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Aphasia

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161. Event Related Potential Study of Language Interaction in Bilingual Aphasia Patients Full Text available with Trip Pro

Event Related Potential Study of Language Interaction in Bilingual Aphasia Patients Half of the global population can be considered bilingual. Nevertheless when faced with patients with aphasia, clinicians and therapists usually ignore the patient's second language (L2) albeit its interference in first language (L1) processing has been shown. The excellent temporal resolution by which each individual linguistic component can be gaged during word-processing, promoted the event-related potential (...) (ERP) technique for studying language processing in healthy bilinguals and monolingual aphasia patients. However, this technique has not yet been applied in the context of bilingual aphasia. In the current study, we report on L2 interference in L1 processing using the ERP technique in bilingual aphasia. We tested four bilingual- and one trilingual patients with aphasia, as well as several young and older (age-matched with patients) healthy subjects as controls. We recorded ERPs when subjects were

2018 Frontiers in human neuroscience

162. The Relationship Between Confrontation Naming and Story Gist Production in Aphasia Full Text available with Trip Pro

The Relationship Between Confrontation Naming and Story Gist Production in Aphasia The purpose of this study was to examine the relationship between picture naming performance and the ability to communicate the gist, or essential elements, of a story. We also sought to determine if this relationship varied according to Western Aphasia Battery-Revised (WAB-R; Kertesz, 2007) aphasia subtype.Demographic information, test scores, and transcripts of 258 individuals with aphasia completing 3 (...) narrative tasks were retrieved from the AphasiaBank database. Narratives were subjected to a main concept analysis to determine gist production. A correlation analysis was used to investigate the relationship between naming scores and main concept production for the whole group of persons with aphasia and for WAB-R subtypes separately.We found strong correlations between naming test scores and narrative gist production for the large sample of persons with aphasia. However, the strength

2018 American Journal of Speech-Language Pathology

163. Links Between Short-Term Memory and Word Retrieval in Aphasia Full Text available with Trip Pro

Links Between Short-Term Memory and Word Retrieval in Aphasia This study explored the relationship between anomia and verbal short-term memory (STM) in the context of an interactive activation language processing model.Twenty-four individuals with aphasia and reduced STM spans (i.e., impaired immediate serial recall of words) completed a picture-naming task and a word pair repetition task (a measure of verbal STM). Correlations between verbal STM and word retrieval errors made on the picture

2018 American Journal of Speech-Language Pathology

164. Response Time Inconsistencies in Object and Action Naming in Anomic Aphasia Full Text available with Trip Pro

Response Time Inconsistencies in Object and Action Naming in Anomic Aphasia The effect of repeated naming on both object and action picture naming in individuals with anomic aphasia is explored. We asked whether repeatedly naming the same items leads to improved accuracy and reduced response latency.Ten individuals with anomic aphasia and 6 healthy adults, 3 young and 3 old, named a set of 27 object pictures and a set of 27 action pictures presented 1 at a time on a computer screen. We examined (...) accuracy and response times (RTs) across the 2 blocks of 10 repeated trials.Results demonstrated higher accuracy and faster RTs for object than for action naming for all participants, with lower accuracy rates and slower RTs for the people with aphasia (PWA) compared with the healthy individuals, and diverging patterns of change across trials. Unlike the healthy participants, whose RTs decreased across trials, PWA continued to demonstrate variability in response latencies across the trials.Our

2018 American Journal of Speech-Language Pathology

165. Describing Phonological Paraphasias in Three Variants of Primary Progressive Aphasia Full Text available with Trip Pro

Describing Phonological Paraphasias in Three Variants of Primary Progressive Aphasia The purpose of this study was to describe the linguistic environment of phonological paraphasias in 3 variants of primary progressive aphasia (semantic, logopenic, and nonfluent) and to describe the profiles of paraphasia production for each of these variants.Discourse samples of 26 individuals diagnosed with primary progressive aphasia were investigated for phonological paraphasias using the criteria

