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Aphasia

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3621. Brain Oxygenation Monitoring in Patients Undergoing Coronary Artery Bypass Surgery

Volunteers: No Criteria Inclusion Criteria: Primary coronary artery bypass surgery Ages 18-90 Voluntary participation with signed informed consent Exclusion Criteria: An unwillingness to participate in the study Inability to obtain informed consent Expressive or receptive aphasia Inability to correctly perform the neurocognitive tests preoperatively Inability to correctly perform the saccadic and anti-saccadic eye movement tests preoperatively Non-English speaking candidates Patients for whom it is known

2005 Clinical Trials

3622. Amantadine for the Treatment of Behavioral Disturbance in Frontotemporal Dementia (FTD)

Dementia and Pick's Disease (McKhann et al, 2001). Diagnosis will be established by clinical interview by a geriatric psychiatrist or neuropsychiatrist, experienced with the diagnosis of FTD. Patients with the language presentation of FTD will be enrolled if their behavioral disturbance meets the inclusion criteria. Use of these diagnostic criteria would allow for enrollment of patients who in a clinical setting carry the diagnosis of: semantic dementia, primary progressive aphasia, cortical-basal (...) Dementia Aphasia, Primary Progressive Pick Disease of the Brain Problem Behavior Brain Diseases Central Nervous System Diseases Nervous System Diseases Neurocognitive Disorders Mental Disorders Frontotemporal Lobar Degeneration TDP-43 Proteinopathies Neurodegenerative Diseases Proteostasis Deficiencies Metabolic Diseases Aphasia Speech Disorders Language Disorders Communication Disorders Neurobehavioral Manifestations Neurologic Manifestations Signs and Symptoms Behavioral Symptoms Amantadine

2005 Clinical Trials

3623. Treatment Study of Frontotemporal Dementia

Dementia or Primary Progressive Aphasia. Ages 45 to 95 years old. Mild-to-moderate (CDR 1 to 2) FTD with an assigned durable power of attorney. EXCLUSION CRITERIA: Diagnosis of any form of dementia besides FTD, including AD, Lewy body dementia, vascular dementia, dementia associated with Parkinson's disease, Corticobasal Degeneration and Progressive Supranuclear Palsy. Severe dementia (CDR 3). Known allergy or serious adverse reaction to quetiapine or dextroamphetamine. Patient is already receiving (...) Frontotemporal Dementia Aphasia, Primary Progressive Pick Disease of the Brain Frontotemporal Lobar Degeneration Brain Diseases Central Nervous System Diseases Nervous System Diseases Neurocognitive Disorders Mental Disorders TDP-43 Proteinopathies Neurodegenerative Diseases Proteostasis Deficiencies Metabolic Diseases Aphasia Speech Disorders Language Disorders Communication Disorders Neurobehavioral Manifestations Neurologic Manifestations Signs and Symptoms

2004 Clinical Trials

3624. Effects of Exercise on Endothelial Function in Stroke Patients

or geropsychiatrist, (b) severe receptive or global aphasia which confounds testing and training, operationally defined as unable to follow 2 point commands, (c) hemiparetic gait from prior stroke preceding the index stroke defining eligibility, (d) non-stroke neurological disorder restricting exercise (e.g. Parkinson's Syndrome), (e) untreated major depression Pregnancy Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact

2008 Clinical Trials

3625. Practice Structure on Motor Learning in Post-Stroke Patients

of multiple strokes, transient ischemic attacks Pathology of the less affected, ipsilateral to stroke upper extremity that would affect ability to perform the task Score of 23 or less on the MMSE Difficulty in comprehension of verbal command and simple instructions Aphasia of comprehension. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided

2008 Clinical Trials

3626. Effects of Tolcapone on Frontotemporal Dementia

Treatment Frontotemporal Dementia Dopamine Frontotemporal Lobar Degeneration Additional relevant MeSH terms: Layout table for MeSH terms Dementia Frontotemporal Dementia Aphasia, Primary Progressive Pick Disease of the Brain Frontotemporal Lobar Degeneration Brain Diseases Central Nervous System Diseases Nervous System Diseases Neurocognitive Disorders Mental Disorders TDP-43 Proteinopathies Neurodegenerative Diseases Proteostasis Deficiencies Metabolic Diseases Aphasia Speech Disorders Language

2008 Clinical Trials

3627. Increasing Use of Mental Health Services

) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Age 60 years and older Homebound Endorse depressive symptoms Exclusion Criteria: Presence of significant alcohol or substance abuse or psychotic disorder High suicide risk, i.e. intent or plan to attempt suicide Cognitive impairment Inability to speak English Aphasia interfering with communication. Current use of antidepressants or psychotherapy Contacts and Locations Go to Information from the National Library

