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Aphasia

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3801. Bromocriptine treatment of nonfluent aphasia. (PubMed)

Bromocriptine treatment of nonfluent aphasia. Using a double-blind, placebo-controlled, crossover design, we studied the effect of bromocriptine (15 mg daily) in 20 men with chronic nonfluent aphasia. The study was conducted over a 28-week period in two phases. In phase I, the patients received either bromocriptine or placebo; in phase II the treatments were crossed over. We evaluated each patient's language and nonverbal cognitive skills at the beginning and end of each phase and 6 weeks after (...) completion of phase II. When compared with placebo treatment, bromocriptine did not significantly improve the patient's speech fluency, language content, overall degree of aphasia severity, or nonverbal cognitive abilities. Based on these results, bromocriptine is not recommended as monotherapy for the treatment of chronic nonfluent aphasia.

1995 Neurology Controlled trial quality: uncertain

3802. A randomized, double-blind, placebo-controlled study of bromocriptine in nonfluent aphasia. (PubMed)

A randomized, double-blind, placebo-controlled study of bromocriptine in nonfluent aphasia. We carried out a double-blind and placebo-controlled study of the efficacy of bromocriptine in the treatment of nonfluent aphasia. Seven patients received bromocriptine (up to 60 mg/d) and an identical placebo in a randomized order. End points were the number of content words, content units, and pauses > 3 seconds during the description of a figure; verbal naming; and verbal fluency. There were

1995 Neurology Controlled trial quality: uncertain

3803. Prosody, linguistic demands, and auditory comprehension in aphasia. (PubMed)

Prosody, linguistic demands, and auditory comprehension in aphasia. Prosody plays a clear role in the auditory comprehension of narratives by aphasic listeners. Previous research, however, has pointed to questions regarding variables which increase task complexity (e.g., memory, reading level) and the influence of the severity of aphasia. This study examined the role of the severity of aphasia and linguistic complexity in narrative comprehension by aphasic listeners. Findings indicate (...) that while all subject groups improved their auditory comprehension when emphasis was present, people with severe aphasia improved significantly more, but only in a low linguistic complexity condition. However, subjects had additional opportunity for improved performance in both low and high linguistic complexity conditions. These results pose additional questions about perceived task difficulty (and performance) and resource allocation strategies.Copyright 1999 Academic Press.

1999 Brain and language Controlled trial quality: uncertain

3804. Piracetam as an adjuvant to language therapy for aphasia: a randomized double-blind placebo-controlled pilot study. (PubMed)

Piracetam as an adjuvant to language therapy for aphasia: a randomized double-blind placebo-controlled pilot study. To determine whether piracetam 4.8 g/day together with intensive language therapy improved language function more than language therapy alone.Double-blind, placebo-controlled parallel group study.Referral speech and language clinic of a university department of neurology.Sixty-six inpatients with aphasia present between 4 weeks and 36 months.Intensive language therapy for 6 weeks (...) in all patients. Thirty-two patients received piracetam 4.8 g daily and 34 patients received placebo.The Aachen Aphasia Test (AAT), a standardized procedure for evaluating the severity of aphasia, was performed at baseline and after 6 weeks' treatment.In 50 patients evaluated for efficacy, a trend toward improvement in the active group was observed in all subtests of the AAT. This trend was statistically significant for absolute differences in recovery of "written language" and "profile level

1997 Archives of physical medicine and rehabilitation Controlled trial quality: uncertain

3805. Bilingual aphasia: semantic organization, strategy use, and productivity in semantic verbal fluency. (PubMed)

Bilingual aphasia: semantic organization, strategy use, and productivity in semantic verbal fluency. A semantic verbal fluency task (Animals, Foods) was administered to 16 aphasic, bilingual adults in French and English. Each subject was tested twice in each language. The two goals of the study were to compare performance across languages and to determine the effect of a deliberate grouping strategy on productivity. All subjects claimed approximately equal prestroke abilities in both languages

1998 Brain and language Controlled trial quality: uncertain

3806. The efficacy of group communication treatment in adults with chronic aphasia. (PubMed)

The efficacy of group communication treatment in adults with chronic aphasia. We examined the effects of group communication treatment on linguistic and communicative performance in adults with chronic aphasia. Participants were randomly assigned to two treatment and two deferred treatment groups. Groups were balanced for age, education level, and initial aphasia severity. Twenty-four participants completed the 4-month treatment trial. While in the treatment condition, all participants received

