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181. Systemic Therapy for Advanced or Recurrent Endometrial Cancer and Advanced or Recurrent Uterine Papillary Serous Carcinoma

chose not to recommend funding because they felt that the guideline did not have a specific enough recommendation regarding the use of paclitaxel. The Gynecology Cancer DSG re-examined the evidence and decided that there was insufficient evidence to make a stronger recommendation regarding the use of paclitaxel at this time. Sub-optimal toxicity comparisons between patients with ovarian and endometrial cancer Section 1: Practice Guideline Report Page 21 appear to demonstrate that paclitaxel (...) ://www.cancercare.on.ca/ or contact the PEBC office at: Phone: 905-527-4322 ext. 42822 Fax: 905-526-6775 E-mail: ccopgi@mcmaster.ca PEBC Report Citation (Vancouver Style): Gawlik C, Carey M, Faught W, Fung Kee Fung M, Chambers A; Members of the Gynecology Cancer Disease Site Group. Systemic therapy for advanced or recurrent endometrial cancer, and advanced or recurrent uterine papillary serous carcinoma. Covens A, Durocher-Allen L, reviewers. Toronto (ON): Cancer Care Ontario; 2004 Aug 17 [Endorsed 2019 Jul 23

2019 Cancer Care Ontario

182. Complex surgery and perioperative systemic therapy for genitourinary cancer of the retroperitoneum

about this document, please contact A. Finelli, the lead author, through the PEBC via: Phone: 905-527-4322 ext. 42822 Fax: 905 526-6775 E-mail: ccopgi@mcmaster.ca For information about the PEBC and the most current version of all reports, please visit the CCO website at http://www.cancercare.on.ca/ or contact the PEBC office at: Phone: 905-527-4322 ext. 42822 Fax: 905 526-6775 E-mail: ccopgi@mcmaster.ca PEBC Report Citation (Vancouver Style): Finelli A, Coakley N, Chin J, Flood T, Loblaw A, Morash C (...) ) can significantly improve after removal; therefore, deterioration of PS due to thrombus should not be an exclusion criterion for surgery. ? There is no distinct surgical method that seems superior for VTT excision, although the surgical method appears to depend on the VTT level and the grade of occlusion of the inferior vena cava (IVC). ? For adequate removal of the thrombus, caval vein control is key, which may require liver mobilisation and cardiac bypass. Preoperative embolization does not seem

2019 Cancer Care Ontario

183. Regional Models of Care for Systemic Treatment: Standards for the Organization and Delivery of Systemic Treatment

For information about this document, please contact Dr. Leta Forbes, the lead author, through the PEBC via: Phone: 905-527-4322 ext. 42822 Fax: 905 526-6775 E-mail: ccopgi@mcmaster.ca For information about the PEBC and the most current version of all reports, please visit the CCO website at http: https://www.cancercareontario.ca/en/guidelines-advice or contact the PEBC office at: Phone: 905-527-4322 ext. 42822 Fax: 905 526-6775 E-mail: ccopgi@mcmaster.ca PEBC Report Citation (Vancouver Style): Forbes L (...) administer intravenous systemic treatment until and unless she/he has received additional education and has demonstrated competency in the delivery of these systemic treatment agents. This requirement is specific to the delivery of systemic treatment and is not to be confused with the national examination process for Certification as an Oncology Nurse through the Canadian Nurses Association. Complexity – Determined by the preparation and administration requirements for systemic treatment, risk

2019 Cancer Care Ontario

184. Shared decision making training programs for doctors: A Rapid Review

such as pocket cards, manuals, decision aids, and visual aids are also used during training. Training outcomes such as patient-physician relationships, communication, patient perception, quality of life, are measured using varied published frameworks, scales and questionnaires. Follow-up ranged from three months to up to three years. Improvements in patient involvement, communication, counselling and advice have been reported following SDM training. Increased understanding of the benefits of SDM, attitude (...) programme useful and increased knowledge After the intervention, • 89% of residents agreed that the intervention was useful; • 83% of residents agreed that it had increased their knowledge; • 78% of residents agreed that it had increased confidence in having conversations with patients at high risk facing a life-threatening surgical emergency. • Summative actions score significantly increased pre- and post-intervention (p=0.04). • Summative attitudes and confidence scores remained unchanged (p>0.05

