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Aphasia

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81. Comparing linguistic complexity and efficiency in conversations from stimulation and conversation therapy in aphasia. (Abstract)

Comparing linguistic complexity and efficiency in conversations from stimulation and conversation therapy in aphasia. Efficacy studies have demonstrated the benefit of group conversation therapy for a person with aphasia (PWA). However, a PWA typically participates in individual therapy prior to group therapy. Stimulation therapy (ST) is the most common type of individual aphasia therapy. Ultimately, the outcome of therapy is to enable the PWA to communicate effectively with others, which

2018 International Journal of Language & Communication Disorders Controlled trial quality: uncertain

82. Does communication partner training improve the conversation skills of speech-language pathology students when interacting with people with aphasia? Full Text available with Trip Pro

Does communication partner training improve the conversation skills of speech-language pathology students when interacting with people with aphasia? Aphasia is a common consequence of stroke. Despite receiving specialised training in communication, speech-language pathology students may lack confidence when communicating with People with Aphasia (PWA). This paper reports data from secondary outcome measures from a randomised controlled trial.The aim of the current study was to examine

2018 Journal of communication disorders Controlled trial quality: uncertain

83. Treatment integrity of elaborated semantic feature analysis aphasia therapy delivered in individual and group settings. Full Text available with Trip Pro

Treatment integrity of elaborated semantic feature analysis aphasia therapy delivered in individual and group settings. This study ran within the framework of the Thales Aphasia Project that investigated the efficacy of elaborated semantic feature analysis (ESFA). We evaluated the treatment integrity (TI) of ESFA, i.e., the degree to which therapists implemented treatment as intended by the treatment protocol, in two different formats: individual and group therapy.Based on the ESFA manual (...) , observation of therapy videos and TI literature, we developed two ESFA integrity checklists, for individual and group therapy, and used them to rate 15 videos of therapy sessions, delivered by three speech-language therapists (SLTs). Thirteen people with aphasia (PwA) were involved in this study. Reliability of the checklists was checked using Kappa statistics. Each session's TI was calculated. Differences in TI scores between the two therapy approaches were calculated using independent sample t-tests

2018 International Journal of Language & Communication Disorders Controlled trial quality: uncertain

84. <sup>18</sup>F-flortaucipir uptake patterns in clinical subtypes of primary progressive aphasia. (Abstract)

18F-flortaucipir uptake patterns in clinical subtypes of primary progressive aphasia. We analyzed 18F-flortaucipir uptake patterns and structural changes in patients with subtypes of primary progressive aphasia (PPA) using 18F-flortaucipir positron emission tomography and volumetric magnetic resonance imaging. We enrolled 34 consecutive patients with PPA (10 nonfluent/agrammatic PPA [nfvPPA], 18 semantic variant PPA [svPPA], and 6 logopenic variant PPA [lvPPA], as well as 20 healthy

2018 Neurobiology of Aging

85. Improving Electronic Written Communication in Aphasia

Improving Electronic Written Communication in Aphasia Improving Electronic Written Communication in Aphasia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Improving Electronic Written Communication (...) in Aphasia (T-WRITE) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03773419 Recruitment Status : Recruiting First Posted : December 12, 2018 Last Update Posted : December 12, 2018 See Sponsor: Shirley Ryan AbilityLab

2018 Clinical Trials

86. Singing for people with aphasia (SPA): a protocol for a pilot randomised controlled trial of a group singing intervention to improve well-being. Full Text available with Trip Pro

Singing for people with aphasia (SPA): a protocol for a pilot randomised controlled trial of a group singing intervention to improve well-being. The singing for people with aphasia (SPA) intervention aims to improve quality of life and well-being for people with poststroke aphasia. A definitive randomised controlled trial (RCT) is required to assess the clinical and cost effectiveness of SPA. The purpose of this pilot study is to assess the feasibility of such a definitive trial and inform its (...) design.A two-group, assessor-blinded, randomised controlled external pilot trial with parallel mixed methods process evaluation and economic evaluation. Forty-eight participants discharged from clinical speech and language therapy will be individually randomised 1:1 to SPA (10 group sessions plus a resource booklet) or control (resource booklet only). Outcome assessment at baseline, 3 and 6 months postrandomisation include: ICEpop CAPability measure for adults, Stroke and Aphasia Quality of Life, EQ-5D

2018 BMJ open Controlled trial quality: predicted high

87. The Incidence of Aphasia, Dysarthria and Dysphagia Following Stroke

The Incidence of Aphasia, Dysarthria and Dysphagia Following Stroke The Incidence of Aphasia, Dysarthria and Dysphagia Following Stroke - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Incidence (...) of Aphasia, Dysarthria and Dysphagia Following Stroke The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03472625 Recruitment Status : Recruiting First Posted : March 21, 2018 Last Update Posted : March 26, 2018 See Sponsor

2018 Clinical Trials

88. The Usage of High-resolution Magnetic Resonance Imaging in Patients With Post-stroke Aphasia for Predicting the Outcome

