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Appearance, Behavior and Attitude Exam

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141. Genome-Wide Sequencing for Unexplained Developmental Disabilities or Multiple Congenital Anomalies

on patient care (including clinical decision making, timing) o Impact of test results on family care (including family planning) Literature Screening A single reviewer conducted an initial screening of titles and abstracts using Covidence 29 and then obtained the full texts of studies that appeared eligible for review according to the inclusion criteria. The same reviewer then examined the full-text articles and selected studies eligible for inclusion. The reviewer also examined reference lists for any (...) , metabolic, and genetic tests over a period of years without diagnosis. Genome-wide sequencing, as whole exome or whole genome sequencing, can examine the entire genetic makeup of a person in a single test, capturing genetic information that other genetic tests (such as targeted gene tests) can miss. A genetic diagnosis can help these people and their families better understand their condition and help them connect with others who have the same condition. This health technology assessment looked at how

2020 Health Quality Ontario

142. Gene Expression Profiling Tests for Early-Stage Invasive Breast Cancer

Screening A single reviewer conducted an initial screening of titles and abstracts using Covidence 42 and then obtained the full texts of studies that appeared eligible for review according to the inclusion criteria. A single reviewer then examined the full-text articles and selected studies eligible for inclusion. The reviewer also examined reference lists for any additional relevant studies not identified through the search. Data Extraction We extracted relevant data on study characteristics and risk (...) economic evaluation showed that all GEP test strategies were more effective (led to more quality-adjusted life-years [QALYs]) than usual care and can be considered cost- effective below a willingness-to-pay of $20,000 per QALY gained. There was some uncertainty in our results. At a willingness-to-pay of $50,000 per QALY gained, the probability of each test March 2020 Ontario Health Technology Assessment Series; Vol. 20: No. 10, pp. 1–234, March 2020 4 being cost-effective compared to usual care

2020 Health Quality Ontario

143. Transcatheter Aortic Valve Implantation in Patients With Severe, Symptomatic Aortic Valve Stenosis at Intermediate Surgical Risk

: No. 2, pp. 1–121, March 2020 14 Literature Screening A single reviewer conducted an initial screening of titles and abstracts using DistillerSR management software (Evidence Partners, Ottawa, Canada), and then obtained the full text of studies that appeared eligible for the review according to the inclusion criteria. The author then examined the full text articles and selected studies that were eligible for inclusion. The author also examined reference lists for any additional relevant studies (...) expensive and, on average, more effective (i.e., it produced more quality-adjusted life-years) than SAVR. The incremental cost-effectiveness ratios showed that TAVI may be cost-effective, but the probability of TAVI being cost-effective versus SAVR was less than 60% at a willingness-to-pay value of $100,000 per quality-adjusted life-year. The net budget impact of publicly funding TAVI in Ontario would be about $2 million to $3 million each year for the next 5 years. This cost may be reduced if people

2020 Health Quality Ontario

144. Toolkit to support the generation of robust estimates of hepatitis C prevalence

of HCV infection in chronically HCV infected individuals 52 Table 13. Linkage to care and treatment of HCV positive individuals 52 TECHNICAL REPORT Technical protocol for hepatitis C prevalence surveys in the general population v Abbreviations HCV Hepatitis C virus HCVcAg HCV core antigen HES Health examination survey LIA Line immunoassay MSM Men who have sex with men MPES Multi-parameter evidence synthesis PWID People who inject drugs TECHNICAL REPORT Technical protocol for hepatitis C prevalence (...) - and cost-intense exercise – especially if there is no recent or planned population survey. Therefore, countries are advised to follow a careful decision process before choosing an appropriate survey type for estimating hepatitis C prevalence in the general population (Figure 1). If a large population-based survey is planned that includes blood samples – for example a health examination survey (HES) with probability-based sampling of the general population and a sample size sufficient to estimate HCV

