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3901. Temporal dissociation of early lexical access and articulation using a delayed naming task--an FMRI study. (Full text)

Temporal dissociation of early lexical access and articulation using a delayed naming task--an FMRI study. Neuroimaging studies of overt speech hold an important practical advantage allowing monitoring of subject performance, particularly valuable in disorders like aphasia. However, speech production is not a monotonic process but a complex sequence of stages. Levelt and colleagues have described these as roughly corresponding to two originally independent systems--conceptual and sensorimotor

2006 Cerebral cortex (New York, N.Y. : 1991) Controlled trial quality: uncertain PubMed abstract

3902. D2 gastrectomy -- a safe operation in experienced hands. (Abstract)

%) patients developed dysphasia, of which two (6%) had anastomotic stricture requiring dilatation. We feel D2 gastrectomy with splenectomy and distal pancreatectomy when performed electively is a safe procedure in experienced hands. Oesophago-jejunal anastomosis can be safely performed using circular stapler.

2005 International journal of clinical practice

3903. Comparing fixed- and randomized-interval spaced retrieval in anomia treatment. (Abstract)

Comparing fixed- and randomized-interval spaced retrieval in anomia treatment. Spaced retrieval (SR) has recently been modified to target anomia in persons with aphasia (PWA). It relies on a strict management of the inter-stimulus interval (ISI) where the time between stimulus presentations is doubled or halved based on response accuracy. Although SR is successful in treating anomia, it remains to be studied whether the strict ISI management is necessary. The present study compared fixed (...) in RISR, is sufficient for successful treatment outcome.Readers will be able to describe the spaced retrieval treatment approach using both fixed- and randomized-interval stimulus schedules, as well as applications of this technique in the treatment of anomia in aphasia.

2005 Journal of communication disorders

3904. The temporal stability of cluster and switch scores using a modified COWAT procedure. (Full text)

The temporal stability of cluster and switch scores using a modified COWAT procedure. This study examined the impact of instructional changes on the temporal stability of cluster and switch scores for the Controlled Oral Word Association Test [COWAT; Benton, A. L., Hamsher, K., & Sivan, A. B. (1994). Multilingual Aphasia Examination (3rd ed.). Iowa City, IA: AJA Associates]. Healthy undergraduates were assigned randomly into experimental (N = 60) and control (N = 60) groups. Experimental group

2005 Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists Controlled trial quality: uncertain PubMed abstract

3906. Factors affecting completion of the SF-36 in older people. (Full text)

of individual questions and time taken to complete.severe functional impairment (Barthel index < or = 12) was found in 22.4% (51/228), cognitive impairment in 54.1% (132/244), depressed mood in 77.0% (151/196) and visuospatial dysfunction in 71.3% (134/188). The median number of impairments was three (interquartile range 1-4). Specific physical impairments were visual in 13.2% (31/235), hearing in 30.2% (74/245), impaired manual dexterity in 18.0% (44/245) and dysphasia in 23% (55/239). In multivariate

2006 Age and ageing PubMed abstract

3907. What patients want: consumer involvement in the design of a randomized controlled trial of routine oxygen supplementation after acute stroke. (Full text)

were held with individuals who have had personal experience of stoke, mostly stoke patients and their partners or carers (an association of young stroke sufferers and 2 dysphasia support groups each from a different town in the West Midlands, UK). The researchers explained the planned oxygen supplementation study and encouraged participants to comment and make suggestions in a semistructured interview. The audience was then asked to complete a questionnaire relating to the study.Seventy-three

2006 Stroke PubMed abstract

3908. Acupuncture treatment for 15 cases of post-traumatic coma. (Abstract)

groups in the therapeutic effects by GCS evaluations as well as in the changes of main symptoms. The results showed that the GCS value in the treatment group was higher than that of the control group, but with no statistical significance (P>0.05). However, the main symptoms of the patients in treatment group, such as aphasia, hemiplegia, and injuries of cranial nerves (including injuries of the facial, oculomotor and abducent nerves) were obviously improved, showing significant differences (...) as compared with the control group (P<0.05). Conclusion can be made that acupuncture combined with point-injection has the consciousness-inducing effect for post-traumatic coma, and shows good effects for the cranial nerve injuries and aphasia.

