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Aspartate Aminotransferase

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181. Utility of liver function tests including aminotransferase-to-platelet ratio index in monitoring liver dysfunction in short-gut infants of varying ages and intestinal lengths. (PubMed)

Utility of liver function tests including aminotransferase-to-platelet ratio index in monitoring liver dysfunction in short-gut infants of varying ages and intestinal lengths. Aspartate aminotransferase-to-platelet ratio index (APRI) has good correlation with liver fibrosis progression in the infant and toddler short-gut population. This study applies laboratory liver function testing, including APRI, to monitor liver dysfunction over time for short-gut infants, with further analysis of at-risk (...) subpopulations.Study inclusion criteria included infants younger than 1 year at initial intestinal resection with subsequent continuous parenteral nutrition dependence of 3 months minimum. Bilirubin, aspartate aminotransferase, alanine aminotransferase, APRI, and biopsies were collected for 26 weeks postresection. Subgroup analysis was stratified by (1) estimated gestational age, (2) age at intestinal resection (AGE), and (3) remaining intestinal length.Thirty-one children were included, all with AGE younger than

2011 Journal of Pediatric Surgery

182. Assessment of Liver Fibrosis and Cirrhosis by Aspartate Aminotransferase-to-Platelet Ratio Index in Children With Biliary Atresia. (Full text)

Assessment of Liver Fibrosis and Cirrhosis by Aspartate Aminotransferase-to-Platelet Ratio Index in Children With Biliary Atresia. In patients with biliary atresia (BA), liver fibrosis and cirrhosis commonly occur even after Kasai hepatoportoenterostomy. Although liver biopsy is the gold standard to evaluate liver fibrosis, it is invasive and may result in life-threatening complications. The aspartate aminotransferase-to-platelet ratio index (APRI) is a safe and simple method to assess liver

2010 Journal of Pediatric Gastroenterology and Nutrition

183. Use of the aspartate aminotransferase to platelet ratio index to follow liver fibrosis progression in infants with short gut. (PubMed)

Use of the aspartate aminotransferase to platelet ratio index to follow liver fibrosis progression in infants with short gut. Infants with parenteral nutrition dependence may develop liver dysfunction and progress to liver failure requiring transplantation. The aspartate aminotransferase-to-platelet ratio index (APRI) has good correlation with liver fibrosis progression in adults. This study applies APRI scoring to parenteral nutrition-dependant, short-gut infants to determine hepatic fibrosis

2010 Journal of Pediatric Surgery

184. Purification, crystallization and preliminary X-ray analysis of the aspartate aminotransferase of Plasmodium falciparum (Full text)

Purification, crystallization and preliminary X-ray analysis of the aspartate aminotransferase of Plasmodium falciparum Aspartate aminotransferases (EC 2.6.1.1) catalyse the conversion of aspartate and alpha-ketoglutarate to oxaloacetate and glutamate in a reversible manner. Thus, the aspartate aminotransferase of Plasmodium falciparum (PfAspAT) plays a central role in the transamination of amino acids. Recent findings suggest that PfAspAT may also play a pivotal role in energy metabolism

2010 Acta Crystallographica Section F: Structural Biology and Crystallization Communications

185. Two Routine Blood Tests-Mean Corpuscular Volume and Aspartate Aminotransferase-as Predictors of Delirium Tremens in Trauma Patients. (PubMed)

Two Routine Blood Tests-Mean Corpuscular Volume and Aspartate Aminotransferase-as Predictors of Delirium Tremens in Trauma Patients. Delirium tremens (DT) in trauma patients is associated with significant morbidity and mortality. Short interview tools have been used to determine the risk of DT but require an alert, compliant patient and a motivated physician. The mean corpuscular volume (MCV) and aspartate aminotransferase (AST) levels are parts of routine laboratory testing, influenced

2010 Journal of Trauma

186. Aspartate aminotransferase to platelet ratio index for the assessment of liver fibrosis severity in patients with chronic hepatitis (Full text)