2020 European Centre for Disease Prevention and Control - Technical Guidance

145. 5-Aminolevulinic Acid Hydrochloride (5-ALA)–Guided Surgical Resection of High-Grade Gliomas

survival • Quality of life • Neurological function • Adverse events Exclusion Criteria • Diagnostic accuracy outcomes (sensitivity, specificity, positive predictive value, negative predictive value) Literature Screening A single reviewer conducted an initial screening of titles and abstracts using Covidence 35 and then obtained the full texts of studies that appeared eligible for review, according to the inclusion criteria. A single reviewer then examined the full-text articles and selected studies (...) the tumour during surgery and guide its removal. After 5-ALA is administered, areas within the tumour glow pink or red, and healthy brain tissue appears blue when exposed to a special blue light during surgery. This health technology assessment looked at how safe and effective 5-ALA–guided surgical resection is for people with high-grade gliomas. It also looked at the budget impact of publicly funding 5-ALA and the experiences, preferences, and values of an adult who had experience with high-grade glioma

2020 Health Quality Ontario

146. The use of comic books, graphic novels, and fotonovelas as a health promotion tool

narrative text and/or speech bubbles (14). Widely read in Latin America, fotonovelas emerged from the romantic fiction genre (14) and utilize dramatic storytelling and photography to fill knowledge gaps and encourage behaviour change (36). Fotonovelas integrate cultural norms and realistic, attractive characters into storylines, delivering sensitive informative in a meaningful way (6, 37). Literature addressing the effectiveness of fotonovelas concerning HIV/AIDS appears to be sparse. G uys like you (...) is taken from a fotonovela designed for female farmworkers, and is available in English and Spanish (42): While no peer-reviewed literature examining the effectiveness of fotonovelas and HIV appeared in our search results, there are several studies detailing interventions with fotonovelas for other health conditions that appear to have a positive impact: human papillomavirus vaccine (6), depression (7), and second hand smoking (8). Evidence for comics as a health education tool Available evidence

2020 Ontario HIV Treatment Network

147. Routine Human Papilloma Virus (HPV) Testing in Squamous Cell Head and Neck Cancer

website at http://www.cancercare.on.ca/ or contact the PEBC office at: Phone: 905-527-4322 ext. 42822 Fax: 905-526-6775 E-mail: ccopgi@mcmaster.ca Guideline Citation (Vancouver Style): Lacchetti, C, Waldron J, Perez-Ordonez, B, Kamel-Reid S, Cripps C, Gilbert R. Routine HPV Testing in Head and Neck Squamous Cell Carcinoma. Perez-Ordonez B, Poon R, reviewers. Toronto (ON): Cancer Care Ontario; 2013 May 13 [Endorsed 2020 January]. Program in Evidence-based Care Evidence-based Series No.: 5-9 Version 2 (...) Further testing by validated PCR or ISH techniques for high-risk HPV subtypes HPV Negative No further testing + ? - EBS 5-9 Version 2 Section 1: Guideline Recommendations Page 6 Technical Considerations for Recommendation 3 While it is not possible to make evidence-based recommendations regarding the minimum set of criteria requiring adherence in a pathology laboratory with respect to HPV testing at this time, the following guidance is offered based on expert opinion and a consensus process by members

2020 Cancer Care Ontario

148. Kidney Biopsy information and education for patients and caregivers

study, patients and caregivers identified the need for education, psychosocial support and self-management for those in need of a renal biopsy(1) Studies of other organ biopsy procedures including prostate, breast and liver have also identified the need for patient information and support.(3- 9) Evidence shows that patients’ ability to cope will determine whether or not they gain any benefit from the information provided and is reflected in the information avoidance or seeking of behaviours.(10 (...) men aged between 46 – 80 years with a history of TRUS-Bx, all participants experienced anticipatory anxiety as they waited for results, first with the screening tests (prostate specific antigen and digital rectal examination) and later the biopsy. 27/30 (90%) of participants experienced needling pain and anxiety which increased as each core specimen was taken.(7) Northouse et al (6) conducted an observational study with 300 women undergoing a breast biopsy and their husbands (n=265). Almost