2008 Clinical Trials

3628. Improving Functional Outcomes in Patients With Unilateral Vocal Cord Paralysis: Assessment of Adaptation Using Functional Magnetic Resonance Imaging

months, significant vaso-occlusive disease, severe or advanced asthma, or renal compromise) History of achalasia History of dysphagia, odynophagia, or aphasia unrelated to present illness. History of significant claustrophobic reactions. Standard contraindications to MR examinations (e.g. implanted stimulators, pregnancy). Exclusion criteria for the healthy subjects includes the following: All of the conditions listed for the UVCP patients. Significant surgery or previous radiation therapy

2008 Clinical Trials

3629. Virtual Reality Training Program for Ambulatory Patients With Chronic Gait Deficits After Stroke

condition or aphasia, dementia or other significant neurological disease limiting ability to train. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00600379 Locations Layout table for location information Israel Sheba Medical Center, Strok Center Tel

2008 Clinical Trials

3630. Structural Neuroplasticity Associated With Aerobic Treadmill Training in Geriatric Chronic Stroke Survivors

. Medical History: recent hospitalization (<3 months) for severe medical disease symptomatic peripheral arterial occlusive disease orthopedic or chronic pain conditions restricting exercise pulmonary or renal failure active cancer poorly controlled hypertension (>160/100) or diabetes mellitis (fasting glucose>180 mg/dl, HbA1C >10%) Neurological history of dementia receptive or global aphasia that confounds testing and training, operationally defined as unable to follow 2 point commands cognitive (...) deficits (other than dementia and aphasia, as above) (e) non-stroke neuromuscular disorder restricting exercise (eg Parkinson's Syndrome) (f) untreated major depression exclusion criteria for MRI scanning (metal implants (e.g. pacemaker), claustrophobia, etc.) Contacts and Locations Go to No Contacts or Locations Provided More Information Go to Layout table for additonal information Responsible Party: Andreas R Luft, Prof, University Hospital Tuebingen ClinicalTrials.gov Identifier: Other Study ID

2008 Clinical Trials

3631. Cardiac Rehabilitation for TIA Patients

, dyslipidemia or cigarette smoking Exclusion Criteria: Inability to speak or understand English or provide informed consent. Severe aphasia that renders communication difficult or impossible. Modified Rankin Scale score of greater than or equal to 3. Mini-Mental Status Examination score of less than or equal to 20. Evidence of intracranial hemorrhage confirmed by CT scan or MRI study. Anticipated or recent (<30 days) carotid endarterectomy, angioplasty and/or stenting. Resides >1 hour travel time from

2007 Clinical Trials

3632. Postoperative Delirium in Hip Fracture Patients

Exclusion Criteria: critical ill/ dying aphasia Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00564434 Locations Layout table for location information Norway Ullevaal Hospital Oslo, Norway Sponsors and Collaborators Ullevaal University Hospital More

2007 Clinical Trials

3633. A Comparison of Two Intensive Walking Training Interventions in Community Dwelling Individuals With History of Stroke

to stroke Community dwelling Approval from physician for participation in study Exclusion Criteria: Walking speed greater than 1.0 m/s without walking aid Within normal limits on Modified Mini Mental Status test (age and education adjusted) Documented global aphasia Legal blindness Unable to exercise due to the any of the following conditions A recent significant change in resting ECG suggesting ischemia Recent Myocardial infarction (within 3 months) or other acute cardiac event Unstable angina Severe

2007 Clinical Trials

3634. Clinical Study on Laparoscopic Gastrectomy for Early Gastric Cancer (COACT_0301)

questionnaire was also used. It incorporates five hypothesized scales—(dysphasia, eating restrictions, pain, reflux and anxiety) and four single items (having a dry mouth, body image, taste, and hair loss) covering disease and treatment-related symptoms and specific emotional consequences of gastric cancer.12 All instruments of the questionnaire were administered preoperatively and postoperatively at seven days, 30 days, 90 days and yearly. Those time points were chosen at usual follow-up schedule for every

2007 Clinical Trials

3635. Memantine (10mg BID) for the Frontal and Temporal Subtypes of Frontotemporal Dementia

to complete neuropsychological and functional assessments. Concurrent Motor Neuron Disease judged by investigator to have bulbar or upper extremity impairments at baseline that would interfere with neuropsychological assessment, or that are expected to lead to such impairments within one month. Exclusion criteria as listed in Neary criteria. Diagnosis of progressive nonfluent aphasia by Neary criteria. Use of memantine within 4 weeks prior to randomization. Evidence of other neurological or psychiatric (...) Dementia Aphasia, Primary Progressive Pick Disease of the Brain Brain Diseases Central Nervous System Diseases Nervous System Diseases Neurocognitive Disorders Mental Disorders Tauopathies Neurodegenerative Diseases Frontotemporal Lobar Degeneration TDP-43 Proteinopathies Proteostasis Deficiencies Metabolic Diseases Aphasia Speech Disorders Language Disorders Communication Disorders Neurobehavioral Manifestations Neurologic Manifestations Signs and Symptoms Memantine Antiparkinson Agents Anti