2019 Monash Health Evidence Reviews

185. Trust in Health Professionals

of trust have been developed within medicine [2]. A 2014 systematic review provides a comprehensive definition: “The expectations of the public that those who serve them will perform their responsibilities in a technically proficient way, that they will assume responsibility and not inappropriately defer to others, and that they will make their patients’ welfare their highest priority” [2]. Determinants of trust Health professionals’ behaviours are central in understanding how trust is formed (...) consisted of systematic reviews, literature reviews and an opinion article. No quality appraisal of included studies was undertaken. Defining Trust Various definitions [1-5] and conceptualisations of trust have been developed within medicine [2]. A 2014 systematic review provides a comprehensive definition: “The expectations of the public that those who serve them will perform their responsibilities in a technically proficient way, that they will assume responsibility and not inappropriately defer

2019 Monash Health Evidence Reviews

186. Preparing Emerging Leaders for Alternative Futures in Health Systems Across Canada

) identifying the personal and professional competencies needed; and 2) identifying mechanisms to bridge existing leadership with emerging leaders and leadership styles. o Ten systematic reviews relevant to the first sub-element identified a wide range of competencies required by leaders at each of the system, organizational and unit or department level. While we were unable to find systematic reviews that directly addressed the second sub-element, we found four systematic reviews examining different (...) gaps in a population and trends towards aging populations, o social attitudes towards and practices and habits related to healthy living and active lifestyles, o growing incidence of chronic diseases, including mental health conditions, o attitudes towards aging, effective retirement age, and activity and participation of older populations within the economy o community involvement, dynamism of civil society, and involvement of local communities in health provision. While the ways in which

2019 McMaster Health Forum

187. Supporting Rapid Learning and Improvement Across Ontario’s Health System

), and communities of practice appear promising to support problem-focused initiatives. • Element 2 – Support local area-focused rapid learning and improvement o This element could include: building local capacity (within health organizations and with front-line staff) and establishing dedicated staff to identify improvement priorities; determining what resources are available in (and beyond) local organizations and how they can be effectively harnessed to support rapid learning and improvement; and creating (...) review examined attempts to adopt the rapid-learning health-system paradigm, with an emphasis on implementation and evaluating the impact on current medical practices, and found minimal focus on evaluating impacts on healthcare delivery and patient outcomes. What implementation considerations need to be kept in mind • While many barriers to implementing these elements may exist at the level of patients, providers, organizations and systems, perhaps the biggest barrier lies in achieving agreement

2019 McMaster Health Forum

188. Guidelines on Supraventricular Tachycardia (for the management of patients with) Full Text available with Trip Pro

by agreement of the expert panel after thorough deliberation. The document was peer-reviewed by official external reviewers. The strengths of the recommendations and levels of evidence of particular management options were weighed and graded according to predefined scales, as outlined above in Tables and , respectively. Overall, these Guidelines include evidence and expert opinions from several countries. The pharmacological and non-pharmacological antiarrhythmic approaches discussed may therefore include (...) outcome measures have shown that patients experience significant improvements in their quality of life following ablation. Patient-reported outcome measures using various questionnaires are useful in the audit of ablation techniques. Women are more often prescribed antiarrhythmic drugs before ablation for SVT than men, and recurrence rates following AVNRT ablation are higher in young women. However, overall, no significant differences in health-related quality of life or access to healthcare resources

