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Aphasia

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3781. Safety and Efficacy of Topamax Versus Carbamazepine in Benign Rolandic Epilepsy

and diurnal seizures consisting of simple partial seizures consisting of brief unilateral facial clonic activity, dysphasia, and drooling. The EEG abnormalities are unique, consisting of generally high amplitude, centrotemporal spikes that are activated by sleep. The seizures typically begin in the first decade and almost always stop by age 16 years. The seizures are usually infrequent although clusters of seizures do occur. When the physician elects to treat, the seizures are usually easily controlled

2005 Clinical Trials

3782. Treatment of Severe Alzheimer's Disease: Evaluation of Efficacy and Safety of Galantamine Hydrobromide in a Controlled Study

: No Criteria Inclusion Criteria: Diagnosis of Alzheimer's type dementia, rated as severe progressive worsening of memory and other cognitive functions brain imaging (CTor MRI scan) within last 3 years ability to be mobile (aided or unaided) with sufficient vision and hearing to comply with testing. Exclusion Criteria: Dementia caused by cerebrovascular disease disturbances of consciousness, delirium, psychosis severe aphasia or major sensorimotor impairment cognitive impairment due to acute cerebral trauma

2005 Clinical Trials

3783. Memantine Treatment for Improving Rehabilitation Outcomes and Preventing Depression in Older Adults

, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Admission to a skilled nursing facility for rehabilitation within 3 months of recent disabling medical event (e.g., hip fracture) Medically stable (e.g., no active seizures, delirium, unstable pulse/blood pressure) Exclusion Criteria: Aphasia or cognitive impairments sufficiently severe to prevent valid assessment (e.g., a score of less than 22 on the Mini Mental State Examination) Current major

2005 Clinical Trials

3784. VA Low Vision Intervention Trial

therapist or vision rehabilitation professional since most recent significant decrease in vision has English literacy less than 5th grade level has habitual visual acuity in better seeing eye of equal to or better than 20/100, less than or equal to 20/500 fails Telephone Interview of Cognitive Status (TICS) screening (score of 30 or lower) has history of stroke with aphasia has other health condition that would preclude follow-up (e.g. significant malignancy or life-threatening disease) is unable

2005 Clinical Trials

3785. Memantine and Constraint-Induced Language Therapy in Chronic Poststroke Aphasia:A Randomized Controlled Trial

Martínez. Recruitment status was: Recruiting First Posted : September 20, 2005 Last Update Posted : September 20, 2005 Sponsor: Gabinete Berthier y Martínez Collaborator: H. Lundbeck A/S Information provided by: Gabinete Berthier y Martínez Study Details Study Description Go to Brief Summary: Aphasia, the loss or impairment of language caused by brain damage, is one of the most devastating cognitive impairments of stroke. Aphasia can be treated with combination of speech-language therapy and drugs (...) . Conventional speech-language therapy in chronic aphasic subjects is of little help and several drugs have been studied with limited success. Therefore other therapeutic strategies are warranted. Recent data suggest that drugs (memantine) acting on the brain chemical glutamate may help the recovery of cognitive deficits, included language, in subjects with vascular dementia. The present study examines the safety profile and efficacy of memantine paired with intensive language therapy in subjects with stroke

2005 Clinical Trials

3786. A Randomized Comparison of Laparoscopic Myotomy and Pneumatic Dilatation for Achalasia

, 2005 Last Update Posted: May 21, 2014 Last Verified: May 2014 Keywords provided by University Health Network, Toronto: laparoscopic myotomy pneumatic dilatation motility disorder dysphasia health-related quality of life Additional relevant MeSH terms: Layout table for MeSH terms Aneurysm Dilatation, Pathologic Esophageal Achalasia Vascular Diseases Cardiovascular Diseases Pathological Conditions, Anatomical Esophageal Motility Disorders Deglutition Disorders Esophageal Diseases Gastrointestinal

2005 Clinical Trials

3787. Double Blind Study of Trp01 in Patients With Alzheimer's Disease

according to DSM-IV criteria : development of multiple cognitive deficits manifested by both memory impairment and one or more of the following cognitive disturbances: aphasia, apraxia, agnosia, disturbance in executive functioning the above-mentioned deficits cause significant impairment in social or occupational functioning they do not occur exclusively during the course of delirium Dementia according to communicative disorders and stroke criteria (NINCDS-ADRDA) dementia established clinically

2005 Clinical Trials

3788. Usefulness of Nasal Continuous Positive Airway Pressure (CPAP) Treatment in Patients With a First Ever Stroke and Sleep Apnea Syndrome

Years to 75 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: First ever stroke Any Sleep Apnea symptom Hypertension Exclusion Criteria: Aphasia Cognitive impairment Hypersomnolence Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its

2005 Clinical Trials

3789. Benefits of Applying Neuroprosthesis for Improving Reaching and Grasping Functions in Stroke Patients

and the stroke must be confirmed with a CT scan. Patients must understand that the role of this study is to enhance recovery and not to guarantee it. Exclusion Criteria: Patients who is motivated and does not sign the letter of consent. Patient who has serious cognitive or psychological impairments. Patients who has skin rush, allergy or wounds. Alcohol or drug abuse. Edema in his/her upper extremity. Patients with Shoulder Hand Syndrome Global aphasia Patients who shows early recovery of the function