2020 KHA-CARI Guidelines

149. Suicide aftercare services

attitudes towards a person who has survived a suicidal crisis and possibly an attempt to end their life. Question 2: The components of effective care are inferred from examining the common components of models that have been shown to reduce suicide attempt risk in randomised controlled trials. With one exception, there has been no examination of mediating factors. This factor, client-rated therapeutic alliance, consistently emerges as predictive of better outcomes across a range of therapeutic models (...) -clinical services and general support services with improved coordination of clinical care and treatment programs appears to be the more effective model of service in terms of benefits to an individual’s quality of life and motivation, but also in achieving observable changes in suicidal behaviour. At the heart of all responses the need for empathic and respectful interactions with the person who has attempted suicide and their families and carers is essential as a measure of service quality. Careful

2020 Sax Institute Evidence Check

150. Navigating later life transitions: An evaluation of emotional and psychological interventions

speak up when you encounter ageist behaviour or attitudes? do you recognise them? skills audit individually read the statements on the back of the cards and sort into four groups to reflect on individual skills linked to people, data, things and ideas. to think about how your skills can be applied during this period of your life to enable you to plan for and develop a fulfilling and purposeful later life finance session the facilitator will share relevant information and as a group, if you feel able (...) on mindfulness, cognitive behavioural therapy and meditation); reflective journals and life satisfaction audit tools. The aim of the evaluation was to find out what impact the courses had on individual attributes that would help people be better prepared for later life transitions; what changes people make as a result of the courses; and what practice, resources or processes in the organisations are important in ensuring their implementation and efficacy. Because the two courses were similar, and because

2020 The Centre for Ageing Better

151. Mid-life support: Insights for employers

in the future + Wanting to avoid a perceived risk + Wanting to make sure certain aspects of life are preserved + Positive experience of planning Barriers – Issue seems a long way off – Risk appears low – Fatalistic attitude about survival to old age Practical Enablers + Sufficient financial resources + Knowledge and skills Barriers – Insufficient financial resources – Poor understanding of planning products and services – Difficulty predicting future timeline and understanding risk Social Enablers + Social (...) life, we conducted an evaluation of two group-based psychosocial courses for people approaching later life (Calouste Gulbenkian Foundation UK Branch and Centre for Ageing Better, 2019). These courses employed well-known therapeutic approaches, such as cognitive behavioural therapy and mindfulness, and examined issues around ageism, resilience, transitions and the life course. Most participants experienced improvements in attributes key to managing transitions, thereby helping them have a more

2020 The Centre for Ageing Better

152. What research has been done to understand substance misuse within the UK student population, and what interventions have been introduced as a result?

that the use of drugs is a criminal offence (7, 17). University students may seek to enhance cognitive functioning by taking smart drugs in an effort to improve their academic performance; students who believed smart drugs to be harmless, and those who felt they knew how to use them safely, tended to have more positive attitudes towards smart drugs (18). Medical students appeared to be less likely to misuse drugs, compared with law students at the same university – the authors suggested that perhaps (...) due to irresponsible drinking; and a 50% reduction in both verbal assaults and major fights occurring during nights out (23). Alcohol reduction interventions should be tailored to suit the target population – those that highlight the negative consequences of binge drinking may modify intentions for first year undergraduates; in later years, attitudes, self-efficacy and perceived behavioural control predict intentions, suggesting that interventions targeting these variables would be effective

