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Aphasia

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3781. Anterior temporal laterality in primary progressive aphasia shifts to the right. Full Text available with Trip Pro

Anterior temporal laterality in primary progressive aphasia shifts to the right. In aphasia due to stroke, language-related activity shifts not only to undamaged cortex within the dominant hemisphere but also toward right-sided areas homotopical to the left-sided lesion. We examined whether a rightward shift takes place in primary progressive aphasia (PPA). Nineteen PPA patients participated, 19 healthy subjects and 14 patients with amnestic mild cognitive impairment who served as controls

2005 Annals of Neurology

3782. A longitudinal study of sentence comprehension difficulty in primary progressive aphasia. Full Text available with Trip Pro

A longitudinal study of sentence comprehension difficulty in primary progressive aphasia. Patients with primary progressive aphasia have sentence comprehension difficulty, but the longitudinal course of this deficit has not been investigated.To determine how grammatical, single word meaning, and working memory factors contribute to longitudinal decline of sentence comprehension in primary progressive aphasia. We hypothesised partially distinct patterns of sentence comprehension difficulty (...) in subgroups of patients with progressive non-fluent aphasia (PNFA) and semantic dementia (SD).Cohort.Institutional out patient referral centre.PNFA (n = 14), SD (n = 10).Sentence comprehension accuracy.PNFA patients were significantly impaired at understanding grammatically complex sentences when first seen, and this was more evident than impairment of their comprehension of grammatically simple sentences (p<0.05). Comprehension of grammatically complex sentences correlated with their working memory

2005 Neurosurgery and Psychiatry

3783. How to improve repetition ability in patients with Wernicke's aphasia: the effect of a disguised task. Full Text available with Trip Pro

How to improve repetition ability in patients with Wernicke's aphasia: the effect of a disguised task. Dissociation "automatico-voluntaire" is a symptom observed in aphasic patients. We elucidated the difference between voluntary and involuntary speech output in a quantitative manner using the same task materials in nine patients with Wernicke's aphasia. All the patients exhibited better ability and less paraphasias in a repetition task elicited in a disguised condition than in an ordinary (...) repetition condition. This result indicates that the output difficulty in Wernicke's aphasia might be a disability of volitional control over the language system.

2005 Neurosurgery and Psychiatry

3784. Aphasia and Wernicke's arc Full Text available with Trip Pro

Aphasia and Wernicke's arc 11309473 2001 06 21 2017 11 14 0022-3050 70 5 2001 May Journal of neurology, neurosurgery, and psychiatry J. Neurol. Neurosurg. Psychiatry Aphasia and Wernicke's arc. 699 Pearce J M JM eng Historical Article Letter England J Neurol Neurosurg Psychiatry 2985191R 0022-3050 IM Aphasia history History, 17th Century Humans Temporal Lobe 2001 4 20 10 0 2001 6 22 10 1 2001 4 20 10 0 ppublish 11309473 PMC1737333

2001 Journal of neurology, neurosurgery, and psychiatry

3785. Verbs: some properties and their consequences for agrammatic Broca's aphasia Full Text available with Trip Pro

Verbs: some properties and their consequences for agrammatic Broca's aphasia It has repeatedly been shown that agrammatic Broca's aphasics have serious problems with the retrieval of verbs on action naming tests (Miceli, Silveri, Villa & Caramazza, 1984; Kohn, Lorch & Pearson, 1989; Basso, Razzano, Faglioni & Zanobio, 1990; Jonkers, 1998; Kim & Thompson, 2000). Less attention has been paid to the production of verbs at the sentence level (but see Miceli, Mazzuchi, Menn & Goodglass, 1983

2002 Journal of neurolinguistics

3786. Unaccusative verb production in agrammatic aphasia: the argument structure complexity hypothesis Full Text available with Trip Pro

