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Aphasia

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3621. A cost-utility analysis comparing omeprazole with ranitidine in the maintenance therapy of peptic esophageal stricture

Cost-utility analysis. Study population Patients with benign peptic strictures previously dilated to the point where they were dysphasia free and were only dilated for recurrent symptoms. Setting Hospital. The economic analysis was conducted in London, Ontario, Canada. Dates to which data relate Effectiveness data were identified from literature published between 1976 and 1994. It is not clear when data for resource use were collected. The price years used were not stated. Source of effectiveness (...) that for mortality following surgery or conservative treatment for perforation was 13%. TABLE C Measure of benefits used in the economic analysis Quality-adjusted life years gained (QALYs) were the benefit measure. A decision tree model was used to estimate expected QALYs gained. The standard gamble method was used to determine disutility associated with dysphasia and the time trade off method was used to determine disutility scores for esophageal dilation, esophageal perforation, surgery and conservative

1998 NHS Economic Evaluation Database.

3622. Stroke rehabilitation after hospital discharge: a randomized trial comparing domiciliary and day-hospital care

, 16%), disability too severe to benefit from rehabilitation (14 patients, 6%), severe dysphasia (13 patients, 5.5%), frailty (9 patients, 4%), advanced dementia (8 patients, 3%), too confused (2 patients, 1%), non-resident (22 patients, 9%), social referral to day-hospital (5 patients, 2%), age less than 55 years (3 patients, 1%), self-discharge (1 patients, 0.5%), other (4 patients, 2%), and unknown (37 patients, 16%). Study design This was a randomised controlled trial. The participants were

2001 NHS Economic Evaluation Database.

3623. Economic consequences of early inpatient discharge to community-based rehabilitation for stroke in an inner-London teaching hospital

examination, and the Frenchay aphasia screening test. Disability was assessed using the modified Barthel score, the Rivermead activities of daily living score, the hospital and depression scale, the 5-metre time walk, and the Nottingham health profile. Caregiver strain (caregiver strain index) and the number and proportion of patients and carers satisfied with hospital care, therapy provision, community support and satisfied in general (stroke-specific questionnaires) were also reported. The authors (...) reported that there were no significant differences between the two groups of patients at baseline and at the time of randomisation in terms of gender, age, ethnic group, recurrent stroke, prior Barthel score, dysphasia and incontinence. The study groups were shown to have been comparable at baseline for the demographic and clinical characteristics. Effectiveness results The authors reported in this study that the only significant difference found between the EAHD and control groups was that EAHD

1999 NHS Economic Evaluation Database.

3624. Recombinant tissue plasminogen activator in acute ischemic stroke

. However, when the question was phrased, “Would you want rtPA if you had an ischemic stroke with aphasia or hemiplegia?”, most said “yes.” In other words, it appears they had qualms about using it on patients, but fewer qualms about having it used on themselves. One physician commented, “For me, personally, the choice is ‘Walk or die!’” William H Cordell, MD In response [Wyer PC: Feedback: Walk or die! [in response]. Ann Emerg Med November 1999;34:661-662.] It is fascinating to see that physicians can

1999 Evidence-Based Emergency Medicine

3625. Variability in language recovery after first-time stroke (Abstract)

Variability in language recovery after first-time stroke Predicting aphasia recovery after stroke has been difficult due to substantial variability in outcomes. Few studies have characterised the nature and extent of recovery, beginning with baselines at 24-72 hours after stroke onset.To characterise the course of language recovery after first-time stroke.Using our Performance and Recovery in Stroke Study (PARIS) database, we evaluated consecutive first-time stroke patients with aphasia

2008 EvidenceUpdates

3626. Improved quality of life outcomes after laparoscopy-assisted distal gastrectomy for early gastric cancer: results of a prospective randomized clinical trial (Abstract)

to intraoperative blood loss (P < 0.001), total amount of analgesics used (P = 0.019), the size of the wound (P < 0.0001), postoperative hospital stay (P < 0.0001), and QOL parameters of global health (P < 0.0001). Most of the scales on patient functioning including physical (P < 0.0005), role (P = 0.0011), emotional (P < 0.0001), social (P < 0.0001), and symptom scales such as fatigue (P < 0.0001), pain (P < 0.0001), appetite loss (P = 0.031), sleep disturbance (P = 0.003), dysphasia (P = 0.0024), gastro

