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Aphasia

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3721. Aphasia therapy on a neuroscience basis Full Text available with Trip Pro

Aphasia therapy on a neuroscience basis BACKGROUND: Brain research has documented that the cortical mechanisms for language and action are tightly interwoven and, concurrently, new approaches to language therapy in neurological patients are being developed that implement language training in the context of relevant linguistic and non-linguistic actions, therefore taking advantage of the mutual connections of language and action systems in the brain. A further well-known neuroscience principle (...) : Advances in theoretical and experimental neuroscience have important implications for clinical practice. We exemplify this in the domain of aphasia rehabilitation. MAIN CONTRIBUTION: Whereas classical wisdom had been that aphasia cannot be significantly improved at a chronic stage, we here review evidence that one type of intensive language-action therapy (ILAT)-constraint-induced aphasia therapy-led to significant improvement of language performance in patients with chronic aphasia. We discuss

2008 Aphasiology

3722. Language in Primary Progressive Aphasia

Language in Primary Progressive Aphasia Language in Primary Progressive Aphasia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Language in Primary Progressive Aphasia The safety and scientific validity (...) Disorders (NIDCD) Information provided by (Responsible Party): Marsel Mesulam, Northwestern University Study Details Study Description Go to Brief Summary: The purpose of this study is to further define the neurological and linguistic deterioration in primary progressive aphasia. Condition or disease Primary Progressive Aphasia Detailed Description: The Language in Primary Progressive Aphasia (PPA) aims to understand the behavioral, anatomical and physiological changes in people with PPA throughout

2007 Clinical Trials

3723. Transcranial Magnetic Stimulation to Improve Speech in Aphasia

Transcranial Magnetic Stimulation to Improve Speech in Aphasia Transcranial Magnetic Stimulation to Improve Speech in Aphasia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Transcranial Magnetic (...) Stimulation to Improve Speech in Aphasia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00608582 Recruitment Status : Completed First Posted : February 6, 2008 Results First Posted : January 31, 2017 Last Update Posted : January 31, 2017 Sponsor: Boston University Collaborators: National Institute

2008 Clinical Trials

3724. Treating Intention In Aphasia: Neuroplastic Substrates

Treating Intention In Aphasia: Neuroplastic Substrates Treating Intention In Aphasia: Neuroplastic Substrates - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Treating Intention In Aphasia: Neuroplastic (...) Disorders (NIDCD) Information provided by (Responsible Party): University of Florida Study Details Study Description Go to Brief Summary: The purpose of this study is to determine if an "intentional act" improves treatment response for patients with nonfluent aphasia. The treatment involves naming pictures and saying members of categories. The "intentional act" requires initiating picture naming or category member trials with a left-hand movement sequence. Nonfluent aphasia is a disorder of language

2007 Clinical Trials

3725. Neural Networks and Language Recovery in Aphasia From Stroke: fMRI Studies

Neural Networks and Language Recovery in Aphasia From Stroke: fMRI Studies Neural Networks and Language Recovery in Aphasia From Stroke: fMRI Studies - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Neural (...) Networks and Language Recovery in Aphasia From Stroke: fMRI Studies The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00467103 Recruitment Status : Active, not recruiting First Posted : April 27, 2007 Last Update Posted : January 14, 2019 Sponsor: VA Office of Research and Development Collaborator: Boston

2007 Clinical Trials

3726. Memantine and Intensive Speech-Language Therapy in Aphasia

Memantine and Intensive Speech-Language Therapy in Aphasia Memantine and Intensive Speech-Language Therapy in Aphasia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Memantine and Intensive Speech-Language (...) Therapy in Aphasia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00640198 Recruitment Status : Completed First Posted : March 21, 2008 Last Update Posted : March 21, 2008 Sponsor: Gabinete Berthier y Martínez Collaborator: H. Lundbeck A/S Information provided by: Gabinete Berthier y Martínez Study