Aspartate aminotransferase to platelet ratio index for the assessment of liver fibrosis severity in patients with chronic hepatitis 22087195 2011 11 23 2018 11 13 1735-3408 11 7 2011 Jul Hepatitis monthly Hepat Mon Aspartate aminotransferase to platelet ratio index for the assessment of liver fibrosis severity in patients with chronic hepatitis. 560-1 Sirli Roxana R Department of Gastroenterology, University of Medicine and Pharmacy, Timisoara, Romania. Sporea Ioan I eng Journal Article Iran (...) Hepat Mon 101277874 1735-143X Aspartate aminotransferase Chronic hepatitis Liver fibrosis 2011 04 09 2011 04 12 2011 04 15 2011 11 17 6 0 2011 11 17 6 0 2011 11 17 6 1 ppublish 22087195 PMC3212765 Hepat Mon. 2011 Feb;11(2):103-6 22087126 J Hepatol. 2009 Jan;50(1):165-73 18977552 Hepatology. 2007 Sep;46(3):912-21 17705266 Ann Hepatol. 2008 Oct-Dec;7(4):350-7 19034235 Aliment Pharmacol Ther. 2011 Feb;33(4):455-65 21235598 Clin Chim Acta. 2011 Jan 14;412(1-2):33-7 20828546 Dig Dis Sci. 2011 Sep;56(9

2011 Hepatitis monthly

187. Combined use of aspartate aminotransferase, platelet count and matrix metalloproteinase 2 measurements to predict liver fibrosis in HIV/hepatitis C virus-coinfected patients. (Full text)

Combined use of aspartate aminotransferase, platelet count and matrix metalloproteinase 2 measurements to predict liver fibrosis in HIV/hepatitis C virus-coinfected patients. Noninvasive tests that can be used in place of liver biopsy to diagnose fibrosis have major limitations. They either leave a significant proportion of patients without a definitive diagnosis or produce inaccurate results. Moreover, the performance of these tests is lower in HIV/hepatitis C virus (HCV) coinfection. Against (...) characteristic curve (AUROC). Positive (PPV) and negative (NPV) predictive values were calculated.Ninety patients were included in the study. Aspartate aminotransferase (AST), platelet count and MMP-2 were predictors of significant fibrosis (F≥2) and cirrhosis (F4). A score constructed using these variables yielded an AUROC of 0.76 for F≥2 and 0.88 for F4. Score cut-offs detected (value ≥3.5) and excluded (value ≤1.5) F≥2 with a PPV of 87% and an NPV of 88%. Thirty-one patients (34%) were correctly diagnosed

2011 HIV medicine

188. Purification and characterization of kynurenine--2-oxoglutarate aminotransferase from the liver, brain and small intestine of rats. (Full text)

and polyacrylamide-disc-gel electrophoresis, it is suggested that liver, brain and small intestinal kynurenine-2-oxoglutarate aminotransferase (isoenzyme 1) is identical with mitochondrial tyrosine-2-oxoglutarate aminotransferase and also with mitochondrial aspartate-2-oxoglutarate aminotransferase. 2. An additional kynurenine-2-oxoglutarate aminotransferase (isoenzyme 2) was purified from the liver. This enzyme was specific for 2-oxoglutarate and L-kynurenine. Sucrose-density-gradient centrifugation gave (...) Purification and characterization of kynurenine--2-oxoglutarate aminotransferase from the liver, brain and small intestine of rats. 1. Kynurenine-2-oxoglutarate aminotransferase (isoenzyme 1) was purified to homogeneity from the liver, brain and small intestine of rats by the same procedure. The three enzyme preparations had nearly identical pH optima, substrate specificities and molecular weights. Isoenzyme 1 was active with 2-oxoglutarate but not with pyruvate as amino acceptor, and utilized

1975 Biochemical Journal

189. Hepatocyte differentiation in culture. Appearance of tyrosine aminotransferase. (Full text)

Hepatocyte differentiation in culture. Appearance of tyrosine aminotransferase. Liver of rat foetuses from 14 to 19 days of gestation and cultured hepatocytes derived from foetuses of 14 or 15 days gestation show a limited capacity to transaminate tyrosine. This low tyrosine transamination activity can be ascribed to aspartate aminotransferase. Definitive tyrosine aminotransferase can be demonstrated in 1-day-old cultures of hepatocytes taken from 19-day foetuses, but not from 15-day foetuses (...) . However, after 3 days of culture hepatocytes from 15-day foetuses are able to synthesize tyrosine aminotransferase. Induction studies reveal that dexamethasone is capable of increasing tyrosine aminotransferase activity once it is detectable in culture.