2005 Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan / sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine Controlled trial quality: uncertain

3909. Stroke: a randomized trial of exercise or relaxation. (Abstract)

Stroke: a randomized trial of exercise or relaxation. To determine the feasibility and effect of exercise training after stroke.Randomized exploratory trial comparing exercise training (including progressive endurance and resistance training) with relaxation (attention control).Interventions were performed in a rehabilitation hospital.Sixty-six independently ambulatory patients (mean age 72, 36 men) without significant dysphasia, confusion, or medical contraindications to exercise training who

2007 Journal of the American Geriatrics Society Controlled trial quality: uncertain

3910. Neural correlates of Dutch Verb Second in speech production. (Abstract)

Neural correlates of Dutch Verb Second in speech production. Dutch speakers with agrammatic Broca's aphasia are known to have problems with the production of finite verbs in main clauses. This performance pattern has been accounted for in terms of the specific syntactic complexity of the Dutch main clause structure, which requires an extra syntactic operation (Verb Second), relative to the basic Subject-Object-Verb order surfacing in Dutch subordinate clauses. We report an fMRI study

2008 Brain and language

3911. [Clinical treatment of apoplectic aphemia with multi-needle puncture of scalp-points in combination with visual-listening-speech training]. (Abstract)

and acupuncture [Dingqu: 1 cun and 2 cun parallel to the line joining Baihui (GV 20) and Qianding (GV 21) respectively on the bilateral sides. Dingqianqu: 1 cun and 2 cun parallel to the line joining GV21 and Xinghui (GV 22) separately on both sides. etc] combined with rehabilitation (Acup+ Rehab) group. Aphasia Battery of Chinese (ABC) was used to assess the patient's speech ability, i.e., aphasia quocient (AQ); The Chinese functional communication (CFCP) test was used to evaluate the patient's daily life (...) speech communication ability, and Boston Diagnostic Aphasia Examination (BDAE) was also conducted to assess the severity of aphasia.After the treatment, the speech ability, oral presentation, listening comprehension, writing ability, AQ index and CFCP were all improved significantly in 3 groups (P < 0.005, 0.01); the total effective rate (85.00%) of Acup+ Rehab group was significantly higher than those of Rehab group (77.78%) and control group (64.71%, P < 0.05, 0.01). The scores of ABC, AQ index

2007 Zhen ci yan jiu = Acupuncture research / [Zhongguo yi xue ke xue yuan Yi xue qing bao yan jiu suo bian ji] Controlled trial quality: uncertain

3912. Effect of fasudil hydrochloride, a protein kinase inhibitor, on cerebral vasospasm and delayed cerebral ischemic symptoms after aneurysmal subarachnoid hemorrhage. (Abstract)

in the nimodipine group. Good recovery evaluated by the Glasgow Outcome Scale was achieved by 23 of 33 patients in the fasudil group and 19 of 34 patients in the nimodipine group. Both drugs significantly improved consciousness levels and neurological deficits such as aphasia. However, fasudil hydrochloride improved motor disturbance more than nimodipine. Adverse reactions occurred in 13 of 37 patients receiving fasudil hydrochloride and 15 of 35 patients receiving nimodipine. There were no serious adverse

2006 Neurologia medico-chirurgica Controlled trial quality: uncertain

3913. Phase II study of single-agent bortezomib for the treatment of patients with fludarabine-refractory B-cell chronic lymphocytic leukemia. (Abstract)

, and hemolytic anemia; Grade 3 nervous system AEs included aphasia; peripheral neuropathy, not otherwise specified; and peripheral sensory neuropathy. Although no objective responses were achieved in patients with fludarabine-refractory B-cell CLL, single-agent bortezomib demonstrated biologic activity. In view of the evidence for its activity, further exploration of bortezomib in combination with other agents is warranted.

