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Aphasia

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121. Analysis of Brain Activity to Uncover Brain-behavior Relationships Related to Therapy Outcomes in Aphasia

Analysis of Brain Activity to Uncover Brain-behavior Relationships Related to Therapy Outcomes in Aphasia Analysis of Brain Activity to Uncover Brain-behavior Relationships Related to Therapy Outcomes in Aphasia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Analysis of Brain Activity to Uncover Brain-behavior Relationships Related to Therapy Outcomes in Aphasia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03550092

2018 Clinical Trials

122. The Effect of Venlafaxine on Language Function in Patients With Subcortical Aphasia: A fMRI Study

The Effect of Venlafaxine on Language Function in Patients With Subcortical Aphasia: A fMRI Study The Effect of Venlafaxine on Language Function in Patients With Subcortical Aphasia: A fMRI Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. The Effect of Venlafaxine on Language Function in Patients With Subcortical Aphasia: A fMRI Study The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03588572 Recruitment Status

2018 Clinical Trials

123. Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Chronic Aphasia

Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Chronic Aphasia Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Chronic Aphasia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Chronic Aphasia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03651700 Recruitment Status : Recruiting

2018 Clinical Trials

124. Transcranial Magnetic Stimulation in Primary Progressive Aphasia

Transcranial Magnetic Stimulation in Primary Progressive Aphasia Transcranial Magnetic Stimulation in Primary Progressive Aphasia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Transcranial Magnetic (...) Stimulation in Primary Progressive Aphasia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03580954 Recruitment Status : Recruiting First Posted : July 10, 2018 Last Update Posted : July 11, 2018 See Sponsor: Hospital San

2018 Clinical Trials

125. Tablet-based Aphasia Therapy in the Acute Phase After Stroke

Tablet-based Aphasia Therapy in the Acute Phase After Stroke Tablet-based Aphasia Therapy in the Acute Phase After Stroke - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Tablet-based Aphasia Therapy (...) , Ghent Information provided by (Responsible Party): Neurologie, University Hospital, Ghent Study Details Study Description Go to Brief Summary: As aphasia is one of the most common and disabling disorders following stroke, in many cases resolving in long-term deficits, it is now thought that intensive aphasia therapy is effective, even in the chronic phase following stroke. However, as intensive aphasia rehabilitation is difficult to achieve in clinical practice, tablet-based aphasia therapies

2018 Clinical Trials

126. Development and Feasibility Analysis of Verbal Expressive Skills Management Programme (VESMP) for Patients With Broca Aphasia

Development and Feasibility Analysis of Verbal Expressive Skills Management Programme (VESMP) for Patients With Broca Aphasia Development and Feasibility Analysis of Verbal Expressive Skills Management Programme (VESMP) for Patients With Broca Aphasia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached (...) the maximum number of saved studies (100). Please remove one or more studies before adding more. Development and Feasibility Analysis of Verbal Expressive Skills Management Programme (VESMP) for Patients With Broca Aphasia (VESMP) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03699605 Recruitment Status

2018 Clinical Trials

127. rTMS for the Treatment of Primary Progressive Aphasia: A Randomized Controlled Trial

rTMS for the Treatment of Primary Progressive Aphasia: A Randomized Controlled Trial rTMS for the Treatment of Primary Progressive Aphasia: A Randomized Controlled Trial - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. rTMS for the Treatment of Primary Progressive Aphasia: A Randomized Controlled Trial The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03448133 Recruitment Status : Not yet recruiting First Posted : February 27

2018 Clinical Trials

128. Telerehabilitation Combined Speech-Language and Cognitive Training Effectively Promoted Recovery in Aphasia Patients. (PubMed)