2005 Clinical Trials

3790. Efficacy and Tolerability of Memantine in Frontotemporal Dementia (FTD) Patients

: Layout table for MeSH terms Dementia Frontotemporal Dementia Aphasia, Primary Progressive Pick Disease of the Brain Brain Diseases Central Nervous System Diseases Nervous System Diseases Neurocognitive Disorders Mental Disorders Frontotemporal Lobar Degeneration TDP-43 Proteinopathies Neurodegenerative Diseases Proteostasis Deficiencies Metabolic Diseases Aphasia Speech Disorders Language Disorders Communication Disorders Neurobehavioral Manifestations Neurologic Manifestations Signs and Symptoms

2005 Clinical Trials

3791. CJD (Creutzfeldt-Jakob Disease) Quinacrine Study

cortical neurologic signs (e.g. neglect, apraxia, aphasia) 18 years of age or older Able to swallow Able to follow simple one-step commands Have had a brain MRI within 6 months and an EEG within 3 months ruling out other etiologies such as masses, strokes, or non-convulsive status epilepticus Consent to autopsy in the event of their death during or after the study Exclusion Criteria: History of other significant or life-threatening disease, including: cancer; end-stage liver or renal disease; severe

2005 Clinical Trials

3792. Donepezil in Preventing Delirium in Hospitalized Elderly

by MMSE score below 10 Metastatic cancer or other comorbid illnesses likely to reduce life expectancy to under 6 months Multiple trauma or pathological fractures Aphasic, legally blind, or deaf Use of Donepezil or other cholinesterase inhibitors within one month prior to surgery Allergy to Donepezil Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided

2005 Clinical Trials

3793. Donepezil in the Prevention of Post-Operative Cognitive Decline

Difficulty performing the activities of daily living not related to mobility as measured by the Bristol scale Current or past history of receiving dementia medications such as Memantine or any cholinesterase inhibitors (Tacrine, Donepezil, Rivastigmine, or Galantamine) Metastatic cancer or other comorbid illnesses likely to reduce life expectancy to under 6 months Multiple trauma or pathological fractures requiring acute hip or knee replacement Aphasic, blind, or deaf Use of neuroleptics one month prior

2005 Clinical Trials

3794. Biomarker Validation for Niemann-Pick Disease, Type C: Safety and Efficacy of N-Acetyl Cysteine

Disease, Type C Biomarkers N-Acetyl Cysteine Oxidized Cholesterol Neurodegeneration NPC Additional relevant MeSH terms: Layout table for MeSH terms Pick Disease of the Brain Aphasia, Primary Progressive Frontotemporal Dementia Niemann-Pick Diseases Niemann-Pick Disease, Type A Niemann-Pick Disease, Type C Frontotemporal Lobar Degeneration Dementia Brain Diseases Central Nervous System Diseases Nervous System Diseases Neurocognitive Disorders Mental Disorders Aphasia Speech Disorders Language Disorders

2009 Clinical Trials

3795. Validating a Delirium Prediction Model for Critically Ill Patients

: admitted < 12 hours on ICU not able to understand Dutch patients with serious hearing and visibility disabilities mentally retarded patients patients suffering from receptive aphasia delirious before admission Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number

2009 Clinical Trials

3796. Central Post-Stroke Pain

, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Sampling Method: Probability Sample Study Population Consecutive stroke patients admitted to the Stroke Unit of the Department of Neurology at Aarhus University Hospital between February 2008 to October 2009 Criteria Inclusion Criteria: Recent cerebrovascular stroke Exclusion Criteria: Severe dementia, aphasia or psychosis Patients who

2009 Clinical Trials

3797. Effects on Clinical and Functional Outcome of Escitalopram in Adult Stroke Patients

: unstable medical conditions unable to understand study aims and procedures severe aphasia other progressive neurological disease previous or concomitant psychiatric illness patients not willing to participate to the study Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier

2009 Clinical Trials

3798. Guanfacine for the Treatment of Spatial Neglect and Impaired Vigilance

Patients with severe coronary insufficiency or myocardial infarction in previous 6 months Cognitive impairment, dysphasia or dementia that prevents patient from giving informed consent Severe mental impairment or physical handicap following stroke that prevents patients from giving consent or performing basic (standard clinical) tests for neglect Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study

2009 Clinical Trials

3799. Brain Computer Interface (BCI) Based Robotic Rehabilitation for Stroke

through practice. Resting brain states determined by FMRI criteria Exclusion Criteria: Recurrent stroke. Previous brain surgery. Spasticity of Modified Ashworth scale > 2. Fixed contracture of any upper limb joint Ataxia, dystonia or tremor of the involved upper limb or previous cervical myelopathy Upper limb pain or painful joints in upper limb. Severe cognitive impairment (Abbreviated Mental Test <7/10), or severe aphasia which may affect ability to participate in training. . History of seizures

2009 Clinical Trials

3800. Imaging of Brain Amyloid Plaques in the Aging Population

, 2018 Last Verified: August 2018 Keywords provided by Val Lowe, Mayo Clinic: Imaging PET PiB FDG MCI Dementia Alzheimer's Disease Brain Amyloid Additional relevant MeSH terms: Layout table for MeSH terms Alzheimer Disease Dementia Frontotemporal Dementia Aphasia, Primary Progressive Pick Disease of the Brain Dementia, Vascular Lewy Body Disease Brain Diseases Central Nervous System Diseases Nervous System Diseases Tauopathies Neurodegenerative Diseases Neurocognitive Disorders Mental Disorders (...) Frontotemporal Lobar Degeneration TDP-43 Proteinopathies Proteostasis Deficiencies Metabolic Diseases Aphasia Speech Disorders Language Disorders Communication Disorders Neurobehavioral Manifestations Neurologic Manifestations Signs and Symptoms Cerebrovascular Disorders Intracranial Arteriosclerosis Intracranial Arterial Diseases Leukoencephalopathies Arteriosclerosis

2009 Clinical Trials

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