2008 EvidenceUpdates Controlled trial quality: uncertain

3627. Progressive multifocal leukoencephalopathy in a patient treated with natalizumab. Full Text available with Trip Pro

. Despite treatment with corticosteroids, cidofovir, and intravenous immune globulin, PML progressed rapidly, rendering the patient quadriparetic, globally aphasic, and minimally responsive. Three months after natalizumab therapy was discontinued, changes consistent with an immune-reconstitution inflammatory syndrome developed. The patient was treated with systemic cytarabine, and two months later, his condition had improved.Copyright 2005 Massachusetts Medical Society.

2005 NEJM

3628. Frontotemporal dementia

of degeneration of the medial prefrontal and frontoinsular cortices. Four clinical subtypes have been identified: semantic dementia, progressive non-fluent aphasia, behavioral variant FTD and right temporal lobar atrophy (see these terms). ORPHA:282 Classification level: Group of disorders Synonym(s): FTD Prevalence: 1-9 / 100 000 Inheritance: Autosomal dominant Age of onset: Adult ICD-10: G31.0 OMIM: UMLS: C0338451 MeSH: D057180 GARD: MedDRA: 10068968 Detailed information Article for general public

2005 Orphanet

3629. Cogan syndrome

, meningitis, hemiparesis or hemiplegia due to a cerebral vascular accident and aphasia due to a transient ischaemic event) and gastrointestinal systems (diarrhea, melena and abdominal pains). Etiology CS is supposed to have an autoimmune etiology, and autoantibodies to inner ear antigens and corneal structures, such as the Cogan peptide are usually present, even if they cannot be considered specific CS serological biomarkers. Diagnostic methods The diagnosis is mainly clinical of exclusion of infections

2005 Orphanet

3630. Benign familial epilepsy of childhood with rolandic spikes

. There is probably a genetic predisposition: an increased rate of RE, febrile seizures, and epilepsy-aphasia spectrum disorders were found among relatives. Pathogenesis seems to be related with the critical and vulnerable phase of brain maturation. Diagnostic methods Diagnosis of RE relies on the clinical features and on EEG findings that show slow, diphasic, high voltage, centrotemporal spikes, activated by sleep. Brain magnetic resonance imaging (MRI) is normal. Differential diagnosis Differential diagnosis

2005 Orphanet

3631. Informativeness ratings of messages created on an AAC processing prosthesis. Full Text available with Trip Pro

Informativeness ratings of messages created on an AAC processing prosthesis. BACKGROUND: SentenceShaper() (SSR) is a computer program that supports spoken language production in aphasia by recording and storing the fragments that the user speaks into the microphone, making them available for playback and allowing them to be combined and integrated into larger structures (i.e., sentences and narratives). A prior study that measured utterance length and grammatical complexity in story-plot (...) narratives produced with and without the aid of SentenceShaper demonstrated an "aided effect" in some speakers with aphasia, meaning an advantage for the narratives that were produced with the support of this communication aid (Linebarger, Schwartz, Romania, Kohn, & Stephens, 2000). The present study deviated from Linebarger et al.'s methods in key respects and again showed aided effects of SentenceShaper in persons with aphasia. AIMS: Aims were (1) to demonstrate aided effects in "functional narratives

2007 Aphasiology Controlled trial quality: uncertain

3632. Motor Learning of a Planning Task in Stroke Patients: the Maze Paradigm Measured Through Time and Error as Variables

by examination of image and finding medical neurologist Time of injury over 6 months Single vascular event Right handed, by applying the Inventory of Dominance Side of Edinburgh Mini mental with scores over 23 points Exclusion Criteria: Aphasia of understanding Instability clinic Other neurological diseases associated (Parkinson's disease, dementias, Alzheimer) Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact

2008 Clinical Trials

3633. Study of NeuroAid In Enhancing Recovery After Stroke

non-ischemic brain lesion which could affect function disability Subject has co-existing systemic diseases: terminal cancer, renal failure (creatinine >200 μmol/L, if known), cirrhosis, severe dementia or psychosis Subject has a history of previous stroke/s Subject has participated in another clinical trial within the last three months Subject has aphasia or any other cognitive disabilities which prevent cooperation with study instructions Subject has dense hemiplegia (grade 0 motor power) Subject