1999 Journal of speech, language, and hearing research : JSLHR Controlled trial quality: uncertain

3807. Constraint-induced therapy of chronic aphasia after stroke. (PubMed)

Constraint-induced therapy of chronic aphasia after stroke. Patients with chronic aphasia were assigned randomly to a group to receive either conventional aphasia therapy or constraint-induced (CI) aphasia therapy, a new therapeutic technique requiring intense practice over a relatively short period of consecutive days. CI aphasia therapy is realized in a communicative therapeutic environment constraining patients to practice systematically speech acts with which they have difficulty. Patients (...) in both groups received the same amount of treatment (30 to 35 hours) as 10 days of massed-practice language exercises for the CI aphasia therapy group (3 hours per day minimum; 10 patients) or over a longer period of approximately 4 weeks for the conventional therapy group (7 patients). CI aphasia therapy led to significant and pronounced improvements on several standard clinical tests, on self-ratings, and on blinded-observer ratings of the patients' communicative effectiveness in everyday life

2001 Stroke Controlled trial quality: uncertain

3808. Reliability of a measure of post-stroke shoulder pain in patients with and without aphasia and/or unilateral spatial neglect. (PubMed)

Reliability of a measure of post-stroke shoulder pain in patients with and without aphasia and/or unilateral spatial neglect. To determine the inter/intra-rater reliability of expert physiotherapists (PTs) measuring post-stroke shoulder pain with 100 mm vertical visual analogue scales (VAS; intensity, frequency and affective response) and a categorical site-of-pain scale.Three PTs independently rated subjects (normal clinical procedure but with a standardized starting position) on three days

2000 Clinical rehabilitation Controlled trial quality: uncertain

3809. Training volunteers as conversation partners using "Supported Conversation for Adults with Aphasia" (SCA): a controlled trial. (PubMed)

Training volunteers as conversation partners using "Supported Conversation for Adults with Aphasia" (SCA): a controlled trial. This article reports the development and evaluation of a new intervention termed "Supported Conversation for Adults with Aphasia" (SCA). The approach is based on the idea that the inherent competence of people with aphasia can be revealed through the skill of a conversation partner. The intervention approach was developed at a community-based aphasia center where (...) volunteers interact with individuals with chronic aphasia and their families. The experimental study was designed to test whether training improves the conversational skills of volunteers, and, if so, whether the improvements affect the communication of their conversation partners with aphasia. Twenty volunteers received SCA training, and 20 control volunteers were merely exposed to people with aphasia. Comparisons between the groups' scores on a Measure of Supported Conversation for Adults with Aphasia

2001 Journal of speech, language, and hearing research : JSLHR Controlled trial quality: uncertain

3810. Restitution of alpha-topography by piracetam in post-stroke aphasia. (PubMed)

Restitution of alpha-topography by piracetam in post-stroke aphasia. Electroencephalographic and clinical effects of piracetam in post-stroke aphasia were evaluated in a prospective, randomized, double-blind, placebo-controlled trial.In 24 patients with mild to moderate aphasia after ischemic stroke, quantitative topographic EEG at rest was studied before and after a 6-week treatment period.In the active treatment group, a significant shift in the alpha-rhythm from frontal to occipital regions

2001 International journal of clinical pharmacology and therapeutics Controlled trial quality: uncertain

3811. A double-blind, placebo-controlled study of the use of amphetamine in the treatment of aphasia. (PubMed)

A double-blind, placebo-controlled study of the use of amphetamine in the treatment of aphasia. A number of studies suggest that drugs which increase the release of norepinephrine promote recovery when administered late (days to weeks) after brain injury in animals. A small number of clinical studies have investigated the effects of the noradrenergic agonist dextroamphetamine in patients recovering from motor deficits following stroke. To determine whether these findings extend to communication (...) for initial aphasia severity and age. At the 6-month follow-up, the difference in gain scores between the groups had increased; however, the difference was not significant (P=0.0482) after correction for multiple comparisons.Administration of dextroamphetamine paired with 10 1-hour sessions of speech/language therapy facilitated recovery from aphasia in a small group of patients in the subacute period after stroke. Neuromodulation with dextroamphetamine, and perhaps other drugs that increase central

