How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

16,763 results for

Aspartate Aminotransferase

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

181. Treatment Intensification With Biphasic Insulin Aspart 30 in Subjects With Type 2 Diabetes Inadequately Controlled on Sitagliptin and Metformin

Treatment Intensification With Biphasic Insulin Aspart 30 in Subjects With Type 2 Diabetes Inadequately Controlled on Sitagliptin and Metformin Treatment Intensification With Biphasic Insulin Aspart 30 in Subjects With Type 2 Diabetes Inadequately Controlled on Sitagliptin and Metformin - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save (...) this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Treatment Intensification With Biphasic Insulin Aspart 30 in Subjects With Type 2 Diabetes Inadequately Controlled on Sitagliptin and Metformin (SIT2MIX) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details

2012 Clinical Trials

182. Glutamic–alanine and glutamic–aspartic transaminases of wheat germ Full Text available with Trip Pro

Glutamic–alanine and glutamic–aspartic transaminases of wheat germ 13546165 2000 07 01 2018 12 01 0264-6021 69 2 1958 Jun The Biochemical journal Biochem. J. Glutamic-alanine and glutamic-aspartic transaminases of wheat germ. 189-95 CRUICKSHANK D H DH ISHERWOOD F A FA eng Journal Article England Biochem J 2984726R 0264-6021 EC 2.6.1.- Transaminases EC 2.6.1.1 Aspartate Aminotransferases OF5P57N2ZX Alanine OM Alanine Aspartate Aminotransferases Transaminases Triticum 5834:38810:602:644

1958 Biochemical Journal

183. The accumulation of aspartate in the presence of ethanol in rat liver. Full Text available with Trip Pro

. The findings support the assumption that 2-oxoglutarate formed by the mitochondrial aspartate aminotransferase is not translocated to the cytosol in the presence of ethanol and NH4+, because it is rapidly converted into glutamate, the dehydrogenation of ethanol providing the required NADH. Aspartate, however, is translocated to the cytosol and accumulates there because of the lack of stoicheiometric amounts of oxoglutarate. (...) The accumulation of aspartate in the presence of ethanol in rat liver. 1. Isolated hepatocytes were used to establish the reasons for the accumulation of aspartate, previously observed when the isolated rat liver was perfused with ethanol in the presence of alanine or ammonium lactate. 2. The isolated cells did not form aspartate when incubated with alanine and ethanol, but much aspartate was formed on incubation with ammonium lactate and ethanol. 3. Urea was the main nitrogenous product

1975 Biochemical Journal

184. Serum aspartate transaminase changes following open-heart surgery with ischaemic arrest (with and without coronary artery perfusion) Full Text available with Trip Pro

Serum aspartate transaminase changes following open-heart surgery with ischaemic arrest (with and without coronary artery perfusion) 5017559 1972 06 17 2018 11 13 0040-6376 27 1 1972 Jan Thorax Thorax Serum aspartate transaminase changes following open-heart surgery with ischaemic arrest (with and without coronary artery perfusion). 102-4 Littler W A WA Meade J B JB Evans C C CC Davies G G eng Journal Article England Thorax 0417353 0040-6376 EC 2.6.1.1 Aspartate Aminotransferases IM Adult Age (...) Factors Aged Aortic Valve surgery Aspartate Aminotransferases blood Coronary Vessels Extracorporeal Circulation Female Heart Defects, Congenital enzymology surgery Heart Valve Diseases enzymology Humans Male Middle Aged Mitral Valve surgery Perfusion Postoperative Complications 1972 1 1 1972 1 1 0 1 1972 1 1 0 0 ppublish 5017559 PMC472473 J Clin Pathol. 1966 May;19(3):220-32 5937606 Scott Med J. 1970 May;15(5):176-83 5446219 Dis Chest. 1964 Sep;46:339-45 14206360 Clin Chim Acta. 1962 Mar;7:199-205