Telerehabilitation Combined Speech-Language and Cognitive Training Effectively Promoted Recovery in Aphasia Patients. The present study investigated the efficacy of a computerized intervention for aphasia that combined speech-language and cognitive training delivered on an inpatient unit or via telerehabilitation to discharged patients. Forty inpatient and discharged aphasia patients were recruited and randomly assigned to the training group or control group. Computerized speech-language (...) and cognitive training was provided for 14 days to the inpatients and 30 days to the discharged patients. Compared with the control group, training group had significantly more improved language function as assessed by the Western Aphasia Battery (WAB) and practical communication skills as assessed by the Communicative Abilities in Daily Living Test (CADL). It was also found that the positive effects of the computerized training when delivered via telerehabilitation to the discharged group were smaller than

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2018 Frontiers in psychology

129. 'What's cooking?' A comparison of an activity-oriented and a table-top programme of therapy on the language performance of people with aphasia. (PubMed)

'What's cooking?' A comparison of an activity-oriented and a table-top programme of therapy on the language performance of people with aphasia. Many people with aphasia have word-finding difficulties, with some showing particular difficulties with verbs. Picture-naming therapy is often used to improve naming, but gains are usually limited to therapy items and do not transfer to conversation. Therapy where words are produced in sentences and in real-life activities may be more effective.The (...) in spoken narratives. Participants predominantly chose positive terms to describe their experience of the programme, but did not prefer one therapy over the other.Preliminary findings suggest that an activity-oriented therapy approach, whether it involves carrying out tasks or paper-based activities, can result in clinically meaningful improvements for people with chronic aphasia. Further research using a randomized control trial is required to determine whether cooking therapy alone is effective.© 2018

2018 International Journal of Language & Communication Disorders

130. Sensitivity of Speech Output to Delayed Auditory Feedback in Primary Progressive Aphasias (PubMed)

Sensitivity of Speech Output to Delayed Auditory Feedback in Primary Progressive Aphasias Delayed auditory feedback (DAF) is a classical paradigm for probing sensori-motor interactions in speech output and has been studied in various disorders associated with speech dysfluency and aphasia. However, little information is available concerning the effects of DAF on degenerating language networks in primary progressive aphasia: the paradigmatic "language-led dementias." Here we studied two forms (...) of speech output (reading aloud and propositional speech) under natural listening conditions (no feedback delay) and under DAF at 200 ms, in a cohort of 19 patients representing all major primary progressive aphasia syndromes vs. healthy older individuals and patients with other canonical dementia syndromes (typical Alzheimer's disease and behavioral variant frontotemporal dementia). Healthy controls and most syndromic groups showed a quantitatively or qualitatively similar profile of reduced speech

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2018 Frontiers in neurology

131. Recovernow: A Multicentre Of Tablet-Based Speech Therapy For Post-Stroke Aphasia

Recovernow: A Multicentre Of Tablet-Based Speech Therapy For Post-Stroke Aphasia Recovernow: Tablet-Based Speech Therapy For Post-Stroke Aphasia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Recovernow (...) : Tablet-Based Speech Therapy For Post-Stroke Aphasia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03755063 Recruitment Status : Not yet recruiting First Posted : November 27, 2018 Last Update Posted : March 5, 2019 See

2018 Clinical Trials

132. The effect of low-frequency repetitive transcranial magnetic stimulation (rTMS) on the treatment of aphasia caused by cerebrovascular accident (CVA) (PubMed)

The effect of low-frequency repetitive transcranial magnetic stimulation (rTMS) on the treatment of aphasia caused by cerebrovascular accident (CVA) Background: Aphasia is a common outcome of Cerebrovascular Accident (CVA) in which clinical interventions have limited effectiveness. Some evidence suggests that noninvasive stimulation of the brain can have beneficial effects in the treatment of CVA induced aphasia. In patients with motor aphasia, repetitive Transcranial Magnetic Stimulation (rTMS (...) ) is used to facilitate long-term improvement in speech ability. Since identifying effective methods for treating CVA induced aphasia can be very important in subsequent decision-making and treatment interventions, the objective of this study was to evaluate the effect of low-frequency TMS in Broca's area in the right hemisphere on the treatment of CVA induced motor aphasia. Methods: This clinical trial enrolled 24 patients with a clinical diagnosis of motor aphasia caused by CVA using convenient

