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Aspartate Aminotransferase

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181. Purification and characterization of kynurenine--2-oxoglutarate aminotransferase from the liver, brain and small intestine of rats. Full Text available with Trip Pro

and polyacrylamide-disc-gel electrophoresis, it is suggested that liver, brain and small intestinal kynurenine-2-oxoglutarate aminotransferase (isoenzyme 1) is identical with mitochondrial tyrosine-2-oxoglutarate aminotransferase and also with mitochondrial aspartate-2-oxoglutarate aminotransferase. 2. An additional kynurenine-2-oxoglutarate aminotransferase (isoenzyme 2) was purified from the liver. This enzyme was specific for 2-oxoglutarate and L-kynurenine. Sucrose-density-gradient centrifugation gave (...) Purification and characterization of kynurenine--2-oxoglutarate aminotransferase from the liver, brain and small intestine of rats. 1. Kynurenine-2-oxoglutarate aminotransferase (isoenzyme 1) was purified to homogeneity from the liver, brain and small intestine of rats by the same procedure. The three enzyme preparations had nearly identical pH optima, substrate specificities and molecular weights. Isoenzyme 1 was active with 2-oxoglutarate but not with pyruvate as amino acceptor, and utilized

1975 Biochemical Journal

182. Activity of aminotransferases in the tissues of developing lambs. Full Text available with Trip Pro

Activity of aminotransferases in the tissues of developing lambs. 5360690 1970 02 05 2018 11 13 0264-6021 115 5 1969 Dec The Biochemical journal Biochem. J. Activity of aminotransferases in the tissues of developing lambs. 39P-40P Smith E M EM Shepherd D A DA Jeacock M K MK eng Journal Article England Biochem J 2984726R 0264-6021 EC 2.6.1.1 Aspartate Aminotransferases EC 2.6.1.2 Alanine Transaminase IM Alanine Transaminase analysis Animals Animals, Newborn Aspartate Aminotransferases analysis

1969 Biochemical Journal

183. Hepatocyte differentiation in culture. Appearance of tyrosine aminotransferase. Full Text available with Trip Pro

Hepatocyte differentiation in culture. Appearance of tyrosine aminotransferase. Liver of rat foetuses from 14 to 19 days of gestation and cultured hepatocytes derived from foetuses of 14 or 15 days gestation show a limited capacity to transaminate tyrosine. This low tyrosine transamination activity can be ascribed to aspartate aminotransferase. Definitive tyrosine aminotransferase can be demonstrated in 1-day-old cultures of hepatocytes taken from 19-day foetuses, but not from 15-day foetuses (...) . However, after 3 days of culture hepatocytes from 15-day foetuses are able to synthesize tyrosine aminotransferase. Induction studies reveal that dexamethasone is capable of increasing tyrosine aminotransferase activity once it is detectable in culture.

1979 Biochemical Journal

184. Active-site-directed irreversible inhibition of rat brain 4-aminobutyrate aminotransferase by ethanolamine O-sulphate in vitro and in vivo Full Text available with Trip Pro

=7.15x10(-4)s(-1)). The inclusion of 4-aminobutyrate markedly slowed the rate of inactivation. 3. Ethanolamine O-sulphate did not inhibit glutamate decarboxylase, alanine aminotransferase or aspartate aminotransferase. 4. Intracisternal injection of ethanolamine O-sulphate into rats led to rapid inactivation of 4-aminobutyrate aminotransferase in vivo. (...) Active-site-directed irreversible inhibition of rat brain 4-aminobutyrate aminotransferase by ethanolamine O-sulphate in vitro and in vivo 1. Partially purified preparations of rat brain 4-aminobutyrate aminotransferase were inhibited in a time-dependent manner by ethanolamine O-sulphate. The inhibition was not reversed by dialysis. 2. The inhibitor formed an initial reversible complex with the enzyme (K(i)=4.4x10(-4)m) and the rate of inactivation followed pseudo-first-order kinetics (k

1972 Biochemical Journal

185. RELATIONSHIP OF A β-ALANINE-PYRUVIC AMINOTRANSFERASE TO REVERSAL OF d-SERINE INHIBITION OF GROWTH Full Text available with Trip Pro