2019 European Society of Cardiology

189. Diagnosis and Management of Acute Pulmonary Embolism Full Text available with Trip Pro

Integration of aggravating conditions and comorbidity into risk assessment of acute pulmonary embolism 20 5.6 Prognostic assessment strategy 20 6 Treatment in the acute phase 22 6.1 Haemodynamic and respiratory support 22 6.1.1 Oxygen therapy and ventilation 22 6.1.2 Pharmacological treatment of acute right ventricular failure 22 6.1.3 Mechanical circulatory support and oxygenation 23 6.1.4 Advanced life support in cardiac arrest 23 6.2 Initial anticoagulation 23 6.2.1 Parenteral anticoagulation 23 6.2.2 (...) of life. In parallel, longitudinal studies have revealed a rising tendency in annual PE incidence rates over time. Together with the substantial hospital-associated, preventable, and indirect annual expenditures for VTE (an estimated total of up to €8.5 billion in the European Union), these data demonstrate the importance of PE and DVT in ageing populations in Europe and other areas of the world. They further suggest that VTE will increasingly pose a burden on health systems worldwide in the years

2019 European Society of Cardiology

190. Management of Dyslipidaemias Full Text available with Trip Pro

population level by promoting healthy lifestyle behaviour, and at the individual level by tackling unhealthy lifestyles and by reducing increased levels of causal CV risk factors, such as LDL cholesterol or blood pressure (BP) levels. 3.2 Development of the Joint Task Force Guidelines for the management of dyslipidaemias The present Guidelines represent an evidence-based consensus of the European Task Force, including the ESC and the EAS. By appraising the current evidence and identifying remaining (...) Lipoprotein measurement 19 5.4.2 Lipid measurements 20 5.4.3 Fasting or non-fasting? 20 5.5 Recommendations for measuring lipids and lipoproteins to estimate risk of atherosclerotic cardiovascular disease 20 6 Treatment targets and goals 21 7 Lifestyle modifications to improve the plasma lipid profile 22 7.1 Influence of lifestyle on total cholesterol and low-density lipoprotein cholesterol levels 24 7.2 Influence of lifestyle on triglyceride levels 24 7.3 Influence of lifestyle on high-density

2019 European Society of Cardiology

191. Evidence for smoking quitlines

studies describing referral pathways to the service 92 References 96 6 EVIDENCE FOR SMOKING QUITLINES | SAX INSTITUTE Abbreviations ACT Acceptance and Commitment Therapy AI/AN American Indian/Alaskan Native ASQ Asian Smokers Quitline ATC Alcohol Tobacco Counselling CA Continuous Abstinence CALD Culturally And Linguistically Diverse CBT Cognitive Behavioural Therapy CDC Centre for Disease Control CI Confidence Interval CO Carbon Monoxide df Degrees of Freedom ENDS Electronic Nicotine Delivery Systems (...) Support PRISMA Preferred Reporting Items for Systematic reviews and Meta-Analyses SAX INSTITUTE | EVIDENCE FOR SMOKING QUITLINES 7 QFL Quit For Life QoL Quality of Life RCT Randomised Controlled Trial RM Repeated Mailings RR Risk Ratio SC Standard Care SD Standard Deviation SH Self-help Group SMS Short Messaging Service SNTQ Swedish National Tobacco Quitline TEQ Technology Enhanced Quitline TOC Tobacco Only Counselling UK United Kingdom US United States Vs Versus WHO World Health Organization 8

2019 Sax Institute Evidence Check

192. Learning from the Experience of Accountable Care Organizations in the U.S.

Response program webpage (www.mcmasterforum.org/find-evidence/rapid- response). Funding RISE is supported by a grant from the Ontario Ministry of Health to the McMaster Health Forum. The opinions, results, and conclusions are those of RISE and are independent of the Ministry. No endorsement by the Ministry is intended or should be inferred. Conflict of interest The authors declare that they have no professional or commercial interests relevant to the rapid synthesis. The funder played no role (...) that of accountable care organizations in the U.S., which were formally implemented as part of the changes to the U.S. Patient Protection and Affordable Care Act, with the goals of linking payment for healthcare to quality outcomes, encouraging integrated health systems, reducing the cost of care and administration, and understanding and addressing health disparities. • Given these similarities between OHTs at maturity and ACOs in the U.S., we examined the design, evolution and effects of U.S. ACOs to identify