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2018 Medical journal of the Islamic Republic of Iran

133. Unification of behavioural, computational and neural accounts of word production errors in post-stroke aphasia (PubMed)

Unification of behavioural, computational and neural accounts of word production errors in post-stroke aphasia Neuropsychological assessment, brain imaging and computational modelling have augmented our understanding of the multifaceted functional deficits in people with language disorders after stroke. Despite the volume of research using each technique, no studies have attempted to assimilate all three approaches in order to generate a unified behavioural-computational-neural model of post (...) -stroke aphasia. The present study included data from 53 participants with chronic post-stroke aphasia and merged: aphasiological profiles based on a detailed neuropsychological assessment battery which was analysed with principal component and correlational analyses; measures of the impairment taken from Dell's computational model of word production; and the neural correlates of both behavioural and computational accounts analysed by voxel-based correlational methodology. As a result, all three

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2018 NeuroImage : Clinical

134. Changes in Resting-State Connectivity following Melody-Based Therapy in a Patient with Aphasia (PubMed)

Changes in Resting-State Connectivity following Melody-Based Therapy in a Patient with Aphasia Melody-based treatments for patients with aphasia rely on the notion of preserved musical abilities in the RH, following left hemisphere damage. However, despite evidence for their effectiveness, the role of the RH is still an open question. We measured changes in resting-state functional connectivity following melody-based intervention, to identify lateralization of treatment-related changes (...) . A patient with aphasia due to left frontal and temporal hemorrhages following traumatic brain injuries (TBI) more than three years earlier received 48 sessions of melody-based intervention. Behavioral measures improved and were maintained at the 8-week posttreatment follow-up. Resting-state fMRI data collected before and after treatment showed an increase in connectivity between motor speech control areas (bilateral supplementary motor areas and insulae) and RH language areas (inferior frontal gyrus

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2018 Neural plasticity

135. Relative contributions of lesion location and lesion size to predictions of varied language deficits in post-stroke aphasia (PubMed)

Relative contributions of lesion location and lesion size to predictions of varied language deficits in post-stroke aphasia Despite the widespread use of lesion-symptom mapping (LSM) techniques to study associations between location of brain damage and language deficits, the prediction of language deficits from lesion location remains a substantial challenge. The present study examined several factors which may impact lesion-symptom prediction by (1) testing the relative predictive advantage (...) lesion location. For both VLSM and SCCAN, overall aphasia severity (Western Aphasia Battery Aphasia Quotient) and object naming deficits were primarily predicted by lesion size, whereas deficits in Speech Production and Speech Recognition were better predicted by a combination of lesion size and location. The implementation of both VLSM and SCCAN raises important considerations regarding controlling for lesion size in lesion-symptom mapping analyses. These findings suggest that lesion-symptom

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2018 NeuroImage : Clinical

136. Robotic Arm Rehabilitation in Chronic Stroke Patients With Aphasia May Promote Speech and Language Recovery (but Effect Is Not Enhanced by Supplementary tDCS) (PubMed)

Robotic Arm Rehabilitation in Chronic Stroke Patients With Aphasia May Promote Speech and Language Recovery (but Effect Is Not Enhanced by Supplementary tDCS) Objective: This study aimed to determine the extent to which robotic arm rehabilitation for chronic stroke may promote recovery of speech and language function in individuals with aphasia. Methods: We prospectively enrolled 17 individuals from a hemiparesis rehabilitation study pairing intensive robot assisted therapy with sham or active (...) tDCS and evaluated their speech (N = 17) and language (N = 9) performance before and after a 12-week (36 session) treatment regimen. Performance changes were evaluated with paired t-tests comparing pre- and post-test measures. There was no speech therapy included in the treatment protocol. Results: Overall, the individuals significantly improved on measures of motor speech production from pre-test to post-test. Of the subset who performed language testing (N = 9), overall aphasia severity

