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Aphasia

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3661. aphasia (sensory transcortical)

aphasia (sensory transcortical) aphasia (sensory transcortical) - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search aphasia (sensory transcortical) The clinical features of a transcortical sensory dysphasia include: impaired comprehension of written and spoken language fluent speech with anomia and paraphasias normal repetition of speech which may degenerate into echolalia The lesion is usually in the posterior parietal

2010 GP Notebook

3662. aphasia

aphasia aphasia - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search aphasia Dysphasia is an acquired deficit in the comprehension or production of language whether spoken or written. Aphasia is a complete loss of language comprehension or production. The main types of dysphasia are: motor receptive conduction Mutism is a global loss of language and is not a good localising sign. Transcortical dysphasias are due to interuption

2010 GP Notebook

3663. Evidence-based systematic review: effects of intensity of treatment and constraint-induced language therapy for individuals with stroke-induced aphasia

Evidence-based systematic review: effects of intensity of treatment and constraint-induced language therapy for individuals with stroke-induced aphasia Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2008 DARE.

3664. Pharmacological treatment for aphasia following stroke. (Abstract)

Pharmacological treatment for aphasia following stroke. Aphasia describes language impairment associated with a brain lesion.The objective of this review was to assess the effects of drugs on language abilities when given to people with aphasia following stroke.We searched the Cochrane Stroke Group Register (last searched: May 2001), and reference lists of relevant articles to December 1998. We also contacted academic institutions and other researchers to identify further published (...) concerns that there may be an increased risk of death from taking piracetam. We could not determine if drug treatment is more effective than speech and language therapy. We could not determine whether one drug is more effective than another.The main conclusion of this review is that drug treatment with piracetam may be effective in the treatment of aphasia after stroke. Further research is needed to explore the effects of drugs for aphasia, in particular piracetam. If a trial is done, this must

2001 Cochrane

3665. Speech and language therapy for aphasia following stroke. (Abstract)

Speech and language therapy for aphasia following stroke. Aphasia describes language impairment associated with a brain lesion.The objective of this review was to assess the effects of formal speech and language therapy and non-professional types of support from untrained providers for people with aphasia after stroke.We searched the Cochrane Stroke Group Trials Register (last searched: March 1999), and reference lists of relevant articles to December 1998. We also contacted academic (...) administered by trained speech and language therapists versus any type of informal support for aphasia, given by speech and language therapists or volunteers, whether these were trained or untrained. 3. One type of speech and language therapy versus another type. Outcome measures included measures of any type of communication, other measures of functioning, numbers of drop-outs, and other non-clinical outcomes.The principal reviewer collected the data, and assessed the quality of the trials

2000 Cochrane

3666. Intensity of aphasia therapy, impact on recovery

Intensity of aphasia therapy, impact on recovery Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2003 DARE.

3667. A meta-analysis of clinical outcomes in the treatment of aphasia

A meta-analysis of clinical outcomes in the treatment of aphasia A meta-analysis of clinical outcomes in the treatment of aphasia A meta-analysis of clinical outcomes in the treatment of aphasia Robey R R Authors' objectives To perform a meta-analysis of clinical outcomes for treatments of acquired aphasia in adulthood. Searching A systematic manual search was conducted in the following periodicals: Aphasiology, Brain and Language, Clinical Aphasiology, Journal of Speech and Hearing Disorders (...) Elicited Language Training Programme for Syntax Stimulation; the Sentence Level Auditory Comprehension and Language Orientated Treatment; and various drug treatments including pyrithioxine, amphetamine, encephabol and lucidril. Participants included in the review Adults with acquired aphasia, as indexed in terms of general communicative functioning. Most samples consisted of male monolingual aphasic individuals suffering a first occlusive or haemorrhagic neuropathology in the left cerebral hemisphere

1998 DARE.

3668. Perispinal Etanercept Produces Rapid Improvement in Primary Progressive Aphasia: Identification of a Novel, Rapidly Reversible TNF-Mediated Pathophysiologic Mechanism Full Text available with Trip Pro

Perispinal Etanercept Produces Rapid Improvement in Primary Progressive Aphasia: Identification of a Novel, Rapidly Reversible TNF-Mediated Pathophysiologic Mechanism Primary progressive aphasia (PPA) is an uncommon form of progressive dementia for which there exists no established treatment. The underlying pathology may be that of either frontotemporal dementia or Alzheimer's disease. Increasing evidence suggests that excess tumor necrosis factor (TNF) may play a central role in Alzheimer's