2019 McMaster Health Forum

193. Management of Poisoning

series 4 Expert opinion Grades of recommendation Grade Recommendation A At least one meta-analysis, systematic review of RCTs, or RCT rated as 1 + + and directly applicable to the target population; or A body of evidence consisting principally of studies rated as 1 + , directly applicable to the target population, and demonstrating overall consistency of results B A body of evidence including studies rated as 2 ++ , directly applicable to the target population, and demonstrating overall consistency (...) should be used (pg 57). Grade D, Level 3 B Patients with actual or potential life threatening cardiac arrhythmia, hyperkalaemia or rapidly progressive toxicity from digoxin poisoning should be treated with digoxin-speci? c antibodies (pg 57). Grade B, Level 2++ B Titrated doses of benzodiazepine should be given in hyperadrenergic- induced tachycardia states resulting from poisoning (pg 57). Grade B, Level 1+ D Non-selective beta-blockers, like propranolol, should be avoided in stimulant toxicity

2020 Ministry of Health, Singapore

194. International Review – consent models for health information

11 2. Summary of current situation in Ireland 12 2.1 eHealth initiatives 12 2.2 Legislation 12 2.3 Consent model 15 2.4 The role of the Data Protection Commission 15 2.5 Patient and public attitudes to the collection, use and sharing of personal health information 16 3. Summary of international evidence 17 4. England 20 3.1 Key organisations 20 4.2 Legislation 23 4.3 Consent model 25 4.4 eHealth developments 27 4.5 Patient engagement 31 4.6 Key learnings 33 5. Northern Ireland 34 5.1 Key (...) of consent models for the collection, use and sharing of health information Health Information and Quality Authority Page 16 of 138 Using its statutory powers, the Data Protection Commission (15) : ? examines complaints from individuals in relation to potential infringements of data protection law ? conducts inquiries and investigations regarding infringements of data protection legislation and takes enforcement action where necessary ? promote awareness amongst members of the public of their rights

2020 HIQA Health Information

195. European Academy of Neurology guideline on the diagnosis of coma and other disorders of consciousness Full Text available with Trip Pro

approaches such as the revised Motor Behavior Tool , or subjective approaches based on caregivers' collective intelligence such as the ‘DoC feeling’ . The examiner should be mindful of confounding factors such as cranial nerve palsies, central and peripheral causes of quadriplegia, severe spasticity, hypokinesia and bradykinesia, and hypertonus or hypotonus . PICO 4 Should the CRS‐R be used to diagnose the level of consciousness in patients with DoC? Eight studies conducted in different centers (...) and countries including 925 patients were available for inclusion , , , , , , , . The relative risk for detecting evidence of consciousness with the CRS‐R compared to other behavioral assessment methods, including unstructured neurological bedside examination, was 1.45 (95% CI 1.32–1.60; P < 0.0001), suggesting that the CRS‐R is more sensitive than other scales for detecting signs of consciousness , , , , , , , . The CRS‐R is also the only scale that includes all criteria for MCS (with the notable exception

2020 European Academy of Neurology

196. A palliative approach to care in the last 12 months of life

be produced, reproduced and published in its entirety, without modification, in any form, including in electronic form, for educational or non-commercial purposes. Should any adaptation of the material be required for any reason, written permission must be obtained from RNAO. Appropriate credit or citation must appear on all copied materials as follows: Registered Nurses’ Association of Ontario. A palliative approach to care in the last 12 months of life. Toronto (ON): Registered Nurses’ Association (...) A palliative approach to care in the last 12 months of life Best Practice Guideline MARCH 2020 A Palliative Approach to Care in the Last 12 Months of LifeDisclaimer These guidelines are not binding on nurses, other health providers or the organizations that employ them. The use of these guidelines should be flexible and based on individual needs and local circumstances. They constitute neither a liability nor discharge from liability. While every effort has been made to ensure the accuracy

