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Aphasia

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3681. The Changing “Face” of Aphasia Therapy Full Text available with Trip Pro

The Changing “Face” of Aphasia Therapy A growing literature suggests that with intensive treatment, individuals with chronic aphasia continue to demonstrate language recovery for years post stroke. For example, Bhogal and colleagues conducted a literature review which suggests that intensive speech language therapy delivered over a short period of time (average of 8.8 hours per week for 11.2 weeks) resulted in significant improvements, while lower-intensity therapy provided over a longer (...) period of time (average of 2 hours per week over 22.9 weeks) did not result in positive change (Bhogal, Teasell, Speechley, & Albert, 2003). Similarly, the constraint induced aphasia therapy data emphasize the importance of massed-practice in the improvement of language skills of individuals with chronic aphasia (Pulvermuller et al., 2001; Maher et al., 2006). However, providing intensive treatment to individuals with chronic aphasia can be costly, and the current healthcare environment in the United

2008 Perspectives on neurophysiology and neurogenic speech and language disorders

3682. Perispinal Etanercept Produces Rapid Improvement in Primary Progressive Aphasia: Identification of a Novel, Rapidly Reversible TNF-Mediated Pathophysiologic Mechanism Full Text available with Trip Pro

Perispinal Etanercept Produces Rapid Improvement in Primary Progressive Aphasia: Identification of a Novel, Rapidly Reversible TNF-Mediated Pathophysiologic Mechanism Primary progressive aphasia (PPA) is an uncommon form of progressive dementia for which there exists no established treatment. The underlying pathology may be that of either frontotemporal dementia or Alzheimer's disease. Increasing evidence suggests that excess tumor necrosis factor (TNF) may play a central role in Alzheimer's

2008 The Medscape Journal of Medicine

3683. Treatment for lexical retrieval in progressive aphasia Full Text available with Trip Pro

Treatment for lexical retrieval in progressive aphasia BACKGROUND: Treatment for lexical retrieval impairment has been shown to yield positive outcomes in individuals with aphasia due to focal lesions, but there has been little research regarding the treatment of such impairments in individuals with progressive aphasia. AIMS: The purpose of this study was to examine the therapeutic effects of a semantic treatment for anomia in progressive aphasia relative to the outcome in an individual (...) with stroke-induced aphasia. METHODS #ENTITYSTARTX00026; PROCEDURES: Two individuals with progressive aphasia and one with aphasia resulting from stroke participated in the study. Each participant presented with fluent, anomic aphasia; however, one of the patients with progressive aphasia demonstrated characteristics indicating a likely progression towards non-fluency. Each participant received a brief, intensive treatment intended to improve lexical retrieval in the context of generative naming

2008 Aphasiology

3684. Neuropsychiatric Symptoms in Behavioral Variant Frontotemporal Dementia and Primary Progressive Aphasia Full Text available with Trip Pro

Neuropsychiatric Symptoms in Behavioral Variant Frontotemporal Dementia and Primary Progressive Aphasia Neuropsychiatric symptoms are well defined in behavioral variant frontotemporal dementia but are not as well studied in primary progressive aphasia. This study compared caregiver reported neuropsychiatric symptoms in these 2 forms of dementia at short and long disease duration. Patients with behavioral variant frontotemporal dementia had more symptoms than patients with primary progressive (...) aphasia. However, when divided by duration of disease, patients with primary progressive aphasia with long duration had a similar number of symptoms to patients with behavioral variant frontotemporal dementia at either duration. Furthermore, this group of patients with primary progressive aphasia had more symptoms typical of behavioral variant frontotemporal dementia and less mood-related symptoms which were more common in patients with primary progressive aphasia with shorter duration. This study

2008 Journal of Geriatric Psychiatry and Neurology

3685. Treatment for Word Retrieval Impairments in Aphasia

Treatment for Word Retrieval Impairments in Aphasia Treatment for Word Retrieval Impairments in Aphasia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Treatment for Word Retrieval Impairments in Aphasia (...) by (Responsible Party): Dr. Anastasia Raymer, Old Dominion University Study Details Study Description Go to Brief Summary: In this study the investigators are examining the effectiveness of two different speech therapy protocols for word retrieval impairments experienced by individuals with stroke-induced aphasia. One treatment involves errorless naming treatment and the other employs verbal plus gestural facilitation of word retrieval. Participants will receive one of the two treatments over several months

