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Aspartate Aminotransferase

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201. Comparison of Biphasic Insulin Aspart 30 Individually Adjusted by the Subject and the Trial Physician, Both Combined With Metformin in Subjects With Type 2 Diabetes

Comparison of Biphasic Insulin Aspart 30 Individually Adjusted by the Subject and the Trial Physician, Both Combined With Metformin in Subjects With Type 2 Diabetes Comparison of Biphasic Insulin Aspart 30 Individually Adjusted by the Subject and the Trial Physician, Both Combined With Metformin in Subjects With Type 2 Diabetes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x (...) × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Comparison of Biphasic Insulin Aspart 30 Individually Adjusted by the Subject and the Trial Physician, Both Combined With Metformin in Subjects With Type 2 Diabetes (SimpleMix™) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been

2011 Clinical Trials

202. Commentary on: Noninvasive assessment of liver fibrosis using aspartate transaminase to platelet ratio index (APRI) in adult patients with chronic liver disease Full Text available with Trip Pro

. Isa Mona M eng Journal Article Iran Hepat Mon 101277874 1735-143X Aspartate aminotransferases Chronic hepatitis C Fatty liver 2011 03 28 2011 04 02 2011 04 12 2011 11 17 6 0 2011 11 17 6 0 2011 11 17 6 1 ppublish 22087166 PMC3212770 J Pediatr Gastroenterol Nutr. 2010 Aug;51(2):198-202 20531020 Hepat Mon. 2011 Feb;11(2):103-6 22087126 J Pediatr Gastroenterol Nutr. 2010 Mar;50(3):344-6 20118806 Orv Hetil. 2010 Nov 21;151(47):1951-5 21071307 Eur J Gastroenterol Hepatol. 2010 Aug;22(8):946-51 20110820 (...) Commentary on: Noninvasive assessment of liver fibrosis using aspartate transaminase to platelet ratio index (APRI) in adult patients with chronic liver disease 22087166 2011 11 23 2018 11 13 1735-3408 11 5 2011 May Hepatitis monthly Hepat Mon Commentary on: Noninvasive assessment of liver fibrosis using aspartate transaminase to platelet ratio index (APRI) in adult patients with chronic liver disease. 378-9 El-Shabrawi Mortada M Pediatric Hepatology Department, Cairo University, Cairo, Egypt

2011 Hepatitis monthly

203. Metabolic fingerprint of ischaemic cardioprotection - importance of the malate-aspartate shuttle. Full Text available with Trip Pro

Metabolic fingerprint of ischaemic cardioprotection - importance of the malate-aspartate shuttle. The convergence of cardioprotective intracellular signalling pathways to modulate mitochondrial function as an end-target of cytoprotective stimuli is well described. However, our understanding of whether the complementary changes in mitochondrial energy metabolism are secondary responses or inherent mechanisms of ischaemic cardioprotection remains incomplete. In the heart, the malate-aspartate (...) by the aminotransferase inhibitor aminooxyacetate induces infarct limitation, improves haemodynamic responses, and modulates glucose metabolism, analogous to effects observed in classical ischaemic preconditioning. On the basis of these findings, the mechanisms through which MAS preserves mitochondrial function and cell survival are reviewed. We conclude that the available evidence is supportive of a down-regulation of mitochondrial respiration during lethal ischaemia with a gradual 'wake-up' during reperfusion

2011 Cardiovascular Research

204. Purification, crystallization and preliminary X-ray analysis of the aspartate aminotransferase of Plasmodium falciparum Full Text available with Trip Pro

Purification, crystallization and preliminary X-ray analysis of the aspartate aminotransferase of Plasmodium falciparum Aspartate aminotransferases (EC 2.6.1.1) catalyse the conversion of aspartate and alpha-ketoglutarate to oxaloacetate and glutamate in a reversible manner. Thus, the aspartate aminotransferase of Plasmodium falciparum (PfAspAT) plays a central role in the transamination of amino acids. Recent findings suggest that PfAspAT may also play a pivotal role in energy metabolism

2010 Acta Crystallographica Section F: Structural Biology and Crystallization Communications

205. Assessment of Liver Fibrosis and Cirrhosis by Aspartate Aminotransferase-to-Platelet Ratio Index in Children With Biliary Atresia. Full Text available with Trip Pro