2018 American Journal of Speech-Language Pathology

166. Abnormal language-related oscillatory responses in primary progressive aphasia Full Text available with Trip Pro

Abnormal language-related oscillatory responses in primary progressive aphasia Patients with Primary Progressive Aphasia (PPA) may react to linguistic stimuli differently than healthy controls, reflecting degeneration of language networks and engagement of compensatory mechanisms. We used magnetoencephalography (MEG) to evaluate oscillatory neural responses in sentence comprehension, in patients with PPA and age-matched controls. Participants viewed sentences containing semantically

2018 NeuroImage : Clinical

167. Diagnostic utility of FDG-PET in the differential diagnosis between different forms of primary progressive aphasia Full Text available with Trip Pro

Diagnostic utility of FDG-PET in the differential diagnosis between different forms of primary progressive aphasia A joint effort of the European Association of Nuclear Medicine (EANM) and the European Academy of Neurology (EAN) aims at clinical guidance for the use of FDG-PET in neurodegenerative diseases. This paper addresses the diagnostic utility of FDG-PET over clinical/neuropsychological assessment in the differentiation of the three forms of primary progressive aphasia (PPA).Seven

2018 European Journal of Nuclear Medicine and Molecular Imaging

168. Effects of a Tablet-Based Home Practice Program With Telepractice on Treatment Outcomes in Chronic Aphasia Full Text available with Trip Pro

Effects of a Tablet-Based Home Practice Program With Telepractice on Treatment Outcomes in Chronic Aphasia The aim of this study was to determine if a tablet-based home practice program with weekly telepractice support could enable long-term maintenance of recent treatment gains and foster new language gains in poststroke aphasia.In a pre-post group study of home practice outcomes, 21 individuals with chronic aphasia were examined before and after a 6-month home practice phase and again (...) , such that individuals with the most severe aphasia made and maintained fewer gains. There was a negative relationship between the amount of training required for iPad proficiency and improvements on practiced and unpracticed pictures and a positive relationship between practice compliance and same improvements.Unsupervised home practice with weekly video teleconferencing support is effective. This study demonstrates that even individuals with chronic severe aphasia, including those with no prior smart device

2018 Journal of speech, language, and hearing research : JSLHR

169. Multimodal Communication in Aphasia: Perception and Production of Co-speech Gestures During Face-to-Face Conversation Full Text available with Trip Pro

Multimodal Communication in Aphasia: Perception and Production of Co-speech Gestures During Face-to-Face Conversation The role of nonverbal communication in patients with post-stroke language impairment (aphasia) is not yet fully understood. This study investigated how aphasic patients perceive and produce co-speech gestures during face-to-face interaction, and whether distinct brain lesions would predict the frequency of spontaneous co-speech gesturing. For this purpose, we recorded samples (...) of conversations in patients with aphasia and healthy participants. Gesture perception was assessed by means of a head-mounted eye-tracking system, and the produced co-speech gestures were coded according to a linguistic classification system. The main results are that meaning-laden gestures (e.g., iconic gestures representing object shapes) are more likely to attract visual attention than meaningless hand movements, and that patients with aphasia are more likely to fixate co-speech gestures overall than

2018 Frontiers in human neuroscience

170. Exploring the efficacy of melodic intonation therapy with Broca’s aphasia in Arabic Full Text available with Trip Pro

Exploring the efficacy of melodic intonation therapy with Broca’s aphasia in Arabic  Even though the efficacy of melodic intonation therapy (MIT) with persons with aphasia (PWA) has been explored in different languages, the efficacy of MIT with Arabic-speaking PWA has never been explored. Aims: To explore the efficacy of MIT, adapted to Arabic, in promoting the expressive abilities of a 70-year-old Jordanian Arabic-speaking male subject with severe Broca's aphasia 3 months post-onset. Methods (...) : An 8-week MIT therapy programme with tapping (1.5 h daily, 6 days a week) was used in a multiple baseline design across two types of trained phrases (i.e. automatic and self-generated phrases). Outcome measures included accuracy of production of trained (at the end of each session) and untrained phrases (at the end of each week). Pre- and post-treatment measures used, were the bilingual aphasia test, the American Speech-Language Hearing Association Functional Assessment of Communicative Skills

