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Aspartate Aminotransferase

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201. COVID 19 rapid evidence summary: Remdesivir for treating hospitalised patients with suspected or confirmed COVID-19

. It was unclear in Wang et al (2020) and Grein et al (2020) whether serious adverse events were related to COVID-19 or remdesivir. Adverse events relating to kidney and liver biomarkers were not significantly different when remdesivir was compared with placebo in the 2 RCTs. This may have been due to the studies excluding patients with impaired renal function and alanine aminotransferase or aspartate aminotransferase 5 times the upper limit of the normal range. Consequently, there are no data in patients (...) of 6gastrointestinal symptoms (anorexia, nausea, and vomiting), aminotransferase or bilirubin increases and worsened cardiopulmonary status. The definition of severe COVID-19 disease differed in the included studies, the common feature was having a peripheral oxygen saturation of 94% or less on room air. Of the included studies, Beigel et al (2020) had a clear definition for both severe and mild or moderate COVID-19 disease. Beigel et al (2020) described 'severe' as requiring invasive or non-invasive mechanical

2020 National Institute for Health and Clinical Excellence - Advice

202. COVID-19 (Novel Coronavirus)

to hospital admission 7 days clinical features included fever in 98% cough in 76% dyspnea in 55% myalgia or fatigue in 44% sputum production in 28% headache in 8% hemoptysis in 5% diarrhea in 3% bilateral multiple lobular and subsegmental areas of consolidation were common findings on chest computed tomography laboratory testing revealed lymphopenia (lymphocyte count < 1 × 10 9 cells/L) in 63% elevated aspartate aminotransferase levels in 37% leukopenia (white blood cell count < 4 × 10 9 cells/L) in 25 (...) patients (mean age 49 years, 73% male) with confirmed COVID-19 pneumonia admitted to Jinyintan Hospital in Wuhan, China, by January 2, 2020, were evaluated Critical_Care Infectious_Diseases Internal_Medicine Pulmonary_Disorders fever and cough most common clinical features in patients with 2019-nCoV pneumonia (Lancet 2020 Jan 24 early online) 01/28/2020 08:59:32 AM laboratory testing revealed lymphopenia (lymphocyte count < 1 × 10 9 cells/L) in 63% elevated aspartate aminotransferase levels in 37

2020 DynaMed Plus

203. Covid-19: Impact on coagulation due to coronavirus

, activated partial thromboplastin time, alanine aminotransferase, aspartate aminotransferase Authors' conclusion: “The data so far reported are suggestive of low-grade intravascular clotting activation, which is evident overall in patients with severe disease. The finding more consistent in support of this hypothesis is the increase of D-dimer” Henry et al, 2020 [4] 21 cohort studies from Asia Laboratory confirmed covid-19 patients, total n=3 377 Hematologic (count of WBC, neutrophil, lymphocyte (...) , monocyte, platelet and eosinophil, CD4, CD8, hemoglobin); Biochemical (albumin, alanine aminotransferase, aspartate aminotransferase, total bilirubin, blood urea nitrogen, creatinine, creatine kinase, lactate dehydrogenase, myoglobin, creatine kinase-MB, cardiac troponin); Coagulation (prothrombin, APTIT, D-dimer); Inflammatory biomarkers (erythrocyte sedimentation rate, CRP, serum ferritin, PCT, IL1, IL-2R, IL-6,IL-8, IL-10, TNF) Authors' conclusion: “Several biomarkers which may potentially aid

2020 Swedish Council on Technology Assessement

205. Danis stent for acute oesophageal variceal bleeds

in Germany and so may not be generalisable to the NHS. A short follow-up period of 60 days. Abbreviations: AST, aspartate aminotransferase; AVB, acute bleeding from oesophageal varices; CI, confidence interval; EBL, endoscopic band ligation; HR, hazard ratio; ICU, intensive care unit; PRS, propensity risk score; SAE, serious adverse events; SEMS, self-expanding oesophageal metal stents; TIPS, transjugular intrahepatic portosystemic shunt. Recent and ongoing studies Effective haemostasis using self

2019 National Institute for Health and Clinical Excellence - Advice

206. LiMAx system for assessing the functional capacity of the liver

of the intravenous 13 C-methacetin administration were observed during injection or follow-up. Strengths and limitations Patients were followed up for a total of 6 months and none of the patients withdrew consent. LiMAx measurements were validated in healthy volunteers and also during anhepatic phase of liver transplant. Histopathology evaluation was done by a blinded pathologist. Data come from a single German centre. Abbreviations: AST, aspartate aminotransferase; AUROC, area under the receiver operating

2019 National Institute for Health and Clinical Excellence - Advice

207. Ivacaftor (combination with ivacaftor/tezacaftor, cystic fibrosis, 12 years and older, with F508del mutation, homozygous) - Addendum to Commission A19-70

