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Aphasia

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3701. Moving a Paralyzed Hand Through Use of a Brain-Computer Interface

regarding the trauma. Absent changes in both Glascow Coma Scale and mental status following injury. Outpatients who are unable to make a 12-week commitment. Inpatients who are unable to make a 15 day commitment. Comprehensive aphasia. EXCLUSION CRITERIA - CHRONIC STROKE PATIENTS: Cerebellar lesions. More than one stroke in the middle cerebral artery territory. Bilateral motor impairment. Initiation of an exercise or rehabilitation program that could affect experimental results. Outpatients who (...) are unable to make a 12-week commitment. Inpatients who are unable to make a 15 day commitment. Comprehensive aphasia. EXCLUSION CRITERIA - HEALTHY VOLUNTEERS: Inability to make a 12-week commitment. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number

2005 Clinical Trials

3702. Usefulness of Nasal Continuous Positive Airway Pressure (CPAP) Treatment in Patients With a First Ever Stroke and Sleep Apnea Syndrome

Years to 75 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: First ever stroke Any Sleep Apnea symptom Hypertension Exclusion Criteria: Aphasia Cognitive impairment Hypersomnolence Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its

2005 Clinical Trials

3703. Double Blind Study of Trp01 in Patients With Alzheimer's Disease

according to DSM-IV criteria : development of multiple cognitive deficits manifested by both memory impairment and one or more of the following cognitive disturbances: aphasia, apraxia, agnosia, disturbance in executive functioning the above-mentioned deficits cause significant impairment in social or occupational functioning they do not occur exclusively during the course of delirium Dementia according to communicative disorders and stroke criteria (NINCDS-ADRDA) dementia established clinically

2005 Clinical Trials

3704. Problem Adaptation Therapy (PATH) vs. Supportive Therapy in Treating Depressed, Cognitively Impaired Older Adults

failure; major surgery; stroke; myocardial infarction during the 3 months prior to entry) Currently taking drugs known to cause depression (e.g., reserpine, alpha-methyl-dopa, steroids) Currently receiving psychotherapy Aphasia Sensory problems Inability to speak English Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer

2006 Clinical Trials

3705. Serotonergic Function and Behavioural and Psychological Symptoms of Frontotemporal Dementia

provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Meet the DSM-IV criteria for primary degenerative dementia Meet standard clinical criteria for frontotemporal dementia (ie., frontotemporal degeneration including both the frontal/behavioural variant and primary progressive aphasia) Have significant behavioural problems (...) Responsible Party: Dr. Nathan Herrmann, Sunnybrook Health Sciences Centre ClinicalTrials.gov Identifier: Other Study ID Numbers: 218-2006 07-48 First Posted: September 14, 2006 Last Update Posted: May 5, 2017 Last Verified: November 2009 Keywords provided by Sunnybrook Health Sciences Centre: frontotemporal lobar degeneration frontotemporal dementia serotonin dementia behavioural disturbances Additional relevant MeSH terms: Layout table for MeSH terms Dementia Frontotemporal Dementia Aphasia, Primary

2006 Clinical Trials

3706. Gait Training and Brain Changes in Stroke Patients

of alcohol or drug abuse or severe language disturbances (aphasia) have uncontrolled medical problems, such as heart, lung or kidney disease, epilepsy or diabetes mellitus, are pregnant. Since the effects of MRI and TMS on fetal development are unknown, women of childbearing age will have pregnancy test prior to the study and pregnant women will be excluded. have a cardiac pacemaker, intracardiac lines, implanted medication pumps, neural stimulators, metal in the cranium, with the exception or dental

2006 Clinical Trials

3707. Beta-hCG + Erythropoietin in Acute Stroke

Naming Test [ Time Frame: 3 mo ] Measure of aphasia or other language disturbance caused by stroke or other dementing disorders. It consists of 60 line drawings graded in difficulty in which patients are to name each picture. Line Cancellation Test [ Time Frame: 3 mo ] Measure of spatial neglect where patients must cross out lines placed in a random orientation. Missed lines may indicate areas of spatial neglect. NIH Stroke Scale [ Time Frame: 3 mo ] Measure of global impairment post stroke