2018 The South African Journal of Communication Disorders

171. The effect of tDCS on functional connectivity in primary progressive aphasia Full Text available with Trip Pro

The effect of tDCS on functional connectivity in primary progressive aphasia Transcranial direct current stimulation (tDCS) is an innovative technique recently shown to improve language outcomes even in neurodegenerative conditions such as primary progressive aphasia (PPA), but the underlying brain mechanisms are not known. The present study tested whether the additional language gains with repetitive tDCS (over sham) in PPA are caused by changes in functional connectivity between

2018 NeuroImage : Clinical

172. Molecular Neuroimaging in an Agraphia Predominant Primary Progressive Aphasia Full Text available with Trip Pro

Molecular Neuroimaging in an Agraphia Predominant Primary Progressive Aphasia A 62-year-old male presented with progressive isolated writing and spelling difficulties. Neurological, neuropsychological, speech, and language evaluations identified only minimal additional abnormalities. The presenting characteristics did not meet criteria for any particular variant of primary progressive aphasia; his clinical presentation is best described as primary progressive aphasia, with a predominant, almost

2018 Neurocase

173. Changes in Resting-State Connectivity following Melody-Based Therapy in a Patient with Aphasia Full Text available with Trip Pro

Changes in Resting-State Connectivity following Melody-Based Therapy in a Patient with Aphasia Melody-based treatments for patients with aphasia rely on the notion of preserved musical abilities in the RH, following left hemisphere damage. However, despite evidence for their effectiveness, the role of the RH is still an open question. We measured changes in resting-state functional connectivity following melody-based intervention, to identify lateralization of treatment-related changes (...) . A patient with aphasia due to left frontal and temporal hemorrhages following traumatic brain injuries (TBI) more than three years earlier received 48 sessions of melody-based intervention. Behavioral measures improved and were maintained at the 8-week posttreatment follow-up. Resting-state fMRI data collected before and after treatment showed an increase in connectivity between motor speech control areas (bilateral supplementary motor areas and insulae) and RH language areas (inferior frontal gyrus

2018 Neural plasticity

174. Telerehabilitation for aphasia – protocol of a pragmatic, exploratory, pilot randomized controlled trial Full Text available with Trip Pro

Telerehabilitation for aphasia – protocol of a pragmatic, exploratory, pilot randomized controlled trial The Cochrane review on the effectiveness of speech and language therapy for aphasia following stroke suggests intensity of therapy is a key predictor for outcome. Current aphasia services cannot provide intervention at the intensity observed within trial contexts because of resource limitations. Telerehabilitation could widen access to speech-language pathologists (SLPs) in geographically (...) remote contexts and reduce the time spent on travel by the therapist and patient. The current academic literature within this field is in its infancy, with few trials of speech and language therapy (SLT) delivered by videoconference. Our pilot randomized controlled trial (RCT) will explore feasibility aspects and effectiveness of telerehabilitation for aphasia in addition to standard SLT.Our study is a pragmatic, exploratory, pilot randomized controlled trial, where participants will be randomized

2018 Trials Controlled trial quality: predicted high

175. Thalamic bacterial abscess presenting with hemiparesis and expressive aphasia Full Text available with Trip Pro

Thalamic bacterial abscess presenting with hemiparesis and expressive aphasia Brain abscesses are relative rare in the developing world, with an incidence of 2% of all space occupying lesions. Deep-seated abscesses such as thalamic and basal ganglia abscesses are much rarer than abscesses in other locations of the brain, comprising 1.3-6% of all brain abscesses. These abscesses may present with hemiparesis, and subcortical aphasia has only been reported in a few cases throughout the literature (...) . Here we present and discuss a case of thalamic brain abscess caused by S. anginosus that presented with subcortical aphasia.

