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3701. Effect of Repetitive Transcranial Magnetic Stimulation on Language in Alzheimer's Disease

to be useful in treating refractory depression and depression in Parkinson's disease. In addition, rTMS has improved naming in patients with Alzheimer's disease and has improved cognitive abilities and memory in non-demented older adults. Two studies found that rTMS improved aphasia in patients with stroke. While these studies are small, a review of the literature suggests that there may be a beneficial role for rTMS in patients with chronic neurological conditions. In addition, rTMS appears to be well (...) tolerated, with transient headaches being the most common side effect. In this small open label study, the investigators wish to investigate the usefulness of bilateral stimulation of the brain region termed the dorsolateral prefrontal cortex (DLPFC) in patients with AD who have naming and language deficits. Condition or disease Intervention/treatment Phase Alzheimer's Disease Aphasia Dementia Device: Repetitive Transcranial Magnetic Coil Stimulation (rTMS) Phase 2 Detailed Description: Subjects

2008 Clinical Trials

3702. Efficacy and Safety Study of Desmoteplase to Treat Acute Ischemic Stroke (DIAS-4)

(aphasia and dysarthria), and neglect. Each item is rated on a 3-, 4-, or 5-point scale ranging from 0 (normal) to the maximum score (extremely severe symptoms). The total score of the 15 items ranges from 0 to 42, where lower scores indicate less impairment. Composite of mRS & NIHSS Response (Percentage of Participants With mRS Scores 0-2 and (NIHSS <= 1 or NIHSS Decrease >= 8) [ Time Frame: Day 90 ] Please see outcomes measure one and two for detailed description of the scales Modified Ranking Scale

2009 Clinical Trials

3703. Enhance of Language Learning With Neurostimulation

): Universitätsklinikum Hamburg-Eppendorf Study Details Study Description Go to Brief Summary: The purpose of this study is to test the effect of transcranial direct current stimulation over the motor cortex of the language dominant hemisphere on language learning in healthy subjects and stroke patients with aphasia. We hypothesize that anodal stimulation enhances the learning of action words compared to sham and cathodal stimulation. Condition or disease Intervention/treatment Phase Stroke Aphasia Aging Device (...) modulates the acquisition of new action words. The results bear the potential to design new rehabilitative strategies in stroke patients with aphasia. The motor cortex might offer an access to the language network that can be used for interventional approaches such as neurostimulation. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 70 participants Allocation: Randomized Intervention Model: Crossover Assignment Masking: Triple

2009 Clinical Trials

3704. Enhancement of Motor Function With Reboxetine and Transcranial Direct Current Stimulation

in the head/neck region pacemaker a psychiatric disorder or neurological disease besides stroke intake of illegal drugs severe aphasia or cognitive deficits that impede contractual capability contraindications for reboxetine (seizures, glaucoma, prostate hyperplasia with urinary retention, cardiac arrhythmias, potential interactions with co-medication) pregnancy breast-feeding patients Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you

2009 Clinical Trials

3705. Genetics of Familial and Sporadic ALS

ID Numbers: Lab01 RO1N505641-04 ( Other Identifier: NINDS ) First Posted: January 13, 2009 Last Update Posted: March 29, 2018 Last Verified: March 2018 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: No Keywords provided by Teepu Siddique, Northwestern University: FALS ALS ALS/FTD SALS MND PLS Additional relevant MeSH terms: Layout table for MeSH terms Sclerosis Dementia Motor Neuron Disease Amyotrophic Lateral Sclerosis Frontotemporal Dementia Aphasia, Primary Progressive (...) Pick Disease of the Brain Pathologic Processes Brain Diseases Central Nervous System Diseases Nervous System Diseases Neurocognitive Disorders Mental Disorders Neurodegenerative Diseases Neuromuscular Diseases Spinal Cord Diseases TDP-43 Proteinopathies Proteostasis Deficiencies Metabolic Diseases Frontotemporal Lobar Degeneration Aphasia Speech Disorders Language Disorders Communication Disorders Neurobehavioral Manifestations Neurologic Manifestations Signs and Symptoms