) Alanine aminotransferase increased 1 (0.5) 0 (0) Aspartate aminotransferase increased 1 (0.5) 0 (0) Gamma-glutamyltransferase increased 1 (0.5) 0 (0) Blood alkaline phosphatase increased 0 (0) 1 (0.5) Immune system disorders 1 (0.5) 0 (0) Drug hypersensitivity 1 (0.5) 0 (0) Injury, poisoning and procedural complications 1 (0.5) 0 (0) Post procedural haematoma 1 (0.5) 0 (0) Neoplasms benign, malignant and unspecified (incl cysts and polyps) 1 (0.5) 2 (1.1) Seminoma 1 (0.5) 0 (0) Colon cancer metastatic

2020 Institute for Quality and Efficiency in Healthcare (IQWiG)

208. Ramucirumab (hepatocellular carcinoma) - Benefit assessment according to §35a Social Code Book V

recorded as AEs (see Section 2.3.2). e: Discrepancy between information in Module 4 and Module 5 of the dossier. The data presented are from additional analyses on Module 4 and are identical with this. The discrepancy is marginal and therefore not relevant. f: Institute’s calculation. g: Since no event occurred in at least one treatment arm, the HR cannot be estimated. h: Includes the PTs “aspartate aminotransferase increased” and “blood bilirubin increased”. AE: adverse event; BSC: best supportive

2020 Institute for Quality and Efficiency in Healthcare (IQWiG)

209. Aminotransferase levels and 20-year risk of metabolic syndrome, diabetes, and cardiovascular disease Full Text available with Trip Pro

. These findings also applied to participants with ALT levels within the normal range (MetS OR, 1.17; P = .006; diabetes OR, 1.34; P =.002). There was an increased risk of CVD in age/gender-adjusted models (hazard ratio, 1.23; P < .0001), but this was attenuated in multivariable-adjusted models (hazard ratio 1.05; P = .27); no association was observed for all-cause mortality. Aspartate aminotransferase levels were found to be associated with an increased risk of only diabetes.Both normal and increased levels (...) Aminotransferase levels and 20-year risk of metabolic syndrome, diabetes, and cardiovascular disease Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of obesity and metabolic syndrome (MetS). Alanine aminotransferase (ALT) levels are used to detect NAFLD and have also been associated with increased risk for MetS, diabetes mellitus, and cardiovascular disease (CVD). We studied the relationship between ALT levels and these disorders in a long-term follow-up study.Framingham

2009 EvidenceUpdates

210. A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)

aminotransferase; ARDS: Acute respiratory distress syndrome; AST: Aspartate aminotransferase; CCEBTCM: China Center for Evidence Based Traditional Chinese Medicine; CDC: Centers for Disease Control and Prevention; CK: Creatine kinase; CPAM: China International Exchange and Promotive Association for Medical and Health Care; CPAP: Continuous positive airway pressure; CRP: C-reactive protein; CRRT: Continuous renal replacement therapies; DIC: Disseminated intravascular coagulation; ECLS: Extracorporeal life

2020 Covid-19 Ad hoc guidelines

211. Care of patients with liver disease during the COVID-19 pandemic: EASL-ESCMID position paper

depending on the antiviral therapy initiated (Table 1). Abbreviations ACE2, angiotensin-converting enzyme 2; ACE-I, angiotensin-converting enzyme inhibitor; ACLF, acute-on-chronic liver failure; ALT, alanine aminotransferase; AST, aspartate aminotransferase; COVID-19, corona- virus disease 2019; EGD, esophagogastroduodenoscopy; ERC, endo- scopic retrograde cholangiography; HCC, hepatocellular carcinoma; MELD, model for end-stage liver disease; NAFLD, non-alcoholic fatty liver disease; NASH, non (...) patients, older patients were identi?ed to be at higher risk of a fatal disease course, with hyper- tension, diabetes and coronary heart disease being themostfrequentcomorbiditiesinthesecohorts. 2,3 COVID-19 and the liver While pre-existing liver disease is not speci?cally listed in the published cohort studies, elevated alanine aminotransferase (ALT) levels, reduced platelet counts and reduced albumin levels at the time of admission have been associated with higher mortality, 2 although not all

2020 European Association for the Study of the Liver

212. Recommendations for the management of patients with acute myeloid leukaemia (AML) during the COVID-19 outbreak

further to 14 days. If using azacitidine the length of treatment could also be reduced to 5 days. • In patients who have not yet been confirmed to be in complete remission the length of subsequent treatment cycles should not be altered. • Patients who do not achieve CR after cycle 2 should be discussed at an MDT. Dose adjustments for non-haematological toxicity: • In patients with grade 3-4 abnormal liver function tests (i.e. alanine aminotransferase [ALT] aspartate aminotransferase [AST

