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Aphasia

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3741. Efficacy of SUN N4057 in Subjects With Acute Ischemic Stroke and Measurable Penumbra on Magnetic Resonance Imaging (MRI)

of symptoms (for un-witnessed stroke, last time seen in normal state or at bedtime for un-witnessed stroke during sleep) Signed informed consent from subject or legally acceptable representative NIHSS score of 6 - 22, inclusive, or at least 2 on the aphasia item of the NIHSS with a location of MRI findings consistent with aphasia MRI-determined inclusion criteria: Acute ischemic stroke with substantial cortical involvement in the middle cerebral artery (MCA) distribution, as verified by the Screening DWI

2006 Clinical Trials

3742. Effect of Soy on Cognition and Hot Flashes in Men With Prostate Cancer Undergoing Testosterone Suppression Therapy

positives.A higher score= higher cognitive function. Cognitive Function as Assessed by the F-A-S Test [ Time Frame: baseline, 6 weeks, 12 weeks ] The F-A-S Test, a subtest of the Neurosensory Center Comprehensive Examination for Aphasia (NCCEA), is a measure of phonemic word fluency, which is a type of verbal fluency. It assesses phonemic fluency by requesting an individual to orally produce as many words as possible that begin with the letters F, A, and S within a prescribed time frame (1 minute

2005 Clinical Trials

3743. Moving a Paralyzed Hand Through Use of a Brain-Computer Interface

regarding the trauma. Absent changes in both Glascow Coma Scale and mental status following injury. Outpatients who are unable to make a 12-week commitment. Inpatients who are unable to make a 15 day commitment. Comprehensive aphasia. EXCLUSION CRITERIA - CHRONIC STROKE PATIENTS: Cerebellar lesions. More than one stroke in the middle cerebral artery territory. Bilateral motor impairment. Initiation of an exercise or rehabilitation program that could affect experimental results. Outpatients who (...) are unable to make a 12-week commitment. Inpatients who are unable to make a 15 day commitment. Comprehensive aphasia. EXCLUSION CRITERIA - HEALTHY VOLUNTEERS: Inability to make a 12-week commitment. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number

2005 Clinical Trials

3744. VA Low Vision Intervention Trial

therapist or vision rehabilitation professional since most recent significant decrease in vision has English literacy less than 5th grade level has habitual visual acuity in better seeing eye of equal to or better than 20/100, less than or equal to 20/500 fails Telephone Interview of Cognitive Status (TICS) screening (score of 30 or lower) has history of stroke with aphasia has other health condition that would preclude follow-up (e.g. significant malignancy or life-threatening disease) is unable

2005 Clinical Trials

3745. Affect Recognition: Enhancing Performance of Persons With Acquired Brain Injury (ABI)

impairment. Perceptual impairment (visual neglect and/or visual discrimination). Impaired verbal expression/ aphasia Alcohol or substance abuse. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00283153 Locations Layout table for location information

2006 Clinical Trials

3746. The Role of Cytokine-Serotonin Interactions in Post-Stroke Depression

, hypothyroidism, or uncontrolled diabetes Significant acute neurologic illness including: impaired consciousness, Parkinson's disease, Huntington's chorea, progressive supranuclear paralysis, brain tumor, subdural hematoma, multiple sclerosis, hydrocephalus, Binswanger's disease, or severe aphasia Presence of a premorbid Axis I psychiatric diagnosis (eg. schizophrenia, bipolar disorder) Depressed group only: contraindications to receiving treatment with citalopram (including previous nonresponse) or serious

2005 Clinical Trials

3747. Benefits of Applying Neuroprosthesis for Improving Reaching and Grasping Functions in Stroke Patients

and the stroke must be confirmed with a CT scan. Patients must understand that the role of this study is to enhance recovery and not to guarantee it. Exclusion Criteria: Patients who is motivated and does not sign the letter of consent. Patient who has serious cognitive or psychological impairments. Patients who has skin rush, allergy or wounds. Alcohol or drug abuse. Edema in his/her upper extremity. Patients with Shoulder Hand Syndrome Global aphasia Patients who shows early recovery of the function

