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Aphasia

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141. [18F]AV-1451 tau-PET and primary progressive aphasia. Full Text available with Trip Pro

[18F]AV-1451 tau-PET and primary progressive aphasia. To assess [18 F]AV-1451 tau-PET (positron emission tomography) uptake patterns across the primary progressive aphasia (PPA) variants (logopenic, semantic, and agrammatic), examine regional uptake patterns of [18 F]AV-1451 independent of clinical diagnosis, and compare the diagnostic utility of [18 F]AV-1451, [18 F]-fluorodeoxygluclose (FDG)-PET and MRI (magnetic resonance imaging) to differentiate the PPA variants.We performed statistical

2018 Annals of Neurology

142. Cerebral microbleeds and CSF Alzheimer biomarkers in primary progressive aphasias. (Abstract)

Cerebral microbleeds and CSF Alzheimer biomarkers in primary progressive aphasias. To reveal the prevalence and localization of cerebral microbleeds (CMBs) in the 3 main variants of primary progressive aphasia (PPA) (logopenic, semantic, and nonfluent/agrammatic), to identify the relationship with underlying Alzheimer pathology, and to explore whether CMBs contribute to language breakdown.We used a cross-sectional design in a multicenter cohort of 82 patients with PPA and 19 similarly aged

2018 Neurology

143. Time for a quick word? The striking benefits of training speed and accuracy of word retrieval in post-stroke aphasia. Full Text available with Trip Pro

Time for a quick word? The striking benefits of training speed and accuracy of word retrieval in post-stroke aphasia. One-third of stroke survivors experience deficits in word retrieval as a core characteristic of their aphasia, which is frustrating, socially limiting and disabling for their professional and everyday lives. The, as yet, undiscovered 'holy grail' of clinical practice is to establish a treatment that not only improves item naming, but also generalizes to patients' connected (...) -focused treatment. Both treatments were evaluated for naming, connected speech outcomes, and related to participants' neuropsychological and lesion profiles. Twenty participants with post-stroke chronic aphasia of varying severity and subtype took part in 12 computer-based treatment sessions over 6 weeks. Four carefully matched word sets were randomly allocated either to the speed- and accuracy-focused treatment, standard accuracy-only treatment, or untreated (two control sets). In the standard

2018 Brain

144. Atrophy and microglial distribution in primary progressive aphasia with TDP-43. Full Text available with Trip Pro

Atrophy and microglial distribution in primary progressive aphasia with TDP-43. To quantitatively determine the density and distribution of activated microglia across cortical regions and hemispheres in the brains of primary progressive aphasia (PPA) participants with pathological diagnoses of frontotemporal lobar degeneration with transactive response DNA-binding protein-43 (TDP-43) inclusions and to examine the relationships between microglial densities, patterns of focal atrophy, (TDP-43

2018 Annals of Neurology

145. Anatomy of aphasia revisited. Full Text available with Trip Pro

Anatomy of aphasia revisited. In most cases, aphasia is caused by strokes involving the left hemisphere, with more extensive damage typically being associated with more severe aphasia. The classical model of aphasia commonly adhered to in the Western world is the Wernicke-Lichtheim model. The model has been in existence for over a century, and classification of aphasic symptomatology continues to rely on it. However, far more detailed models of speech and language localization in the brain have (...) been formulated. In this regard, the dual stream model of cortical brain organization proposed by Hickok and Poeppel is particularly influential. Their model describes two processing routes, a dorsal stream and a ventral stream, that roughly support speech production and speech comprehension, respectively, in normal subjects. Despite the strong influence of the dual stream model in current neuropsychological research, there has been relatively limited focus on explaining aphasic symptoms

2018 Brain

146. Tablet-based Aphasia Therapy in the Acute Phase After Stroke

Tablet-based Aphasia Therapy in the Acute Phase After Stroke Tablet-based Aphasia Therapy in the Acute Phase After Stroke - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Tablet-based Aphasia Therapy (...) , Ghent Information provided by (Responsible Party): Neurologie, University Hospital, Ghent Study Details Study Description Go to Brief Summary: As aphasia is one of the most common and disabling disorders following stroke, in many cases resolving in long-term deficits, it is now thought that intensive aphasia therapy is effective, even in the chronic phase following stroke. However, as intensive aphasia rehabilitation is difficult to achieve in clinical practice, tablet-based aphasia therapies