2020 Royal College of Pathologists

213. Darolutamide (Nubeqa) - prostate cancer

), feeling unwell, decreased neutrophil count (a type of white blood cell that fights infection), increased blood levels of bilirubin (a breakdown product of red blood cells made in the liver, indicating liver problems) and certain liver enzymes (aspartate aminotransferase). For the full list of side effects of Nubeqa, see the package leaflet. Nubeqa is not for use in women and must not be used in women who are or who may be pregnant. For the full list of restrictions, see the package leaflet. Why

2020 European Medicines Agency - EPARs

214. First-Line Therapy, Autologous Stem Cell Transplantation, and Post-Transplant Maintenance in the Management of Patients Newly Diagnosed with Mantle Cell Lymphoma

plus dexamethasone, high-dose cytarabine, and cisplatin); MRCT, myeloablative radio chemotherapy; AraC, cytarabine; RB, rituximab bendamustine; RH, rituximab plus hyperfractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone (hyperCVAD) alternating with high dose cytarabine and methotrexate (MTX); AST, aspartate aminotransferase; ALT, alanine aminotransferase; HR, hazard ratio; MIPI, MCL prognostic index (age, performance status, S-lactate dehydrogenase, and white blood cell count

2020 Cancer Care Ontario

215. Acute pancreatitis

Sjogren's syndrome pancreas divisum pancreatic cancer sphincter of Oddi dysfunction family history of pancreatitis Diagnostic investigations serum lipase or amylase aspartate aminotransferase/alanine aminotransferase FBC and differential CRP haematocrit arterial blood gas abdominal plain film CXR trans-abdominal ultrasound ratio of serum lipase:amylase abdominal CT scan magnetic resonance cholangiopancreatography (MRCP) endoscopic ultrasound (EUS) urinary trypsinogen-2 serum interleukin-6 serum

2019 BMJ Best Practice

216. Cytomegalovirus infection

disease acute illness in intensive care setting newborn in CMV infection during pregnancy Diagnostic investigations FBC serum creatinine serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) serum alkaline phosphatase serology pp65 antigenaemia nucleic acid detection CD4 count chest x-ray chest CT scan histopathology of biopsy upper gastrointestinal endoscopy and colonoscopy serial fetal ultrasound examinations (congenital CMV infection) amniocentesis or fetal blood sampling

2019 BMJ Best Practice

217. Abiraterone acetate (prostate cancer) - Benefit assessment according to §35a Social Code Book V

(prostate cancer) 13 March 2018 Institute for Quality and Efficiency in Health Care (IQWiG) - v - List of abbreviations Abbreviation Meaning ACT appropriate comparator therapy ADT androgen deprivation therapy AE adverse event ALT alanine aminotransferase AST aspartate aminotransferase BFI Brief Fatigue Inventory BPI-SF Brief Pain Inventory-Short Form CTCAE Common Terminology Criteria for Adverse Events ECOG Eastern Cooperative Oncology Group EORTC QLQ-C30 European Organisation for Research and Treatment (...) a statistically significant effect to the disadvantage of abiraterone-P-ADT in comparison with ADT. This resulted in a hint of greater harm from abiraterone-P-ADT in comparison with ADT. Side effects – aspartate aminotransferase increased (CTCAE grade 3–4) Results for the outcome “aspartate aminotransferase increased” (CTCAE grade 3–4) were only available for the LATITUDE study. A statistically significant effect to the disadvantage of abiraterone-P-ADT in comparison with ADT was shown. This resulted

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

218. HELLP syndrome

antithrombin level haptoglobin level maternal upper abdomen ultrasound, CT, or MRI lactate dehydrogenase (LDH)-to-aspartate aminotransferase (AST) ratio Treatment algorithm INITIAL ACUTE Contributors Authors Professor of Obstetrics and Gynecology Vice Chair for Research and Academic Development Director of the Divisions of Maternal-Fetal Medicine and Research University of Mississippi Medical Center Jackson MI Disclosures JNM Jr is a maternal-foetal medicine consultant and obstetrician gynaecologist

2019 BMJ Best Practice

220. Options for national testing and surveillance for hepatitis E virus in the EU/EEA

partial thromboplastin time AST Aspartate aminotransferase AP Alkaline phosphatase ECDC European Centre for Disease Prevention and Control EEA European Economic Area EASL European Association for the Study of the Liver EFSA European Food Safety Authority EU European Union HEV Hepatitis E virus LFT Liver function test NAT Nucleic acid test PT Prothrombin time SoHO Substances of human origin WHO World Health Organization Options for national testing and surveillance for hepatitis E virus in the EU/EEA (...) surveillance system. i Group of tests to detect, evaluate and monitor liver disease or damage. The tests include prothrombin time, activated partial thromboplastin time, albumin, bilirubin (direct and indirect), alanine transaminase and aspartate aminotransferase, alkaline phosphatase and others. TECHNICAL REPORT Options for national testing and surveillance for hepatitis E virus in the EU/EEA – Operational guidance 8 The group also emphasised that genotype 1 or 2 infections during pregnancy have a higher

2019 European Centre for Disease Prevention and Control - Technical Guidance

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