Pantothenic Acid 30KYC7MIAI Aspartic Acid 452VLY9402 Serine 50SG953SK6 Mitomycin 5V5IOJ8338 Pyridoxal Phosphate 6Q205EH1VU Vancomycin 95IK5KI84Z Cycloserine EC 2.6.1.- Transaminases EC 2.6.1.2 Alanine Transaminase OF5P57N2ZX Alanine OM Alanine Alanine Transaminase Aspartic Acid Cycloserine Flavobacterium Ketoglutaric Acids Mitomycin Mitomycins Pantothenic Acid Penicillins Pharmacology Pyridoxal Phosphate Pyruvates Research Serine Transaminases Vancomycin beta-Alanine ALANINE ALANINE AMINOTRANSFERASE (...) RELATIONSHIP OF A β-ALANINE-PYRUVIC AMINOTRANSFERASE TO REVERSAL OF d-SERINE INHIBITION OF GROWTH 14234816 1996 12 01 2018 12 01 0021-9193 88 1964 Nov Journal of bacteriology J. Bacteriol. RELATIONSHIP OF A BETA-ALANINE-PYRUVIC AMINOTRANSFERASE TO REVERSAL OF D-SERINE INHIBITION OF GROWTH. 1525-6 DURHAM N N NN JACOBS C D CD FERGUSON D D eng Journal Article United States J Bacteriol 2985120R 0021-9193 0 Ketoglutaric Acids 0 Mitomycins 0 Penicillins 0 Pyruvates 11P2JDE17B beta-Alanine 19F5HK2737

1964 Journal of bacteriology

186. Inhibition of alanine aminotransferase by L-penicillamine. Full Text available with Trip Pro

Inhibition of alanine aminotransferase by L-penicillamine. 5767039 1969 04 18 2018 11 13 0264-6021 111 3 1969 Feb The Biochemical journal Biochem. J. Inhibition of alanine aminotransferase by L-penicillamine. 15P-16P Evered D F DF Hargreaves B M BM Verjee Z H ZH eng Journal Article England Biochem J 2984726R 0264-6021 EC 2.6.1.1 Aspartate Aminotransferases EC 2.6.1.2 Alanine Transaminase GNN1DV99GX Penicillamine IM Alanine Transaminase antagonists & inhibitors Animals Aspartate (...) Aminotransferases metabolism In Vitro Techniques Myocardium enzymology Penicillamine pharmacology Plants enzymology Rats Swine 1969 2 1 1969 2 1 0 1 1969 2 1 0 0 ppublish 5767039 PMC1187537 Hoppe Seylers Z Physiol Chem. 1968 Mar;349(3):310-6 5725541 Arch Biochem Biophys. 1957 May;68(1):69-75 13435895 Arch Biochem Biophys. 1957 Jul;69:130-7 13445187 J Biol Chem. 1950 May;184(1):63-70 15421973

1969 Biochemical Journal

187. [Ornithine aspartate and naloxone combined therapy for hepatic encephalopathy affects cognitive function, prognosis, and neuropeptide levels]. (Abstract)

to consciousness, blood ammonia, the liver function markers alanine aminotransferase, gamma-glutamyl-transpeptidase and total bilirubin, and the neuropeptides arginine vasopressin and beta-endorphin were remarkably improved after treatment in the research group, as compared with that in the control group.Supplementing the traditional treatment for hepatic encephalopathy with ornithine aspartate plus naloxone combination therapy provides better therapeutic outcome than traditional treatment alone. (...) [Ornithine aspartate and naloxone combined therapy for hepatic encephalopathy affects cognitive function, prognosis, and neuropeptide levels]. To investigate the potential effects on cognitive function, prognosis, and neuropeptide levels of patients in response to combination therapy with ornithine aspartate plus naloxone for hepatic encephalopathy.Eighty-four consecutive patients diagnosed with hepatic encephalopathy were randomly divided into two equal groups. The control group (n = 42

2013 Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology Controlled trial quality: uncertain

188. Treatment Intensification With Biphasic Insulin Aspart 30 in Subjects With Type 2 Diabetes Inadequately Controlled on Sitagliptin and Metformin

Treatment Intensification With Biphasic Insulin Aspart 30 in Subjects With Type 2 Diabetes Inadequately Controlled on Sitagliptin and Metformin Treatment Intensification With Biphasic Insulin Aspart 30 in Subjects With Type 2 Diabetes Inadequately Controlled on Sitagliptin and Metformin - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save (...) this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Treatment Intensification With Biphasic Insulin Aspart 30 in Subjects With Type 2 Diabetes Inadequately Controlled on Sitagliptin and Metformin (SIT2MIX) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details