2008 The Medscape Journal of Medicine

3669. Treatment for lexical retrieval in progressive aphasia Full Text available with Trip Pro

Treatment for lexical retrieval in progressive aphasia BACKGROUND: Treatment for lexical retrieval impairment has been shown to yield positive outcomes in individuals with aphasia due to focal lesions, but there has been little research regarding the treatment of such impairments in individuals with progressive aphasia. AIMS: The purpose of this study was to examine the therapeutic effects of a semantic treatment for anomia in progressive aphasia relative to the outcome in an individual (...) with stroke-induced aphasia. METHODS #ENTITYSTARTX00026; PROCEDURES: Two individuals with progressive aphasia and one with aphasia resulting from stroke participated in the study. Each participant presented with fluent, anomic aphasia; however, one of the patients with progressive aphasia demonstrated characteristics indicating a likely progression towards non-fluency. Each participant received a brief, intensive treatment intended to improve lexical retrieval in the context of generative naming

2008 Aphasiology

3670. Neuropsychiatric Symptoms in Behavioral Variant Frontotemporal Dementia and Primary Progressive Aphasia Full Text available with Trip Pro

Neuropsychiatric Symptoms in Behavioral Variant Frontotemporal Dementia and Primary Progressive Aphasia Neuropsychiatric symptoms are well defined in behavioral variant frontotemporal dementia but are not as well studied in primary progressive aphasia. This study compared caregiver reported neuropsychiatric symptoms in these 2 forms of dementia at short and long disease duration. Patients with behavioral variant frontotemporal dementia had more symptoms than patients with primary progressive (...) aphasia. However, when divided by duration of disease, patients with primary progressive aphasia with long duration had a similar number of symptoms to patients with behavioral variant frontotemporal dementia at either duration. Furthermore, this group of patients with primary progressive aphasia had more symptoms typical of behavioral variant frontotemporal dementia and less mood-related symptoms which were more common in patients with primary progressive aphasia with shorter duration. This study

2008 Journal of Geriatric Psychiatry and Neurology

3671. Treatment for Word Retrieval Impairments in Aphasia

Treatment for Word Retrieval Impairments in Aphasia Treatment for Word Retrieval Impairments in Aphasia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Treatment for Word Retrieval Impairments in Aphasia (...) by (Responsible Party): Dr. Anastasia Raymer, Old Dominion University Study Details Study Description Go to Brief Summary: In this study the investigators are examining the effectiveness of two different speech therapy protocols for word retrieval impairments experienced by individuals with stroke-induced aphasia. One treatment involves errorless naming treatment and the other employs verbal plus gestural facilitation of word retrieval. Participants will receive one of the two treatments over several months

2008 Clinical Trials

3672. Effects of semantic treatment on verbal communication and linguistic processing in aphasia after stroke: a randomized controlled trial. Full Text available with Trip Pro

Effects of semantic treatment on verbal communication and linguistic processing in aphasia after stroke: a randomized controlled trial. Semantic deficits, deficits in word meaning, have a large impact on aphasic patients' verbal communication. We investigated the effects of semantic treatment on verbal communication in a randomized controlled trial.Fifty-eight patients with a combined semantic and phonological deficit were randomized to receive either semantic treatment or the control treatment

2004 Stroke Controlled trial quality: predicted high

3673. Long-term antidepressant treatment with moclobemide for aphasia in acute stroke patients: a randomised, double-blind, placebo-controlled study. (Abstract)

Long-term antidepressant treatment with moclobemide for aphasia in acute stroke patients: a randomised, double-blind, placebo-controlled study. Pharmacotherapy aimed at stroke rehabilitation through direct central nervous effects may be assumed to work in a similar way for language recovery and sensory-motor recovery. Some data suggest that antidepressant drugs could be beneficial also for functional improvement. This prompted us to investigate whether regression from aphasia after acute stroke (...) could be enhanced by antidepressive drug therapy.We randomised 90 acute stroke patients with aphasia to either 600 mg moclobemide or placebo daily for 6 months, within 3 weeks of the onset of stroke. Aphasia was assessed prior to treatment and at 6 months, using Reinvang's 'Grunntest for afasi' and the Amsterdam-Nijmegen-Everyday-Language-Test (ANELT).The degree of aphasia decreased significantly at 6 months, with no difference between the moclobemide- and the placebo-treated groups. Multivariate

2005 Cerebrovascular diseases (Basel, Switzerland) Controlled trial quality: predicted high

3674. Evolution of phonemic word fluency performance in post-stroke aphasia. (Abstract)

Evolution of phonemic word fluency performance in post-stroke aphasia. In this longitudinal study, quantitative and qualitative changes in responses of people with aphasia were examined on a phonemic fluency task. Eighteen patients were tested at 3-month intervals on the letters F-A-S while they received comprehensive, intensive treatment from 3 to 12 months post-stroke. They returned for a follow-up evaluation at an average of 10 months post-intervention. Mean group scores improved (...) since onset and the linguistic and cognitive stimulation that patients received in therapy.Readers of this paper should (1) gain a better understanding of verbal fluency performance in the assessment of aphasia, (2) recognize the importance of analyzing qualitative aspects of single word production in aphasia, and (3) contribute to their clinical judgment of long term improvement in aphasia.