2006 Clinical Trials

3708. Evaluation of Biochemical Markers and Clinical Investigation of Niemann-Pick Disease, Type C

Drug Product: No Studies a U.S. FDA-regulated Device Product: No Keywords provided by National Institutes of Health Clinical Center (CC) ( Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) ): Lysosomal Storage Biomarkers Longitudinal Niemann Pick Type C NPC Lysosomal Storage Disorder Additional relevant MeSH terms: Layout table for MeSH terms Pick Disease of the Brain Aphasia, Primary Progressive Frontotemporal Dementia Niemann-Pick Diseases Niemann-Pick (...) Disease, Type A Niemann-Pick Disease, Type C Frontotemporal Lobar Degeneration Dementia Brain Diseases Central Nervous System Diseases Nervous System Diseases Neurocognitive Disorders Mental Disorders Aphasia Speech Disorders Language Disorders Communication Disorders Neurobehavioral Manifestations Neurologic Manifestations Signs and Symptoms TDP-43 Proteinopathies Neurodegenerative Diseases Proteostasis Deficiencies Metabolic Diseases Sphingolipidoses Lysosomal Storage Diseases, Nervous System Brain

2006 Clinical Trials

3709. Pilot Study

weeks Patients with an upper extremity plegia (Medical Research Council [MRC] grade 2 or less at the shoulder joint), Patients or their next of kin (in the absence of their being able to) provide with a written informed consent. Aphasic alert patients provided they could follow simple directions given by verbal or gestural cues. Exclusion criteria: Patients with anterior or severe inferior shoulder subluxation (3 cms) of the plegic arm Patients without shoulder pain on passive range of 75 degrees

2006 Clinical Trials

3710. Adapting Tools to Implement Stroke Risk Management to Veterans

impairments; life expectancy of at least 6 mos; willingness to follow-up in Veterans Administration outpatient care. Exclusion Criteria: Severe aphasia or cognitive impairment; active alcohol or substance abuse; cannot or unwilling to participate; does not speak or understand English; life expectancy less than 6 mos; no access to telephone; no Veterans Administration outpatient follow-up. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you

2006 Clinical Trials

3711. Recovery of Hand Function Through Mental Practice.

. For general information, Layout table for eligibility information Ages Eligible for Study: Child, Adult, Older Adult Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Confirmed diagnosis of stroke in the last 1-6 months Persisting upper limb weakness - Exclusion Criteria: Alcohol/ Drug abuse Psychiatric history Previous illness that has impacted on individuals Activity of Daily living - Dementia (assessed by MSQ) Severe Aphasia Contacts and Locations Go

2006 Clinical Trials

3712. Effect of Soy on Cognition and Hot Flashes in Men With Prostate Cancer Undergoing Testosterone Suppression Therapy

positives.A higher score= higher cognitive function. Cognitive Function as Assessed by the F-A-S Test [ Time Frame: baseline, 6 weeks, 12 weeks ] The F-A-S Test, a subtest of the Neurosensory Center Comprehensive Examination for Aphasia (NCCEA), is a measure of phonemic word fluency, which is a type of verbal fluency. It assesses phonemic fluency by requesting an individual to orally produce as many words as possible that begin with the letters F, A, and S within a prescribed time frame (1 minute

2005 Clinical Trials

3713. IVPCA in the Management of Pain Following Major Intracranial Surgery

: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Adults undergoing intracranial surgery Exclusion Criteria: Patient refusal Pregnancy Aphasia Respiratory failure Allergy/intolerance to fentanyl Opioids use History of opioid-dependent pain, Patient has been in an investigational drug trial (except chemotherapy) in the month preceding the day of enrollment Mental or physical limitations that would prevent patient assessment or PCA use Chronic painful conditions unrelated to the reason

