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3641. Enhancing Fitness in Older Pre-diabetic Veterans

% Unstable angina Recent history of ventricular tachycardia Unstable chronic obstructive pulmonary disease (two hospitalizations within the previous 12 months and/or on oxygen) Uncontrolled hypertension (diastolic blood pressure >110 mm/Hg or systolic > 200mm/Hg) Stroke with moderate to severe aphasia Diagnosis of chronic pain which may interfere with their ability to be physically active Diagnosis of unstable mental or behavioral disorder Diagnosis of memory loss or dementia Visual or hearing loss

2008 Clinical Trials

3642. Levels of Inflammatory Markers in the Treatment of Stroke—An SPS3 Ancillary Study

be randomized within 6 months of qualifying small subcortical stroke (S3) or subcortical TIA One of the following lacunar syndromes: PMH; pure sensory stroke; sensorimotor stroke; ataxic hemiparesis; dysarthria; hemiballism; PMH with facial sparing, horizontal gaze palsy, contralateral III palsy, contralateral VI palsy; Ataxia with contralateral III palsy; pure dysarthria Absence of cortical dysfunction (aphasia, apraxia, agnosia) No ipsilateral cervical carotid stenosis (>= 50%) if S3 is hemispheric

2007 Clinical Trials

3643. Effectiveness of Case Management Versus Case Management Plus Problem-solving Therapy to Treat Depression in Low-income Elders

) even with assistance Aphasia interfering with communication Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its identifier (NCT number): NCT00540865 Locations Layout table for location information United States, California University of California - San Francisco San Francisco

2007 Clinical Trials

3644. Neuropsychological Cognitive Behavioral Therapy for Patients With Acquired Brain Injury

psychosis or bipolar disorder Current or past diagnosis of substance dependency History of mental retardation Currently in psychotherapy Severe lateralized disorder (e.g. aphasia, neglect) Lacking minimum basic skills for attending therapy (e.g. not orientated to person, place, time, and events; unable to sustain attention for an hour-long session; cannot state cognitive strengths and weaknesses; cannot state areas in everyday functioning that are impaired due to the acquired brain injury) Contacts

2008 Clinical Trials

3645. Transfer of Grasp Control Across Hands After Stroke

deficits, aphasia, neglect, or apraxia as determined by clinical neurologic examination that may interfere with the research protocol Presence of sensory deficits in control subjects and in the non-involved hand of stroke subjects on testing of two-point discrimination History of surgery or other significant injury to the upper extremities Botulinum toxin injections in the upper extremity musculature in the three months prior to enrollment in the study. Current treatment with intrathecal baclofen

2007 Clinical Trials

3646. Clazosentan in Reducing Vasospasm-related Morbidity and All-cause Mortality in Adult Patients With Aneurysmal Subarachnoid Hemorrhage Treated by Surgical Clipping

, or with only a local clot. Presence of cerebral vasospasm seen on angiography prior to the clipping procedure. Patients who experienced a major complication during the clipping procedure, such as massive bleeding, major arterial occlusion, a large territorial cerebral infarct defined as involving > 1/3 of a vascular territory, or a new major neurological deficit post-procedure (e.g., hemiplegia or aphasia lasting > or = 12 hours post-aneurysm clipping).* Patients for whom study drug cannot be started

2007 Clinical Trials

3647. Study to Determine The Effect of a Drug Called Neupogen on Stroke Recovery

Stroke Score less than 18. The stroke involves the non-dominant hemisphere including the cerebral cortex and results in hemiparesis. The inclusion of sub-cortical strokes will be permitted if the size is of 3 cm or greater. Patients suffering strokes involving the dominant hemisphere resulting in mild dysphasia are also eligible. The stroke is classified as a partial anterior cerebral syndrome by the Oxfordshire Criteria. NIHSS at baseline evaluation with: *Level of consciousness is not impaired