1972 Thorax

185. Mechanisms for the formation of alanine and aspartate on rat liver in vivo after administration of ammonium chloride Full Text available with Trip Pro

in [oxoglutarate] and in the [3-hydroxybutyrate]/[acetoacetate] ratio. 4. Prior administration of l-arginine to fed rats resulted in smaller increases in [alanine] and [aspartate] after the ammonia load. This is presumably due to stimulation of the urea cycle. 5. Increased formation of alanine in starved rats occurred after prior administration of dihydroxyacetone to increase the availability of pyruvate. 6. Administration of l-cycloserine, an inhibitor of glutamate-alanine aminotransferase, completely (...) Mechanisms for the formation of alanine and aspartate on rat liver in vivo after administration of ammonium chloride 1. The time-course of the changes in the concentrations of hepatic metabolites in response to a non-toxic load of NH(4)Cl were measured in fed and starved rats. 2. There was a rapid increase (after 2min) in [alanine] and [aspartate] which remained high for 10-15min; the absolute increase in [alanine] was smaller in starved rats. 3. These changes were accompanied by a decrease

1974 Biochemical Journal

186. Standardization of clinical enzyme assays: a reference method for aspartate and alanine transaminases. Full Text available with Trip Pro

Standardization of clinical enzyme assays: a reference method for aspartate and alanine transaminases. 4648539 1973 03 21 2018 11 13 0021-9746 25 11 1972 Nov Journal of clinical pathology J. Clin. Pathol. Standardization of clinical enzyme assays: a reference method for aspartate and alanine transaminases. 940-4 Wilkinson J H JH Baron D N DN Moss D W DW Walker P G PG eng Journal Article England J Clin Pathol 0376601 0021-9746 EC 2.6.1.1 Aspartate Aminotransferases EC 2.6.1.2 Alanine (...) Transaminase AIM IM Alanine Transaminase analysis blood Aspartate Aminotransferases analysis blood Clinical Enzyme Tests standards Methods Spectrophotometry Temperature 1972 11 1 1972 11 1 0 1 1972 11 1 0 0 ppublish 4648539 PMC477570 Clin Chem. 1969 Sep;15(9):839-63 5823080 Klin Wochenschr. 1970 Jul 15;48(14):838-47 5522171 J Clin Pathol. 1971 Nov;24(8):740-3 5130540 J Clin Invest. 1955 Jan;34(1):131-3 13221664 Am J Clin Pathol. 1957 Jul;28(1):56-63 13458125 Scand J Clin Lab Invest. 1958;10(1):53-8

1972 Journal of Clinical Pathology

187. Phosphoenolpyruvate Carboxylation and Aspartate Synthesis in Acetobacter suboxydans Full Text available with Trip Pro

carboxylation mechanism have failed. (14)C-aspartate was synthesized when phosphoenolpyruvate, H(14)Co(3) (-), pyridoxal phosphate, and glutamate were added to dialyzed extracts. Chromatographic and spectrophotometric analyses and chemical degradation further demonstrate the presence of a reversible aspartate aminotransferase. The function of oxalacetate synthesis in a bacterium that reportedly lacks an operative tricarboxylic acid cycle is discussed. (...) Phosphoenolpyruvate Carboxylation and Aspartate Synthesis in Acetobacter suboxydans Dialyzed extracts of Acetobacter suboxydans ATCC 621 catalyze (14)CO(2) assimilation in the presence of phosphoenolpyruvate and a divalent cation. The formation of (14)C-oxalacetate was demonstrated and found not to be dependent upon the presence of orthophosphate or diphosphonucleotides. Oxalacetate synthesis was stimulated by orthophosphate and inhibited by aspartate. All attempts to demonstrate a reversible

1969 Journal of bacteriology

188. THE SITE OF BINDING OF PYRIDOXAL-5′-PHOSPHATE TO HEAR GLUTAMIC-ASPARTIC TRANSAMINASE Full Text available with Trip Pro