2020 Registered Nurses' Association of Ontario

197. Female Genital Cosmetic Surgery

dysmorphic disorder, cri- teria for which, according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, includeapreoccupationwithanimaginedphysicaldefect or exaggerated concern about a physical defect that wouldnotbeapparenttothecasualobserver,orahistory of repetitive or obsessive behaviors (such as repeated examination or attempts to conceal the flaw, or contin- ually seeking reassurance from others) (25, 26). In women who have suspected psychological concerns, a referral (...) not indicate abnormal anatomy. Modified from Kreklau A, Vaz I, Oehme F, Strub F, Brechbuhl R, Christmann C, et al. Measurements of a ’normal vulva’ in women aged 15–84: a cross-sectional prospective single-centre study. BJOG 2018;125:1656–61. e40 Committee Opinion Female Genital Cosmetic Surgery OBSTETRICS & GYNECOLOGYclinically competent to perform the procedure (31). Extensive familiarity with appearance and function, as well as the ability to manage complications, are expected from obstetrician

2020 American College of Obstetricians and Gynecologists

198. Sexual Misconduct

Sexual Misconduct ACOGCOMMITTEEOPINION Number 796 (Replaces Committee Opinion No. 373, August 2007) Committee on Ethics This Committee Opinion was developed by the American College of Obstetrician and Gynecologists’ Committee on Ethics in collaboration with committee member David I. Shalowitz, MD, MSHP. Sexual Misconduct ABSTRACT: The practice of obstetrics and gynecology includes interaction in times of intense emotion and vulnerability for patients and involves sensitive physical examinations (...) about patients’ health care, and ultimately be detrimental to patients’ long-term health (19, 20). Fur- thermore, an uncomfortable or traumatic experience in a physician’s office may become a major barrier to seek- ing needed health care in the future. Sexual or romantic behavior by a physician toward a current patient constitutes misconduct regardless of whether a patient appears to initiate or consent to such behavior. Physicians’ professional codes of ethics have historically precluded

2020 American College of Obstetricians and Gynecologists

199. The impacts of agroforestry on agricultural productivity, ecosystem services, and human well-being in low- and middle-income countries: An evidence and gap map Full Text available with Trip Pro

as duplicates, leaving 16,535 studies that were screened on title and abstract. After title and abstract screening, there remained 1,557 studies which were screened at full text. We identified 12 SRs and 384 primary studies that met our inclusion criteria. Of the primary studies, 40 studies examined the impacts of specific agroforestry interventions, of which only eight used quantitative impact evaluation methods. The other 32 intervention studies measured the outcomes of an agroforestry intervention (...) against a comparator, but they did not use experimental or quasiexperimental methods to account for nonrandom assignment to treatment and control groups. The other 344 primary studies examined the outcomes of agroforestry practices (without a specific intervention associated with the practice) against a nonagroforestry comparator. The eight impact evaluations came from different country contexts, with only Kenya yielding more than one study. Together, they examined four of the six intervention types

2019 Campbell Collaboration

200. What works to improve early grade literacy in Latin America and the Caribbean? A systematic review and meta?analysis Full Text available with Trip Pro

policy, practice, and programs in an evidence‐driven manner. 2.2 Objectives This systematic review examines the effectiveness of various programs implemented in the LAC region that aim to improve EGL outcomes, including teacher training, school feeding, computer‐aided instruction, programs with an emphasis on nutrition, and technology in education programs. In addition, we assess the fidelity of implementation of programs that aim to improve EGL outcomes as well as the factors that predict EGL (...) outcomes. Finally, we examine the experiences and perspectives of various stakeholders about EGL in the LAC region. Specifically, this review addressed the following research questions: 1. What is the impact of reading programs, practices, policies, and products aimed at improving the reading skills of children from birth through Grade 3 on reading outcomes in the LAC region? 2. What factors predict the reading outcomes of children from birth through Grade 3? 3. What factors contribute to improving

2019 Campbell Collaboration

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