2008 Clinical Trials

3648. Percutaneous Recanalization in Ischemic Stroke Management (PRIISM): A Feasibility Clinical Study

First Posted: December 17, 2008 Results First Posted: July 26, 2012 Last Update Posted: July 26, 2012 Last Verified: June 2012 Keywords provided by MindFrame, Inc.: Cerebral Infarction Stroke Vascular Diseases Central Nervous System Diseases Penumbra Functional Outcome Aphasia Hemiplegia Left sided weakness Right Sided weakness Additional relevant MeSH terms: Layout table for MeSH terms Stroke Ischemia Cerebral Infarction Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases

2008 Clinical Trials

3649. Hematopoietic Stem Cell Transplantation (HCT) for Inborn Errors of Metabolism

: December 28, 2017 Last Verified: December 2017 Keywords provided by Masonic Cancer Center, University of Minnesota: Inborn errors of metabolism Sphingolipidoses Recessive Leukodystrophies- GLD, Krabbe disease, MLD Peroxisomal Disorders Wolman syndrome Niemann-Pick B patients Niemann-Pick C subtype 2 Additional relevant MeSH terms: Layout table for MeSH terms Syndrome Metabolism, Inborn Errors Pick Disease of the Brain Aphasia, Primary Progressive Frontotemporal Dementia Niemann-Pick Diseases Niemann

2008 Clinical Trials

3650. Study of a Neuroprotective Drug to Limit the Extent of Damage From an Ischemic Stroke

of Health [NIH] Stroke Scale >/= 1) Exclusion Criteria: allergy to tetracycline antibiotics women of child-bearing potential known hepatic and/or renal insufficiency Thrombocytopenia history of intolerance to minocycline dizziness at the time of stroke or in the past month (by self-report) aphasia likely to interfere with patients ability to report adverse effects previous functional disability stuporous or comatose presence of another serious illness likely to confound the study unlikely

2008 Clinical Trials

3651. A Pilot Trial of Lithium in Subjects With Progressive Supranuclear Palsy or Corticobasal Degeneration

: Gradually progressive akinetic disorder Unequivocal and prominent slowing of vertical saccades or vertical supranuclear gaze palsy Early prominent postural instability or early falls Poor or absent response to levodopa Probable CBD: Chronic progressive course Asymmetric onset Presence of higher cortical dysfunction (apraxia, apraxia of speech, non-fluent aphasia, cortical sensory loss, or alien limb) Movement disorder: rigid/akinetic syndrome resistant to levodopa and either dystonic limb posturing

2008 Clinical Trials

3652. P-glycoprotein Function in Brain Diseases

terms: Layout table for MeSH terms Parkinson Disease Alzheimer Disease Frontotemporal Dementia Aphasia, Primary Progressive Pick Disease of the Brain Frontotemporal Lobar Degeneration Parkinsonian Disorders Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Nervous System Diseases Movement Disorders Neurodegenerative Diseases Dementia Tauopathies Neurocognitive Disorders Mental Disorders TDP-43 Proteinopathies Proteostasis Deficiencies Metabolic Diseases Aphasia Speech Disorders

2008 Clinical Trials

3653. Memantine

of probable Alzheimer's disease consistent with NINCDS- ADRDA criteria or with DSM IV TR criteria for Dementia of the Alzheimer's type. Mini Mental State Examination (MMSE) total score is less than 20 Patients treated with any acetylcholinesterase inhibitor (AChEI) may be included, when treatment has started at least 6 months prior screening and was stable during the last 3 months. Exclusion Criteria: Any type of evident aphasia, which may interfere with patient's communication difficulties caused

2008 Clinical Trials

3654. IV vs. IA tPA (Activase) in Acute Ischemic Stroke With CTA Evidence of Major Vessel Occlusion

with study assessments for the full duration of the study. Age > 18 years NIHSS ≥ 4 or isolated aphasia or isolated hemianopsia Exclusion Criteria: NIHSS >30 Coma Rapidly improving symptoms History of stroke in the last 6 weeks Seizure at onset Subarachnoid Hemorrhage (SAH ) or suspected SAH Any history of Intracrannial Hemorrhage (ICH) Neoplasm Septic embolism Surgery, biopsy, trauma or LP in last 30 days Head trauma in the last 90 days Bleeding diathesis, or INR >1.7 or PTT >1.5 times baseline

