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Aphasia

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181. Noun and verb processing in aphasia: Behavioural profiles and neural correlates Full Text available with Trip Pro

Noun and verb processing in aphasia: Behavioural profiles and neural correlates The behavioural and neural processes underpinning different word classes, particularly nouns and verbs, have been a long-standing area of interest in psycholinguistic, neuropsychology and aphasiology research. This topic has theoretical implications concerning the organisation of the language system, as well as clinical consequences related to the management of patients with language deficits. Research findings (...) , in a relatively large cohort of 48 patients with chronic post-stroke aphasia. A data-driven approach, principal component analysis (PCA), was also used to determine how noun and verb production and comprehension were related to the patients' underlying fundamental language domains. The results revealed no performance differences between noun and verb production and comprehension once matched on multiple psycholinguistic features including, most critically, imageability. Interestingly, the noun-verb

2018 NeuroImage : Clinical

182. The role of language proficiency and linguistic distance in cross-linguistic treatment effects in aphasia Full Text available with Trip Pro

The role of language proficiency and linguistic distance in cross-linguistic treatment effects in aphasia Current findings from intervention in bilingual aphasia are inconclusive regarding the extent to which levels of language proficiency and degree of linguistic distance between treated and non-treated languages influence cross-language generalisation and changes in levels of language activation and inhibition following treatment. In this study, we enrolled a 65-year-old multilingual speaker (...) with aphasia and administered treatment in his L1, Dutch. We assessed pre- and post-treatment performance for seven of his languages, five of high proficiency and two of lower proficiency. We asked whether treatment in L1 would generalise to his other languages or increase interference among them. Forty hours of treatment were completed over the course of five weeks. Each language was tested three times at pretreatment and at post-treatment. Testing included measures of narrative production, answering

2018 Clinical linguistics & phonetics

183. Telerehabilitation for aphasia – protocol of a pragmatic, exploratory, pilot randomized controlled trial Full Text available with Trip Pro

Telerehabilitation for aphasia – protocol of a pragmatic, exploratory, pilot randomized controlled trial The Cochrane review on the effectiveness of speech and language therapy for aphasia following stroke suggests intensity of therapy is a key predictor for outcome. Current aphasia services cannot provide intervention at the intensity observed within trial contexts because of resource limitations. Telerehabilitation could widen access to speech-language pathologists (SLPs) in geographically (...) remote contexts and reduce the time spent on travel by the therapist and patient. The current academic literature within this field is in its infancy, with few trials of speech and language therapy (SLT) delivered by videoconference. Our pilot randomized controlled trial (RCT) will explore feasibility aspects and effectiveness of telerehabilitation for aphasia in addition to standard SLT.Our study is a pragmatic, exploratory, pilot randomized controlled trial, where participants will be randomized

2018 Trials Controlled trial quality: predicted high

184. Malignant atrophic papulosis with motor aphasia and intestinal perforation: A case report and review of published works Full Text available with Trip Pro

Malignant atrophic papulosis with motor aphasia and intestinal perforation: A case report and review of published works Malignant atrophic papulosis (MAP) is a rare type of obliterating vasculopathy that can present as pure cutaneous lesions or a systemic entity affecting multiple organs. Systemic disease, such as gastrointestinal or central nervous system involvement, may predispose the patients to poorer or even fatal outcomes. We present a 30-year-old female patient with systemic (...) manifestation of MAP 10 days after delivery of a full-term pregnancy who subsequently developed motor aphasia and intestinal perforation. The patient was administrated empirical treatment with an antiplatelet, anticoagulant, methylprednisolone sodium succinate and alprostadil. Antibiotics were administrated due to intestinal perforation and secondary sepsis. Despite all treatment, the patient died a week later. We summarized all the previous reports of MAP based on thorough review of previous published work

2018 The Journal of dermatology

185. CNKSR2 mutation causes the X-linked epilepsy-aphasia syndrome: A case report and review of literature Full Text available with Trip Pro

CNKSR2 mutation causes the X-linked epilepsy-aphasia syndrome: A case report and review of literature The mutation in CNKSR2 leads to a broad spectrum of phenotypic variability and manifests as an X-linked intellectual disability. However, we reported that the male patient in this study not only had intellectual disability but also epileptic seizures. In addition, there were progressive language impairment, attention deficit hyperactivity disorder and autism. Electroencephalograms showed (...) continuous spike-and-wave during sleep. Genetic testing revealed a de novo mutation of the CNKSR2 gene (c.2185C>T, p.Arg729Ter) in the child that was not detected in the parents. Therefore, the child was diagnosed with X-linked epilepsy aphasia syndrome. Deletion of the CNKSR2 gene has been rarely reported in epilepsy aphasia syndrome, but no de novo mutation has been found in this gene. This report not only adds to the spectrum of epilepsy aphasia syndrome but also helps clinicians in diagnosis

2018 World journal of clinical cases

186. Sensitivity of Speech Output to Delayed Auditory Feedback in Primary Progressive Aphasias Full Text available with Trip Pro

Sensitivity of Speech Output to Delayed Auditory Feedback in Primary Progressive Aphasias Delayed auditory feedback (DAF) is a classical paradigm for probing sensori-motor interactions in speech output and has been studied in various disorders associated with speech dysfluency and aphasia. However, little information is available concerning the effects of DAF on degenerating language networks in primary progressive aphasia: the paradigmatic "language-led dementias." Here we studied two forms (...) of speech output (reading aloud and propositional speech) under natural listening conditions (no feedback delay) and under DAF at 200 ms, in a cohort of 19 patients representing all major primary progressive aphasia syndromes vs. healthy older individuals and patients with other canonical dementia syndromes (typical Alzheimer's disease and behavioral variant frontotemporal dementia). Healthy controls and most syndromic groups showed a quantitatively or qualitatively similar profile of reduced speech