2020 Public Health England - Evidence Briefings

153. Employment support for over 50s: Rapid evidence review

people aged 50 and over to access work > The potential for people in mid/later life to become self-employed 6 Centre for Ageing Better (2018), A silver lining for the UK economy? The intergenerational case for supporting longer working lives. London. Available at: https://www.ageing-better.org.uk/ sites/default/files/2018-02/Silver-lining-UK-economy-crucial.pdf7 © Centre for Ageing Better 2019 > The nature and effects of age-bias in recruitment, selection and other employment practices > Attitudes (...) for how advisor support might be developed further. - Motivational support and attitudinal challenge: Motivational, asset-based support to sustain engagement along with support to develop more positive attitudes and expectations of job search and employment appears to be a strong predictor of subsequent success in employment outcomes among this age group. - Conducive support and engagement environment: The environment in which support is provided must be one that older jobseekers are comfortable

2020 The Centre for Ageing Better

154. What is the current evidence for the efficacy of drug consumption rooms?

BDL. Self-reported changes in drug use behaviors and syringe disposal methods following the opening of a supervised injecting facility in Copenhagen, Denmark. Harm Reduction Journal. 2014;11(1):29. 16. Bravo MJ, Royuela L, De la Fuente L, Brugal MT, Barrio G, Domingo-Salvany A. Use of supervised injection facilities and injection risk behaviours among young drug injectors. Addiction. 2009;104(4):614-9. 17. Patterson T, Bharmal A, Padhi S, Buchner C, Gibson E, Lee V. Opening Canada's first Health (...) to 11 th March 2019. Key messages • Research has found evidence of effectiveness of drug consumption rooms (DCRs) in reducing harms associated with drug use, particularly high- risk injection behaviours. Provision of sterile equipment to reduce infection transmission is a core function. • Some areas where DCRs are operating have had reductions in public drug consumption and publicly discarded drug-related litter, e.g. syringes. • People who use drugs are more likely to use a DCR if they are homeless

2020 Public Health England - Evidence Briefings

155. Heritable mutations associated with familial hypercholesterolaemia - Clinical Utility Card application

gained from cascade testing, not testing of affected individuals. Diagnosing non-symptomatic family members can lead to a change in management through, for example, lifestyle and behavioural changes, and uptake of LLT. Five before-and-after case series (two of them Australian with overlapping populations) reported reductions in LDL cholesterol in family members (adults and children) after cascade screening. ESC noted that three qualitative publications were identified that examined the psychological (...) -utility analysis and cost-effectiveness analysis Outcomes Quality-adjusted life years gained Life-years gained Sources of evidence Systematic review of the literature (which had inconclusive findings). Additional AIHW data, published literature, unpublished data and expert opinion where required. Methods used to generate results Decision tree and Markov model. Cohorts modelled FH affected individuals Adult relatives of FH affected individuals Child/adolescent relatives of FH affected individuals Age

2020 Medical Services Advisory Committee

156. The Politics of Disease Epidemics: a Comparative Analysis of the SARS, Zika, and Ebola Outbreaks Full Text available with Trip Pro

in a government” (Merriam-Webster ). However, in the “politics of epidemics” literature, politics often refers to the extensive and diverse influence of local, national, and international governments and organizations, on the health outcomes of communities during disease outbreaks. For the purposes of this paper, politics will also refer to how scholars talked about epidemics, and whose narratives are reported in the reviewed literature. Several key themes emerge when examining scholarly narratives about (...) the politics of epidemics namely the socioeconomic distribution of disease, decision-making in research and development, the credibility of evidence that informs response pathways, and attribution of responsibility for causing the outbreak and determining who is responsible for responding. While the literature presents obviously competing narratives that explain disease outbreaks, a close examination of these reveals a high prevalence of certain narratives, which reflect the influence of power