2012 Clinical Trials

189. Glutamic–alanine and glutamic–aspartic transaminases of wheat germ Full Text available with Trip Pro

Glutamic–alanine and glutamic–aspartic transaminases of wheat germ 13546165 2000 07 01 2018 12 01 0264-6021 69 2 1958 Jun The Biochemical journal Biochem. J. Glutamic-alanine and glutamic-aspartic transaminases of wheat germ. 189-95 CRUICKSHANK D H DH ISHERWOOD F A FA eng Journal Article England Biochem J 2984726R 0264-6021 EC 2.6.1.- Transaminases EC 2.6.1.1 Aspartate Aminotransferases OF5P57N2ZX Alanine OM Alanine Aspartate Aminotransferases Transaminases Triticum 5834:38810:602:644

1958 Biochemical Journal

190. The accumulation of aspartate in the presence of ethanol in rat liver. Full Text available with Trip Pro

. The findings support the assumption that 2-oxoglutarate formed by the mitochondrial aspartate aminotransferase is not translocated to the cytosol in the presence of ethanol and NH4+, because it is rapidly converted into glutamate, the dehydrogenation of ethanol providing the required NADH. Aspartate, however, is translocated to the cytosol and accumulates there because of the lack of stoicheiometric amounts of oxoglutarate. (...) The accumulation of aspartate in the presence of ethanol in rat liver. 1. Isolated hepatocytes were used to establish the reasons for the accumulation of aspartate, previously observed when the isolated rat liver was perfused with ethanol in the presence of alanine or ammonium lactate. 2. The isolated cells did not form aspartate when incubated with alanine and ethanol, but much aspartate was formed on incubation with ammonium lactate and ethanol. 3. Urea was the main nitrogenous product

1975 Biochemical Journal

191. Serum aspartate transaminase changes following open-heart surgery with ischaemic arrest (with and without coronary artery perfusion) Full Text available with Trip Pro

Serum aspartate transaminase changes following open-heart surgery with ischaemic arrest (with and without coronary artery perfusion) 5017559 1972 06 17 2018 11 13 0040-6376 27 1 1972 Jan Thorax Thorax Serum aspartate transaminase changes following open-heart surgery with ischaemic arrest (with and without coronary artery perfusion). 102-4 Littler W A WA Meade J B JB Evans C C CC Davies G G eng Journal Article England Thorax 0417353 0040-6376 EC 2.6.1.1 Aspartate Aminotransferases IM Adult Age (...) Factors Aged Aortic Valve surgery Aspartate Aminotransferases blood Coronary Vessels Extracorporeal Circulation Female Heart Defects, Congenital enzymology surgery Heart Valve Diseases enzymology Humans Male Middle Aged Mitral Valve surgery Perfusion Postoperative Complications 1972 1 1 1972 1 1 0 1 1972 1 1 0 0 ppublish 5017559 PMC472473 J Clin Pathol. 1966 May;19(3):220-32 5937606 Scott Med J. 1970 May;15(5):176-83 5446219 Dis Chest. 1964 Sep;46:339-45 14206360 Clin Chim Acta. 1962 Mar;7:199-205

1972 Thorax

192. Mechanisms for the formation of alanine and aspartate on rat liver in vivo after administration of ammonium chloride Full Text available with Trip Pro

in [oxoglutarate] and in the [3-hydroxybutyrate]/[acetoacetate] ratio. 4. Prior administration of l-arginine to fed rats resulted in smaller increases in [alanine] and [aspartate] after the ammonia load. This is presumably due to stimulation of the urea cycle. 5. Increased formation of alanine in starved rats occurred after prior administration of dihydroxyacetone to increase the availability of pyruvate. 6. Administration of l-cycloserine, an inhibitor of glutamate-alanine aminotransferase, completely (...) Mechanisms for the formation of alanine and aspartate on rat liver in vivo after administration of ammonium chloride 1. The time-course of the changes in the concentrations of hepatic metabolites in response to a non-toxic load of NH(4)Cl were measured in fed and starved rats. 2. There was a rapid increase (after 2min) in [alanine] and [aspartate] which remained high for 10-15min; the absolute increase in [alanine] was smaller in starved rats. 3. These changes were accompanied by a decrease

1974 Biochemical Journal

193. Standardization of clinical enzyme assays: a reference method for aspartate and alanine transaminases. Full Text available with Trip Pro