Pyridoxal Phosphate EC 2.6.1.- Transaminases EC 2.6.1.1 Aspartate Aminotransferases OM Aspartate Aminotransferases Heart Myocardium metabolism Phosphates chemistry Pyridoxal Phosphate Transaminases chemistry MYOCARDIUM/metabolism PHOSPHATES/chemistry TRANSAMINASES/chemistry 1962 9 15 1962 9 15 0 1 1962 9 15 0 0 ppublish 14449825 PMC221009 Biochem J. 1955 Aug;60(4):541-56 13249947 J Biol Chem. 1954 Dec;211(2):907-13 13221596 J Biol Chem. 1956 Apr;219(2):623-42 13319284 Biochim Biophys Acta. 1957 Jul;25(1 (...) THE SITE OF BINDING OF PYRIDOXAL-5′-PHOSPHATE TO HEAR GLUTAMIC-ASPARTIC TRANSAMINASE 14449825 1998 11 01 2018 12 01 0027-8424 48 1962 Sep 15 Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. The site of binding of pyridoxal-5'-phosphate to heart glutamic-aspartic transaminase. 1615-8 HUGHES R C RC JENKINS W T WT FISCHER E H EH eng Journal Article United States Proc Natl Acad Sci U S A 7505876 0027-8424 0 Phosphates 5V5IOJ8338

1962 Proceedings of the National Academy of Sciences of the United States of America

189. Glutamic-aspartic transaminase of Dolichos lablab: participation by iron as a cofactor Full Text available with Trip Pro

Glutamic-aspartic transaminase of Dolichos lablab: participation by iron as a cofactor 14430956 1998 11 01 2018 12 01 0264-6021 75 1960 May The Biochemical journal Biochem. J. Glutamic-aspartic transaminase of Dolichos lablab: participation by iron as a cofactor. 401-8 PATWARDHAN M V MV eng Journal Article England Biochem J 2984726R 0264-6021 E1UOL152H7 Iron EC 2.6.1.1 Aspartate Aminotransferases OM Aspartate Aminotransferases Dolichos Iron chemistry Plants chemistry IRON/chemistry PLANTS

1960 Biochemical Journal

190. Serum markers for necroinflammatory activity in patients with chronic viral hepatitis and normal or mildly elevated aminotransferase levels. (Abstract)

with normal or mildly elevated serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels (≤60 IU/L) were enrolled in this study. Significant inflammation was defined as inflammatory grade ≥3 activities using the Batt-Ludwig scoring system. The correlation between liver histology and serum markers of liver inflammation was analysed.Forty-eight (21.1%) and eight patients (3.5%) had grade 3 and 4 inflammation respectively. Univariate analysis revealed that age, platelet coun, and AST (...) Serum markers for necroinflammatory activity in patients with chronic viral hepatitis and normal or mildly elevated aminotransferase levels. Reports on the usefulness of serum markers for predicting liver necroinflammation are limited. The aim of this study was to determine the serum markers that predict significant inflammation in patients with chronic hepatitis B (CHB) and C (CHC) and normal or mildly elevated serum aminotransferase levels.Two hundred twenty-seven patients with CHB or CHC

2011 Liver International

191. Engineering homooligomeric proteins to detect weak intersite allosteric communication: Aminotransferases, a case study Full Text available with Trip Pro

Engineering homooligomeric proteins to detect weak intersite allosteric communication: Aminotransferases, a case study The existence of low levels of intersubunit communication in homooligomeric enzymes is often difficult to discover, as the identical active sites cannot be probed individually to dissect their interdependent contributions. The homodimeric paralogs, E. coli aspartate- (AATase) and tyrosine aminotransferase (TATase), have not been demonstrated to show allostery. To address (...) this question, we engineered a hybrid aminotransferase containing two distinct catalytic pockets: an AATase and a TATase site. The TATase/AATase hybrid was constructed by grafting an engineered TATase active site into one of the catalytic pockets of E. coli AATase. Each active site conserves its specific catalytic and inhibitor binding properties, and the hybrid catalyzes simultaneously each aminotransferase reaction at the respective site. Importantly, association of a selective inhibitor into one