2020 Covid-19 Ad hoc papers

157. Regional Therapies for Colorectal Cancer Liver Metastases

this recommendation is of high quality and high certainty. The desirable effect of increased survival with the addition of TARE did not occur. The undesirable side effects were moderate. The benefits of the addition of TARE did not outweigh the risks. ? Although the Working Group looked at survival, local control, quality of life, and toxicity, OS was considered to be the most important outcome. The Working Group was unanimous in their opinion that patients would also value the importance placed on survival (...) Beecroft, the lead authors, through the PEBC via: Phone: 905-527-4322 ext. 42822 Fax: 905 526-6775 E-mail: ccopgi@mcmaster.ca For information about the PEBC and the most current version of all reports, please visit the OH (CCO) website at http://www.cancercare.on.ca/ or contact the PEBC office at: Phone: 905-527-4322 ext. 42822 Fax: 905 526-6775 E-mail: ccopgi@mcmaster.ca PEBC Report Citation (Vancouver Style): Karanicolas P, Beecroft R, Cosby R, David E, Kalyvas M, Kennedy E, Sapisochin G, Wong R

2020 Cancer Care Ontario

158. Minimal Residual Disease Testing in Acute Leukemia

but appear to have more variability in methodology and timing of MRD testing, making it very difficult to conclude definitively that these assays can impact patient outcome when there is a need to decide between different therapies [33]. However, those studying adult ALL have taken lessons from their pediatric colleagues through the adoption of pediatric-style chemotherapy regimens and applying a similar level of MRD monitoring. The UKALL 2003 randomized trial in pediatrics [3,4] demonstrated (...) the preferred back-up plan. Only one study attempted to examine a risk adapted approach in AML, but although it appeared to demonstrate a usefulness to altering therapy based on MRD status, it was not randomized and has not been repeated or replicated [42]. The intermediate AML risk group, defined by a normal karyotype, is very heterogeneous. While this group is often directed toward transplant, there are many patients who have been cured without a transplant [43,44]. Additional prognostication

2020 Cancer Care Ontario

159. Clinical care of severe acute respiratory infections – Tool kit

References and resources 115 10.1 Numerical pain assessment scales 117 10.2 Behavioural pain assessment scales 118 10.3 COMFORT-B Scale to assess sedation in children 122 10.4 Richmond Agitation-Sedation Scale (RASS) 125 10.5 Flowchart and worksheet for the Confusion Assessment Method of the ICU for adults (CAM-ICU) 126 10.6 Flowchart and worksheet for the Confusion Assessment Method of the ICU for children (pCAM-ICU) 128 10.7 Procedure for assessing attention: attention screening exam (ASE) for adults (...) and Quality (United States of America) AMS altered mental state ARDS acute respiratory distress syndrome ARI acute respiratory infection ART arterial pressure ASE attention screening exam AVPU alert, verbal, pain, unresponsive (scale for assessing level of consciousness) bCPAP bubble continuous positive airway pressure BEC basic emergency care BEE basal energy expenditure BPM beats per minute BPS Behavioural Pain Scale BSI blood stream infection CAM-ICU confusion assessment method for the intensive care

2020 WHO Coronavirus disease (COVID-19) Pandemic

160. The Geriatricians’ Perspective on Medical Services to Residential Aged Care Facilities (RCFs) in Australia.

Zealand Society for Geriatric Medicine. This Statement was approved by the Federal Council of the ANZSGM on 22nd August 2011. Authors: Drs Penny Harvey and Sam Scherer. BACKGROUND PAPER Introduction The practice of medicine in the complex circumstances of a RCF requires a doctor with particular skills, interests, attitudes [1] and competence in aged care, preferably acquired through dedicated post-graduate training [2]. Adverse events suffered by aged care residents when treated sub- optimally (...) ) was introduced in the USA in 1990 and has been utilised as an international benchmark for practice and research in quality health care for long term care settings. The RAI attempts to link regulation and funding with quality care processes and outcomes and has in the US been demonstrated to reduce the use of psychotropic drugs, restraints, indwelling catheters as well as increasing continence, documented advance directives and behaviour management. [8, 9,10,11,12] Local research studies into the use of RAI

2020 Australian and New Zealand Society for Geriatric Medicine

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