2009 Clinical Trials

3706. Improvement of Language Disturbances After Stroke by Intensive Training and Electrical Brain Stimulation

a stroke. Condition or disease Intervention/treatment Phase Aphasia Stroke Device: anodal tDCS Device: cathodal tDCS Device: sham stimulation Phase 2 Phase 3 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 20 participants Allocation: Randomized Intervention Model: Crossover Assignment Masking: Double (Participant, Outcomes Assessor) Primary Purpose: Treatment Official Title: Improvement of Aphasia After Stroke by Intensive (...) stimulation Placebo Comparator: 3 sham stimulation Device: sham stimulation sham stimulation Outcome Measures Go to Primary Outcome Measures : Number of words correctly named after training plus tDCS [ Time Frame: 1 year ] Secondary Outcome Measures : Communicative-Activity-Log & Stroke-and-Aphasia-Quality-of-Life-Scale [ Time Frame: 1 year ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your

2009 Clinical Trials

3707. Using Transcranial Direct Current Stimulation (tDCS) to Enhance the Benefit of Movement Training in Stoke Patients

as assessed by the study physician by patient questioning Aphasia or language disturbances that would interfere with performing the study tasks Uncontrolled medical problems (e.g., active cancer or renal disease, any type of end-stage pulmonary or cardiovascular disease, diabetes, or other medical conditions, as determined by the study physician, that would interfere with participation in this study). Increased intracranial pressure as evaluated by clinical means (fundoscopic exam). Severe neglect

2008 Clinical Trials

3708. Apneic Oxygenation Via Nasal Cannulae Prevents Arterial Hypoxemia

stenosis and/or regurgitation, EF < 50% if known) Inability to lie flat (skeletal deformities, orthopnea, congestive cardiac failure) PaO2 < 200 mmHg on ABG after adequate preoxygenation to an ETO2 > 85% Hemoglobin < 100 g/L BMI > 40 kg/ m2 Pregnancy Patient unwillingness or refusal to participate Inability to consent (dementia) or cooperate (mentally challenged) Inability to communicate well or to understand English (language barrier, dysphasia) Neuromuscular disorders Known or presumed cervical spine

2008 Clinical Trials

3709. ACT NoW: Assessing the Effectiveness of Communication Therapy in the North West

: Stroke is the leading cause of long-term disability in the UK. About a third of stroke survivors will suffer some level of communication problems following the stroke. Such problems can affect parts or all of the motor apparatus responsible for producing speech, thus affecting clarity of speech and overall intelligibility (a condition known as dysarthria). Alternatively, stroke can affect the cognitive system for comprehending and formulating language (a condition known as dysphasia or aphasia). Some (...) people will suffer impairment of both speech and language. For these people, Speech and Language Therapy is often offered. Solid research evidence is a pre-requisite for planning evidence-based service delivery and systematic reviews for dysarthria and aphasia highlighted a lack of good quality research evidence of the effectiveness of Speech and Language Therapy. To try and rectify this situation, the ACT NoW study has been commissioned and funded by the NIHR Health Technology Assessment Programme

2009 Clinical Trials

3710. Safety Escalating Repeat IV, in Stroke Patients

immediately prior to the current stroke. Subjects who are not alert or are unresponsive as defined by a score of 2 or 3 on the NIHSS Level of Consciousness question (question #1a). Presence of significant aphasia as likely to confound or interfere with completion of the study assessments. Presence of peripheral neuropathy, including diabetic neuropathy, which is clinically active and symptomatic at time of screening. Presence of neurological or psychiatric disease, such as dementia or mild cognitive

2009 Clinical Trials

3711. Enhancing Rehabilitation After Stroke

bleed or untreated gastric ulcer; myocardial infarction, poorly controlled congestive heart failure, or coronary bypass surgery within the last 3 months; current required use of an anticholinergic medication (e.g., for bladder spasm); current aphasia severe enough to prevent valid neuropsychiatric assessment (e.g., a score < 9 on the Token Test, part I and a score of < 14 (or <80% accuracy) on the repetition task of the Boston Diagnostic Aphasia Examination); current Major Depressive Episode

2009 Clinical Trials

3712. Strength Training for Skeletal Muscle Adaptation After Stroke

hypertension (greater than 190/110) recent hospitalization for severe disease or surgery severe or global receptive aphasia which confounds reliable testing and training Allergy to lidocaine Known muscle disorder Taking Coumadin or Lovenox (contraindication for muscle biopsies) Dementia Untreated major depression Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information