Standardization of clinical enzyme assays: a reference method for aspartate and alanine transaminases. 4648539 1973 03 21 2018 11 13 0021-9746 25 11 1972 Nov Journal of clinical pathology J. Clin. Pathol. Standardization of clinical enzyme assays: a reference method for aspartate and alanine transaminases. 940-4 Wilkinson J H JH Baron D N DN Moss D W DW Walker P G PG eng Journal Article England J Clin Pathol 0376601 0021-9746 EC 2.6.1.1 Aspartate Aminotransferases EC 2.6.1.2 Alanine (...) Transaminase AIM IM Alanine Transaminase analysis blood Aspartate Aminotransferases analysis blood Clinical Enzyme Tests standards Methods Spectrophotometry Temperature 1972 11 1 1972 11 1 0 1 1972 11 1 0 0 ppublish 4648539 PMC477570 Clin Chem. 1969 Sep;15(9):839-63 5823080 Klin Wochenschr. 1970 Jul 15;48(14):838-47 5522171 J Clin Pathol. 1971 Nov;24(8):740-3 5130540 J Clin Invest. 1955 Jan;34(1):131-3 13221664 Am J Clin Pathol. 1957 Jul;28(1):56-63 13458125 Scand J Clin Lab Invest. 1958;10(1):53-8

1972 Journal of Clinical Pathology

194. Phosphoenolpyruvate Carboxylation and Aspartate Synthesis in Acetobacter suboxydans Full Text available with Trip Pro

carboxylation mechanism have failed. (14)C-aspartate was synthesized when phosphoenolpyruvate, H(14)Co(3) (-), pyridoxal phosphate, and glutamate were added to dialyzed extracts. Chromatographic and spectrophotometric analyses and chemical degradation further demonstrate the presence of a reversible aspartate aminotransferase. The function of oxalacetate synthesis in a bacterium that reportedly lacks an operative tricarboxylic acid cycle is discussed. (...) Phosphoenolpyruvate Carboxylation and Aspartate Synthesis in Acetobacter suboxydans Dialyzed extracts of Acetobacter suboxydans ATCC 621 catalyze (14)CO(2) assimilation in the presence of phosphoenolpyruvate and a divalent cation. The formation of (14)C-oxalacetate was demonstrated and found not to be dependent upon the presence of orthophosphate or diphosphonucleotides. Oxalacetate synthesis was stimulated by orthophosphate and inhibited by aspartate. All attempts to demonstrate a reversible

1969 Journal of bacteriology

195. THE SITE OF BINDING OF PYRIDOXAL-5′-PHOSPHATE TO HEAR GLUTAMIC-ASPARTIC TRANSAMINASE Full Text available with Trip Pro

Pyridoxal Phosphate EC 2.6.1.- Transaminases EC 2.6.1.1 Aspartate Aminotransferases OM Aspartate Aminotransferases Heart Myocardium metabolism Phosphates chemistry Pyridoxal Phosphate Transaminases chemistry MYOCARDIUM/metabolism PHOSPHATES/chemistry TRANSAMINASES/chemistry 1962 9 15 1962 9 15 0 1 1962 9 15 0 0 ppublish 14449825 PMC221009 Biochem J. 1955 Aug;60(4):541-56 13249947 J Biol Chem. 1954 Dec;211(2):907-13 13221596 J Biol Chem. 1956 Apr;219(2):623-42 13319284 Biochim Biophys Acta. 1957 Jul;25(1 (...) THE SITE OF BINDING OF PYRIDOXAL-5′-PHOSPHATE TO HEAR GLUTAMIC-ASPARTIC TRANSAMINASE 14449825 1998 11 01 2018 12 01 0027-8424 48 1962 Sep 15 Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. The site of binding of pyridoxal-5'-phosphate to heart glutamic-aspartic transaminase. 1615-8 HUGHES R C RC JENKINS W T WT FISCHER E H EH eng Journal Article United States Proc Natl Acad Sci U S A 7505876 0027-8424 0 Phosphates 5V5IOJ8338

1962 Proceedings of the National Academy of Sciences of the United States of America

196. Glutamic-aspartic transaminase of Dolichos lablab: participation by iron as a cofactor Full Text available with Trip Pro

Glutamic-aspartic transaminase of Dolichos lablab: participation by iron as a cofactor 14430956 1998 11 01 2018 12 01 0264-6021 75 1960 May The Biochemical journal Biochem. J. Glutamic-aspartic transaminase of Dolichos lablab: participation by iron as a cofactor. 401-8 PATWARDHAN M V MV eng Journal Article England Biochem J 2984726R 0264-6021 E1UOL152H7 Iron EC 2.6.1.1 Aspartate Aminotransferases OM Aspartate Aminotransferases Dolichos Iron chemistry Plants chemistry IRON/chemistry PLANTS