2008 Clinical Trials

3655. A Qualitative Study of Delays in Hospital Admission in Patient With Acute Stroke

who had involved in the process of decision making were also invited to the interview. Criteria Inclusion Criteria: patients with confirmed acute ischemic stroke by brain image and were able to communicate in Mandarin or Taiwanese. Exclusion Criteria: patients who had cerebral hemorrhage, aphasia, cognitive dysfunction or severe stroke with unstable vital sign. Contacts and Locations Go to No Contacts or Locations Provided More Information Go to Layout table for additonal information Responsible

2008 Clinical Trials

3656. Effectiveness of Virtual Reality Exercises in STroke Rehabilitation (EVREST)

confirmed by CT head (ischemic or hemorrhagic) Time: Onset of symptoms within 6 months prior to randomization Measurable Chedoke-McMaster scale stage of =>4 on the "arm" item (10) Functional independence prior to present stroke (baseline mRS = 0-1) Patient is alert, medically stable according to the treating physician and able to follow simple verbal commands Exclusion Criteria: Acute stroke onset more than 6 months ago Patient is unable to follow verbal commands or has global aphasia Severe illness

2008 Clinical Trials

3657. Efficacy and Safety of Donepezil Hydrochloride in Preadolescent and Adolescent Children With Attention Impairment Following Cancer Treatment

the study: Inability to perform the required tests (for example, because of aphasia, motor deficits affecting the dominant hand, or mental retardation). Motor coordination not sufficient, according to tests to be conducted at the time of screening. Recurrence of cancer. If this happens, the subject will have to withdraw from the study. Mental retardation/developmental disability. Certain medications, such as methylphenidate, are not allowed during the study. Major depression. Problems with the digestive

2008 Clinical Trials

3658. A Spinal Functional Magnetic Resonance Imagine (fMRI) Study of Resting-State, Motor Task and Acupoint Stimulation

of dementia inability to give consent because of impaired cognition or receptive aphasia diseases in spine/spinal cord with factors which make subjects unsuitable to receive MR examination Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its identifier (NCT number): NCT00629655 Locations

2008 Clinical Trials

3659. Speech and Language Therapy After Stroke

provided by (Responsible Party): University of Chicago Study Details Study Description Go to Brief Summary: Our overall goal is to advance the state of functional brain imaging in aphasia, and then to apply the method to an intensive, imitation-based treatment for non-fluent aphasia. Condition or disease Intervention/treatment Phase Ischemic Stroke Behavioral: Imitate Therapy Not Applicable Detailed Description: Detailed information will follow in the next progress report. Study Design Go to Layout (...) table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 34 participants Allocation: Randomized Intervention Model: Single Group Assignment Masking: Double (Participant, Outcomes Assessor) Primary Purpose: Treatment Official Title: Neurophysiological Measurement in Aphasia Treatment Study Start Date : August 2007 Actual Primary Completion Date : January 2012 Actual Study Completion Date : January 2012 Resource links provided by the National Library of Medicine

2008 Clinical Trials

3660. Cognitive Effects of Inhalational Versus Intravenous General Anesthesia in the Elderly

and Symbol Search subtests of the Processing Speed Index of the Wechsler Adult Intelligence Scale-III (WAIS-III; Wechsler, 1997) and the Controlled Oral Word Association subtest of the Multilingual Aphasia Examination. The outcomes were constructed as summed z-score composites. They are scaled as standard deviations. Thus, a score of 0 was central on each composite, and 95% of the scores would fall within -2.0 and +2.0. While there is no minimum or maximum value is rare for any score (<1%) to fall

2008 Clinical Trials

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