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3641. Survival in frontotemporal dementia. (Abstract)

classified pathologically as tau-positive and tau-negative.Of the 61 patients with FTD, 26 presented with frontal variant (fvFTD), 9 with semantic dementia, 8 with progressive nonfluent aphasia (PNFA), 9 with associated motor neuron disease (FTD-MND), and 9 with corticobasal degeneration features. There was no difference between the groups in age at symptom onset (overall mean 58.5 +/- 7.8 years), but at diagnosis the PNFA (68.3 +/- 2.7) group was significantly older than the fvFTD (59.9 +/- 7.4) and FTD

2003 Neurology

3642. Plasticity of motor cortex excitability induced by rehabilitation therapy for writing. (Abstract)

Plasticity of motor cortex excitability induced by rehabilitation therapy for writing. The mechanisms of rehabilitation-induced plasticity in the motor system after stroke are not defined. The authors studied seven patients with residual poststroke agraphia, aphasia, and right hemiparesis. After a 40-minute rehabilitation therapy that promoted use of the paretic hand for writing, the authors observed a task-specific increase in recruitment of ipsilateral corticospinal pathways. Rehabilitation

2003 Neurology

3643. Language function and dysfunction in corticobasal degeneration. (Abstract)

Language function and dysfunction in corticobasal degeneration. S: The authors assessed language functioning in corticobasal degeneration (CBD), an area that has received little systematic study. Aphasia has been reported occasionally, and the authors hypothesized that appropriate assessments would reveal at least mild language impairment, particularly affecting phonologic (sound-based) processing, even in cases without frank aphasia.A series of 10 unselected patients with CBD (one (...) of patients had deficits in semantic memory, naming, and reading, but the impairments were usually mild.The authors found phonologic impairment to be a typical feature of CBD. There is substantial overlap between progressive nonfluent aphasia and CBD, and the linguistic impairment can be thought of as a continuum, with mild phonologic impairment at one end and severe aphasia at the other.

2003 Neurology

3644. Slowly progressive spread of the stroke-like lesions in MELAS. (Abstract)

in all four stroke-like episodes, followed by hemianopsia, psychosis, and aphasia. In three episodes, epileptic seizure developed subsequently in close association with a progression of stroke-like lesion. In all four episodes, serial MRI showed a slowly progressive spread of the stroke-like lesion evolving from the temporal cortex to the surrounding parietal or occipital cortex over a few weeks following the onset of initial symptoms. Apparent diffusion coefficient (ADC) maps showed slightly

2003 Neurology

3645. Strokes restricted to the insular cortex. (Abstract)

with partial distribution); 2) gustatory disorder in a patient with left posterior insular infarct; 3) vestibular-like syndrome, with dizziness, gait instability, and tendency to fall, but no nystagmus, in three patients with posterior insular strokes; 4) cardiovascular disturbances, consisting of hypertensive episodes in a patient with a right posterior insular infarct; and 5) neuropsychological disorders, including aphasia (left posterior insula), dysarthria, and transient somatoparaphrenia (right (...) posterior insula).Strokes restricted to the posterior insula may present with pseudothalamic sensory and vestibular-like syndromes as prominent clinical manifestations, but also dysarthria and aphasia (in left lesions), somatoparaphrenia (right lesions) and gustatory dysfunction and blood pressure with hypertensive episodes in right lesions; we did not find acute dysphagia reported in anterior, insular strokes.

2002 Neurology

3646. Progressive affective aprosodia and prosoplegia. (Abstract)

. The authors suggest that this patient has a form of frontotemporal dementia, analogous to primary progressive aphasia but disrupting right frontal lobe-mediated functions.