2008 Clinical Trials

3686. Effects of semantic treatment on verbal communication and linguistic processing in aphasia after stroke: a randomized controlled trial. Full Text available with Trip Pro

Effects of semantic treatment on verbal communication and linguistic processing in aphasia after stroke: a randomized controlled trial. Semantic deficits, deficits in word meaning, have a large impact on aphasic patients' verbal communication. We investigated the effects of semantic treatment on verbal communication in a randomized controlled trial.Fifty-eight patients with a combined semantic and phonological deficit were randomized to receive either semantic treatment or the control treatment

2004 Stroke Controlled trial quality: predicted high

3687. Long-term antidepressant treatment with moclobemide for aphasia in acute stroke patients: a randomised, double-blind, placebo-controlled study. (Abstract)

Long-term antidepressant treatment with moclobemide for aphasia in acute stroke patients: a randomised, double-blind, placebo-controlled study. Pharmacotherapy aimed at stroke rehabilitation through direct central nervous effects may be assumed to work in a similar way for language recovery and sensory-motor recovery. Some data suggest that antidepressant drugs could be beneficial also for functional improvement. This prompted us to investigate whether regression from aphasia after acute stroke (...) could be enhanced by antidepressive drug therapy.We randomised 90 acute stroke patients with aphasia to either 600 mg moclobemide or placebo daily for 6 months, within 3 weeks of the onset of stroke. Aphasia was assessed prior to treatment and at 6 months, using Reinvang's 'Grunntest for afasi' and the Amsterdam-Nijmegen-Everyday-Language-Test (ANELT).The degree of aphasia decreased significantly at 6 months, with no difference between the moclobemide- and the placebo-treated groups. Multivariate

2005 Cerebrovascular diseases (Basel, Switzerland) Controlled trial quality: predicted high

3688. Evolution of phonemic word fluency performance in post-stroke aphasia. (Abstract)

Evolution of phonemic word fluency performance in post-stroke aphasia. In this longitudinal study, quantitative and qualitative changes in responses of people with aphasia were examined on a phonemic fluency task. Eighteen patients were tested at 3-month intervals on the letters F-A-S while they received comprehensive, intensive treatment from 3 to 12 months post-stroke. They returned for a follow-up evaluation at an average of 10 months post-intervention. Mean group scores improved (...) since onset and the linguistic and cognitive stimulation that patients received in therapy.Readers of this paper should (1) gain a better understanding of verbal fluency performance in the assessment of aphasia, (2) recognize the importance of analyzing qualitative aspects of single word production in aphasia, and (3) contribute to their clinical judgment of long term improvement in aphasia.

2004 Journal of communication disorders Controlled trial quality: uncertain

3689. Inference revision processing in adults with and without aphasia. (Abstract)

Inference revision processing in adults with and without aphasia. Processing abilities in aphasia, and the nature of processing breakdowns, were the focuses of this investigation. Individuals with either fluent or nonfluent aphasia, plus a control group, participated in a cross-modal lexical priming task designed to elicit priming effects when activation of inference interpretations occurred. Comprehension of inferences was measured by responses to four types of questions that related (...) to the inferences. Results indicated that both the control group, as well as the nonfluent aphasia group, activated the intended meaning of the stimuli whereas the fluent aphasics did not. Comprehension of the inferences was best demonstrated by control participants, nonfluent aphasic participants, and fluent aphasic participants, in that order.

2004 Brain and language Controlled trial quality: uncertain

3690. Mapping therapy for sentence production impairments in nonfluent aphasia. Full Text available with Trip Pro

Mapping therapy for sentence production impairments in nonfluent aphasia. This study investigated a new treatment in which sentence production abilities were trained in a small group of individuals and nonfluent aphasia. It was based upon a mapping therapy approach which holds that sentence production and comprehension impairments are due to difficulties in mapping between the meaning form (thematic roles) and the syntactic form of sentences. We trained production of both canonical

2005 Neuropsychological rehabilitation Controlled trial quality: uncertain

3691. A randomized, double-blind trial of bromocriptine efficacy in nonfluent aphasia after stroke. (Abstract)

A randomized, double-blind trial of bromocriptine efficacy in nonfluent aphasia after stroke. The authors assessed the efficacy of bromocriptine in nonfluent aphasia after stroke in a 16-week, randomized, double-blind, placebo-controlled clinical trial conducted from June 2002 to April 2004. In all 38 patients after 4 months of treatment, improvement in both the bromocriptine and placebo treatment groups was observed (p < 0.001). The analysis of repeated-measures analysis of variance revealed (...) bromocriptine did not improve nonfluent aphasia.