Unaccusative verb production in agrammatic aphasia: the argument structure complexity hypothesis This study examined patterns of verb production in narrative samples of eight individuals with agrammatic aphasia and seven education- and age-matched normal subjects. Comprehension and constrained production of two types of intransitive verbs-unaccusatives whose argument structure triggers a complex syntactic derivation and unergatives that are considered syntactically simple- was also tested

2003 Journal of neurolinguistics

3787. Effects of increased cholinergic activity on naming in aphasia. (Abstract)

Effects of increased cholinergic activity on naming in aphasia. 9228973 1997 08 08 2015 06 16 0140-6736 350 9071 1997 Jul 12 Lancet (London, England) Lancet Effects of increased cholinergic activity on naming in aphasia. 116-7 Tanaka Y Y Miyazaki M M Albert M L ML eng Clinical Trial Letter Randomized Controlled Trial England Lancet 2985213R 0140-6736 0 Benzhydryl Compounds 0 Cholinergic Agents 0 Nootropic Agents EC 3.1.1.7 Acetylcholinesterase Z4501GN13G bifemelane AIM IM Acetylcholinesterase (...) cerebrospinal fluid Aged Anomia drug therapy rehabilitation Aphasia drug therapy rehabilitation Benzhydryl Compounds therapeutic use Cerebral Infarction complications physiopathology Cholinergic Agents therapeutic use Cognition Follow-Up Studies Humans Language Male Middle Aged Nootropic Agents therapeutic use Pilot Projects Speech Therapy Temporal Lobe drug effects physiopathology 1997 7 12 1997 7 12 0 1 1997 7 12 0 0 ppublish 9228973 S0140-6736(05)61820-X 10.1016/S0140-6736(05)61820-X

1997 Lancet (London, England) Controlled trial quality: uncertain

3788. Treatment of acquired aphasia: speech therapists and volunteers compared. Full Text available with Trip Pro

Treatment of acquired aphasia: speech therapists and volunteers compared. This paper reports on a multicentre trial comparing the effects of speech therapists and untrained volunteers on recovery from aphasia following stroke. One hundred and fifty-five patients entered the study and 96 completed it. Patients in both treatment groups improved, and there were no differences overall in the amount of progress made. A small subgroup of patients who started treatment much later had equivalent

1982 Journal of neurology, neurosurgery, and psychiatry

3789. The role of piracetam in the treatment of acute and chronic aphasia. (Abstract)

The role of piracetam in the treatment of acute and chronic aphasia. Piracetam has been shown to improve speech in aphasic patients. This paper reviews the evidence for this benefit in aphasic patients with acute stroke and, in conjunction with language treatment, in post-acute and chronic aphasia. Early double-blind, placebo-controlled trials in acute stroke showed improvement in several neurologic parameters including aphasia. Subsequently two randomized double-blind placebo-controlled (...) studies were performed which utilised the Aachen Aphasia Test (AAT), a validated and standardized procedure, to assess language function. Patients received placebo or piracetam 4.8g daily for 12 weeks in one study and for 6 weeks in the other. In both studies patients received concomitant intensive speech therapy; one included patients 6-9 weeks after stroke while in the other the duration of aphasia varied between 4 weeks and 3 years. Compared with placebo there was improvement in both studies

1999 Pharmacopsychiatry

3790. Constraint-induced therapy of chronic aphasia after stroke. (Abstract)

Constraint-induced therapy of chronic aphasia after stroke. Patients with chronic aphasia were assigned randomly to a group to receive either conventional aphasia therapy or constraint-induced (CI) aphasia therapy, a new therapeutic technique requiring intense practice over a relatively short period of consecutive days. CI aphasia therapy is realized in a communicative therapeutic environment constraining patients to practice systematically speech acts with which they have difficulty. Patients (...) in both groups received the same amount of treatment (30 to 35 hours) as 10 days of massed-practice language exercises for the CI aphasia therapy group (3 hours per day minimum; 10 patients) or over a longer period of approximately 4 weeks for the conventional therapy group (7 patients). CI aphasia therapy led to significant and pronounced improvements on several standard clinical tests, on self-ratings, and on blinded-observer ratings of the patients' communicative effectiveness in everyday life