2003 Neurology

3647. Art and the brain: the influence of frontotemporal dementia on an accomplished artist. (Abstract)

Art and the brain: the influence of frontotemporal dementia on an accomplished artist. A talented artist developed a progressive aphasia syndrome associated with frontotemporal dementia (FTD). As her disease progressed, language and executive skills declined, but her paintings became freer and more original. She demonstrates that artistic development can occur in the setting of language-dominant types of FTD. The study of artistic development in the setting of FTD suggests that language

2003 Neurology

3648. A case of gliosarcoma appearing as ischaemic stroke. Full Text available with Trip Pro

A case of gliosarcoma appearing as ischaemic stroke. Ischaemic stroke attributable to malignant brain tumour is a rarely reported phenomenon and even various imaging techniques including angiography do not necessarily lead to an accurate diagnosis.A 46-year-old, previously healthy man developed apoplectic symptoms with slight right sided hemiparesis and global aphasia. The computed tomography (CT) scan showed lesions of the left temporal lobe and the paraventricular white matter suggestive

2003 Neurosurgery and Psychiatry

3649. Magnetic resonance imaging abnormalities in familial temporal lobe epilepsy with auditory auras. Full Text available with Trip Pro

with auditory auras.We performed detailed clinical and molecular studies as well as MRI evaluation (including volumetry) in all available individuals from one family, segregating FTLE from auditory auras.We evaluated 18 of 23 possibly affected individuals, and 13 patients reported auditory auras. In one patient, auditory auras were associated with déjà vu; in one patient, with ictal aphasia; and in 2 patients, with visual misperception. Most patients were not taking medication at the time, although all

2003 Archives of Neurology

3650. Acute infarction limited to the lenticular nucleus: clinical, etiologic, and topographic features. (Abstract)

to the putamen. Two of them had ataxic motor hemisyndrome and 7 had sensorimotor hemisyndrome (with ataxia in 4, left hemineglect in 1, and deep pain in the arm and leg in 1). Four patients had a lesion of putamen and globus pallidus externus. Three of them had motor hemisyndrome (with nonfluent aphasia in 2 and ataxia in 1) and 1 had ataxic sensorimotor hemisyndrome. All infarcts were in the territory of the medial perforating branches of the medial cerebral artery. Presumed cause of stroke was small-artery (...) disease in 5, artery-to-artery embolism in 4, cardioembolism in 3 and undetermined in 1.Acute lenticular infarction induces mainly hemiparesis but no movement disorder. Associated sensory deficits, aphasia, and hemineglect underline clinically the function of the lenticular nucleus in connection with the prefrontal, temporal, and parietal cortices.

2003 Archives of Neurology

3651. Right orbitofrontal tumor with pedophilia symptom and constructional apraxia sign. (Abstract)

and constructional deficits, including agraphia, resolved following tumor resection.For patients with acquired sociopathy and paraphilia, an orbitofrontal localization requires consideration. This case further illustrates that constructional apraxia can arise from right prefrontal lobe dysfunction. Agraphia may represent a manifestation of constructional apraxia in the absence of aphasia and ideomotor apraxia.

2003 Archives of Neurology

3652. Frontal lobe atrophy due to a mutation in the cholesterol binding protein HE1/NPC2. (Abstract)

, neurolysosomal storage with oligolamellar inclusion and tau-positive neurofibrillary tangles. Of the 119 family members screened, only a married 42-year-old sister displayed symptoms of a dementia. Both women displayed vertical supranuclear ophthalmoplegia; expressive aphasia; concrete, stimulus-bound, perseverative behavior; and impaired conceptualization and planning. Cultured fibroblasts showed decreased cholesterol esterification and positive filipin staining, but no mutation was detected in coding

2002 Annals of Neurology

3653. LGI1 is mutated in familial temporal lobe epilepsy characterized by aphasic seizures. (Abstract)

mutation is associated with autosomal dominant lateral temporal lobe epilepsy in a large Norwegian family showing unusual clinical features like short-lasting sensory aphasia and auditory symptoms.

