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Aphasia

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161. Event Related Potential Study of Language Interaction in Bilingual Aphasia Patients (Full text)

Event Related Potential Study of Language Interaction in Bilingual Aphasia Patients Half of the global population can be considered bilingual. Nevertheless when faced with patients with aphasia, clinicians and therapists usually ignore the patient's second language (L2) albeit its interference in first language (L1) processing has been shown. The excellent temporal resolution by which each individual linguistic component can be gaged during word-processing, promoted the event-related potential (...) (ERP) technique for studying language processing in healthy bilinguals and monolingual aphasia patients. However, this technique has not yet been applied in the context of bilingual aphasia. In the current study, we report on L2 interference in L1 processing using the ERP technique in bilingual aphasia. We tested four bilingual- and one trilingual patients with aphasia, as well as several young and older (age-matched with patients) healthy subjects as controls. We recorded ERPs when subjects were

2018 Frontiers in human neuroscience PubMed

162. Malignant atrophic papulosis with motor aphasia and intestinal perforation: A case report and review of published works (Full text)

Malignant atrophic papulosis with motor aphasia and intestinal perforation: A case report and review of published works Malignant atrophic papulosis (MAP) is a rare type of obliterating vasculopathy that can present as pure cutaneous lesions or a systemic entity affecting multiple organs. Systemic disease, such as gastrointestinal or central nervous system involvement, may predispose the patients to poorer or even fatal outcomes. We present a 30-year-old female patient with systemic (...) manifestation of MAP 10 days after delivery of a full-term pregnancy who subsequently developed motor aphasia and intestinal perforation. The patient was administrated empirical treatment with an antiplatelet, anticoagulant, methylprednisolone sodium succinate and alprostadil. Antibiotics were administrated due to intestinal perforation and secondary sepsis. Despite all treatment, the patient died a week later. We summarized all the previous reports of MAP based on thorough review of previous published work

2018 The Journal of dermatology PubMed

163. Molecular Neuroimaging in an Agraphia Predominant Primary Progressive Aphasia (Full text)

Molecular Neuroimaging in an Agraphia Predominant Primary Progressive Aphasia A 62-year-old male presented with progressive isolated writing and spelling difficulties. Neurological, neuropsychological, speech, and language evaluations identified only minimal additional abnormalities. The presenting characteristics did not meet criteria for any particular variant of primary progressive aphasia; his clinical presentation is best described as primary progressive aphasia, with a predominant, almost

2018 Neurocase PubMed

164. Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia. (PubMed)

Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia. To estimate the prevalence of amyloid positivity, defined by positron emission tomography (PET)/cerebrospinal fluid (CSF) biomarkers and/or neuropathological examination, in primary progressive aphasia (PPA) variants.We conducted a meta-analysis with individual participant data from 1,251 patients diagnosed with PPA (including logopenic [lvPPA, n = 443], nonfluent [nfvPPA, n = 333], semantic [svPPA, n = 401

2018 Annals of Neurology

165. Singing for people with aphasia (SPA): a protocol for a pilot randomised controlled trial of a group singing intervention to improve well-being. (Full text)

Singing for people with aphasia (SPA): a protocol for a pilot randomised controlled trial of a group singing intervention to improve well-being. The singing for people with aphasia (SPA) intervention aims to improve quality of life and well-being for people with poststroke aphasia. A definitive randomised controlled trial (RCT) is required to assess the clinical and cost effectiveness of SPA. The purpose of this pilot study is to assess the feasibility of such a definitive trial and inform its (...) design.A two-group, assessor-blinded, randomised controlled external pilot trial with parallel mixed methods process evaluation and economic evaluation. Forty-eight participants discharged from clinical speech and language therapy will be individually randomised 1:1 to SPA (10 group sessions plus a resource booklet) or control (resource booklet only). Outcome assessment at baseline, 3 and 6 months postrandomisation include: ICEpop CAPability measure for adults, Stroke and Aphasia Quality of Life, EQ-5D

