015 Journal of Medical Toxicology

54. Aspartate Aminotransferase to Platelet Ratio and Fibrosis-4 as Biomarkers in Biopsy Validated Pediatric Cystic Fibrosis Liver Disease. Full Text available with Trip Pro

Aspartate Aminotransferase to Platelet Ratio and Fibrosis-4 as Biomarkers in Biopsy Validated Pediatric Cystic Fibrosis Liver Disease. Up to 10% of cystic fibrosis (CF) children develop cirrhosis by the first decade. We evaluated the utility of two simple biomarkers, aspartate aminotransferase to platelet ratio index (APRI) and FIB-4, in predicting degree of fibrosis in pediatric CF liver disease (CFLD) validated by liver biopsy. In this retrospective, cross-sectional study, 67 children

2015 Hepatology

55. The value of serum aspartate aminotransferase and gamma-glutamyl transpetidase as biomarkers in hepatotoxicity. (Abstract)

The value of serum aspartate aminotransferase and gamma-glutamyl transpetidase as biomarkers in hepatotoxicity. The current definition of the pattern of liver injury in hepatotoxicity (DILI) is given by the R (ratio) value, dividing alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in upper limits of normal at DILI onset. We aimed to explore the validity of using aspartate aminotransferase (AST) and gamma-glutamyl transpeptidase (GGT) as biomarkers of hepatocelullar and cholestatic

2015 Liver International

56. Aspartate aminotransferase to platelet ratio index as a prospective predictor of hepatocellular carcinoma risk in patients with chronic hepatitis B virus infection. Full Text available with Trip Pro

Aspartate aminotransferase to platelet ratio index as a prospective predictor of hepatocellular carcinoma risk in patients with chronic hepatitis B virus infection. APRI (aspartate aminotransferase [AST] to platelet ratio index) is widely used to assess fibrosis and cirrhosis risk, especially in hepatitis C virus (HCV)-infected patients. Few studies have evaluated APRI and hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) risk. Prospective evidence is needed to assess whether APRI

2015 Journal of gastroenterology and hepatology

57. Transient elastography and aspartate aminotransferase to platelet ratio predict liver injury in pediatric intestinal failure. (Abstract)

Transient elastography and aspartate aminotransferase to platelet ratio predict liver injury in pediatric intestinal failure. We aimed to evaluate the value of AST to platelet ratio (APRI) and transient elastography (TE) as predictors of liver histopathology in children with intestinal failure (IF).Altogether 93 liver biopsies from 57 children with parenteral nutrition (PN) duration ≥3 months were analysed. APRI measurement and TE (n = 46) were performed at the time of biopsy.IF was caused

2015 Liver International

58. Validation of aspartate aminotransferase to platelet ratio for diagnosis of liver fibrosis and prediction of postoperative prognosis in infants with biliary atresia Full Text available with Trip Pro

Validation of aspartate aminotransferase to platelet ratio for diagnosis of liver fibrosis and prediction of postoperative prognosis in infants with biliary atresia To validate the value of aspartate aminotransferase to platelet ratio index (APRI) in assessment of liver fibrosis and prediction of postoperative prognosis of biliary atresia (BA) infants from Mainland China.Medical records of 153 BA infants who were hospitalized from January 2010 to June 2013 were reviewed. The efficacy of APRI

2015 World journal of gastroenterology : WJG

59. Predictive value of aspartate aminotransferase and alanine aminotransferase levels in vaginal fluid for the diagnosis of premature rupture of membranes Full Text available with Trip Pro

Predictive value of aspartate aminotransferase and alanine aminotransferase levels in vaginal fluid for the diagnosis of premature rupture of membranes Preterm premature rupture of membranes (PPROM) occurs in 3% of pregnancies and 30-40% of preterm labors are related to this problem. Early diagnosis of PPROM is very important due to its impact on pregnancy outcomes.To determine the diagnostic value of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in vaginal fluid

2014 Iranian Journal of Reproductive Medicine

60. Insulin degludec/Insulin aspart (Ryzodeg 70/30)

Insulin degludec/Insulin aspart (Ryzodeg 70/30) CENTER FOR DRUG EVALUATION AND RESEARCH APPLICATION NUMBER: 203313Orig1s000 203314Orig1s000 MEDICAL REVIEW(S) CLINICAL REVIEW Application Type NDA Application Number(s) 203313 and 203314 Priority or Standard Class 2 resubmission Submit Date(s) 26 March 2015 Received Date(s) 26 March 2015 PDUFA Goal Date 26 September 2015 Division / Office DMEP/ODEII Reviewer Name(s) Tania A. Condarco Review Completion Date 31 August 2015 Established Name Insulin (...) degludec Insulin degludec/Insulin aspart 70/30 (Proposed) Trade Name Tresiba for insulin degludec; Ryzodeg 70/30 for insulin degludec/insulin aspart 70/30 Therapeutic Class Tresiba: Long-acting (basal) insulin analog; Ryzodeg: Fixed-ratio combination of long- and short-acting insulin analogs Applicant Novo Nordisk Formulation(s) Tresiba: IDeg U100 (600 nmol/mL) and IDeg U200 (1200 nmol/mL) Ryzodeg Dosing Regimen Individualized dose administered subcutaneously once daily using a fixed or flexible dosing

2015 FDA - Drug Approval Package

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