2011 Protein science : a publication of the Protein Society

192. Effect of a probiotic on liver aminotransferases in nonalcoholic fatty liver disease patients: a double blind randomized clinical trial. (Abstract)

in a double blind randomized clinical trial. Patients were randomized to one of the following treatments during 3 months: group I, treated with one tablet per day with 500 million of Lactobacillus bulgaricus and Streptococcus thermophilus and group II, treated with one placebo tablet (120 mg of starch).In group I, alanine amino transferase (ALT: 67.7 +/- 25.1 vs. 60.4 +/- 30.4 UI/L; p < 0.05), aspartate aminotransferase activity (AST: 41.3 +/- 15.5 vs. 35.6 +/- 10.4 UI/L; p < 0.05) and gammaglutamine (...) transferase levels (gammaGT: 118.2 +/- 63.1 vs. 107.7 +/- 60.8 UI/L; p < 0.05) decreased. In group II, all liver function parameters remained unchanged (ALT: 60.7 +/- 32.1 vs. 64.8 +/- 35.5 UI/L; p < 0.05), aspartate aminotransferase activity (AST: 31.7 +/- 13.1 vs. 36.4 +/- 13.8 UI/L; ns) and gammaglutamine transferase levels (gammaGT: 82.1 +/- 55.1 vs. 83.6 +/- 65.3 UI/L; ns). Anthropometric parameters and cardiovascular risk factors remained unchanged after treatment in both groups.A tablet of 500

2011 European review for medical and pharmacological sciences Controlled trial quality: uncertain

193. Utility of liver function tests including aminotransferase-to-platelet ratio index in monitoring liver dysfunction in short-gut infants of varying ages and intestinal lengths. (Abstract)

Utility of liver function tests including aminotransferase-to-platelet ratio index in monitoring liver dysfunction in short-gut infants of varying ages and intestinal lengths. Aspartate aminotransferase-to-platelet ratio index (APRI) has good correlation with liver fibrosis progression in the infant and toddler short-gut population. This study applies laboratory liver function testing, including APRI, to monitor liver dysfunction over time for short-gut infants, with further analysis of at-risk (...) subpopulations.Study inclusion criteria included infants younger than 1 year at initial intestinal resection with subsequent continuous parenteral nutrition dependence of 3 months minimum. Bilirubin, aspartate aminotransferase, alanine aminotransferase, APRI, and biopsies were collected for 26 weeks postresection. Subgroup analysis was stratified by (1) estimated gestational age, (2) age at intestinal resection (AGE), and (3) remaining intestinal length.Thirty-one children were included, all with AGE younger than

2011 Journal of Pediatric Surgery

194. Comparison of Biphasic Insulin Aspart 30 Individually Adjusted by the Subject and the Trial Physician, Both Combined With Metformin in Subjects With Type 2 Diabetes

Comparison of Biphasic Insulin Aspart 30 Individually Adjusted by the Subject and the Trial Physician, Both Combined With Metformin in Subjects With Type 2 Diabetes Comparison of Biphasic Insulin Aspart 30 Individually Adjusted by the Subject and the Trial Physician, Both Combined With Metformin in Subjects With Type 2 Diabetes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x (...) × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Comparison of Biphasic Insulin Aspart 30 Individually Adjusted by the Subject and the Trial Physician, Both Combined With Metformin in Subjects With Type 2 Diabetes (SimpleMix™) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been

2011 Clinical Trials

195. Commentary on: Noninvasive assessment of liver fibrosis using aspartate transaminase to platelet ratio index (APRI) in adult patients with chronic liver disease Full Text available with Trip Pro

. Isa Mona M eng Journal Article Iran Hepat Mon 101277874 1735-143X Aspartate aminotransferases Chronic hepatitis C Fatty liver 2011 03 28 2011 04 02 2011 04 12 2011 11 17 6 0 2011 11 17 6 0 2011 11 17 6 1 ppublish 22087166 PMC3212770 J Pediatr Gastroenterol Nutr. 2010 Aug;51(2):198-202 20531020 Hepat Mon. 2011 Feb;11(2):103-6 22087126 J Pediatr Gastroenterol Nutr. 2010 Mar;50(3):344-6 20118806 Orv Hetil. 2010 Nov 21;151(47):1951-5 21071307 Eur J Gastroenterol Hepatol. 2010 Aug;22(8):946-51 20110820 (...) Commentary on: Noninvasive assessment of liver fibrosis using aspartate transaminase to platelet ratio index (APRI) in adult patients with chronic liver disease 22087166 2011 11 23 2018 11 13 1735-3408 11 5 2011 May Hepatitis monthly Hepat Mon Commentary on: Noninvasive assessment of liver fibrosis using aspartate transaminase to platelet ratio index (APRI) in adult patients with chronic liver disease. 378-9 El-Shabrawi Mortada M Pediatric Hepatology Department, Cairo University, Cairo, Egypt