2006 Clinical Trials

3714. The Effect of Aerobic Exercise on Learning After Stroke

to be controlled < month receptive or expressive aphasia as indicated on MMSE multiple strokes or other neuromuscular conditions major depression that is untreated using the Beck depression inventory Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00228306

2005 Clinical Trials

3715. Propofol Injection for Daily Headache

, Those having language barriers (e.g. illiterate, not English-speaking, dysphasic), Known or suspected difficult airway or sleep apnea, Severe respiratory disease, Neuromuscular disease, Seizure disorder, Severe cardiac disease, Severe gastroesophageal reflux disease, Pancreatitis, Lipid disorders, Receiving Total Parenteral Nutrition, Body mass index > 35, diabetes or major endocrine disorder, Hepatic or renal failure, Unstable psychiatric disorder, Known drug abuse, Pregnancy, Cognitively impaired

2005 Clinical Trials

3716. Acetylcholinesterase Inhibitors to Improve Cognitive Function and Overall Rehabilitation After a Stroke

) Stroke was within 30 days of being admitted Medically stable Presence of memory and/or attentional impairments and evidence that these impairments were not present or were less severe prior to the stroke (assessed via interview with family) Approval by individual's attending physician at the rehabilitation hospital Exclusion Criteria: Aphasia or cognitive (or behavioral) impairments severe enough to prevent valid neuropsychiatric assessment Currently experiencing a major depressive episode (unless

2005 Clinical Trials

3717. Combined transcranial direct current stimulation and robot-assisted arm training in subacute stroke patients: a pilot study. (Abstract)

Aphasie Test.No major side effects occurred. Arm function of three patients (two with a subcortical lesion) improved significantly, with FM scores increasing from 6 to 28, 10 to 49 and 11 to 48. In the remaining seven patients, all with cortical lesions, arm function changed little, FM scores did not increase more than 5 points. Unexpectedly, aphasia improved in 4 patients.These procedures are safe, and easy to use in a clinical setting. In future studies, patients should be stratified by degree (...) of arm weakness and lesion site, also the unexpected aphasia improvement warrants following-up.

2007 Restorative neurology and neuroscience

3718. Noninvasive brain stimulation improves language learning. (Abstract)

Noninvasive brain stimulation improves language learning. Anodal transcranial direct current stimulation (tDCS) is a reliable technique to improve motor learning. We here wanted to test its potential to enhance associative verbal learning, a skill crucial for both acquiring new languages in healthy individuals and for language reacquisition after stroke-induced aphasia. We applied tDCS (20 min, 1 mA) over the posterior part of the left peri-sylvian area of 19 young right-handed individuals

2008 Journal of cognitive neuroscience

3719. The Role of Methylcobalamin in Early Dementia Patients With Vitamin B12 Deficiency and Hyperhomocysteinaemia ?

(Adult, Older Adult) Sexes Eligible for Study: All Criteria Inclusion: Patients with Dementia Serum B12 < 200 pmol/l Serum Homocysteine level > 11.0 micro mol/L Exclusion: Significant communication problems deafness, dysarthria, dysphasia etc. unstable DM or hypertension alcohol abuse co-existing diseases which may affect cognition e.g. cognitive cardiac failure, respiratory failure folate < 10 g/dl haemoglobin concentration < 10g/d abnormal thyroid function test or VDRL Contacts and Locations Go

2005 Clinical Trials

3720. Treatment of Depressed Chronic Obstructive Pulmonary Disease Patients

information Ages Eligible for Study: 50 Years to 95 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Chronic obstructive pulmonary disease by American Thoracic Society criteria Major depression by DSM-IV criteria 17-item Hamilton score >14 English speaking Exclusion Criteria: Inability to give informed consent MiniMental score <24 Aphasia Nursing home placement after discharge Contacts and Locations Go to Information from the National

2005 Clinical Trials

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