2004 Journal of communication disorders Controlled trial quality: uncertain

3675. Inference revision processing in adults with and without aphasia. (Abstract)

Inference revision processing in adults with and without aphasia. Processing abilities in aphasia, and the nature of processing breakdowns, were the focuses of this investigation. Individuals with either fluent or nonfluent aphasia, plus a control group, participated in a cross-modal lexical priming task designed to elicit priming effects when activation of inference interpretations occurred. Comprehension of inferences was measured by responses to four types of questions that related (...) to the inferences. Results indicated that both the control group, as well as the nonfluent aphasia group, activated the intended meaning of the stimuli whereas the fluent aphasics did not. Comprehension of the inferences was best demonstrated by control participants, nonfluent aphasic participants, and fluent aphasic participants, in that order.

2004 Brain and language Controlled trial quality: uncertain

3676. Mapping therapy for sentence production impairments in nonfluent aphasia. Full Text available with Trip Pro

Mapping therapy for sentence production impairments in nonfluent aphasia. This study investigated a new treatment in which sentence production abilities were trained in a small group of individuals and nonfluent aphasia. It was based upon a mapping therapy approach which holds that sentence production and comprehension impairments are due to difficulties in mapping between the meaning form (thematic roles) and the syntactic form of sentences. We trained production of both canonical

2005 Neuropsychological rehabilitation Controlled trial quality: uncertain

3677. A randomized, double-blind trial of bromocriptine efficacy in nonfluent aphasia after stroke. (Abstract)

A randomized, double-blind trial of bromocriptine efficacy in nonfluent aphasia after stroke. The authors assessed the efficacy of bromocriptine in nonfluent aphasia after stroke in a 16-week, randomized, double-blind, placebo-controlled clinical trial conducted from June 2002 to April 2004. In all 38 patients after 4 months of treatment, improvement in both the bromocriptine and placebo treatment groups was observed (p < 0.001). The analysis of repeated-measures analysis of variance revealed (...) bromocriptine did not improve nonfluent aphasia.

2006 Neurology Controlled trial quality: predicted high

3678. The TCM-combined treatment for aphasia due to cerebrovascular disorders. (Abstract)

The TCM-combined treatment for aphasia due to cerebrovascular disorders. To evaluate the therapeutic effects of scalp acupuncture (with the cluster needling, a long needle-retention and an intermittent manipulation) combined with the Schuell's stimulation and psychological care for treatment of aphasia due to cerebrovascular disorders.36 eligible cases of aphasia were randomly assigned into a treatment group and a control group. The scoring system for assessment of aphasia in speaking Chinese (...) set by CMA Neurological Branch and that of BADE were adopted for grading the severity/degree of aphasia before and after the treatment.The total effective rate in the treatment group was 84.21%, and that in the control group was 70.59%, with a very statistically significant difference (P < 0.01).The combined scheme produced a better therapeutic effect.

2006 Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan / sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine Controlled trial quality: uncertain

3679. A randomized, placebo-controlled study of donepezil in poststroke aphasia. Full Text available with Trip Pro

A randomized, placebo-controlled study of donepezil in poststroke aphasia. We studied 26 patients in a randomized, placebo-controlled, double-blind parallel trial to evaluate the efficacy and safety of donepezil in chronic poststroke aphasia. Donepezil (10 mg/day) improved aphasia severity at endpoint (week 16) relative to placebo (p = 0.037).

2006 Neurology Controlled trial quality: uncertain

3680. A prospective, randomized, parallel group, controlled study of the effect of intensity of speech and language therapy on early recovery from poststroke aphasia. (Abstract)

A prospective, randomized, parallel group, controlled study of the effect of intensity of speech and language therapy on early recovery from poststroke aphasia. To examine whether the amount of speech and language therapy influences the recovery from poststroke aphasia.A hospital stroke unit and community.A prospective, randomized controlled trial.Aphasic stroke patients were randomly allocated to receive 5 hours (intensive therapy group, n=51) or 2 hours (standard therapy group) of speech (...) and language therapy per week for 12 consecutive weeks starting as soon as practicable after the stroke. Another 19 patients were recruited for 2 hours per week of therapy and were treated by National Health Service (NHS) staff (NHS group). OUTCOME MEASURE AND ASSESSMENT: The Western Aphasia Battery. Assessments were made blind to randomization at baseline and 4, 8, 12 and 24 weeks after the start of therapy. Data were analysed by intention to treat.The mean (SD) Western Aphasia Battery score at week 12

2007 Clinical rehabilitation Controlled trial quality: predicted high

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