2002 Annals of Neurology

3654. Myelinoclastic diffuse sclerosis (Schilder's disease): report of a case and review of the literature. (Abstract)

-handed young man presenting with left hemiplegia, aphasia and behavioural changes. Magnetic resonance imaging showed two large lesions, irregular contrast-enhancing, in the subcortical white matter of the right frontal and parietal lobes, and increased intracranial pressure. Definitive diagnosis was made with biopsy. The characteristic pathological features are demyelinization of the white matter, lymphocytic perivascular infiltrates, microglial proliferation and immunohistochemical signs

2002 British Journal of Neurosurgery

3655. Pick's complex and FTDP-17. (Abstract)

Pick's complex and FTDP-17. This essay advances the thesis with a review of the evidence that Pick's disease, frontotemporal dementia, primary progressive aphasia, corticobasal degeneration, and progressive supranuclear palsy should be regarded as a clinically and biologically cohesive spectrum. The historically correct eponymic term Pick's complex, for both the clinical and pathological varieties is preferred. The discovery of tau mutations in frontotemporal dementia and parkinsonism linked

2003 Movement Disorders

3656. Corticobasal degeneration as a cognitive disorder. (Abstract)

, and nonfluent aphasia. The limb apraxia is associated with deficits in drawing, copying, and handwriting, but there is emerging evidence that the problems with handwriting are not due exclusively to the apraxia. The findings with respect to episodic memory are more variable, but when there is impairment in this area, it tends to be milder than that seen in Alzheimer's disease. Semantic memory functioning appears relatively preserved but has been poorly studied. Problems with speech are common, and may (...) be due to dysarthria or buccofacial apraxia. Aphasia, although initially considered rare, is in fact a common accompaniment of CBD, may be the presenting feature, and is typically nonfluent in type. More systematic investigation of the clinical and neuropathological overlap between progressive nonfluent aphasia (generally considered to be a form of frontotemporal dementia) and CBD is needed.

2003 Movement Disorders

3657. Incidence of adverse effects during acupuncture therapy-a multicentre survey. (Abstract)

(paraesthesia) and increase of pain. In one case, aphasia was reported lasting 1h after acupuncture.Acupuncture has adverse effects, like any therapeutic approach. If it is used according to established safety rules and carefully at appropriate anatomic regions, it is a safe treatment method.

2003 Complementary Therapies In Medicine

3658. Effect of amphetamines on speech defects in the mentally retarded. (Abstract)

Effect of amphetamines on speech defects in the mentally retarded. In a double-blind study, 106 mentally retarded patients with speech defects were given 15 mg. of d-Amphetamine daily, or a placebo, for a three-month period. Speech defect types were: Stuttering, immature production, oral inaccuracy, lisp, psychotic, mongoloid, aphasia, deafness, and cleft palate. Only the stutterers showed obvious improvement in comparison with the placebo group. Three severe, long-term stutterers showed

1998 California Medicine Controlled trial quality: uncertain

3659. The influence of information and daily contact on children's attitudes towards aphasic children. (Abstract)

The influence of information and daily contact on children's attitudes towards aphasic children. 3970820 1985 04 19 2004 11 17 0007-0998 55 ( Pt 1) 1985 Feb The British journal of educational psychology Br J Educ Psychol The influence of information and daily contact on children's attitudes towards aphasic children. 1-10 Zakay D D eng Clinical Trial Journal Article Randomized Controlled Trial England Br J Educ Psychol 0370636 0007-0998 IM Aphasia psychology Aphasia, Broca psychology Attitude

1985 The British journal of educational psychology Controlled trial quality: uncertain

3660. Accidental carotid artery injury caused by a horse rope Full Text available with Trip Pro

Accidental carotid artery injury caused by a horse rope A 37 year old woman who had bred horses for more than 20 years was leading two horses in a horse corral. One horse bolted and the lead rope wrapped around her neck. Four hours after the accident, she developed sudden aphasia, right facial palsy, and right arm weakness. Conventional and magnetic resonance angiography showed complete traumatic occlusion of the left common carotid artery due to thrombosis at the C6/7 level. There was good

2003 British Journal of Sports Medicine

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