2005 Clinical Trials

3748. Treadmill Exercise Prescriptions to Improve Fitness Versus Ambulatory Function After Stroke.

mellitus (fasting glucose greater than 180 mg/dl, HgA1C greater than 10%) unable to be controlled medically within 3 months; g) Anemia defined by hematocrit less than 30 . (5) Neurological history of dementia with Mini-Mental Status Score less than 23 (less than 17 if education level at or below 8th grade), and diagnostic confirmation by neurologist or psychiatrist, severe receptive or global aphasia which confounds testing and training, operationally defined as unable to follow 2 point commands

2007 Clinical Trials

3749. Screening and Treatment of Depression in the Community

Inclusion Criteria: > 60 years without dementia, Major depressive disorder, Bipolar disorder, Dysthymia disorder, Anxiety disorder, Mania/hypomania Exclusion Criteria: Severe post-stroke dementia or aphasia, History of mania, psychiatric consultation or admission to hospital in past 3 months, MMSE score <18, Fully dependent at 3 or more basic activities of daily living, Very high BDI score (>=30), Serious suicidal risk, Current psychotic symptoms, Current alcohol abuse, Very high GDS score (>=12

2007 Clinical Trials

3750. Brain Oxygenation Monitoring in Patients Undergoing Coronary Artery Bypass Surgery

Volunteers: No Criteria Inclusion Criteria: Primary coronary artery bypass surgery Ages 18-90 Voluntary participation with signed informed consent Exclusion Criteria: An unwillingness to participate in the study Inability to obtain informed consent Expressive or receptive aphasia Inability to correctly perform the neurocognitive tests preoperatively Inability to correctly perform the saccadic and anti-saccadic eye movement tests preoperatively Non-English speaking candidates Patients for whom it is known

2005 Clinical Trials

3751. Role of the Right Brain in Recovery of Language Function in Chronic Stroke

will include patients with thromboembolic non-hemorrhagic hemispheric lesions and with hemorrhagic hemispheric lesions (as documented by CT or MRI) at least 12 months after the stroke. We will choose subjects with chronic stable aphasia, that initially presented with severe aphasia and have partially recovered. Assessment of the initial functional state will be taken either from patient report or medical records. All of the aphasic patients are already known to the investigators from the NIDCD. EXCLUSION (...) ) Information provided by: National Institutes of Health Clinical Center (CC) Study Details Study Description Go to Brief Summary: This study will examine in healthy individuals and in patients with aphasia (a language disturbance that is usually caused by stroke, brain disease, or injury) which parts of the brain are involved in naming everyday objects. In most people, language and speech originate in the left side of the brain. When this side of the brain is damaged, language function is often impaired

2004 Clinical Trials

3752. Direct Current Brain Polarization in Frontotemporal Dementia

table for additonal information ClinicalTrials.gov Identifier: Other Study ID Numbers: 040122 04-N-0122 First Posted: February 13, 2004 Last Update Posted: March 4, 2008 Last Verified: August 2005 Keywords provided by National Institutes of Health Clinical Center (CC): Treatment Transcranial Stimulation Frontal Lobe Pick's Disease Cognitive Impairment Dementia Frontotemporal Dementia FTD Additional relevant MeSH terms: Layout table for MeSH terms Dementia Frontotemporal Dementia Aphasia, Primary (...) Progressive Pick Disease of the Brain Brain Diseases Central Nervous System Diseases Nervous System Diseases Neurocognitive Disorders Mental Disorders Frontotemporal Lobar Degeneration TDP-43 Proteinopathies Neurodegenerative Diseases Proteostasis Deficiencies Metabolic Diseases Aphasia Speech Disorders Language Disorders Communication Disorders Neurobehavioral Manifestations Neurologic Manifestations Signs and Symptoms

2004 Clinical Trials

3753. L-Carnitine to Treat Fatigue in AIDS Patients

or alcohol use or dependence History of any central nervous system disease involving the brain that may put the patient at risk for seizure (e.g., primary or metastatic brain tumor, stroke) or history of seizure History of dementia, aphasia, or other deficits of cognition or speech/language function Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided

2004 Clinical Trials

3754. Assessing the Effectiveness of Communication Therapy in the North West (The ACT NoW Pilot Study)

: NHS Health Technology Assessment Programme Information provided by: NHS Health Technology Assessment Programme Study Details Study Description Go to Brief Summary: This study investigates the effectiveness and cost-effectiveness of speech and language therapy for adults who suffer communication difficulties following a stroke. Condition or disease Intervention/treatment Phase Speech or Language Impairment Following Stroke Procedure: Speech and Language therapy for dysarthria and/or aphasia (...) effectiveness and net benefit of the intervention group compared to the control group from a societal perspective. The qualitative study will examine service users' and carers' perspectives on the process and effects of Speech and Language Therapy or the control treatment. Sample Group: Adults with dysarthria or aphasia, seen early after admission to hospital with a stroke. Exclusions: subarachnoid haemorrhage, progressive dementia, expected recovery without therapy. Study Design Go to Layout table

