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3681. Improving Therapeutic Outcomes in the Tongue Carcinoma Patient: Assessment of Adaptation Using Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging

. History of previous moderate to severe traumatic brain injury. History of significant cardiovascular, respiratory, gastrointestinal or renal disease (e.g.myocardial infarction within the previous 12 months, significant vaso-occlusive disease,severe or advanced asthma, COPD, emphysema, gastroesophageal reflux disease, or renal compromise) History of achalasia History of other neoplasms involving the brain, head and neck, or gastrointestinal system. History of dysphagia, odynophagia, or aphasia (...) unrelated to present illness. History of significant claustrophobic reactions. Standard contraindications to MR examinations (e.g. implanted stimulators). Exclusion criteria for the healthy subjects includes the all of the conditions listed for the tongue: Carcinoma patients and additionally includes history of significant surgery or previous radiation therapy to the head and neck Previous history of dysphagia, odynophagia, aphasia, pregnancy,and standard contraindications to MR examinations. Contacts

2008 Clinical Trials

3682. Enhancing Fitness in Older Pre-diabetic Veterans

% Unstable angina Recent history of ventricular tachycardia Unstable chronic obstructive pulmonary disease (two hospitalizations within the previous 12 months and/or on oxygen) Uncontrolled hypertension (diastolic blood pressure >110 mm/Hg or systolic > 200mm/Hg) Stroke with moderate to severe aphasia Diagnosis of chronic pain which may interfere with their ability to be physically active Diagnosis of unstable mental or behavioral disorder Diagnosis of memory loss or dementia Visual or hearing loss

2008 Clinical Trials

3683. Autologous Bone Marrow Stem Cells in Ischemic Stroke.

to the TACS phenotype (weakness, homonymous hemianopia and a focal cognitive deficit (e.g. aphasia) or reduction in consciousness) or PACS phenotype (two out of the three TACS criteria) An age range of 30-80 years old Stroke confined to MCA territory on CT or MRI brain imaging NIHSS score >/= 8 Exclusion Criteria: Known defect of clotting or platelet function (but patients on anti-platelet agents can enrol) Haematological causes of stroke Severe co-morbidity Hepatic or renal dysfunction The patient

2007 Clinical Trials

3684. A Study of C105 on Cognitive Dysfunction in Persons With Multiple Sclerosis

as determined by the Principal Investigator Active malignancy within one year of study participation Known human immunodeficiency virus (HIV) Current diagnosis of unstable glaucoma History of myocardial infarction of symptomatic Coronary Artery Disease Evidence of ongoing ischemia or uncontrolled atrial or ventricular arrhythmias as shown by ECG History of epilepsy or other seizure disorders Clinically significant motor or speech residual neurological deficits (e.g., hemiparesis, aphasia) that interfere

2007 Clinical Trials

3685. Effects of Oral Levosimendan on Ambulatory Electrocardiographic Variables

or dysphasia, haemodynamically significant uncorrected valve disease or hypertrophic cardiomyopathy or restrictive cardiomyopathy, any acute coronary event or angioplasty or any other major surgery within 1 month, any major surgery during the planned study period History of life-threatening ventricular arrhythmia within 3 months. History of Torsades de Pointes (TdP) or family history of long QT-syndrome Heart rate (HR) < 50 or > 100 bpm. Systolic blood pressure (SBP) < 100 mmHg or > 180 mmHg, or diastolic

2008 Clinical Trials

3686. Efficacy and Safety of Donepezil Hydrochloride in Preadolescent and Adolescent Children With Attention Impairment Following Cancer Treatment

the study: Inability to perform the required tests (for example, because of aphasia, motor deficits affecting the dominant hand, or mental retardation). Motor coordination not sufficient, according to tests to be conducted at the time of screening. Recurrence of cancer. If this happens, the subject will have to withdraw from the study. Mental retardation/developmental disability. Certain medications, such as methylphenidate, are not allowed during the study. Major depression. Problems with the digestive