2001 Stroke Controlled trial quality: uncertain

3791. Training volunteers as conversation partners using "Supported Conversation for Adults with Aphasia" (SCA): a controlled trial. (Abstract)

Training volunteers as conversation partners using "Supported Conversation for Adults with Aphasia" (SCA): a controlled trial. This article reports the development and evaluation of a new intervention termed "Supported Conversation for Adults with Aphasia" (SCA). The approach is based on the idea that the inherent competence of people with aphasia can be revealed through the skill of a conversation partner. The intervention approach was developed at a community-based aphasia center where (...) volunteers interact with individuals with chronic aphasia and their families. The experimental study was designed to test whether training improves the conversational skills of volunteers, and, if so, whether the improvements affect the communication of their conversation partners with aphasia. Twenty volunteers received SCA training, and 20 control volunteers were merely exposed to people with aphasia. Comparisons between the groups' scores on a Measure of Supported Conversation for Adults with Aphasia

2001 Journal of speech, language, and hearing research : JSLHR Controlled trial quality: uncertain

3792. A double-blind, placebo-controlled study of the use of amphetamine in the treatment of aphasia. (Abstract)

A double-blind, placebo-controlled study of the use of amphetamine in the treatment of aphasia. A number of studies suggest that drugs which increase the release of norepinephrine promote recovery when administered late (days to weeks) after brain injury in animals. A small number of clinical studies have investigated the effects of the noradrenergic agonist dextroamphetamine in patients recovering from motor deficits following stroke. To determine whether these findings extend to communication (...) for initial aphasia severity and age. At the 6-month follow-up, the difference in gain scores between the groups had increased; however, the difference was not significant (P=0.0482) after correction for multiple comparisons.Administration of dextroamphetamine paired with 10 1-hour sessions of speech/language therapy facilitated recovery from aphasia in a small group of patients in the subacute period after stroke. Neuromodulation with dextroamphetamine, and perhaps other drugs that increase central

2001 Stroke Controlled trial quality: uncertain

3793. Comparison of clinic, home, and deferred language treatment for aphasia. A Veterans Administration Cooperative Study. (Abstract)

Comparison of clinic, home, and deferred language treatment for aphasia. A Veterans Administration Cooperative Study. Aphasic patients who met stringent selection criteria were assigned randomly to three groups: clinic treatment by a speech pathologist for 12 weeks, followed by 12 weeks of no treatment; home treatment by a trained volunteer for 12 weeks, followed by 12 weeks of no treatment; or deferred treatment for 12 weeks, followed by 12 weeks of treatment by a speech pathologist. At 12 (...) weeks after entry, language measures indicated that the clinic-treatment patients made significantly more improvement than did the deferred-treatment patients, and improvement in home-treatment patients did not differ significantly from either clinic- or deferred-treatment patients. At 24 weeks after entry, after deferred-treatment patients had received clinic treatment, there were no significant differences among the groups. These results suggest that clinic treatment for aphasia is efficacious

1986 Archives of neurology Controlled trial quality: uncertain

3794. Bromocriptine treatment of nonfluent aphasia. (Abstract)

Bromocriptine treatment of nonfluent aphasia. Using a double-blind, placebo-controlled, crossover design, we studied the effect of bromocriptine (15 mg daily) in 20 men with chronic nonfluent aphasia. The study was conducted over a 28-week period in two phases. In phase I, the patients received either bromocriptine or placebo; in phase II the treatments were crossed over. We evaluated each patient's language and nonverbal cognitive skills at the beginning and end of each phase and 6 weeks after (...) completion of phase II. When compared with placebo treatment, bromocriptine did not significantly improve the patient's speech fluency, language content, overall degree of aphasia severity, or nonverbal cognitive abilities. Based on these results, bromocriptine is not recommended as monotherapy for the treatment of chronic nonfluent aphasia.