2005 Clinical Trials

3755. Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

2008 Keywords provided by Assistance Publique - Hôpitaux de Paris: Amyotrophic lateral sclerosis Frontotemporal dementia Mutations spectrum Linkage studies Genetic epidemiology Additional relevant MeSH terms: Layout table for MeSH terms Sclerosis Dementia Motor Neuron Disease Amyotrophic Lateral Sclerosis Frontotemporal Dementia Aphasia, Primary Progressive Pick Disease of the Brain Pathologic Processes Brain Diseases Central Nervous System Diseases Nervous System Diseases Neurocognitive Disorders (...) Mental Disorders Neurodegenerative Diseases Neuromuscular Diseases Spinal Cord Diseases TDP-43 Proteinopathies Proteostasis Deficiencies Metabolic Diseases Frontotemporal Lobar Degeneration Aphasia Speech Disorders Language Disorders Communication Disorders Neurobehavioral Manifestations Neurologic Manifestations Signs and Symptoms

2005 Clinical Trials

3756. Treatment of Depressed Chronic Obstructive Pulmonary Disease Patients

information Ages Eligible for Study: 50 Years to 95 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Chronic obstructive pulmonary disease by American Thoracic Society criteria Major depression by DSM-IV criteria 17-item Hamilton score >14 English speaking Exclusion Criteria: Inability to give informed consent MiniMental score <24 Aphasia Nursing home placement after discharge Contacts and Locations Go to Information from the National

2005 Clinical Trials

3757. Treatment of Depression in the Elderly

. deafness, blindness, severe aphasia Patients who cannot speak Danish well enough to make psychometric assessment possible and meaningful Patients with congenital or early acquired intellectual deficits Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number

2005 Clinical Trials

3758. Treatment Study of Frontotemporal Dementia

Dementia or Primary Progressive Aphasia. Ages 45 to 95 years old. Mild-to-moderate (CDR 1 to 2) FTD with an assigned durable power of attorney. EXCLUSION CRITERIA: Diagnosis of any form of dementia besides FTD, including AD, Lewy body dementia, vascular dementia, dementia associated with Parkinson's disease, Corticobasal Degeneration and Progressive Supranuclear Palsy. Severe dementia (CDR 3). Known allergy or serious adverse reaction to quetiapine or dextroamphetamine. Patient is already receiving (...) Frontotemporal Dementia Aphasia, Primary Progressive Pick Disease of the Brain Frontotemporal Lobar Degeneration Brain Diseases Central Nervous System Diseases Nervous System Diseases Neurocognitive Disorders Mental Disorders TDP-43 Proteinopathies Neurodegenerative Diseases Proteostasis Deficiencies Metabolic Diseases Aphasia Speech Disorders Language Disorders Communication Disorders Neurobehavioral Manifestations Neurologic Manifestations Signs and Symptoms

2004 Clinical Trials

3759. Diabetes Telemedicine Consultation: A Systems Improvement Intervention

) Current prescription of insulin or an oral hypoglycemic agent 2) A1c > 7.0% 3) fasting glucose levels > 130 mg/dl 4) referred to see a consultant and are seen during the active intervention phase. Patients with either Type I or Type II DM will be included A Primary Care Provider for a Cleveland CBOC Exclusion Criteria: 1) primary care obtained at more than one site (based on stop codes with evidence of more than 1 CBOC involved in care during the last 6 months) 2) documented dementia, aphasia

2005 Clinical Trials

3760. Telephone Disease Management At-Risk Drinking (TDM II)

diagnosis of current alcohol dependence current hallucinations and delusions current symptoms of PTSD a history of mania or hypomania. have adequate hearing to participate in telephone assessments and access to a telephone. Subjects will also show an absence of other barriers to verbal communication (e.g., aphasia) and will be cognitively intact (Brief Orientation Memory and Concentration task greater than 15 for those over age 54). not actively participating in specialized addiction treatment within

2005 Clinical Trials

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