2008 Clinical Trials

3727. Cortical activation and language task difficulty in aphasia Full Text available with Trip Pro

Cortical activation and language task difficulty in aphasia BACKGROUND: Previous research using functional MRI (fMRI) suggests changes in cortical activation as a function of increased task difficulty. This relationship has not been explored in persons with aphasia even though it may have significant implications for pre- and post-treatment interpretation of fMRI data. AIMS: The purpose of this exploratory study was to investigate the relationship between changes in language task difficulty (...) and cortical activation in persons with aphasia. METHODS #ENTITYSTARTX00026; PROCEDURES: Four persons with chronic anomic or Broca's aphasia and four matched control participants underwent fMRI while performing a picture-word matching task. OUTCOMES #ENTITYSTARTX00026; RESULTS: Compared to the more difficult task condition, all participants performed with greater accuracy on the easier condition. Moreover, greater mean blood oxygenated level dependent (BOLD) signal intensity and area recruitment were

2005 Aphasiology

3728. Aphasia and auditory extinction: Preliminary evidence of binding Full Text available with Trip Pro

Aphasia and auditory extinction: Preliminary evidence of binding Background: McNeil, Odell, and Tseng (1991), and Murray and colleagues (Murray, 2000; Murray, Holland, & Beeson, 1997a, 1997b) have suggested that variability of performance in patients with aphasia may be due to nonlinguistic cognitive variables, such as attention (i.e., resources, capacity, effort), which affect language comprehension and production. Given the research that has supported the relationship between aphasia (...) and attention deficits, it is important to determine what effect this breakdown in attention may have on cognitive processes for individuals with aphasia.Aims: This study aims to determine if auditory extinction is present in individuals with aphasia, and if so, if this is due to a breakdown in binding. If extinction is found for individuals with aphasia, it would further support the notion that auditory attention difficulties are present among individuals with aphasia, since visual and auditory research

2005 Aphasiology

3729. Organizing a Series of Education and Support Conferences for Caregivers of Individuals With Frontotemporal Dementia and Primary Progressive Aphasia Full Text available with Trip Pro

Organizing a Series of Education and Support Conferences for Caregivers of Individuals With Frontotemporal Dementia and Primary Progressive Aphasia Frontotemporal dementia and primary progressive aphasia are relatively rare dementias, with average age of onset in the 40s to 60s, and cause initial degeneration in behavior and language, respectively. Caregivers of diagnosed individuals report that there is little information available about these diseases. In response to this need, we designed

2006 Alzheimer's care quarterly

3730. Communicative value of self cues in aphasia: A re-evaluation Full Text available with Trip Pro

Communicative value of self cues in aphasia: A re-evaluation BACKGROUND: Adults with aphasia often try mightily to produce specific words, but their word-finding attempts are frequently unsuccessful. However, the word retrieval process may contain rich information that communicates a desired message regardless of word-finding success. AIMS: The original article reprinted here reports an investigation that assessed whether patient-generated self cues inherent in the word retrieval process could (...) be interpreted by listener/observers and improve on communicative effectiveness for adults with aphasia. The newly added commentary identifies and reports tentative conclusions from 18 investigations of self-generated cues in aphasia since the 1982 paper. It further provides a rationale for increasing research on self-generated cueing and notes a surprising lack of attention to the questions investigated in the original article. The original research is also connected with more recent qualitative

2006 Aphasiology

3731. Successful syllable detection in aphasia despite processing impairments as revealed by event-related potentials Full Text available with Trip Pro

Successful syllable detection in aphasia despite processing impairments as revealed by event-related potentials The role of impaired sound and speech sound processing for auditory language comprehension deficits in aphasia is unclear. No electrophysiological studies of attended speech sound processing in aphasia have been performed for stimuli that are discriminable even for patients with severe auditory comprehension deficits.Event-related brain potentials (ERPs) were used to study speech (...) sound processing in a syllable detection task in aphasia. In an oddball paradigm, the participants had to detect the infrequent target syllable /ta:/ amongst the frequent standard syllable /ba:/. 10 subjects with moderate and 10 subjects with severe auditory comprehension impairment were compared to 11 healthy controls.N1 amplitude was reduced indicating impaired primary stimulus analysis; N1 reduction was a predictor for auditory comprehension impairment. N2 attenuation suggests reduced attended