The Usage of High-resolution Magnetic Resonance Imaging in Patients With Post-stroke Aphasia for Predicting the Outcome The Usage of High-resolution Magnetic Resonance Imaging in Patients With Post-stroke Aphasia for Predicting the Outcome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. The Usage of High-resolution Magnetic Resonance Imaging in Patients With Post-stroke Aphasia for Predicting the Outcome The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03475745 Recruitment Status : Active

2018 Clinical Trials

89. Choir Singing in Aphasia Rehabilitation

of Helsinki and Uusimaa Helsinki-Uusimaa Aphasia and Stroke Association Finnish Brain Association Outloud Ltd University of Barcelona University of Melbourne Harvard Medical School Information provided by (Responsible Party): Teppo Sarkamo, Helsinki University Study Details Study Description Go to Brief Summary: This study evaluates the verbal, cognitive, emotional, and neural efficacy of a choir singing intervention in chronic aphasic patients and their caregivers. Using a cross-over RCT design, half (...) and right hemisphere. The capacity to sing is often preserved in aphasia after stroke, and singing-based methods, such as Melodic Intonation Therapy (MIT), can be effective in rehabilitating speech production in aphasics. Also emotionally and socially, singing could provide a powerful alternative channel for aphasic patients to express their emotions and interact with others, but the communal or group-level use of singing in aphasia rehabilitation has not been systematically studied. AIMS: The purpose

2018 Clinical Trials

90. rTMS for the Treatment of Primary Progressive Aphasia: A Randomized Controlled Trial

rTMS for the Treatment of Primary Progressive Aphasia: A Randomized Controlled Trial rTMS for the Treatment of Primary Progressive Aphasia: A Randomized Controlled Trial - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. rTMS for the Treatment of Primary Progressive Aphasia: A Randomized Controlled Trial The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03448133 Recruitment Status : Not yet recruiting First Posted : February 27

2018 Clinical Trials

91. Rehabilitating and Decelerating Language Loss in Primary Progressive Aphasia With tDCS Plus Language Therapy

Rehabilitating and Decelerating Language Loss in Primary Progressive Aphasia With tDCS Plus Language Therapy Rehabilitating and Decelerating Language Loss in Primary Progressive Aphasia With tDCS Plus Language Therapy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Rehabilitating and Decelerating Language Loss in Primary Progressive Aphasia With tDCS Plus Language Therapy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier

2018 Clinical Trials

92. Transcranial Direct Current Stimulation vs Sham Stimulation to Treat Aphasia After Stroke: A Randomized Clinical Trial. Full Text available with Trip Pro

Transcranial Direct Current Stimulation vs Sham Stimulation to Treat Aphasia After Stroke: A Randomized Clinical Trial. Aphasia is a debilitating language disorder for which behavioral speech therapy is the most efficient treatment, but therapy outcomes are variable and full recovery is not always achieved. It remains unclear if adjunctive brain stimulation (anodal transcranial direct current stimulation [A-tDCS]) applied during aphasia therapy can improve outcomes.To examine the futility (...) a volunteer sample, and 89 patients were screened. Patients with long-term (>6 months) aphasia due to 1 previous left hemisphere stroke were enrolled. In comparing A-tDCS and sham tDCS, patients were matched based on site (University of South Carolina or Medical University of South Carolina), baseline age, type of aphasia, and aphasia severity.Outpatient speech therapy for 3 weeks (15 sessions, 45 minutes each) combined with either A-tDCS vs sham tDCS applied to preserved left temporal lobe regions.The

2018 JAMA neurology Controlled trial quality: predicted high

93. CSF Biomarkers of Neurodegeneration in Progressive Non-fluent Aphasia and Other Forms of Frontotemporal Dementia: Clues for Pathomechanisms? Full Text available with Trip Pro

CSF Biomarkers of Neurodegeneration in Progressive Non-fluent Aphasia and Other Forms of Frontotemporal Dementia: Clues for Pathomechanisms? Frontotemporal Dementia (FTD) encompasses distinct pathophysiologically heterogenous disorders with different genetic and cellular disease mechanisms. The objective of this study is to compare the constellation of biomarkers of neurodegeneration in the cerebrospinal fluid (CSF) to the FTD type categorized by clinical symptoms. We investigated the levels (...) of Phospho181-tau, Total-tau, Beta-amyloid1-42, Neurofilament light chain, and Progranulin in the CSF of n = 99 FTD patients regarding to the different subtypes of FTD, including semantic dementia (SD), progressive non-fluent aphasia (PNFA), behavioral variant FTD (bvFTD). We compared these groups to patients without neurodegenerative disorders and another cohort encompassing tauopathies with distinct clinical syndromes (Cortico basal syndrome and progressive supranuclear palsy) and logopenic PNFA (lPPA