Assessment of Liver Fibrosis and Cirrhosis by Aspartate Aminotransferase-to-Platelet Ratio Index in Children With Biliary Atresia. In patients with biliary atresia (BA), liver fibrosis and cirrhosis commonly occur even after Kasai hepatoportoenterostomy. Although liver biopsy is the gold standard to evaluate liver fibrosis, it is invasive and may result in life-threatening complications. The aspartate aminotransferase-to-platelet ratio index (APRI) is a safe and simple method to assess liver

2010 Journal of Pediatric Gastroenterology and Nutrition

206. Two Routine Blood Tests-Mean Corpuscular Volume and Aspartate Aminotransferase-as Predictors of Delirium Tremens in Trauma Patients. (Abstract)

Two Routine Blood Tests-Mean Corpuscular Volume and Aspartate Aminotransferase-as Predictors of Delirium Tremens in Trauma Patients. Delirium tremens (DT) in trauma patients is associated with significant morbidity and mortality. Short interview tools have been used to determine the risk of DT but require an alert, compliant patient and a motivated physician. The mean corpuscular volume (MCV) and aspartate aminotransferase (AST) levels are parts of routine laboratory testing, influenced

2010 Journal of Trauma

207. Use of the aspartate aminotransferase to platelet ratio index to follow liver fibrosis progression in infants with short gut. (Abstract)

Use of the aspartate aminotransferase to platelet ratio index to follow liver fibrosis progression in infants with short gut. Infants with parenteral nutrition dependence may develop liver dysfunction and progress to liver failure requiring transplantation. The aspartate aminotransferase-to-platelet ratio index (APRI) has good correlation with liver fibrosis progression in adults. This study applies APRI scoring to parenteral nutrition-dependant, short-gut infants to determine hepatic fibrosis

2010 Journal of Pediatric Surgery

209. Danis stent for acute oesophageal variceal bleeds

in Germany and so may not be generalisable to the NHS. A short follow-up period of 60 days. Abbreviations: AST, aspartate aminotransferase; AVB, acute bleeding from oesophageal varices; CI, confidence interval; EBL, endoscopic band ligation; HR, hazard ratio; ICU, intensive care unit; PRS, propensity risk score; SAE, serious adverse events; SEMS, self-expanding oesophageal metal stents; TIPS, transjugular intrahepatic portosystemic shunt. Recent and ongoing studies Effective haemostasis using self

2019 National Institute for Health and Clinical Excellence - Advice

210. LiMAx system for assessing the functional capacity of the liver

of the intravenous 13 C-methacetin administration were observed during injection or follow-up. Strengths and limitations Patients were followed up for a total of 6 months and none of the patients withdrew consent. LiMAx measurements were validated in healthy volunteers and also during anhepatic phase of liver transplant. Histopathology evaluation was done by a blinded pathologist. Data come from a single German centre. Abbreviations: AST, aspartate aminotransferase; AUROC, area under the receiver operating

2019 National Institute for Health and Clinical Excellence - Advice

211. Aminotransferase levels and 20-year risk of metabolic syndrome, diabetes, and cardiovascular disease Full Text available with Trip Pro

. These findings also applied to participants with ALT levels within the normal range (MetS OR, 1.17; P = .006; diabetes OR, 1.34; P =.002). There was an increased risk of CVD in age/gender-adjusted models (hazard ratio, 1.23; P < .0001), but this was attenuated in multivariable-adjusted models (hazard ratio 1.05; P = .27); no association was observed for all-cause mortality. Aspartate aminotransferase levels were found to be associated with an increased risk of only diabetes.Both normal and increased levels (...) Aminotransferase levels and 20-year risk of metabolic syndrome, diabetes, and cardiovascular disease Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of obesity and metabolic syndrome (MetS). Alanine aminotransferase (ALT) levels are used to detect NAFLD and have also been associated with increased risk for MetS, diabetes mellitus, and cardiovascular disease (CVD). We studied the relationship between ALT levels and these disorders in a long-term follow-up study.Framingham

