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Aphasia

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3761. Study of Tenecteplase (TNK) in Acute Ischemic Stroke (TNK-S2B)

to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patients with at least a serious, measurable deficit on the NIH Stroke Scale in language (aphasia score > 1), motor power (arm or leg > 1

2005 Clinical Trials

3762. Vestibular Stimulation to Treat Hemispatial Neglect

of aphasia on clinical examination (crossed aphasia) A significant history of other neurological or psychiatric illness or drug/alcohol abuse Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00271388 Locations Layout table for location information United

2005 Clinical Trials

3763. A Study on the Use of Tanakan® for Recovery of Neurological Impairment Following Ischaemic Stroke

than 1/3 hemisphere Patient having a score below the cut-off point at Frenchay Aphasia Short Test Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00276380 Locations Layout table for location information Czechia Faculty of Medicine in Hradec Kralove

2006 Clinical Trials

3764. Efficacy of SUN N4057 in Subjects With Acute Ischemic Stroke and Measurable Penumbra on Magnetic Resonance Imaging (MRI)

of symptoms (for un-witnessed stroke, last time seen in normal state or at bedtime for un-witnessed stroke during sleep) Signed informed consent from subject or legally acceptable representative NIHSS score of 6 - 22, inclusive, or at least 2 on the aphasia item of the NIHSS with a location of MRI findings consistent with aphasia MRI-determined inclusion criteria: Acute ischemic stroke with substantial cortical involvement in the middle cerebral artery (MCA) distribution, as verified by the Screening DWI

2006 Clinical Trials

3765. Safety Study of the Bispecific T-cell Engager Blinatumomab (MT103) in Patients With Relapsed NHL

as defined below: Peripheral lymphocyte count > 20 x 10^9/L Platelet counts ≤ 75,000/µL Hemoglobin level ≤ 9 g/dL Venous pH value out of normal range or oxygen saturation ≤ 90% Known or suspected central nervous system (CNS) involvement by NHL a)History of or current relevant CNS pathology as epilepsy, seizure, paresis,aphasia, apoplexia, severe brain injuries, cerebellar disease, organic brain syndrome, psychosis b)Evidence for presence of inflammatory lesions and/or vasculitis on cerebral MRI

2006 Clinical Trials

3766. Headache Study to Compare Aggrenox Full Dose and Reduced Dose

Criteria: Patients with known or suspected prior intracranial haemorrhage or history of brain injury or brain tumor. Disorders related to syncope, drop attacks, congenital vascular malformation, aneurysm, angioma, or epilepsy, psychiatric disorders. Peptic ulcer or gastrointestinal bleeding within 6 months. History of hypersensitivity or intolerance to study drugs or aspirin. Experienced habitual headache (any form) within the past 3 months. History of dysphasia, dysphagia, dementia, or unconsciousness

2006 Clinical Trials

3767. The Role of Cytokine-Serotonin Interactions in Post-Stroke Depression

, hypothyroidism, or uncontrolled diabetes Significant acute neurologic illness including: impaired consciousness, Parkinson's disease, Huntington's chorea, progressive supranuclear paralysis, brain tumor, subdural hematoma, multiple sclerosis, hydrocephalus, Binswanger's disease, or severe aphasia Presence of a premorbid Axis I psychiatric diagnosis (eg. schizophrenia, bipolar disorder) Depressed group only: contraindications to receiving treatment with citalopram (including previous nonresponse) or serious

2005 Clinical Trials

3768. mCIMT and Eye Patching for Neglect Rehabilitation Post Stroke: A Longitudinal Study of Separate and Combined Effects

part movement in the affected upper extremity and a minimum of 20 degrees of active wrist extension and 10 degrees of finger extension; (4) no severe aphasia that hampers command following; (5) no severe cognitive impairments (Mini-Mental State Examination score >= 22); (6) being right-handed premorbidly by self-report. Exclusion Criteria: Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research

2005 Clinical Trials

3769. Caffeinol Hypothermia Protocol

, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Age 18-80 years Clinical presentation of acute ischemic stroke Computed tomography (CT) scan compatible with acute ischemic stroke. Time to caffeinol treatment < 240 minutes from stroke onset. Time to hypothermia initiation < 300 minutes from stroke onset. Presumed cortical location of stroke (must have at least on sign such as aphasia, neglect, visual field cut) National Institutes of Health

2006 Clinical Trials

3770. IVPCA in the Management of Pain Following Major Intracranial Surgery

: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Adults undergoing intracranial surgery Exclusion Criteria: Patient refusal Pregnancy Aphasia Respiratory failure Allergy/intolerance to fentanyl Opioids use History of opioid-dependent pain, Patient has been in an investigational drug trial (except chemotherapy) in the month preceding the day of enrollment Mental or physical limitations that would prevent patient assessment or PCA use Chronic painful conditions unrelated to the reason