2007 Clinical Trials

3636. Efficacy of Tacrolimus and I.V.-Immunoglobulins in Rasmussen Encephalitis

. Hemispherectomy is an effective means of surgical treatment of the epilepsy. It renders the patient, however, hemiplegic, hemianopic and (if the language dominant hemisphere is affected) aphasic. To slow down or even stop the progressive inflammatory damage to the affected brain hemisphere, immunotherapies may be beneficial. According to a literature survey, tacrolimus (twice daily intake of capsules) and intravenous immunoglobulins (monthly infusions) are the most promising compounds

2007 Clinical Trials

3637. PET Evaluation of Brain Peripheral Benzodiazepine Receptors Using [11C]PBR28 in Frontotemporal Dementia

Posted: February 12, 2008 Last Update Posted: April 3, 2019 Last Verified: July 13, 2017 Keywords provided by National Institutes of Health Clinical Center (CC) ( National Institute of Mental Health (NIMH) ): Inflammation Frontotemporal Dementia Dementia PBR28 PET Imaging Additional relevant MeSH terms: Layout table for MeSH terms Dementia Frontotemporal Dementia Aphasia, Primary Progressive Pick Disease of the Brain Frontotemporal Lobar Degeneration Brain Diseases Central Nervous System Diseases (...) Nervous System Diseases Neurocognitive Disorders Mental Disorders TDP-43 Proteinopathies Neurodegenerative Diseases Proteostasis Deficiencies Metabolic Diseases Aphasia Speech Disorders Language Disorders Communication Disorders Neurobehavioral Manifestations Neurologic Manifestations Signs and Symptoms

2008 Clinical Trials

3638. COGNITIVE

: verbal learning - the Rey's AVLT test direct verbal memory - number repeating attempt from the WAIS-R/PL test direct nonverbal memory - Memory Test of Geometric Figures by Benton operating memory test - TMT test the cognitive interference test - a modified Stroop test verbal fluence - according to the Boston Test of Aphasia concentration and work effectiveness - by the Number Symbol test by Wechsler. mood - Beck's depression scale NEECHAM Delirium Scale - during the first 24-36 hours after surgery

2007 Clinical Trials

3639. Open Label Pilot Study of the Effects of Memantine on FDG-PET in Frontotemporal Dementia

: Must meet criteria for frontotemporal lobar degeneration (FTD) by Neary et al. criteria. 28 Subjects may have either the behavioural or the aphasic variant of FTD. Able to undergo psychometric testing. Must have reliable informant with daily contact with patient May be taking concurrent psychotropic medications, but must be on stable dosing regimen for 3 months prior to trial enrollment On the basis of a physical examination, medical history (including psychiatric and neurological), and results (...) Research Institute at Baycrest ClinicalTrials.gov Identifier: Other Study ID Numbers: Baycrest.Ebixa.FTD-001 Lundbeck 11627A First Posted: January 16, 2008 Last Update Posted: June 4, 2012 Last Verified: June 2012 Keywords provided by Tiffany Chow, MD, Rotman Research Institute at Baycrest: PET frontotemporal dementia memantine Pick's disease Additional relevant MeSH terms: Layout table for MeSH terms Dementia Frontotemporal Dementia Aphasia, Primary Progressive Pick Disease of the Brain Brain Diseases

2008 Clinical Trials

3640. Improving Therapeutic Outcomes in the Tongue Carcinoma Patient: Assessment of Adaptation Using Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging

. History of previous moderate to severe traumatic brain injury. History of significant cardiovascular, respiratory, gastrointestinal or renal disease (e.g.myocardial infarction within the previous 12 months, significant vaso-occlusive disease,severe or advanced asthma, COPD, emphysema, gastroesophageal reflux disease, or renal compromise) History of achalasia History of other neoplasms involving the brain, head and neck, or gastrointestinal system. History of dysphagia, odynophagia, or aphasia (...) unrelated to present illness. History of significant claustrophobic reactions. Standard contraindications to MR examinations (e.g. implanted stimulators). Exclusion criteria for the healthy subjects includes the all of the conditions listed for the tongue: Carcinoma patients and additionally includes history of significant surgery or previous radiation therapy to the head and neck Previous history of dysphagia, odynophagia, aphasia, pregnancy,and standard contraindications to MR examinations. Contacts

2008 Clinical Trials

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