2009 EvidenceUpdates

212. Abiraterone acetate (prostate cancer) - Benefit assessment according to §35a Social Code Book V

(prostate cancer) 13 March 2018 Institute for Quality and Efficiency in Health Care (IQWiG) - v - List of abbreviations Abbreviation Meaning ACT appropriate comparator therapy ADT androgen deprivation therapy AE adverse event ALT alanine aminotransferase AST aspartate aminotransferase BFI Brief Fatigue Inventory BPI-SF Brief Pain Inventory-Short Form CTCAE Common Terminology Criteria for Adverse Events ECOG Eastern Cooperative Oncology Group EORTC QLQ-C30 European Organisation for Research and Treatment (...) a statistically significant effect to the disadvantage of abiraterone-P-ADT in comparison with ADT. This resulted in a hint of greater harm from abiraterone-P-ADT in comparison with ADT. Side effects – aspartate aminotransferase increased (CTCAE grade 3–4) Results for the outcome “aspartate aminotransferase increased” (CTCAE grade 3–4) were only available for the LATITUDE study. A statistically significant effect to the disadvantage of abiraterone-P-ADT in comparison with ADT was shown. This resulted

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

213. HELLP syndrome

antithrombin level haptoglobin level maternal upper abdomen ultrasound, CT, or MRI lactate dehydrogenase (LDH)-to-aspartate aminotransferase (AST) ratio Treatment algorithm INITIAL ACUTE Contributors Authors Professor of Obstetrics and Gynecology Vice Chair for Research and Academic Development Director of the Divisions of Maternal-Fetal Medicine and Research University of Mississippi Medical Center Jackson MI Disclosures JNM Jr is a maternal-foetal medicine consultant and obstetrician gynaecologist

2019 BMJ Best Practice

214. Acute pancreatitis

Sjogren's syndrome pancreas divisum pancreatic cancer sphincter of Oddi dysfunction family history of pancreatitis Diagnostic investigations serum lipase or amylase aspartate aminotransferase/alanine aminotransferase FBC and differential CRP haematocrit arterial blood gas abdominal plain film CXR trans-abdominal ultrasound ratio of serum lipase:amylase abdominal CT scan magnetic resonance cholangiopancreatography (MRCP) endoscopic ultrasound (EUS) urinary trypsinogen-2 serum interleukin-6 serum

2019 BMJ Best Practice

215. Cytomegalovirus infection

disease acute illness in intensive care setting newborn in CMV infection during pregnancy Diagnostic investigations FBC serum creatinine serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) serum alkaline phosphatase serology pp65 antigenaemia nucleic acid detection CD4 count chest x-ray chest CT scan histopathology of biopsy upper gastrointestinal endoscopy and colonoscopy serial fetal ultrasound examinations (congenital CMV infection) amniocentesis or fetal blood sampling

2019 BMJ Best Practice

216. Istradefylline (Nourianz) - Parkinson's disease

% Occurring in Pool 2. MedDRA System Organ Class (preferred term) IST 20 mg N=60 % IST 40 mg N=1501 % IST 60 mg N=332 % All IST N=1893 % Blood Creatine Phosphokinase Increased 0 4.3 2.7 3.9 Lipase Increased 5 1.6 3.6 2.1 Amylase Increased 3.3 0.8 3.3 1.3 Blood Glucose Increased 5 1.3 0.6 1.3 Aspartate Aminotransferase Increased 3.3 0.7 0.9 0.8 Alanine Aminotransferase Increased 3.3 0.7 0.3 0.7 CDER Clinical Review Template Version date: September 6, 2017 for all NDAs and BLAs Reference ID: 4482736

2019 FDA - Drug Approval Package

217. Gilteritinib (Xospata) - acute myeloid leukaemia (AML)

of chemotherapy. What are the risks associated with Xospata? The most common side effects with Xospata (which may affect more than 1 in 10 people) are increased levels of some enzymes in the blood (creatine phosphokinase, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase), diarrhoea, tiredness, nausea (feeling sick), constipation, cough, peripheral oedema (swelling, especially of the ankles and feet), dyspnoea (shortness of breath), dizziness, hypotension (low blood pressure), pain

2019 European Medicines Agency - EPARs

220. Non-Surgical Management of Advanced Hepatocellular Carcinoma

to 0.87, p 0.999 Post-procedural pain 22 (24.7) 63 (71.6) p=0.001 All other AEs p=ns *Treatment-related SAEs with 30 days of treatment Abbreviations: AE=adverse event; ALT=alanine aminotransferase; AST=aspartate aminotransferase; cTACE = conventional transarterial chemoembolization; DEB-TACE=drug eluting bead transarterial chemoembolization; LVEF=left ventricular ejection fraction; NR=not reported; ORR=objective response rate; OS=overall survival; RCT=randomized controlled trial; SAE=serious adverse

2019 Cancer Care Ontario

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