2001 Stroke Controlled trial quality: uncertain

3812. Spared musical abilities in a conductor with global aphasia and ideomotor apraxia. (PubMed)

Spared musical abilities in a conductor with global aphasia and ideomotor apraxia. A conductor suddenly developed global aphasia and severe ideomotor apraxia as a result of an infarct in the territory of the left middle cerebral artery. Although aphasia and apraxia remained unchanged during the following six years, his musical capacities were largely spared and he was still able to conduct. This case provides some evidence in favour of right hemisphere dominance for music.

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1985 Journal of neurology, neurosurgery, and psychiatry

3813. Deep left parietal lobe syndrome: conduction aphasia and other neurobehavioural disorders due to a small subcortical lesion. (PubMed)

Deep left parietal lobe syndrome: conduction aphasia and other neurobehavioural disorders due to a small subcortical lesion. A patient with sudden onset of conduction aphasia in the context of an ischaemic stroke is reported. Other neurological and neuropsychological findings included bilateral ideomotor apraxia, right hemisensory defect and paradoxical left ear extinction on a dichotic listening test. Lesion location, as inferred from magnetic resonance imaging, involved a restricted

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1987 Journal of neurology, neurosurgery, and psychiatry

3814. Wernicke aphasia and cardiac embolism. (PubMed)

Wernicke aphasia and cardiac embolism. 3625222 1987 10 22 2017 11 14 0022-3050 50 7 1987 Jul Journal of neurology, neurosurgery, and psychiatry J. Neurol. Neurosurg. Psychiatry Wernicke aphasia and cardiac embolism. 938-9 Harrison M J MJ Marshall J J eng Letter England J Neurol Neurosurg Psychiatry 2985191R 0022-3050 IM Aphasia etiology Aphasia, Wernicke etiology Carotid Artery Thrombosis complications Coronary Disease complications Coronary Thrombosis complications Humans Retrospective Studies

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1987 Journal of neurology, neurosurgery, and psychiatry

3815. Age and type of aphasia in patients with stroke. (PubMed)

Age and type of aphasia in patients with stroke. The age and gender of a series of patients with different types of aphasia were analysed. Regardless of gender, patients with Broca and conduction aphasias were significantly younger than those with Wernicke and global aphasias. Considering the established cerebral localisation of each of those aphasia types, it appears that, with age, stroke in the territory of the middle cerebral artery will tend to either shift posteriorly (producing Wernicke (...) aphasia) or occupy most of the middle cerebral artery territory (producing global aphasia). But in the absence of concurrent verification of the locus of lesion in each of the cases in our sample, a possible alternative hypothesis must be entertained: that there might be age-related changes in the neurophysiological mechanism subserving language, such that some types of aphasia would tend to be more prevalent with age, regardless of lesion location.

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1981 Journal of neurology, neurosurgery, and psychiatry

3816. Recovery from aphasia and neglect after subcortical stroke: neuropsychological and cerebral perfusion study. (PubMed)

Recovery from aphasia and neglect after subcortical stroke: neuropsychological and cerebral perfusion study. Cortical regional cerebral perfusion was assessed by N, N, N1-trimethyl-N1-(2)-hydroxy-3-methyl-5-(I-123) iodobenzyl-1, 3-propanediamine 2 HCl I-123 (HIPDM) and single photon emission computerised tomography (SPECT) in six aphasic and two neglect patients with unilateral subcortical vascular lesions. Assessments were carried out both in the acute phase and after a period ranging from 1 (...) to 6 months after stroke onset. In all patients an almost complete spontaneous recovery occurred and was associated with a significant improvement of cortical perfusion. A relationship between severity of aphasia and degree of cortical hypoperfusion was found, in both the acute and the follow up assessments, in the aphasic subgroup.