2018 BMJ open PubMed

166. Parkinsonism is associated with altered primary motor cortex plasticity in frontotemporal dementia-primary progressive aphasia variant. (PubMed)

Parkinsonism is associated with altered primary motor cortex plasticity in frontotemporal dementia-primary progressive aphasia variant. In frontotemporal dementia (FTD), the behavioral variant (bv-FTD) and nonfluent variant of primary progressive aphasia (nfv-PPA) reflect a prominent neurodegenerative involvement of the frontal lobe networks, which may include the premotor and motor areas and thus cause heterogeneous clinical symptoms including parkinsonism. With the technique of transcranial

2018 Neurobiology of Aging

167. A 38-Year-Old Woman With Global Aphasia and Migraine. (PubMed)

A 38-Year-Old Woman With Global Aphasia and Migraine. A 38-year-old right-handed woman presented to the hospital with subtle right facial palsy and global aphasia of 4 days' duration. She found that she had aphasia when she suddenly woke up at midnight and reported a headache lasting for several hours. She had no fever, vomiting, seizures, or limb paralysis. She had had migraines with an occasional visual aura for > 10 years. She was not taking any medication and was a nondrinker and nonsmoker

2018 Chest

168. Retraining speech production and fluency in non-fluent/agrammatic primary progressive aphasia. (Full text)

Retraining speech production and fluency in non-fluent/agrammatic primary progressive aphasia. The non-fluent/agrammatic variant of primary progressive aphasia (nfvPPA) presents with a gradual decline in grammar and motor speech resulting from selective degeneration of speech-language regions in the brain. There has been considerable progress in identifying treatment approaches to remediate language deficits in other primary progressive aphasia variants; however, interventions for the core (...) deficits in nfvPPA have yet to be systematically investigated. Further, the neural mechanisms that support behavioural restitution in the context of neurodegeneration are not well understood. We examined the immediate and long-term benefits of video implemented script training for aphasia (VISTA) in 10 individuals with nfvPPA. The treatment approach involved repeated rehearsal of individualized scripts via structured treatment with a clinician as well as intensive home practice with an audiovisual

2018 Brain PubMed

169. <sup>18</sup>F-flortaucipir uptake patterns in clinical subtypes of primary progressive aphasia. (PubMed)

18F-flortaucipir uptake patterns in clinical subtypes of primary progressive aphasia. We analyzed 18F-flortaucipir uptake patterns and structural changes in patients with subtypes of primary progressive aphasia (PPA) using 18F-flortaucipir positron emission tomography and volumetric magnetic resonance imaging. We enrolled 34 consecutive patients with PPA (10 nonfluent/agrammatic PPA [nfvPPA], 18 semantic variant PPA [svPPA], and 6 logopenic variant PPA [lvPPA], as well as 20 healthy

2018 Neurobiology of Aging

170. Improving Electronic Written Communication in Aphasia

Improving Electronic Written Communication in Aphasia Improving Electronic Written Communication in Aphasia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Improving Electronic Written Communication (...) in Aphasia (T-WRITE) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03773419 Recruitment Status : Recruiting First Posted : December 12, 2018 Last Update Posted : December 12, 2018 See Sponsor: Shirley Ryan AbilityLab

2018 Clinical Trials

171. Efficacy of intensive aphasia therapy in patients with chronic stroke: a randomised controlled trial. (PubMed)

Efficacy of intensive aphasia therapy in patients with chronic stroke: a randomised controlled trial. Recent evidence has fuelled the debate on the role of massed practice in the rehabilitation of chronic post-stroke aphasia. Here, we further determined the optimal daily dosage and total duration of intensive speech-language therapy.Individuals with chronic aphasia more than 1 year post-stroke received Intensive Language-Action Therapy in a randomised, parallel-group, blinded-assessment (...) , controlled trial. Participants were randomly assigned to one of two outpatient groups who engaged in either highly-intensive practice (Group I: 4 hours daily) or moderately-intensive practice (Group II: 2 hours daily). Both groups went through an initial waiting period and two successive training intervals. Each phase lasted 2 weeks. Co-primary endpoints were defined after each training interval.Thirty patients-15 per group-completed the study. A primary outcome measure (Aachen Aphasia Test) revealed