1995 Neurology Controlled trial quality: uncertain

3795. A randomized, double-blind, placebo-controlled study of bromocriptine in nonfluent aphasia. (Abstract)

A randomized, double-blind, placebo-controlled study of bromocriptine in nonfluent aphasia. We carried out a double-blind and placebo-controlled study of the efficacy of bromocriptine in the treatment of nonfluent aphasia. Seven patients received bromocriptine (up to 60 mg/d) and an identical placebo in a randomized order. End points were the number of content words, content units, and pauses > 3 seconds during the description of a figure; verbal naming; and verbal fluency. There were

1995 Neurology Controlled trial quality: uncertain

3796. Reliability of a measure of post-stroke shoulder pain in patients with and without aphasia and/or unilateral spatial neglect. (Abstract)

Reliability of a measure of post-stroke shoulder pain in patients with and without aphasia and/or unilateral spatial neglect. To determine the inter/intra-rater reliability of expert physiotherapists (PTs) measuring post-stroke shoulder pain with 100 mm vertical visual analogue scales (VAS; intensity, frequency and affective response) and a categorical site-of-pain scale.Three PTs independently rated subjects (normal clinical procedure but with a standardized starting position) on three days

2000 Clinical rehabilitation Controlled trial quality: uncertain

3797. Correlation of aphasia and/or neglect with cortical infarction in a subpopulation of RANTTAS. (Abstract)

Correlation of aphasia and/or neglect with cortical infarction in a subpopulation of RANTTAS. Classically in neurology, aphasia and neglect were accepted as reliable markers of cortical lesions. The actual prognostic values of aphasia and neglect have yet to be formally tested. This analysis sought to determine the predictive accuracy of aphasia and/or neglect in acute stroke for cortical infarction. Data from the RANTTAS investigation of tirilazad mesylate in stroke patients were reanalyzed (...) , comparing acute National Institutes of Health Stroke Scale (NIHSS) measures of aphasia and neglect to lesion location on day 7-10 CT scans. Correlations between the presence of aphasia and/or neglect and the presence of a cortical lesion were only in the moderate range, and positive predictive values were far from perfect, as would be expected. 'Subcortical' aphasia or neglect was more likely in large, subcortical lesions. Aphasia and neglect, as determined in the acute setting by the NIHSS, are only

2001 Cerebrovascular diseases (Basel, Switzerland)

3798. Restitution of alpha-topography by piracetam in post-stroke aphasia. (Abstract)

Restitution of alpha-topography by piracetam in post-stroke aphasia. Electroencephalographic and clinical effects of piracetam in post-stroke aphasia were evaluated in a prospective, randomized, double-blind, placebo-controlled trial.In 24 patients with mild to moderate aphasia after ischemic stroke, quantitative topographic EEG at rest was studied before and after a 6-week treatment period.In the active treatment group, a significant shift in the alpha-rhythm from frontal to occipital regions

2001 International journal of clinical pharmacology and therapeutics Controlled trial quality: uncertain

3799. Comparison of formal language therapy with supportive counseling for aphasia due to acute vascular accident. (Abstract)

Comparison of formal language therapy with supportive counseling for aphasia due to acute vascular accident. A total of 60 right-handed patients with acute aphasia due to left hemispheral stroke were randomly assigned to two modes of therapy for six months, beginning one month after the ictus. Conventional speech therapy provided by professional speech pathologists twice weekly was compared with emotionally supportive counseling therapy, also provided by professional speech pathologists

1987 Archives of neurology Controlled trial quality: uncertain

3800. Anxiety, alcohol, aphasia, and ums. (Abstract)

Anxiety, alcohol, aphasia, and ums. Although several studies have documented a link between anxiety and filled pauses (ums, ers, and uhs), numerous failures make it impossible to believe that the two are linked in any simple way. This article suggests anxiety may increase ums not when it makes the speech task harder but when it causes the speaker to pay attention to the speech. Two experiments examined this idea. One manipulated evaluation apprehension, and the other manipulated self

1996 Journal of personality and social psychology Controlled trial quality: uncertain

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