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1988 Journal of neurology, neurosurgery, and psychiatry

3817. Progressive aphasia with right-sided extrapyramidal signs: another manifestation of localised cerebral atrophy. (PubMed)

Progressive aphasia with right-sided extrapyramidal signs: another manifestation of localised cerebral atrophy. 2468739 1989 05 26 2018 11 13 0022-3050 52 1 1989 Jan Journal of neurology, neurosurgery, and psychiatry J. Neurol. Neurosurg. Psychiatry Progressive aphasia with right-sided extrapyramidal signs: another manifestation of localised cerebral atrophy. 128-30 Goulding P J PJ Northen B B Snowden J S JS Macdermott N N Neary D D eng Case Reports Letter England J Neurol Neurosurg Psychiatry (...) 2985191R 0022-3050 IM Aphasia pathology Atrophy Basal Ganglia Diseases pathology Cerebral Cortex pathology Dominance, Cerebral physiology Humans Male Middle Aged 1989 1 1 1989 1 1 0 1 1989 1 1 0 0 ppublish 2468739 PMC1032675 J Neurol Neurosurg Psychiatry. 1987 Sep;50(9):1101-9 3499484 Neurology. 1986 Jul;36(7):879-87 3487046 Ann Neurol. 1987 Oct;22(4):527-32 3435071 Arch Neurol. 1988 Apr;45(4):392-6 3258512 J Neurol Neurosurg Psychiatry. 1978 Oct;41(10):903-6 731239 Acta Neurol Scand. 1979 May;59(5

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1989 Journal of neurology, neurosurgery, and psychiatry

3818. The temporal sequence of aura-sensations in patients with complex focal seizures with particular attention to ictal aphasia. (PubMed)

The temporal sequence of aura-sensations in patients with complex focal seizures with particular attention to ictal aphasia. The sequences of aura sensations in 143 patients with complex partial seizures, were analysed with special emphasis on aphasic symptoms. Anxiety, epigastric sensation and visual hallucination were experienced early in the course of the aura, while illusion of familiarity and aphasia occurred late in the course of the aura. Three groups of interconnections of aura (...) sensations were found which corresponded possibly to the types of seizure constellations proposed by Weiser. Close interconnections between impairment of verbal comprehension during seizures and paroxysmal thought disorder, as well as between paroxysmal paraphasia and illusion of familiarity were noted. Paroxysmal aphasia in patients with complex partial seizures was characterised as a positive symptom in contrast to stable aphasia.

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1989 Journal of neurology, neurosurgery, and psychiatry

3819. Familial progressive aphasia: its relationship to other forms of lobar atrophy. (PubMed)

Familial progressive aphasia: its relationship to other forms of lobar atrophy. Two brothers presented with slowly progressive aphasia. One brother, who became behaviourally disturbed only at the end of his illness, was found at necropsy to have predominant left frontotemporal atrophy. The other brother developed severe behavioural disturbances shortly after the onset of language impairment. His brain revealed bilateral frontotemporal atrophy. In both there was non-Alzheimer's disease pathology (...) with the histological features of loss of large cortical nerve cells, spongiform change and mild gliosis. The differential anatomical atrophy supports the view that clinical manifestations of lobar atrophy are dictated by the topographical distribution of a common underlying pathology, linking the syndromes of progressive aphasia to dementia of frontal lobe type (DFT) and DFT with motor neuron disease.

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1993 Journal of neurology, neurosurgery, and psychiatry

3820. Depression in acute and chronic aphasia: symptoms, pathoanatomical-clinical correlations and functional implications. (PubMed)

Depression in acute and chronic aphasia: symptoms, pathoanatomical-clinical correlations and functional implications. Depressive alterations were investigated in 21 acute and 21 chronic aphasic patients with single left sided strokes. The assessment of depression was based on a psychometrically evaluated German version of the Cornell Scale for Depression (CDS) and the Research Diagnostic Criteria (RDC). No significant difference was found concerning depression sum-scores between the two aphasic (...) groups. The acute group, however, exhibited significantly higher ratings in items related to physical signs of depression and disturbances of cyclic functions. Patients corresponding to the RDC-syndrome of major depression were only found in the acute group. Neither age, sex nor degree of hemiparesis discriminated the patients on the severity of depressive symptoms. In the acute patient group, nonfluency of aphasia was the only parameter that could be identified which had an effect on the mood

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1993 Journal of neurology, neurosurgery, and psychiatry

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