2006 Clinical Trials

3771. Telerehabilitation for the Hand and Arm After Stroke and Traumatic Brain Injury

of less than 23 in the Mini-Mental Test Inability to understand informed consent form Inability to follow 3-step instructions Pregnancy Receptive aphasia Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00295399 Contacts Layout table for location

2006 Clinical Trials

3772. Affect Recognition: Enhancing Performance of Persons With Acquired Brain Injury (ABI)

impairment. Perceptual impairment (visual neglect and/or visual discrimination). Impaired verbal expression/ aphasia Alcohol or substance abuse. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00283153 Locations Layout table for location information

2006 Clinical Trials

3773. Problem Adaptation Therapy (PATH) vs. Supportive Therapy in Treating Depressed, Cognitively Impaired Older Adults

failure; major surgery; stroke; myocardial infarction during the 3 months prior to entry) Currently taking drugs known to cause depression (e.g., reserpine, alpha-methyl-dopa, steroids) Currently receiving psychotherapy Aphasia Sensory problems Inability to speak English Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer

2006 Clinical Trials

3774. Beta-hCG + Erythropoietin in Acute Stroke

Naming Test [ Time Frame: 3 mo ] Measure of aphasia or other language disturbance caused by stroke or other dementing disorders. It consists of 60 line drawings graded in difficulty in which patients are to name each picture. Line Cancellation Test [ Time Frame: 3 mo ] Measure of spatial neglect where patients must cross out lines placed in a random orientation. Missed lines may indicate areas of spatial neglect. NIH Stroke Scale [ Time Frame: 3 mo ] Measure of global impairment post stroke

2006 Clinical Trials

3775. The Effect of Additional Arm Therapy on Arm Function After Stroke

) or neurological conditions (e.g., Parkinson's disease) due to conditions other than stroke, receptive aphasia Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00359255 Locations Layout table for location information Canada, British Columbia Kelowna General

2006 Clinical Trials

3776. Oral HYCAMTIN Plus Whole Brain Radiation Therapy In Treatment Of Brain Metastases Resulting From Non-Small Lung Cancer

with ADLs; life threatening, disabling. Number of Participants With the Indicated Investigator Assessment of Language (Dysphasia or Aphasia) at Baseline, Month 1, and Month 3 [ Time Frame: Baseline, Month 1, and Month 3 ] The investigator assessed participants' status of language (dysphasia or aphasia) and assigned each participant to one of the following categories: absent; awareness of receptive or expressive aphasia, not impairing ability to communicate (not impaired); receptive or expressive (...) dysphasia, impairing ability to communicate (impaired); inability to communicate (unable). Number of Participants With the Indicated Investigator Assessment of Strength (Right Upper Extremity) at Baseline, Month 1, and Month 3 [ Time Frame: Baseline, Month 1, and Month 3 ] The investigator assessed participants' status of strength (right upper extremity) and assigned each participant to one of the following categories: normal; Grade 1, asymptomatic with weakness on physical examination; Grade 2

2006 Clinical Trials

3777. Recovery of Hand Function Through Mental Practice.

. For general information, Layout table for eligibility information Ages Eligible for Study: Child, Adult, Older Adult Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Confirmed diagnosis of stroke in the last 1-6 months Persisting upper limb weakness - Exclusion Criteria: Alcohol/ Drug abuse Psychiatric history Previous illness that has impacted on individuals Activity of Daily living - Dementia (assessed by MSQ) Severe Aphasia Contacts and Locations Go

2006 Clinical Trials

3778. The Effect of Aerobic Exercise on Learning After Stroke

to be controlled < month receptive or expressive aphasia as indicated on MMSE multiple strokes or other neuromuscular conditions major depression that is untreated using the Beck depression inventory Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00228306

2005 Clinical Trials

3779. Propofol Injection for Daily Headache

, Those having language barriers (e.g. illiterate, not English-speaking, dysphasic), Known or suspected difficult airway or sleep apnea, Severe respiratory disease, Neuromuscular disease, Seizure disorder, Severe cardiac disease, Severe gastroesophageal reflux disease, Pancreatitis, Lipid disorders, Receiving Total Parenteral Nutrition, Body mass index > 35, diabetes or major endocrine disorder, Hepatic or renal failure, Unstable psychiatric disorder, Known drug abuse, Pregnancy, Cognitively impaired

2005 Clinical Trials

3780. Acetylcholinesterase Inhibitors to Improve Cognitive Function and Overall Rehabilitation After a Stroke

) Stroke was within 30 days of being admitted Medically stable Presence of memory and/or attentional impairments and evidence that these impairments were not present or were less severe prior to the stroke (assessed via interview with family) Approval by individual's attending physician at the rehabilitation hospital Exclusion Criteria: Aphasia or cognitive (or behavioral) impairments severe enough to prevent valid neuropsychiatric assessment Currently experiencing a major depressive episode (unless

2005 Clinical Trials

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