2018 Clinical Trials

147. Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Chronic Aphasia

Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Chronic Aphasia Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Chronic Aphasia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Chronic Aphasia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03651700 Recruitment Status : Recruiting

2018 Clinical Trials

148. Development and Feasibility Analysis of Verbal Expressive Skills Management Programme (VESMP) for Patients With Broca Aphasia

of satisfaction of aphasic stroke patients.Control group received traditional therapy and experimental group received therapy through VESMP programme on their smart phones. Condition or disease Intervention/treatment Phase Aphasia, Broca Stroke Other: VESMP Other: Traditional Therapy Not Applicable Detailed Description: Speech therapy makes an integral part of the non-pharmacological, conservative management of Post stroke aphasia. Routine speech therapy aims to improve comprehension and verbal skills (...) using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 40 Years to 60 Years (Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: The 40-60 year Broca aphasia patients The severe Broca aphasia patients (more than 03 month of onset of stroke) Both infarct and hemorrhagic stroke Either gender Informed consent Exclusion Criteria: • Broca Aphasic patients having cognitive impairment

2018 Clinical Trials

149. Validation of a prediction model for long-term outcome of aphasia after stroke. Full Text available with Trip Pro

Validation of a prediction model for long-term outcome of aphasia after stroke. About 30% of stroke patients suffer from aphasia. As aphasia strongly affects daily life, most patients request a prediction of outcome of their language function. Prognostic models provide predictions of outcome, but external validation is essential before models can be used in clinical practice. We aim to externally validate the prognostic model from the Sequential Prognostic Evaluation of Aphasia after stroKe (...) (SPEAK-model) for predicting the long-term outcome of aphasia caused by stroke.We used data from the Rotterdam Aphasia Therapy Study - 3 (RATS-3), a multicenter RCT with inclusion criteria similar to SPEAK, an observational prospective study. Baseline assessment in SPEAK was four days after stroke and in RATS-3 eight days. Outcome of the SPEAK-model was the Aphasia Severity Rating Scale (ASRS) at 1 year, dichotomized into good (ASRS-score of 4 or 5) and poor outcome (ASRS-score < 4). In RATS-3, ASRS

2018 BMC Neurology

150. Accessibility and Applicability of Currently Available e-Mental Health Programs for Depression for People With Poststroke Aphasia: Scoping Review. Full Text available with Trip Pro

Accessibility and Applicability of Currently Available e-Mental Health Programs for Depression for People With Poststroke Aphasia: Scoping Review. Depression affects approximately 60% of people with aphasia 1 year post stroke and is associated with disability, lower quality of life, and mortality. Web-delivered mental health (e-mental health) programs are effective, convenient, and cost-effective for the general population and thus are increasingly used in the management of depression. However (...) , (2) communicative accessibility for people with aphasia via an aphasia-specific communicative accessibility evaluation tool, and (3) empirical evidence for the general population and stroke survivors with and without aphasia. The program that met the most general evaluation criteria and aphasia-specific communicative accessibility evaluation criteria was then trialed by a small subgroup of people with poststroke aphasia.A total of 8 programs were identified. Of these, 4 had published evidence

2018 Journal of medical Internet research

151. Brain networks' functional connectivity separates aphasic deficits in stroke. Full Text available with Trip Pro

Brain networks' functional connectivity separates aphasic deficits in stroke. To investigate whether different language deficits are distinguished by the relative strengths of their association with the functional connectivity (FC) at rest of the language network (LN) and cingulo-opercular network (CON) after aphasic stroke.In a group of patients with acute stroke and left-hemisphere damage, we identified 3 distinct, yet correlated, clusters of deficits including comprehension/lexical semantic

2018 Neurology

152. Transcranial Direct Current Stimulation (tDCS) and Intensive Therapy in Aphasia

Transcranial Direct Current Stimulation (tDCS) and Intensive Therapy in Aphasia Transcranial Direct Current Stimulation (tDCS) and Intensive Therapy in Aphasia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Transcranial Direct Current Stimulation (tDCS) and Intensive Therapy in Aphasia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03510182 Recruitment Status : Recruiting First Posted : April 27, 2018 Last Update Posted : April 27

2018 Clinical Trials

153. Analysis of Brain Activity to Uncover Brain-behavior Relationships Related to Therapy Outcomes in Aphasia

Analysis of Brain Activity to Uncover Brain-behavior Relationships Related to Therapy Outcomes in Aphasia Analysis of Brain Activity to Uncover Brain-behavior Relationships Related to Therapy Outcomes in Aphasia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Analysis of Brain Activity to Uncover Brain-behavior Relationships Related to Therapy Outcomes in Aphasia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03550092