2009 Clinical Trials

3713. Multimodal Treatment of Phonological Alexia: Behavioral & fMRI Outcomes

Party): VA Office of Research and Development Study Details Study Description Go to Brief Summary: This study offers 90-120 hours of 1:1 training to improve reading skills in adults who have poor reading skills following a stroke. Specifically, this study is designed to improve skill in sounding out words for reading and spelling. The overall time commitment for participation in this study is approximately 11-30 weeks. Condition or disease Intervention/treatment Phase Aphasia Stroke Dyslexia (...) ID Numbers: B6699-W First Posted: January 22, 2009 Last Update Posted: November 30, 2017 Last Verified: November 2017 Keywords provided by VA Office of Research and Development: Dyslexia Reading Aphasia Stroke Additional relevant MeSH terms: Layout table for MeSH terms Aphasia Dyslexia Dyslexia, Acquired Speech Disorders Language Disorders Communication Disorders Neurobehavioral Manifestations Neurologic Manifestations Nervous System Diseases Signs and Symptoms Learning Disorders

2009 Clinical Trials

3714. Fitness Intervention Trial for Stroke

of greater Montreal and greater Halifax. Exclusion Criteria: severe cognitive deficits as evaluated by the Telephone Version of the Mini-Mental State Examination such that the subject does not understand their participation in the study, receptive aphasia as evaluated by the Canadian Neurological Scale48 or the treating speech therapist, illness or disability precluding participation in either rehabilitation intervention. failure to pass a standard cardiology orientated history and physical examination

2008 Clinical Trials

3715. Exploring New Approaches in Reaching Behavior Post Stroke

for eligibility information Ages Eligible for Study: Child, Adult, Older Adult Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: Individuals all scored between 20 and 44 on the Upper-Arm subsection of the Fugl-Meyer Scale (FM- Poole & Whitney, 1988) and demonstrated some trunk movement during the pretest reaching performance scale measures (RPS, Levin 2006) Exclusion Criteria: Individuals were referred if they had no receptive aphasia, apraxia or other cognitive

2009 Clinical Trials

3716. Behaviour and Cognitive Evaluation for Dialysis Elderly Patients (BCDE)

the duration of pre-dialysis follow-up by the nephrologist("post-dialysis cohort"), Signed and dated informed consent. Exclusion Criteria: Moderately severe to severe dementia (MMS ≤ 15), Major depression and/or GDS-15 > 10/15, Severe dependency (ADL < 3/6), Psychosis, mutism or aphasia, Malignancy or any pathology with life expectancy < one year, Ongoing specialized geriatric care Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your

2009 Clinical Trials

3717. 30-Day Cardiac Event Monitor Belt for Recording Atrial Fibrillation After a Cerebral Ischemic Event

a legally authorized representative if the patient is not competent, e.g. due to stroke-related cognitive impairment, aphasia, or anosognosia). The patient is expected to survive at least 6 months. The patient has a valid provincial health insurance number. The index event will be defined as the event leading to medical presentation Exclusion: Any previously documented atrial fibrillation or atrial flutter, i.e. a past history of atrial fibrillation/flutter or atrial fibrillation/flutter detected on ECG

2009 Clinical Trials

3718. Improving the Delivery of Smoking Cessation Guidelines in Hospitalized Veterans

. Exclusion Criteria: Hospitalization for less than 18 hours (e.g., patients admitted for overnight observation); Acute medical decomposition (e.g., acute respiratory failure requiring intubation, cardiac arrest, septic shock); Altered mental status; Unstable psychiatric disorder (e.g., acute psychosis); Dementia; Communication barrier (unable to speak English, hard of hearing, aphasic); Pregnancy; Terminal illness (<12 month life expectancy); No access to a phone or the absence of a permanent address

2008 Clinical Trials

3719. Sensor-Augmented Insulin Delivery: Insulin Plus Glucagon Versus Insulin Alone

to screening. Enrollment or participation in any other research studies 30 days prior to and during the entirety of sensor insertion. Current alcohol abuse, substance abuse, or severe mental illness (as judged by the Principal Investigator (PI)). Any prior cerebrovascular accident or major permanent neurological damage such as aphasia, hemiparesis, or dementia. A history of cerebrovascular disease or cardiovascular disease regardless of the time since occurrence. Coronary artery disease (symptomatic

2008 Clinical Trials

3720. Cognitive Effects of Inhalational Versus Intravenous General Anesthesia in the Elderly

and Symbol Search subtests of the Processing Speed Index of the Wechsler Adult Intelligence Scale-III (WAIS-III; Wechsler, 1997) and the Controlled Oral Word Association subtest of the Multilingual Aphasia Examination. The outcomes were constructed as summed z-score composites. They are scaled as standard deviations. Thus, a score of 0 was central on each composite, and 95% of the scores would fall within -2.0 and +2.0. While there is no minimum or maximum value is rare for any score (<1%) to fall

2008 Clinical Trials

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