2007 Behavioral and Brain Functions

3732. Exclusion and inclusion criteria for people with aphasia in studies of depression after stroke: a systematic review and future recommendations. (Abstract)

Exclusion and inclusion criteria for people with aphasia in studies of depression after stroke: a systematic review and future recommendations. A third of individuals are depressed following stroke. A similar proportion have aphasia. The extent of their inclusion in depression following stroke studies affects the generalizability of findings.We systematically reviewed published studies (to December 2005) that diagnosed depression following stroke. We identified aphasia screening methods (...) , aphasia exclusion and inclusion criteria and respective numbers of individuals with aphasia.Of 129 studies (n = 19,183), aphasia screening methods were only reported by 57 (31 described a published aphasia-specific tool). No mention of aphasia was made in 13 studies. Most studies (92, 71%) reported some exclusion of people with aphasia (49 reported how many: n = 3,082, range = 2-554). Almost half of the studies (60, 47%) actually reported participants with aphasia (37 specified numbers: n = 829, range

2007 Neuroepidemiology

3733. Are regular and irregular verbs dissociated in non-fluent aphasia? A meta-analysis. (Abstract)

Are regular and irregular verbs dissociated in non-fluent aphasia? A meta-analysis. The cognitive mechanisms and neuroanatomical substrates used by the brain to effortlessly generate morphologically complex words (write + ing --> writing) are little understood. The left inferior frontal gyrus (LIFG, including Broca's area) is often implicated as being involved, although its specific role is unclear. Data from brain damaged individuals, particularly those with Broca's aphasia, are often used (...) is a synthesis of research studies investigating the production of morphologically complex regular and irregular verbs in individuals with Broca's aphasia. The question being asked is if there is a robust and consistent dissociation, and if this dissociation can be tied to lesions of the left frontal lobe. This meta-analysis of 75 patients failed to show a single consistent dissociation pattern and over half the datasets had no significant difference between regulars and irregulars. There was also

2007 Brain research bulletin

3734. Measures for rating social participation in people with aphasia: a systematic review. (Abstract)

Measures for rating social participation in people with aphasia: a systematic review. Re-establishing participation in social life is an important aim of rehabilitation, but instruments to measure participation in people with aphasia are rare.To identify and describe measures of social participation that may be specifically useful when measuring participation in people with aphasia.A systematic review of the literature concerning participation instruments was conducted. Then six speech (...) and language therapists evaluated the suitability of selected participation measures for use in people with aphasia and a systematic literature review concerning the feasibility, internal consistency, validity, reliability and responsiveness of the measures selected by the therapists was carried out.In total 12 instruments measuring aspects of participation were found: seven measured actual performance and five measured actual performance combined with experienced problems. Two were considered unsuitable

2008 Clinical rehabilitation

3735. Evidence-based systematic review: effects of intensity of treatment and constraint-induced language therapy for individuals with stroke-induced aphasia. (Abstract)

Evidence-based systematic review: effects of intensity of treatment and constraint-induced language therapy for individuals with stroke-induced aphasia. This systematic review summarizes evidence for intensity of treatment and constraint-induced language therapy (CILT) on measures of language impairment and communication activity/participation in individuals with stroke-induced aphasia.A systematic search of the aphasia literature using 15 electronic databases (e.g., PubMed, CINAHL) identified (...) 10 studies meeting inclusion/exclusion criteria. A review panel evaluated studies for methodological quality. Studies were characterized by research stage (i.e., discovery, efficacy, effectiveness, cost-benefit/public policy research), and effect sizes (ESs) were calculated wherever possible.In chronic aphasia, studies provided modest evidence for more intensive treatment and the positive effects of CILT. In acute aphasia, 1 study evaluated high-intensity treatment positively; no studies examined