2006 Neurology Controlled trial quality: predicted high

3692. The TCM-combined treatment for aphasia due to cerebrovascular disorders. (Abstract)

The TCM-combined treatment for aphasia due to cerebrovascular disorders. To evaluate the therapeutic effects of scalp acupuncture (with the cluster needling, a long needle-retention and an intermittent manipulation) combined with the Schuell's stimulation and psychological care for treatment of aphasia due to cerebrovascular disorders.36 eligible cases of aphasia were randomly assigned into a treatment group and a control group. The scoring system for assessment of aphasia in speaking Chinese (...) set by CMA Neurological Branch and that of BADE were adopted for grading the severity/degree of aphasia before and after the treatment.The total effective rate in the treatment group was 84.21%, and that in the control group was 70.59%, with a very statistically significant difference (P < 0.01).The combined scheme produced a better therapeutic effect.

2006 Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan / sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine Controlled trial quality: uncertain

3693. A randomized, placebo-controlled study of donepezil in poststroke aphasia. Full Text available with Trip Pro

A randomized, placebo-controlled study of donepezil in poststroke aphasia. We studied 26 patients in a randomized, placebo-controlled, double-blind parallel trial to evaluate the efficacy and safety of donepezil in chronic poststroke aphasia. Donepezil (10 mg/day) improved aphasia severity at endpoint (week 16) relative to placebo (p = 0.037).

2006 Neurology Controlled trial quality: uncertain

3694. A prospective, randomized, parallel group, controlled study of the effect of intensity of speech and language therapy on early recovery from poststroke aphasia. (Abstract)

A prospective, randomized, parallel group, controlled study of the effect of intensity of speech and language therapy on early recovery from poststroke aphasia. To examine whether the amount of speech and language therapy influences the recovery from poststroke aphasia.A hospital stroke unit and community.A prospective, randomized controlled trial.Aphasic stroke patients were randomly allocated to receive 5 hours (intensive therapy group, n=51) or 2 hours (standard therapy group) of speech (...) and language therapy per week for 12 consecutive weeks starting as soon as practicable after the stroke. Another 19 patients were recruited for 2 hours per week of therapy and were treated by National Health Service (NHS) staff (NHS group). OUTCOME MEASURE AND ASSESSMENT: The Western Aphasia Battery. Assessments were made blind to randomization at baseline and 4, 8, 12 and 24 weeks after the start of therapy. Data were analysed by intention to treat.The mean (SD) Western Aphasia Battery score at week 12

2007 Clinical rehabilitation Controlled trial quality: predicted high

3695. Galantamine in frontotemporal dementia and primary progressive aphasia. (Abstract)

Galantamine in frontotemporal dementia and primary progressive aphasia. The treatment of frontotemporal dementia (FTD) has been mainly symptomatic. Small randomized or open-label case control studies of neurotransmitters have been inconclusive. We tried galantamine in the 2 most common varieties of FTD.Thirty-six behavioral variety FTD and primary progressive aphasia (PPA) patients were treated in an open-label period of 18 weeks and a randomized, placebo-controlled phase for 8 weeks (...) with galantamine. The primary efficacy measures were the Frontal Behavioral Inventory, the Aphasia Quotient of the Western Aphasia Battery, the Clinical Global Impression of Severity and the Clinical Global Impression of Improvement.No significant differences in behavior or language were found for the total group. A treatment effect (p = 0.009), in a subgroup of subjects with PPA in the global severity score, in favor of galantamine was detected in the placebo-controlled withdrawal phase but was not considered

2008 Dementia and Geriatric Cognitive Disorders Controlled trial quality: uncertain

3696. Dexamphetamine boosts naming treatment effects in chronic aphasia. Full Text available with Trip Pro

Dexamphetamine boosts naming treatment effects in chronic aphasia. To date, minimal research has investigated the effect of combining dexamphetamine with standard naming therapy after stroke. The present study used a double-blind, placebo-controlled, multiple baseline, crossover design with two individuals in the chronic stage of stroke recovery. Each individual attended two 4-week blocks of naming therapy (two to three treatment sessions per week). Dexamphetamine (10 mg) was administered (...) improvement on a control task (nonword reading) in either individual. The results provide preliminary evidence that dexamphetamine paired with combined semantic and phonological therapy may be beneficial for the treatment of naming disorders in chronic aphasia.