2011 Hepatitis monthly

196. Metabolic fingerprint of ischaemic cardioprotection - importance of the malate-aspartate shuttle. Full Text available with Trip Pro

Metabolic fingerprint of ischaemic cardioprotection - importance of the malate-aspartate shuttle. The convergence of cardioprotective intracellular signalling pathways to modulate mitochondrial function as an end-target of cytoprotective stimuli is well described. However, our understanding of whether the complementary changes in mitochondrial energy metabolism are secondary responses or inherent mechanisms of ischaemic cardioprotection remains incomplete. In the heart, the malate-aspartate (...) by the aminotransferase inhibitor aminooxyacetate induces infarct limitation, improves haemodynamic responses, and modulates glucose metabolism, analogous to effects observed in classical ischaemic preconditioning. On the basis of these findings, the mechanisms through which MAS preserves mitochondrial function and cell survival are reviewed. We conclude that the available evidence is supportive of a down-regulation of mitochondrial respiration during lethal ischaemia with a gradual 'wake-up' during reperfusion

2011 Cardiovascular Research

197. Purification, crystallization and preliminary X-ray analysis of the aspartate aminotransferase of Plasmodium falciparum Full Text available with Trip Pro

Purification, crystallization and preliminary X-ray analysis of the aspartate aminotransferase of Plasmodium falciparum Aspartate aminotransferases (EC 2.6.1.1) catalyse the conversion of aspartate and alpha-ketoglutarate to oxaloacetate and glutamate in a reversible manner. Thus, the aspartate aminotransferase of Plasmodium falciparum (PfAspAT) plays a central role in the transamination of amino acids. Recent findings suggest that PfAspAT may also play a pivotal role in energy metabolism

2010 Acta Crystallographica Section F: Structural Biology and Crystallization Communications

198. Use of the aspartate aminotransferase to platelet ratio index to follow liver fibrosis progression in infants with short gut. (Abstract)

Use of the aspartate aminotransferase to platelet ratio index to follow liver fibrosis progression in infants with short gut. Infants with parenteral nutrition dependence may develop liver dysfunction and progress to liver failure requiring transplantation. The aspartate aminotransferase-to-platelet ratio index (APRI) has good correlation with liver fibrosis progression in adults. This study applies APRI scoring to parenteral nutrition-dependant, short-gut infants to determine hepatic fibrosis

2010 Journal of Pediatric Surgery

199. Assessment of Liver Fibrosis and Cirrhosis by Aspartate Aminotransferase-to-Platelet Ratio Index in Children With Biliary Atresia. Full Text available with Trip Pro

Assessment of Liver Fibrosis and Cirrhosis by Aspartate Aminotransferase-to-Platelet Ratio Index in Children With Biliary Atresia. In patients with biliary atresia (BA), liver fibrosis and cirrhosis commonly occur even after Kasai hepatoportoenterostomy. Although liver biopsy is the gold standard to evaluate liver fibrosis, it is invasive and may result in life-threatening complications. The aspartate aminotransferase-to-platelet ratio index (APRI) is a safe and simple method to assess liver

2010 Journal of Pediatric Gastroenterology and Nutrition

200. Two Routine Blood Tests-Mean Corpuscular Volume and Aspartate Aminotransferase-as Predictors of Delirium Tremens in Trauma Patients. (Abstract)

Two Routine Blood Tests-Mean Corpuscular Volume and Aspartate Aminotransferase-as Predictors of Delirium Tremens in Trauma Patients. Delirium tremens (DT) in trauma patients is associated with significant morbidity and mortality. Short interview tools have been used to determine the risk of DT but require an alert, compliant patient and a motivated physician. The mean corpuscular volume (MCV) and aspartate aminotransferase (AST) levels are parts of routine laboratory testing, influenced

2010 Journal of Trauma

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>