2008 Journal of speech, language, and hearing research : JSLHR

3736. Poststroke aphasia : epidemiology, pathophysiology and treatment. (Abstract)

Poststroke aphasia : epidemiology, pathophysiology and treatment. Aphasia, the loss or impairment of language caused by brain damage, is one of the most devastating cognitive impairments of stroke. Aphasia is present in 21-38% of acute stroke patients and is associated with high short- and long-term morbidity, mortality and expenditure. Recovery from aphasia is possible even in severe cases. While speech-language therapy remains the mainstay treatment of aphasia, the effectiveness (...) of conventional therapies has not been conclusively proved. This has motivated attempts to integrate knowledge from several domains in an effort to plan more rational therapies and to introduce other therapeutic strategies, including the use of intensive language therapy and pharmacological agents. Several placebo-controlled trials suggest that piracetam is effective in recovery from aphasia when started soon after the stroke, but its efficacy vanishes in patients with chronic aphasia. Drugs acting

2005 Drugs & Aging

3737. Clusters of cognitive and behavioral disorders clearly distinguish primary progressive aphasia from frontal lobe dementia, and Alzheimer's disease. Full Text available with Trip Pro

Clusters of cognitive and behavioral disorders clearly distinguish primary progressive aphasia from frontal lobe dementia, and Alzheimer's disease. Frontal lobe dementia (FLD) and primary nonfluent progressive aphasia (PnPA) are two forms of frontotemporal lobe degeneration. The relationship between these conditions remains unclear. Our study aimed to better define the behavioral and cognitive clusters characterizing PnPA patients.We cognitively and behaviorally evaluated three groups of newly

2007 Dementia and Geriatric Cognitive Disorders

3738. Pearls & Oy-sters: selective postictal aphasia: cerebral language organization in bilingual patients. Full Text available with Trip Pro

Pearls & Oy-sters: selective postictal aphasia: cerebral language organization in bilingual patients. Ictal and postictal language dysfunction is common and strongly predictive of language laterality in monolingual patients. For bilingual patients, selective dysfunction has been reported for a single language with focal cerebral lesions, electrical brain stimulation, and intracarotid sodium amytal.Two right-handed Ukrainian-English bilingual patients with left perisylvian structural lesions (...) , late onset complex-partial seizures, and postictal aphasia for English are presented and discussed with regard to mechanisms of selective aphasia and factors contributory to language lateralization in bilingual patients.Ukrainian was the native language of both patients with English acquired after 7 years of age. Regular/video-EEG showed left temporal epileptogenesis. A 56-year-old man, who had a left hemorrhagic stroke at age 50 and had not spoken Ukrainian for 40 years, was unable to speak

2008 Neurology

3739. Recurrent expressive aphasia as a presentation of cat-scratch encephalopathy. (Abstract)

Recurrent expressive aphasia as a presentation of cat-scratch encephalopathy. Cat-scratch disease is a common disease, occurring in an estimated 24,000 patients annually in the United States, and is one of the most common causes of chronic lymphadenitis in children. A wide array of neurologic complications occurs as a result of cat-scratch disease. However, there have been no reports of acute-onset, self-resolving, recurrent, expressive aphasia, as we report here in an adolescent boy. In our

2007 Pediatrics

3740. Primary progressive aphasia: reversed asymmetry of atrophy and right hemisphere language dominance. (Abstract)

Primary progressive aphasia: reversed asymmetry of atrophy and right hemisphere language dominance. Primary progressive aphasia (PPA) is almost always associated with asymmetrical left hemisphere degeneration. The authors report that right hemisphere atrophy in a patient with PPA was associated with atypical right hemisphere dominance for language. This suggests that neuronal damage in PPA is therefore tightly linked to the underlying anatomy of the language network.

2005 Neurology

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