1960 Biochemical Journal

197. Effect of a probiotic on liver aminotransferases in nonalcoholic fatty liver disease patients: a double blind randomized clinical trial. (Abstract)

in a double blind randomized clinical trial. Patients were randomized to one of the following treatments during 3 months: group I, treated with one tablet per day with 500 million of Lactobacillus bulgaricus and Streptococcus thermophilus and group II, treated with one placebo tablet (120 mg of starch).In group I, alanine amino transferase (ALT: 67.7 +/- 25.1 vs. 60.4 +/- 30.4 UI/L; p < 0.05), aspartate aminotransferase activity (AST: 41.3 +/- 15.5 vs. 35.6 +/- 10.4 UI/L; p < 0.05) and gammaglutamine (...) transferase levels (gammaGT: 118.2 +/- 63.1 vs. 107.7 +/- 60.8 UI/L; p < 0.05) decreased. In group II, all liver function parameters remained unchanged (ALT: 60.7 +/- 32.1 vs. 64.8 +/- 35.5 UI/L; p < 0.05), aspartate aminotransferase activity (AST: 31.7 +/- 13.1 vs. 36.4 +/- 13.8 UI/L; ns) and gammaglutamine transferase levels (gammaGT: 82.1 +/- 55.1 vs. 83.6 +/- 65.3 UI/L; ns). Anthropometric parameters and cardiovascular risk factors remained unchanged after treatment in both groups.A tablet of 500

2011 European review for medical and pharmacological sciences Controlled trial quality: uncertain

198. Utility of liver function tests including aminotransferase-to-platelet ratio index in monitoring liver dysfunction in short-gut infants of varying ages and intestinal lengths. (Abstract)

Utility of liver function tests including aminotransferase-to-platelet ratio index in monitoring liver dysfunction in short-gut infants of varying ages and intestinal lengths. Aspartate aminotransferase-to-platelet ratio index (APRI) has good correlation with liver fibrosis progression in the infant and toddler short-gut population. This study applies laboratory liver function testing, including APRI, to monitor liver dysfunction over time for short-gut infants, with further analysis of at-risk (...) subpopulations.Study inclusion criteria included infants younger than 1 year at initial intestinal resection with subsequent continuous parenteral nutrition dependence of 3 months minimum. Bilirubin, aspartate aminotransferase, alanine aminotransferase, APRI, and biopsies were collected for 26 weeks postresection. Subgroup analysis was stratified by (1) estimated gestational age, (2) age at intestinal resection (AGE), and (3) remaining intestinal length.Thirty-one children were included, all with AGE younger than

2011 Journal of Pediatric Surgery

199. Serum markers for necroinflammatory activity in patients with chronic viral hepatitis and normal or mildly elevated aminotransferase levels. (Abstract)

with normal or mildly elevated serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels (≤60 IU/L) were enrolled in this study. Significant inflammation was defined as inflammatory grade ≥3 activities using the Batt-Ludwig scoring system. The correlation between liver histology and serum markers of liver inflammation was analysed.Forty-eight (21.1%) and eight patients (3.5%) had grade 3 and 4 inflammation respectively. Univariate analysis revealed that age, platelet coun, and AST (...) Serum markers for necroinflammatory activity in patients with chronic viral hepatitis and normal or mildly elevated aminotransferase levels. Reports on the usefulness of serum markers for predicting liver necroinflammation are limited. The aim of this study was to determine the serum markers that predict significant inflammation in patients with chronic hepatitis B (CHB) and C (CHC) and normal or mildly elevated serum aminotransferase levels.Two hundred twenty-seven patients with CHB or CHC

2011 Liver International

200. Engineering homooligomeric proteins to detect weak intersite allosteric communication: Aminotransferases, a case study Full Text available with Trip Pro

Engineering homooligomeric proteins to detect weak intersite allosteric communication: Aminotransferases, a case study The existence of low levels of intersubunit communication in homooligomeric enzymes is often difficult to discover, as the identical active sites cannot be probed individually to dissect their interdependent contributions. The homodimeric paralogs, E. coli aspartate- (AATase) and tyrosine aminotransferase (TATase), have not been demonstrated to show allostery. To address (...) this question, we engineered a hybrid aminotransferase containing two distinct catalytic pockets: an AATase and a TATase site. The TATase/AATase hybrid was constructed by grafting an engineered TATase active site into one of the catalytic pockets of E. coli AATase. Each active site conserves its specific catalytic and inhibitor binding properties, and the hybrid catalyzes simultaneously each aminotransferase reaction at the respective site. Importantly, association of a selective inhibitor into one

2011 Protein science : a publication of the Protein Society

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