2018 IDCases

176. Distinct [18F]THK5351 binding patterns in primary progressive aphasia variants Full Text available with Trip Pro

Distinct [18F]THK5351 binding patterns in primary progressive aphasia variants To assess the binding of the PET tracer [18F]THK5351 in patients with different primary progressive aphasia (PPA) variants and its correlation with clinical deficits. The majority of patients with nonfluent variant (NFV) and logopenic variant (LV) PPA have underlying tauopathy of the frontotemporal lobar or Alzheimer disease type, respectively, while patients with the semantic variant (SV) have predominantly

2018 European Journal of Nuclear Medicine and Molecular Imaging

177. Conduction Aphasia as Initial Manifestation of Tuberculous Meningitis Full Text available with Trip Pro

Conduction Aphasia as Initial Manifestation of Tuberculous Meningitis Conduction aphasia being the arcuate fasciculus of the site of structural injury is a speech disorder characterized by fluent, spontaneous speech and paraphasias, intact auditory comprehension, and limited repetition. One of the causes of stroke in young adults is the Mycobacterium tuberculosis (MTB) infection, which may cause cerebral ischemia secondary to artery obliteration. In this case report, we present a previously (...) healthy 24-year-old woman that presented with a sudden onset of aphasia; MTB was identified as the etiological agent. Tuberculous meningitis (TBM) has a wide range of clinical manifestations with aphasia being one of the rarest forms of initial presentation.

2018 Cureus

178. CSF Biomarkers of Neurodegeneration in Progressive Non-fluent Aphasia and Other Forms of Frontotemporal Dementia: Clues for Pathomechanisms? Full Text available with Trip Pro

CSF Biomarkers of Neurodegeneration in Progressive Non-fluent Aphasia and Other Forms of Frontotemporal Dementia: Clues for Pathomechanisms? Frontotemporal Dementia (FTD) encompasses distinct pathophysiologically heterogenous disorders with different genetic and cellular disease mechanisms. The objective of this study is to compare the constellation of biomarkers of neurodegeneration in the cerebrospinal fluid (CSF) to the FTD type categorized by clinical symptoms. We investigated the levels (...) of Phospho181-tau, Total-tau, Beta-amyloid1-42, Neurofilament light chain, and Progranulin in the CSF of n = 99 FTD patients regarding to the different subtypes of FTD, including semantic dementia (SD), progressive non-fluent aphasia (PNFA), behavioral variant FTD (bvFTD). We compared these groups to patients without neurodegenerative disorders and another cohort encompassing tauopathies with distinct clinical syndromes (Cortico basal syndrome and progressive supranuclear palsy) and logopenic PNFA (lPPA

2018 Frontiers in neurology

179. Therapy-Induced Neuroplasticity in Chronic Aphasia After Phonological Component Analysis: A Matter of Intensity Full Text available with Trip Pro

Therapy-Induced Neuroplasticity in Chronic Aphasia After Phonological Component Analysis: A Matter of Intensity Despite the growing evidence regarding the importance of intensity and dose in aphasia therapy, few well-controlled studies contrasting the effects of intensive and non-intensive treatment have been conducted to date. Phonological components analysis (PCA) treatment for anomia has been associated with improvements in some patients with chronic aphasia; however, the effect of treatment (...) reflects the need to suppress errors to improve naming. Thus, both short-term intensive and standard, non-intensive, PCA treatment can improve word retrieval in chronic aphasia, but neuroimaging data suggest that improved naming is associated with different neural activation patterns in the two treatment conditions.

2018 Frontiers in neurology

180. Unification of behavioural, computational and neural accounts of word production errors in post-stroke aphasia Full Text available with Trip Pro

Unification of behavioural, computational and neural accounts of word production errors in post-stroke aphasia Neuropsychological assessment, brain imaging and computational modelling have augmented our understanding of the multifaceted functional deficits in people with language disorders after stroke. Despite the volume of research using each technique, no studies have attempted to assimilate all three approaches in order to generate a unified behavioural-computational-neural model of post (...) -stroke aphasia. The present study included data from 53 participants with chronic post-stroke aphasia and merged: aphasiological profiles based on a detailed neuropsychological assessment battery which was analysed with principal component and correlational analyses; measures of the impairment taken from Dell's computational model of word production; and the neural correlates of both behavioural and computational accounts analysed by voxel-based correlational methodology. As a result, all three

2018 NeuroImage : Clinical

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