2018 Clinical Trials

154. Transcranial Magnetic Stimulation in Primary Progressive Aphasia

Transcranial Magnetic Stimulation in Primary Progressive Aphasia Transcranial Magnetic Stimulation in Primary Progressive Aphasia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Transcranial Magnetic (...) Stimulation in Primary Progressive Aphasia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03580954 Recruitment Status : Recruiting First Posted : July 10, 2018 Last Update Posted : July 11, 2018 See Sponsor: Hospital San

2018 Clinical Trials

155. Effect of Music on Reading Comprehension in Patients With Aphasia

Effect of Music on Reading Comprehension in Patients With Aphasia Effect of Music on Reading Comprehension in Patients With Aphasia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect of Music on Reading (...) Comprehension in Patients With Aphasia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03600987 Recruitment Status : Enrolling by invitation First Posted : July 26, 2018 Last Update Posted : August 22, 2018 Sponsor: Carilion Clinic Information provided by (Responsible Party): Jacqueline Treichler, Carilion

2018 Clinical Trials

156. Tablet-based Aphasia Therapy in the Chronic Phase

Tablet-based Aphasia Therapy in the Chronic Phase Tablet-based Aphasia Therapy in the Chronic Phase - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Tablet-based Aphasia Therapy in the Chronic Phase (...) by (Responsible Party): Neurologie, University Hospital, Ghent Study Details Study Description Go to Brief Summary: Aphasia is one of the most common and disabling disorders following stroke, in many cases resolving in long-term deficits. There is evidence that intensive aphasia therapy is effective for language recovery, even in the chronic phase post-stroke. However, as many patients are left with residual language disorders and intensive aphasia rehabilitation is difficult to achieve, the investigators

2018 Clinical Trials

157. The Effect of Venlafaxine on Language Function in Patients With Subcortical Aphasia: A fMRI Study

The Effect of Venlafaxine on Language Function in Patients With Subcortical Aphasia: A fMRI Study The Effect of Venlafaxine on Language Function in Patients With Subcortical Aphasia: A fMRI Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. The Effect of Venlafaxine on Language Function in Patients With Subcortical Aphasia: A fMRI Study The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03588572 Recruitment Status

2018 Clinical Trials

158. Strategy Training for People With Aphasia After Stroke

Strategy Training for People With Aphasia After Stroke Strategy Training for People With Aphasia After Stroke - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Strategy Training for People With Aphasia After (...) the design of future inclusive clinical trials seeking to reduce disability after stroke. Condition or disease Intervention/treatment Phase Strategy Training Behavioral: Strategy Training Not Applicable Detailed Description: This pilot study will use a descriptive case series design with repeated measures to assess the feasibility of an adapted form of strategy training for people with communication impairments after acute stroke. The investigators will recruit people with aphasia due to stroke admitted

2018 Clinical Trials

159. Combining Language Therapy With rTMS in Aphasia

Combining Language Therapy With rTMS in Aphasia Combining Language Therapy With rTMS in Aphasia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Combining Language Therapy With rTMS in Aphasia (ILAT+rTMS (...) by (Responsible Party): Paula Heikkinen, Helsinki University Study Details Study Description Go to Brief Summary: With the present RCT, the investigators aimed at finding an optimal protocol for the neurorehabilitation of chronic post-stroke aphasia by combining two promising methods, ILAT (Intensive language action therapy) and 1-Hz rTMS to the right-hemispheric homologue of the anterior language area of Broca (pars triangularis), thus taking advantage of recent research in speech and language sciences

2018 Clinical Trials

160. The Intensive Comprehensive Aphasia Program (ICAP)

The Intensive Comprehensive Aphasia Program (ICAP) The Intensive Comprehensive Aphasia Program (ICAP) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Intensive Comprehensive Aphasia Program (ICAP (...) Information provided by (Responsible Party): Leora Cherney, Shirley Ryan AbilityLab Study Details Study Description Go to Brief Summary: The purpose of this study is to conduct a randomized clinical trial that assesses the efficacy and cost-effectiveness of an Intensive Comprehensive Aphasia Program (ICAP), specifically focusing on the variable of intensity. Half of the participants will receive 60 hours of intensive treatment over three weeks, while the other half will receive the same amount and type

2018 Clinical Trials

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