2008 Clinical Trials

3634. Speech and Language Therapy After Stroke

provided by (Responsible Party): University of Chicago Study Details Study Description Go to Brief Summary: Our overall goal is to advance the state of functional brain imaging in aphasia, and then to apply the method to an intensive, imitation-based treatment for non-fluent aphasia. Condition or disease Intervention/treatment Phase Ischemic Stroke Behavioral: Imitate Therapy Not Applicable Detailed Description: Detailed information will follow in the next progress report. Study Design Go to Layout (...) table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 34 participants Allocation: Randomized Intervention Model: Single Group Assignment Masking: Double (Participant, Outcomes Assessor) Primary Purpose: Treatment Official Title: Neurophysiological Measurement in Aphasia Treatment Study Start Date : August 2007 Actual Primary Completion Date : January 2012 Actual Study Completion Date : January 2012 Resource links provided by the National Library of Medicine

2008 Clinical Trials

3635. Safety and Efficacy Study of Pyridorin in Patients With Nephropathy Due to Type 2 Diabetes

liver disease or transaminase (alanine aminotransferase and aspartate aminotransferase) levels >2.5 x upper limit of normal measured at the Screening Visit; Patients with bilirubin levels >1.5 x upper limit of normal measured at the Screening Visit; Patients with a history of allergic or other adverse response to vitamin B preparations; Patients who require >50 mg of vitamin B6 daily; Patients who have a history of dysphasia and swallowing disorders; Patients with a history of hypersensitivity

2008 Clinical Trials

3636. Functional Recovery in Stroke Patients With Task-Specific Robot-Aided Arm Therapy

with the neurological examiner such that the validity of the patient's data could be compromised cyber sickness pace-maker or other implanted electric devices body weight > 120kg serious cognitive deficits and aphasia preventing the performance of the ARMin treatment participation in any therapeutic treatment ("outside therapy") performed with the paralyzed arm during the planned study - including baseline and follow up. Contacts and Locations Go to Information from the National Library of Medicine To learn more

2008 Clinical Trials

3637. Effects of Oral Levosimendan on Ambulatory Electrocardiographic Variables

or dysphasia, haemodynamically significant uncorrected valve disease or hypertrophic cardiomyopathy or restrictive cardiomyopathy, any acute coronary event or angioplasty or any other major surgery within 1 month, any major surgery during the planned study period History of life-threatening ventricular arrhythmia within 3 months. History of Torsades de Pointes (TdP) or family history of long QT-syndrome Heart rate (HR) < 50 or > 100 bpm. Systolic blood pressure (SBP) < 100 mmHg or > 180 mmHg, or diastolic

2008 Clinical Trials

3638. Clinical Findings in General Paresis

Medical University, China Study Start Date : April 2008 Actual Primary Completion Date : December 2008 Actual Study Completion Date : January 2009 Resource links provided by the National Library of Medicine resources: Groups and Cohorts Go to Group/Cohort Mr Q, 40 years old Dementia, sensory aphasia, irritability, hallucination MRI showed cortical lesion, mesial temporal lobe atrophy. Mr Guo,35 years old Dementia, sensory aphasia, tremor, gait disturbance MRI showed cortical lesion, enlarged ventricle

2008 Clinical Trials

3639. Testing of a Functional Outcome Measure for Those With Visual Field Defects

of photogenic seizures Inability to complete Vision Restoration Therapy Significant cognitive impairment Complete blindness or the inability to focus on a fixation point Severe physical or behavioral limitations Aphasia Onset of Visual field defect less than 3 months prior to enrollment Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor

2008 Clinical Trials

3640. Air Muscle and Task Practice in Upper Limb Stroke Rehab

treating the dominant limb. Distributions of dominance and hand preference have been acquired from patients meeting eligibility criteria in 1998 at several sites for determining participation of sites for the EXCITE trial and side of cerebral pathology showed remarkably equal left-right distribution. Exclusion criteria a score of less than 24 on the Folstein Mini-Mental State Examination or a score of 36 or below on the Token Test of the Multilingual Aphasia Examination a first stroke less than 3

2008 Clinical Trials

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