2008 Clinical Trials

3687. Far Infrared Irradiation for the Management, Control and Treatment of Frontotemporal Dementia

Lobar Atrophy (Brain) Pick Disease Pick's Disease Picks Disease of Brain Additional relevant MeSH terms: Layout table for MeSH terms Dementia Frontotemporal Dementia Aphasia, Primary Progressive Pick Disease of the Brain Brain Diseases Central Nervous System Diseases Nervous System Diseases Neurocognitive Disorders Mental Disorders Frontotemporal Lobar Degeneration TDP-43 Proteinopathies Neurodegenerative Diseases Proteostasis Deficiencies Metabolic Diseases Aphasia Speech Disorders Language

2008 Clinical Trials

3688. To Evaluate Oral Phase Swallowing Function Using Submental Ultrasound

. Combined real-time B mode and M mode ultrasound, it was reported the potential of digital data analysis of oral phase swallowing. Kuhl V et al reported the usefulness of ultrasound in the evaluation of laryngeal elevation in patients with dysphagia [8]. They found significant decrease of laryngeal elevation in patients diagnosed as neurogenic dysphasia [8]. Casas et al successfully combined ultrasound examination and plethysmography to evaluate the swallowing condition of children with cerebral palsy

2008 Clinical Trials

3689. Treatment Response of Geriatric Depression

or 10 mg), or eszopiclone (1 or 2 mg).Low and stable doses of diazepam and other anxiolytics should be tapered at screening; inability to tolerate taper is not an exclusion criteria. Inability to perform any of the ADLs (MAI: ADL subscale) even with assistance, e.g. walking with a cane is not an exclusion criterion Inability to speak English Aphasia Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study

2008 Clinical Trials

3690. A Qualitative Study of Delays in Hospital Admission in Patient With Acute Stroke

who had involved in the process of decision making were also invited to the interview. Criteria Inclusion Criteria: patients with confirmed acute ischemic stroke by brain image and were able to communicate in Mandarin or Taiwanese. Exclusion Criteria: patients who had cerebral hemorrhage, aphasia, cognitive dysfunction or severe stroke with unstable vital sign. Contacts and Locations Go to No Contacts or Locations Provided More Information Go to Layout table for additonal information Responsible

2008 Clinical Trials

3691. Hematopoietic Stem Cell Transplantation (HCT) for Inborn Errors of Metabolism

: December 28, 2017 Last Verified: December 2017 Keywords provided by Masonic Cancer Center, University of Minnesota: Inborn errors of metabolism Sphingolipidoses Recessive Leukodystrophies- GLD, Krabbe disease, MLD Peroxisomal Disorders Wolman syndrome Niemann-Pick B patients Niemann-Pick C subtype 2 Additional relevant MeSH terms: Layout table for MeSH terms Syndrome Metabolism, Inborn Errors Pick Disease of the Brain Aphasia, Primary Progressive Frontotemporal Dementia Niemann-Pick Diseases Niemann

2008 Clinical Trials

3692. Early Supported Discharge After Stroke in Bergen

' trunk control? Are initial localization and size of the stroke predictive for the patients' trunk control 3 months post stroke? Another collaborating project is carried out by PhD candidate Hedda Døli (Language outcome after stroke: lesion location, prognosis and consequences). The aim of her first study in the PhD project is to investigate the relationship between lesion location and aphasia severity one week post-stroke. Thereafter a follow-up study of the same patients 12 months post-stroke (...) investigates the prognosis of aphasia and the variables that may influence recovery. In the third study the aim is to investigate the health-related quality of life and the occurrence of depression in patients with aphasia. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 306 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Early Supported

2008 Clinical Trials

3693. Speech and Language Therapy After Stroke

provided by (Responsible Party): University of Chicago Study Details Study Description Go to Brief Summary: Our overall goal is to advance the state of functional brain imaging in aphasia, and then to apply the method to an intensive, imitation-based treatment for non-fluent aphasia. Condition or disease Intervention/treatment Phase Ischemic Stroke Behavioral: Imitate Therapy Not Applicable Detailed Description: Detailed information will follow in the next progress report. Study Design Go to Layout (...) table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 34 participants Allocation: Randomized Intervention Model: Single Group Assignment Masking: Double (Participant, Outcomes Assessor) Primary Purpose: Treatment Official Title: Neurophysiological Measurement in Aphasia Treatment Study Start Date : August 2007 Actual Primary Completion Date : January 2012 Actual Study Completion Date : January 2012 Resource links provided by the National Library of Medicine