2018 Frontiers in neurology

94. Lesion mapping in acute stroke aphasia and its implications for recovery Full Text available with Trip Pro

Lesion mapping in acute stroke aphasia and its implications for recovery Patients with stroke offer a unique window into understanding human brain function. Mapping stroke lesions poses several challenges due to the complexity of the lesion anatomy and the mechanisms causing local and remote disruption on brain networks. In this prospective longitudinal study, we compare standard and advanced approaches to white matter lesion mapping applied to acute stroke patients with aphasia. Eighteen (...) patients with acute left hemisphere stroke were recruited and scanned within two weeks from symptom onset. Aphasia assessment was performed at baseline and six-month follow-up. Structural and diffusion MRI contrasts indicated an area of maximum overlap in the anterior external/extreme capsule with diffusion images showing a larger overlap extending into posterior perisylvian regions. Anatomical predictors of recovery included damage to ipsilesional tracts (as shown by both structural and diffusion

2018 Neuropsychologia

95. Structural, Microstructural, and Metabolic Alterations in Primary Progressive Aphasia Variants Full Text available with Trip Pro

Structural, Microstructural, and Metabolic Alterations in Primary Progressive Aphasia Variants Neuroimaging studies have described the brain alterations in primary progressive aphasia (PPA) variants (semantic, logopenic, nonfluent/agrammatic). However, few studies combined T1, FDG-PET, and diffusion MRI techniques to study atrophy, hypometabolism, and tract alterations across the three PPA main variants. We therefore explored a large early-stage cohort of semantic, logopenic and nonfluent (...) /agrammatic variants (N = 86) and of 23 matched healthy controls with anatomical MRI (cortical thickness), FDG PET (metabolism) and diffusion MRI (white matter tracts analyses), aiming at identifying cortical and sub-cortical brain alterations, and confronting these alterations across imaging modalities and aphasia variants. In the semantic variant, there was cortical thinning and hypometabolism in anterior temporal cortices, with left-hemisphere predominance, extending toward posterior temporal regions

2018 Frontiers in neurology

96. Types of naming errors in chronic post-stroke aphasia are dissociated by dual stream axonal loss Full Text available with Trip Pro

Types of naming errors in chronic post-stroke aphasia are dissociated by dual stream axonal loss The types of errors during speech production can vary across individuals with chronic post-stroke aphasia, possibly due to the location and extent of brain damage. In this study, we evaluated the relationship between semantic vs. phonemic errors during confrontational naming, and their relationship with the degree of damage to ventral and dorsal white matter pathways extending beyond the necrotic

2018 Scientific reports

97. Single-word comprehension deficits in the nonfluent variant of primary progressive aphasia Full Text available with Trip Pro

Single-word comprehension deficits in the nonfluent variant of primary progressive aphasia A subset of patients with the nonfluent variant of primary progressive aphasia (PPA) exhibit concomitant single-word comprehension problems, constituting a 'mixed variant' phenotype. This phenotype is rare and currently not fully characterized. The aim of this study was twofold: to assess the prevalence and nature of single-word comprehension problems in the nonfluent variant and to study multimodal

2018 Alzheimer's research & therapy

98. Impairments in the Comprehension of Indoor Object/Body Part Words and Family Relationships in a Patient with Aphasia due to Cerebral Infarction of the Left Parietal and Temporal Lobes Full Text available with Trip Pro

Impairments in the Comprehension of Indoor Object/Body Part Words and Family Relationships in a Patient with Aphasia due to Cerebral Infarction of the Left Parietal and Temporal Lobes The present report discusses the case of a 73-year-old right-handed man who exhibited signs of aphasia caused by cerebral infarction in the left temporoparietal region. Neuropsychological evaluation revealed that he had difficulty in comprehending words related to indoor objects, body parts, and family

2018 Case reports in neurology

99. Retained capacity for perceptual learning of degraded speech in primary progressive aphasia and Alzheimer’s disease Full Text available with Trip Pro

Retained capacity for perceptual learning of degraded speech in primary progressive aphasia and Alzheimer’s disease Processing of degraded speech is a promising model for understanding communication under challenging listening conditions, core auditory deficits and residual capacity for perceptual learning and cerebral plasticity in major dementias.We compared the processing of sine-wave-degraded speech in 26 patients with primary progressive aphasia (non-fluent, semantic, and logopenic (...) variants), 10 patients with typical Alzheimer's disease and 17 healthy control subjects. Participants were required to identify sine-wave words that were more predictable (three-digit numbers) or less predictable (place names). The change in identification performance within each session indexed perceptual learning. Neuroanatomical associations of degraded speech processing were assessed using voxel-based morphometry.Patients with non-fluent and logopenic progressive aphasia and typical Alzheimer's

2018 Alzheimer's research & therapy

100. Clustering Analysis of FDG-PET Imaging in Primary Progressive Aphasia Full Text available with Trip Pro

Clustering Analysis of FDG-PET Imaging in Primary Progressive Aphasia Background: Primary progressive aphasia (PPA) is a clinical syndrome characterized by the neurodegeneration of language brain systems. Three main clinical forms (non-fluent, semantic, and logopenic PPA) have been recognized, but applicability of the classification and the capacity to predict the underlying pathology is controversial. We aimed to study FDG-PET imaging data in a large consecutive case series of patients

2018 Frontiers in aging neuroscience

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