1979 Biochemical Journal

190. RELATIONSHIP OF A β-ALANINE-PYRUVIC AMINOTRANSFERASE TO REVERSAL OF d-SERINE INHIBITION OF GROWTH (Full text)

Pantothenic Acid 30KYC7MIAI Aspartic Acid 452VLY9402 Serine 50SG953SK6 Mitomycin 5V5IOJ8338 Pyridoxal Phosphate 6Q205EH1VU Vancomycin 95IK5KI84Z Cycloserine EC 2.6.1.- Transaminases EC 2.6.1.2 Alanine Transaminase OF5P57N2ZX Alanine OM Alanine Alanine Transaminase Aspartic Acid Cycloserine Flavobacterium Ketoglutaric Acids Mitomycin Mitomycins Pantothenic Acid Penicillins Pharmacology Pyridoxal Phosphate Pyruvates Research Serine Transaminases Vancomycin beta-Alanine ALANINE ALANINE AMINOTRANSFERASE (...) RELATIONSHIP OF A β-ALANINE-PYRUVIC AMINOTRANSFERASE TO REVERSAL OF d-SERINE INHIBITION OF GROWTH 14234816 1996 12 01 2018 12 01 0021-9193 88 1964 Nov Journal of bacteriology J. Bacteriol. RELATIONSHIP OF A BETA-ALANINE-PYRUVIC AMINOTRANSFERASE TO REVERSAL OF D-SERINE INHIBITION OF GROWTH. 1525-6 DURHAM N N NN JACOBS C D CD FERGUSON D D eng Journal Article United States J Bacteriol 2985120R 0021-9193 0 Ketoglutaric Acids 0 Mitomycins 0 Penicillins 0 Pyruvates 11P2JDE17B beta-Alanine 19F5HK2737

1964 Journal of bacteriology

191. Activity of aminotransferases in the tissues of developing lambs. (Full text)

Activity of aminotransferases in the tissues of developing lambs. 5360690 1970 02 05 2018 11 13 0264-6021 115 5 1969 Dec The Biochemical journal Biochem. J. Activity of aminotransferases in the tissues of developing lambs. 39P-40P Smith E M EM Shepherd D A DA Jeacock M K MK eng Journal Article England Biochem J 2984726R 0264-6021 EC 2.6.1.1 Aspartate Aminotransferases EC 2.6.1.2 Alanine Transaminase IM Alanine Transaminase analysis Animals Animals, Newborn Aspartate Aminotransferases analysis

1969 Biochemical Journal

192. Inhibition of alanine aminotransferase by L-penicillamine. (Full text)

Inhibition of alanine aminotransferase by L-penicillamine. 5767039 1969 04 18 2018 11 13 0264-6021 111 3 1969 Feb The Biochemical journal Biochem. J. Inhibition of alanine aminotransferase by L-penicillamine. 15P-16P Evered D F DF Hargreaves B M BM Verjee Z H ZH eng Journal Article England Biochem J 2984726R 0264-6021 EC 2.6.1.1 Aspartate Aminotransferases EC 2.6.1.2 Alanine Transaminase GNN1DV99GX Penicillamine IM Alanine Transaminase antagonists & inhibitors Animals Aspartate (...) Aminotransferases metabolism In Vitro Techniques Myocardium enzymology Penicillamine pharmacology Plants enzymology Rats Swine 1969 2 1 1969 2 1 0 1 1969 2 1 0 0 ppublish 5767039 PMC1187537 Hoppe Seylers Z Physiol Chem. 1968 Mar;349(3):310-6 5725541 Arch Biochem Biophys. 1957 May;68(1):69-75 13435895 Arch Biochem Biophys. 1957 Jul;69:130-7 13445187 J Biol Chem. 1950 May;184(1):63-70 15421973