2018 Journal of neurology, neurosurgery, and psychiatry

172. Transcranial Direct Current Stimulation Does Not Improve Language Outcome in Subacute Poststroke Aphasia. (PubMed)

Transcranial Direct Current Stimulation Does Not Improve Language Outcome in Subacute Poststroke Aphasia. The aim of the present study is to investigate the effect of transcranial direct current stimulation on word-finding treatment outcome in subacute poststroke aphasia.In this multi-center, double-blind, randomized controlled trial with 6-month follow-up, we included 58 patients with subacute aphasia (<3 months poststroke), who were enrolled in a stroke rehabilitation program. Patients

2018 Stroke

173. Transcranial Direct Current Stimulation Does Not Improve Language Outcome in Subacute Poststroke Aphasia. (PubMed)

Transcranial Direct Current Stimulation Does Not Improve Language Outcome in Subacute Poststroke Aphasia. The aim of the present study is to investigate the effect of transcranial direct current stimulation on word-finding treatment outcome in subacute poststroke aphasia.In this multi-center, double-blind, randomized controlled trial with 6-month follow-up, we included 58 patients with subacute aphasia (<3 months poststroke), who were enrolled in a stroke rehabilitation program. Patients

2018 Stroke

174. Computer therapy compared with usual care for people with long-standing aphasia poststroke: a pilot randomized controlled trial (Full text)

Computer therapy compared with usual care for people with long-standing aphasia poststroke: a pilot randomized controlled trial Computer therapy compared with usual care for people with long-standing aphasia poststroke: a pilot randomized controlled trial Computer therapy compared with usual care for people with long-standing aphasia poststroke: a pilot randomized controlled trial Palmer R, Enderby P, Cooper C, Latimer N, Julious S, Paterson G, Dimairo M, Dixon S, Mortley J, Hilton R, Delaney (...) aphasia after stroke. The authors concluded that their results indicated that the computer therapy was feasible and could be cost-effective, and it would be practical to recruit sufficient participants for a larger trial. There were issues with the reporting and methods, but the authors' conclusions appear to be appropriate for their objective. Type of economic evaluation Cost-utility analysis Study objective The objective was to assess the feasibility of conducting a randomised controlled trial

2012 NHS Economic Evaluation Database. PubMed

175. Therapeutic interventions for aphasia initiated more than six months post stroke: a review of the evidence

Therapeutic interventions for aphasia initiated more than six months post stroke: a review of the evidence Therapeutic interventions for aphasia initiated more than six months post stroke: a review of the evidence Therapeutic interventions for aphasia initiated more than six months post stroke: a review of the evidence Allen L, Mehta S, McClure JA, Teasell R CRD summary The authors concluded that there was evidence to support the use of several treatments for chronic aphasia post-stroke (...) , but further research was required. Most individual interventions were assessed by only one small study, reducing the reliability of the results, but the authors' overall conclusion is supported by the limited evidence available. Authors' objectives To assess the effectiveness of therapeutic interventions for aphasia, initiated more than six months post-stroke. Searching Multiple databases were searched for English language studies, including MEDLINE, EMBASE, CINAHL and Scopus; search terms were reported

2012 DARE.

176. Aphasia friendly resources launched to help researchers include stroke survivors with aphasia in their research

Aphasia friendly resources launched to help researchers include stroke survivors with aphasia in their research Aphasia friendly resources launched - The Stroke Elf Keeping you up to date with reliable stroke research, policy & guidance SEARCH Feb 18 2015 Posted by Around 20-30% of stroke survivors are thought to have aphasia: a specific difficulty with language. This can include problems speaking, finding words or understanding speech or written text. With almost one third of the stroke (...) population experiencing aphasia, it is important to ensure that they are not excluded from research. Excluding those with aphasia can affect how relevant the research is in clinical or ‘real world’ settings. Developing a very effective rehabilitation intervention, for example, may not be so effective if it cannot be accessed by and has not been researched in one third of the stroke population. A new set of resources has been developed by the ‘NIHR Clinical Research Network: Stroke’ to encourage and help