2007 Journal of the International Neuropsychological Society : JINS Controlled trial quality: uncertain

3697. Clinical and prognostic properties of standardized and functional aphasia assessments. Full Text available with Trip Pro

Clinical and prognostic properties of standardized and functional aphasia assessments. To compare standardized and functional aphasia tests in patients after acute stroke.Data were collected at baseline and at 6 months in 2 prospective single-centre studies: one observational study (study I, n=119) and one randomized trial of moclobemide vs placebo (study II, n=89).Patients with aphasia after acute stroke.Degree of aphasia was examined using the Coefficient (Coeff) in Norsk Grunntest for Afasi (...) (standardized) and the Amsterdam-Nijmegen Everyday Language Test (ANELT) (functional). Statistical comparisons were made using one-way analysis of variance and multivariate regression analyses.The degree of aphasia measured with Coeff and ANELT correlated closely throughout the study (r2=0.71-0.87, p<0.0001). In study I, 24 patients recovered completely within 6 months. A Coeff >or= 49 and ANELT >or= 3.5 predicted complete recovery equally well. Coeff was sensitive to differentiate between patients with low

2007 Journal of rehabilitation medicine : official journal of the UEMS European Board of Physical and Rehabilitation Medicine Controlled trial quality: uncertain

3698. Psychophysiological analysis of the influence of vasopressin on speech in patients with post-stroke aphasias. (Abstract)

Psychophysiological analysis of the influence of vasopressin on speech in patients with post-stroke aphasias. Speech is an attribute of the human species. Central speech disorders following stroke are unique models for the investigation of the organization of speech. Achievements in neurobiology suggest that there are possible neuroendocrine mechanisms involved in the organization of speech. It is known that the neuropeptide vasotocin, analogous of vasopressin in mammals, modulates various (...) components of vocalization in animals. Furthermore, the positive influence of vasopressin on memory, which plays an important role in the formation of speech, has been described. In this study, speech organization processes and their recovery with the administration of vasopressin (1-desamino-8-D-arginin-vasopressin) to 26 patients with chronic aphasias after stroke were investigated. Results showed that sub-endocrine doses of the neuropeptide with intranasal administration had positive influence

2007 The Spanish journal of psychology

3699. [Clinical observation on treatment of cerebral infarction-induced broca aphasia by Tiaoshen Fuyin acupuncture therapy combined with language training]. (Abstract)

[Clinical observation on treatment of cerebral infarction-induced broca aphasia by Tiaoshen Fuyin acupuncture therapy combined with language training]. To observe therapeutic effect of Tiaoshen Fuyin acupuncture therapy on cerebral infarction-induced Broca aphasia.Sixty cases were randomly divided into an observation group and a control group, 30 cases in each group. The observation group were treated with Tiaoshen Fuyin acupuncture therapy and language training, and the control group (...) with simple language training. For the acupuncture treatment, Sishencong (EX-HN 1), Benshen (GB 13), Shenting (GV 24), Lianquan (CV 23), Xinshu (BL 15), Shentang (BL 44), Shendao (GV 11), Lingtao (HT 4) were selected and language training included training of phonatory organs in mouth, the mouth shape, sound, spoken language expression and practical exchange ability. They were treated for 5 therapeutic courses. Language examination was conducted once each before and after treatment with "Aphasia Battery

2008 Zhongguo zhen jiu = Chinese acupuncture & moxibustion Controlled trial quality: uncertain

3700. Design and methods of a randomized controlled trial on early speech and language therapy in patients with acute stroke and aphasia. (Abstract)

Design and methods of a randomized controlled trial on early speech and language therapy in patients with acute stroke and aphasia. Most clinicians would recommend speech and language therapy (SLT) for aphasic patients. The question of when and for how long SLT should be administered still remains controversial. The aim of this trial is to evaluate the efficacy of early SLT in patients with acute stroke and aphasia in a randomized controlled trial. This report will present design and methods (...) and discuss feasibility.Consecutive patients with first ever ischemic stroke and aphasia are assessed by the Amsterdam-Nijmegen Everyday Language Test (ANELT) and a short version of the Norsk Grunntest for Afasi. The treatment is language enrichment therapy, and the therapy is given 45 min/day for 15 weekdays. The primary outcome is the difference in the degree of aphasia between the SLT treated group and the control group measured by ANELT at 3 weeks.Around 10% of acute consecutive patients with aphasia

2008 Topics in stroke rehabilitation Controlled trial quality: uncertain

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