1969 Biochemical Journal

193. Active-site-directed irreversible inhibition of rat brain 4-aminobutyrate aminotransferase by ethanolamine O-sulphate in vitro and in vivo (Full text)

=7.15x10(-4)s(-1)). The inclusion of 4-aminobutyrate markedly slowed the rate of inactivation. 3. Ethanolamine O-sulphate did not inhibit glutamate decarboxylase, alanine aminotransferase or aspartate aminotransferase. 4. Intracisternal injection of ethanolamine O-sulphate into rats led to rapid inactivation of 4-aminobutyrate aminotransferase in vivo. (...) Active-site-directed irreversible inhibition of rat brain 4-aminobutyrate aminotransferase by ethanolamine O-sulphate in vitro and in vivo 1. Partially purified preparations of rat brain 4-aminobutyrate aminotransferase were inhibited in a time-dependent manner by ethanolamine O-sulphate. The inhibition was not reversed by dialysis. 2. The inhibitor formed an initial reversible complex with the enzyme (K(i)=4.4x10(-4)m) and the rate of inactivation followed pseudo-first-order kinetics (k

1972 Biochemical Journal

194. Treatment Intensification With Biphasic Insulin Aspart 30 in Subjects With Type 2 Diabetes Inadequately Controlled on Sitagliptin and Metformin

Treatment Intensification With Biphasic Insulin Aspart 30 in Subjects With Type 2 Diabetes Inadequately Controlled on Sitagliptin and Metformin Treatment Intensification With Biphasic Insulin Aspart 30 in Subjects With Type 2 Diabetes Inadequately Controlled on Sitagliptin and Metformin - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save (...) this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Treatment Intensification With Biphasic Insulin Aspart 30 in Subjects With Type 2 Diabetes Inadequately Controlled on Sitagliptin and Metformin (SIT2MIX) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details

2012 Clinical Trials

195. Metabolic fingerprint of ischaemic cardioprotection - importance of the malate-aspartate shuttle. (Full text)

Metabolic fingerprint of ischaemic cardioprotection - importance of the malate-aspartate shuttle. The convergence of cardioprotective intracellular signalling pathways to modulate mitochondrial function as an end-target of cytoprotective stimuli is well described. However, our understanding of whether the complementary changes in mitochondrial energy metabolism are secondary responses or inherent mechanisms of ischaemic cardioprotection remains incomplete. In the heart, the malate-aspartate (...) by the aminotransferase inhibitor aminooxyacetate induces infarct limitation, improves haemodynamic responses, and modulates glucose metabolism, analogous to effects observed in classical ischaemic preconditioning. On the basis of these findings, the mechanisms through which MAS preserves mitochondrial function and cell survival are reviewed. We conclude that the available evidence is supportive of a down-regulation of mitochondrial respiration during lethal ischaemia with a gradual 'wake-up' during reperfusion

2011 Cardiovascular Research

196. Comparison of Biphasic Insulin Aspart 30 Individually Adjusted by the Subject and the Trial Physician, Both Combined With Metformin in Subjects With Type 2 Diabetes

Comparison of Biphasic Insulin Aspart 30 Individually Adjusted by the Subject and the Trial Physician, Both Combined With Metformin in Subjects With Type 2 Diabetes Comparison of Biphasic Insulin Aspart 30 Individually Adjusted by the Subject and the Trial Physician, Both Combined With Metformin in Subjects With Type 2 Diabetes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x (...) × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Comparison of Biphasic Insulin Aspart 30 Individually Adjusted by the Subject and the Trial Physician, Both Combined With Metformin in Subjects With Type 2 Diabetes (SimpleMix™) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been