2006 Cancer Controlled trial quality: uncertain

3914. [Clinical features and management of multiple sclerosis in children]. (Abstract)

1993 to May 2006 were collected and analyzed.Among the 25 cases, 16 were female and the F:M ratio was 1.78:1. The relapsing-remitting type was seen in 21 cases, the secondary progressive MS in 3 cases and the classification was impossible in one case. The mean age of onset was 6.7 years (2-12) with various initial symptoms including visual loss (11 cases), cortical symptoms (8 cases with seizures, consciousness disturbance, aphasia and apraxia, etc.), myeleterosis (3 cases), symptoms of brainstem

2007 Zhonghua er ke za zhi. Chinese journal of pediatrics

3915. Equivalence of functional communication assessment in speech pathology using videoconferencing. (Abstract)

Equivalence of functional communication assessment in speech pathology using videoconferencing. We examined the equivalence of videoconferencing assessment of communication by speech-language pathologists (SLPs). Using a randomized, double-crossover agreement study, 24 post-stroke patients were randomized to a remote or face-to-face administration of a subset of the Boston Diagnostic Aphasia Examination and to remote or face-to-face assessment of speech comprehension, speech expression (...) and motor speech. The videoconferencing equipment was operated at a transmission speed of 384 kbit/s. Each patient was simultaneously scored by both the face-to-face and the remote SLPs. SLPs were blind to each other's results. Percentage agreement within the 95% limits of agreement ranged from 92% to 100% for each functional communication measure, regardless of assessment site and administration of the aphasia examination. The results suggest that assessment of a patient's functional communication

2007 Journal of telemedicine and telecare Controlled trial quality: uncertain

3916. Rehabilitation of limb apraxia improves daily life activities in patients with stroke. (Full text)

Rehabilitation of limb apraxia improves daily life activities in patients with stroke. We randomly assigned 33 patients with left hemisphere stroke, limb apraxia, and aphasia to an apraxia or a control (aphasia) treatment group. Before and after each treatment, patients underwent a comprehensive neuropsychological testing battery and a caregiver evaluation of patient's activities of daily life (ADL) independence. Apraxia severity was related with ADL independence. Control (aphasia) treatment

2006 Neurology Controlled trial quality: uncertain PubMed abstract

3917. Neurological signs in relation to type of cerebrovascular disease in vascular dementia. (Full text)

presented (10%). Measures of small vessel disease were associated with an increased prevalence of dysarthria, dysphagia, parkinsonian gait disorder, rigidity, and hypokinesia and as well to hemimotor dysfunction. By contrast, in the presence of a cerebral infarct, aphasia, hemianopia, hemimotor dysfunction, hemisensory dysfunction, reflex asymmetry, and hemiplegic gait disorder were more often observed.The specific neurological signs demonstrated by patients with VaD differ according to type of imaged (...) cerebrovascular disease. Even in people who meet restrictive VaD criteria, small vessel disease is often seen with more subtle signs, including extrapyramidal signs, whereas large vessel disease is more often related to lateralized sensorimotor changes and aphasia.

2008 Stroke PubMed abstract

3918. The effect of topical application of pure honey on radiation-induced mucositis: a randomized clinical trial. (Abstract)

The effect of topical application of pure honey on radiation-induced mucositis: a randomized clinical trial. Radiation-induced mucositis is an early effect of head and neck radiotherapy. Mucositis can cause ulcers, and patients may experience pain and dysphasia which need treatment. The aim of this study is to evaluate the effect of pure natural honey on radiation induced mucositis.In this randomized single blind (examiner blind) clinical trial 40 patients with head and neck cancer requiring

2008 The journal of contemporary dental practice Controlled trial quality: uncertain

3919. Levodopa: faster and better word learning in normal humans. (Full text)

Levodopa: faster and better word learning in normal humans. Dopamine is a potent modulator of learning and has been implicated in the encoding of stimulus salience. Repetition, however, as required for the acquisition and reacquisition of sensorimotor or cognitive skills (e.g., in aphasia therapy), decreases salience. We here tested whether increasing brain levels of dopamine during repetitive training improves learning success. Forty healthy humans took 100mg of the dopamine precursor levodopa

2004 Annals of neurology Controlled trial quality: uncertain PubMed abstract

3920. A randomized controlled trial of early supported discharge and continued rehabilitation at home after stroke: five-year follow-up of patient outcome. (Full text)

Southwest Stockholm, mildly or moderately impaired 5 to 7 days after acute stroke, were enrolled in a randomized controlled trial. The core components of the ESD service were initial treatment in a stroke unit and the involvement of an outreach team to deliver and coordinate home-based rehabilitation in partnership with the patient. At the 5-year follow-up, measures used to assess patient outcome included survival, motor capacity, dysphasia, activities of daily living (ADL), social activities

2005 Stroke Controlled trial quality: uncertain PubMed abstract

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