2008 Clinical Trials

3694. A Pilot Trial of Lithium in Subjects With Progressive Supranuclear Palsy or Corticobasal Degeneration

: Gradually progressive akinetic disorder Unequivocal and prominent slowing of vertical saccades or vertical supranuclear gaze palsy Early prominent postural instability or early falls Poor or absent response to levodopa Probable CBD: Chronic progressive course Asymmetric onset Presence of higher cortical dysfunction (apraxia, apraxia of speech, non-fluent aphasia, cortical sensory loss, or alien limb) Movement disorder: rigid/akinetic syndrome resistant to levodopa and either dystonic limb posturing

2008 Clinical Trials

3695. Effectiveness of Virtual Reality Exercises in STroke Rehabilitation (EVREST)

confirmed by CT head (ischemic or hemorrhagic) Time: Onset of symptoms within 6 months prior to randomization Measurable Chedoke-McMaster scale stage of =>4 on the "arm" item (10) Functional independence prior to present stroke (baseline mRS = 0-1) Patient is alert, medically stable according to the treating physician and able to follow simple verbal commands Exclusion Criteria: Acute stroke onset more than 6 months ago Patient is unable to follow verbal commands or has global aphasia Severe illness

2008 Clinical Trials

3696. P-glycoprotein Function in Brain Diseases

terms: Layout table for MeSH terms Parkinson Disease Alzheimer Disease Frontotemporal Dementia Aphasia, Primary Progressive Pick Disease of the Brain Frontotemporal Lobar Degeneration Parkinsonian Disorders Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Nervous System Diseases Movement Disorders Neurodegenerative Diseases Dementia Tauopathies Neurocognitive Disorders Mental Disorders TDP-43 Proteinopathies Proteostasis Deficiencies Metabolic Diseases Aphasia Speech Disorders

2008 Clinical Trials

3697. Mirror-Box Training in Adults With Chronic Hemiparesis Secondary to Stroke

score of >2 History of botulinum toxin injection in affected upper extremity in the past 4 months Lacking >40 degrees of passive elbow extension Less than 45 degrees of passive shoulder flexion Global or receptive aphasia present on physical exam Hemispatial neglect present on physical exam Patient participating in constraint-induced therapy during study time period Severe visual deficits or visual field deficits as determined by ability to ascertain number of fingers held up on visual field testing

2008 Clinical Trials

3698. European Study on Prediction of Outcome in Patients With Idiopathic Normal Pressure Hydrocephalus

and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Clinical diagnosis (neurological and radiological criteria) of idiopathic normal pressure hydrocephalus Typical INPH Clinical criteria: Gradually developed gait disturbance of both legs, unexplained by other conditions. Disturbance of tandem walking, multi-step turning, small steps and wide base must be present at least. MMSE score 21-30 without aphasia, apraxia and agnosia Bladder

2009 Clinical Trials

3699. fMRI of Language Recovery Following Stroke in Adults

by (Responsible Party): Jerzy P Szaflarski, University of Alabama at Birmingham Study Details Study Description Go to Brief Summary: The purpose of this study is to test the effectiveness of constraint-induced aphasia therapy. Condition or disease Intervention/treatment Phase Aphasia Stroke Behavioral: CIAT Not Applicable Detailed Description: Aphasia (difficulty speaking) is one of the most dreaded consequences of stroke. It is associated with high mortality and severe motor, social, and cognitive disability (...) . During the past decade, therapies administered by stroke teams have made great strides in limiting the damage due to a stroke. Unfortunately, progress in aphasia rehabilitation has not experienced the same rapid advancement. Evidence suggests that the brain may have untapped potential for recovery of aphasia after stroke. Using functional magnetic resonance imaging (fMRI), researchers now are able to examine the areas of the brain that are responsible for language recovery after stroke. Such data may

2009 Clinical Trials

3700. Pharmacological Management of Delirium

speaking Exclusion Criteria: Admitted directly to a regular non-ICU ward Previously enrolled in the study Not eligible for delirium assessment as determined by RASS scores Prior history of severe mental illness Alcohol-related delirium Pregnant or nursing Have had an aphasic stroke Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor

2009 Clinical Trials

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