2011 Clinical Trials

197. The accumulation of aspartate in the presence of ethanol in rat liver. (Full text)

. The findings support the assumption that 2-oxoglutarate formed by the mitochondrial aspartate aminotransferase is not translocated to the cytosol in the presence of ethanol and NH4+, because it is rapidly converted into glutamate, the dehydrogenation of ethanol providing the required NADH. Aspartate, however, is translocated to the cytosol and accumulates there because of the lack of stoicheiometric amounts of oxoglutarate. (...) The accumulation of aspartate in the presence of ethanol in rat liver. 1. Isolated hepatocytes were used to establish the reasons for the accumulation of aspartate, previously observed when the isolated rat liver was perfused with ethanol in the presence of alanine or ammonium lactate. 2. The isolated cells did not form aspartate when incubated with alanine and ethanol, but much aspartate was formed on incubation with ammonium lactate and ethanol. 3. Urea was the main nitrogenous product

1975 Biochemical Journal

198. Glutamic-aspartic transaminase of Dolichos lablab: participation by iron as a cofactor (Full text)

Glutamic-aspartic transaminase of Dolichos lablab: participation by iron as a cofactor 14430956 1998 11 01 2018 12 01 0264-6021 75 1960 May The Biochemical journal Biochem. J. Glutamic-aspartic transaminase of Dolichos lablab: participation by iron as a cofactor. 401-8 PATWARDHAN M V MV eng Journal Article England Biochem J 2984726R 0264-6021 E1UOL152H7 Iron EC 2.6.1.1 Aspartate Aminotransferases OM Aspartate Aminotransferases Dolichos Iron chemistry Plants chemistry IRON/chemistry PLANTS

1960 Biochemical Journal

199. THE SITE OF BINDING OF PYRIDOXAL-5′-PHOSPHATE TO HEAR GLUTAMIC-ASPARTIC TRANSAMINASE (Full text)

Pyridoxal Phosphate EC 2.6.1.- Transaminases EC 2.6.1.1 Aspartate Aminotransferases OM Aspartate Aminotransferases Heart Myocardium metabolism Phosphates chemistry Pyridoxal Phosphate Transaminases chemistry MYOCARDIUM/metabolism PHOSPHATES/chemistry TRANSAMINASES/chemistry 1962 9 15 1962 9 15 0 1 1962 9 15 0 0 ppublish 14449825 PMC221009 Biochem J. 1955 Aug;60(4):541-56 13249947 J Biol Chem. 1954 Dec;211(2):907-13 13221596 J Biol Chem. 1956 Apr;219(2):623-42 13319284 Biochim Biophys Acta. 1957 Jul;25(1 (...) THE SITE OF BINDING OF PYRIDOXAL-5′-PHOSPHATE TO HEAR GLUTAMIC-ASPARTIC TRANSAMINASE 14449825 1998 11 01 2018 12 01 0027-8424 48 1962 Sep 15 Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. The site of binding of pyridoxal-5'-phosphate to heart glutamic-aspartic transaminase. 1615-8 HUGHES R C RC JENKINS W T WT FISCHER E H EH eng Journal Article United States Proc Natl Acad Sci U S A 7505876 0027-8424 0 Phosphates 5V5IOJ8338

1962 Proceedings of the National Academy of Sciences of the United States of America

200. Phosphoenolpyruvate Carboxylation and Aspartate Synthesis in Acetobacter suboxydans (Full text)

carboxylation mechanism have failed. (14)C-aspartate was synthesized when phosphoenolpyruvate, H(14)Co(3) (-), pyridoxal phosphate, and glutamate were added to dialyzed extracts. Chromatographic and spectrophotometric analyses and chemical degradation further demonstrate the presence of a reversible aspartate aminotransferase. The function of oxalacetate synthesis in a bacterium that reportedly lacks an operative tricarboxylic acid cycle is discussed. (...) Phosphoenolpyruvate Carboxylation and Aspartate Synthesis in Acetobacter suboxydans Dialyzed extracts of Acetobacter suboxydans ATCC 621 catalyze (14)CO(2) assimilation in the presence of phosphoenolpyruvate and a divalent cation. The formation of (14)C-oxalacetate was demonstrated and found not to be dependent upon the presence of orthophosphate or diphosphonucleotides. Oxalacetate synthesis was stimulated by orthophosphate and inhibited by aspartate. All attempts to demonstrate a reversible

1969 Journal of bacteriology

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