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2018 Frontiers in neurology

137. CNKSR2 mutation causes the X-linked epilepsy-aphasia syndrome: A case report and review of literature (PubMed)

CNKSR2 mutation causes the X-linked epilepsy-aphasia syndrome: A case report and review of literature The mutation in CNKSR2 leads to a broad spectrum of phenotypic variability and manifests as an X-linked intellectual disability. However, we reported that the male patient in this study not only had intellectual disability but also epileptic seizures. In addition, there were progressive language impairment, attention deficit hyperactivity disorder and autism. Electroencephalograms showed (...) continuous spike-and-wave during sleep. Genetic testing revealed a de novo mutation of the CNKSR2 gene (c.2185C>T, p.Arg729Ter) in the child that was not detected in the parents. Therefore, the child was diagnosed with X-linked epilepsy aphasia syndrome. Deletion of the CNKSR2 gene has been rarely reported in epilepsy aphasia syndrome, but no de novo mutation has been found in this gene. This report not only adds to the spectrum of epilepsy aphasia syndrome but also helps clinicians in diagnosis

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2018 World journal of clinical cases

138. Relating resting-state hemodynamic changes to the variable language profiles in post-stroke aphasia (PubMed)

Relating resting-state hemodynamic changes to the variable language profiles in post-stroke aphasia Linking both structural lesions and the functional integrity of remaining brain tissue to patients' behavioural profile may be critical in discovering the limits of behavioural recovery post stroke. In the present study, we explored the relationship between temporal hemodynamic changes and language performance in chronic post-stroke aphasia. We collected detailed language and neuropsychological (...) data for 66 patients with chronic (>1 year) post-stroke aphasia. We used principal component analysis to extract their core language-neuropsychological features. From resting-state fMRI scans in 35 patients, we calculated the lag in the time-course of the intact brain voxels in each patient. Finally, variation across the language-cognitive factors was related to both the patients' structural damage and the time-course changes in each patient's intact tissue. Phonological abilities were correlated

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2018 NeuroImage : Clinical

139. Clinical, Anatomical, and Pathological Features in the Three Variants of Primary Progressive Aphasia: A Review (PubMed)

Clinical, Anatomical, and Pathological Features in the Three Variants of Primary Progressive Aphasia: A Review Primary progressive aphasias (PPA) are neurodegenerative diseases clinically characterized by an early and relatively isolated language impairment. Three main clinical variants, namely the nonfluent/agrammatic variant (nfvPPA), the semantic variant (svPPA), and the logopenic variant (lvPPA) have been described, each with specific linguistic/cognitive deficits, corresponding anatomical

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2018 Frontiers in neurology

140. The Association Between Post-stroke Depression, Aphasia, and Physical Independence in Stroke Patients at 3-Month Follow-Up (PubMed)

The Association Between Post-stroke Depression, Aphasia, and Physical Independence in Stroke Patients at 3-Month Follow-Up Objective: Few studies have examined the association between post-stroke depression (PSD), aphasia, and physical independence in Chinese patients. This study investigated the above association in stroke patients in China at 3-month follow-up. Methods: Altogether 270 patients within 14 days after ischemic stroke were recruited and followed up at 3 months. PSD, aphasia (...) , and physical functional status were measured using the Stroke Aphasia Depression Questionnaire (SADQ), Western Aphasia Battery (WAB), and modified Rankin Scale (mRS), respectively. Patients with mRS total score >2 were considered as having "physical dependence." Results: Out of 248 patients at 3-month follow up, 119 (48%) were rated as having physical dependence. Multiple logistic regression analyses revealed that female (p = 0.04; OR = 2.2; 95% CI: 1.0-5.1), more severe stroke at admission (p < 0.01

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2018 Frontiers in Psychiatry

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