2015 The Stroke Elf

177. Aphasia friendly resources launched to help researchers include stroke survivors with aphasia in their research

Aphasia friendly resources launched to help researchers include stroke survivors with aphasia in their research Aphasia friendly resources launched - The Stroke Elf Keeping you up to date with reliable stroke research, policy & guidance SEARCH Feb 18 2015 Posted by Around 20-30% of stroke survivors are thought to have aphasia: a specific difficulty with language. This can include problems speaking, finding words or understanding speech or written text. With almost one third of the stroke (...) population experiencing aphasia, it is important to ensure that they are not excluded from research. Excluding those with aphasia can affect how relevant the research is in clinical or ‘real world’ settings. Developing a very effective rehabilitation intervention, for example, may not be so effective if it cannot be accessed by and has not been researched in one third of the stroke population. A new set of resources has been developed by the ‘NIHR Clinical Research Network: Stroke’ to encourage and help

2015 The Stroke Elf

178. Volunteer involvement in the support of self-managed computerised aphasia treatment: The volunteer perspective. (Full text)

Volunteer involvement in the support of self-managed computerised aphasia treatment: The volunteer perspective. The speech-language pathology profession has explored a number of approaches to support efficient delivery of interventions for people with stroke-induced aphasia. This study aimed to explore the role of volunteers in supporting self-managed practice of computerised language exercises.A qualitative interview study of the volunteer support role was carried out alongside a pilot (...) randomised controlled trial of computer aphasia therapy. Patients with aphasia practised computer exercises tailored for them by a speech-language pathologist at home regularly for 5 months. Eight of the volunteers who supported the intervention took part in semi-structured interviews. Interviews were audio recorded, transcribed verbatim and analysed thematically.Emergent themes included: training and support requirements; perception of the volunteer role; challenges facing the volunteer, in general

2017 International journal of speech-language pathology PubMed

179. Clinical study of acupuncture treatment on motor aphasia after stroke. (Full text)

Clinical study of acupuncture treatment on motor aphasia after stroke. To study the safety and effectiveness of the Heart-Gallbladder acupuncture treatment for motor aphasia after stroke via clinical studies.Sixty valid patients were divided into two groups randomly with a ratio of 1:1. The treatment group was the Heart-Gallbladder acupuncture group and the control group was the conventional acupuncture group. The two groups underwent testing before and after treatments, which included (...) : the Aphasia Battery of Chinese (ABC), the Chinese functional communication profile (CFCP), and the Boston diagnostic aphasia examination (BDAE).All the BDAE, CFCP and ABC results showed a significant difference between the two groups after treatment (P< 0.05), indicating that the Heart-Gallbladder acupuncture treatment for motor aphasia after stroke can reduce the degree of aphasia and improve patients' daily communication skills more than the conventional acupuncture treatment. The Heart-Gallbladder

2017 Technology and health care : official journal of the European Society for Engineering and Medicine PubMed

180. Using language for social interaction: Communication mechanisms promote recovery from chronic non-fluent aphasia. (Full text)

Using language for social interaction: Communication mechanisms promote recovery from chronic non-fluent aphasia. Clinical research highlights the importance of massed practice in the rehabilitation of chronic post-stroke aphasia. However, while necessary, massed practice may not be sufficient for ensuring progress in speech-language therapy. Motivated by recent advances in neuroscience, it has been claimed that using language as a tool for communication and social interaction leads (...) to synergistic effects in left perisylvian eloquent areas. Here, we conducted a crossover randomized controlled trial to determine the influence of communicative language function on the outcome of intensive aphasia therapy.Eighteen individuals with left-hemisphere lesions and chronic non-fluent aphasia each received two types of training in counterbalanced order: (i) Intensive Language-Action Therapy (ILAT, an extended form of Constraint-Induced Aphasia Therapy) embedding verbal utterances in the context

2017 Cortex; a journal devoted to the study of the nervous system and behavior PubMed

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