2018 Frontiers in neurology

187. The Role of Language Severity and Education in Explaining Performance on Object and Action Naming in Primary Progressive Aphasia Full Text available with Trip Pro

The Role of Language Severity and Education in Explaining Performance on Object and Action Naming in Primary Progressive Aphasia Despite the common assumption that atrophy in a certain brain area would compromise the function that it subserves, this is not always the case, especially in complex clinical syndromes such as primary progressive aphasia (PPA). Clinical and demographic information may contribute to PPA phenotypes and explain the manifested impairments better than atrophy

2018 Frontiers in aging neuroscience

188. Recovernow: A Multicentre Of Tablet-Based Speech Therapy For Post-Stroke Aphasia

longer hospital stays, more severe disability, greater nursing care dependency, are at a greater risk for depression, are discharged to long-term care more frequently, and are less likely to return to work, even when younger. When compared to non-aphasic patients with similar physical abilities, well-being and social supports, patients with aphasia engage in fewer instrumental activities of daily living (iADL) and report worse quality of life. Investigators launched the RecoverNow research program (...) Recovernow: A Multicentre Of Tablet-Based Speech Therapy For Post-Stroke Aphasia Recovernow: Tablet-Based Speech Therapy For Post-Stroke Aphasia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Recovernow

2018 Clinical Trials

189. Changes in the corpus callosum during the recovery of aphasia: A case report. Full Text available with Trip Pro

Changes in the corpus callosum during the recovery of aphasia: A case report. The corpus callosum, which is the most important fiber pathway linking the bilateral hemispheres, plays a key role in information access, as well as the functional coordination and reorganization between the bilateral hemispheres. However, whether the corpus callosum will undergo structural changes during the recovery of aphasia is still unclear. In the current study, a Chinese aphasic patient with stroke was reported (...) to develop changes in the corpus callosum after speech therapy.A 33-year-old right-handed male patient had aphasia only without limb paralysis at 14 months after stroke.Neuroimaging evaluation confirmed a diagnosis of cerebral infarction in the left frontal lobe, insula and basal ganglia.He underwent 5-month speech therapy and received language function evaluation and DTI examination before and after speech therapy.The result ABC showed that the language functions in the patient, including spontaneous

2018 Medicine

190. Parkinsonism is associated with altered primary motor cortex plasticity in frontotemporal dementia-primary progressive aphasia variant. (Abstract)

Parkinsonism is associated with altered primary motor cortex plasticity in frontotemporal dementia-primary progressive aphasia variant. In frontotemporal dementia (FTD), the behavioral variant (bv-FTD) and nonfluent variant of primary progressive aphasia (nfv-PPA) reflect a prominent neurodegenerative involvement of the frontal lobe networks, which may include the premotor and motor areas and thus cause heterogeneous clinical symptoms including parkinsonism. With the technique of transcranial

2018 Neurobiology of Aging

191. Modeling Treated Recovery From Aphasia

Modeling Treated Recovery From Aphasia Modeling Treated Recovery From Aphasia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Modeling Treated Recovery From Aphasia The safety and scientific validity (...) Communication Disorders (NIDCD) Information provided by (Responsible Party): Julius Fridriksson, PhD, University of South Carolina Study Details Study Description Go to Brief Summary: Stroke is the leading cause of adult disability in the United States, and aphasia is common following a stroke to the left hemisphere of the brain. Aphasia therapy can improve aphasia recover; however, very little is known about how different patients respond to different types of treatments. The purpose of this study

2018 Clinical Trials

192. Communication and well-being outcomes of a hybrid service delivery model of intensive impairment-based treatment for aphasia in the hospital setting: a pilot study. (Abstract)

Communication and well-being outcomes of a hybrid service delivery model of intensive impairment-based treatment for aphasia in the hospital setting: a pilot study. This pilot study aimed to evaluate the effects of an intensive hybrid service delivery model (i.e., combining face-to-face individual, computer and group therapy) on communication and well-being for people with aphasia (PWA) in the hospital setting.The study explored two different intensities of the hybrid model, 4 h/week (Hybrid-4 (...) in communication and well-being for some PWA across different stages of recovery. Implications for rehabilitation The present findings help bridge the gap between what evidence suggests is effective intensity of rehabilitation for aphasia and what can be practically delivered in real-world hospital settings. Findings support the potential clinical value of employing a hybrid service model (using computer, group and individual therapy) to deliver intensive rehabilitation to people with aphasia in the hospital

2018 Disability and rehabilitation Controlled trial quality: uncertain

193. Communicative effectiveness of pantomime gesture in people with aphasia. Full Text available with Trip Pro

, listener comprehension was more accurate in the combined pantomime gesture and speech condition as compared with the gesture- or speech-only conditions. Participants achieved greater accuracy in the multiple-choice task as compared with the free-description task, but only in the gesture-only condition. The communicative effectiveness of the pantomime gestures increased as the fluency of the participants with aphasia decreased.These results indicate that when pantomime gesture was presented with aphasic (...) Communicative effectiveness of pantomime gesture in people with aphasia. Human communication occurs through both verbal and visual/motoric modalities. Simultaneous conversational speech and gesture occurs across all cultures and age groups. When verbal communication is compromised, more of the communicative load can be transferred to the gesture modality. Although people with aphasia produce meaning-laden gestures, the communicative value of these has not been adequately investigated.To

2018 International Journal of Language & Communication Disorders Controlled trial quality: uncertain

194. Effectiveness of speech language therapy either alone or with add-on computer-based language therapy software (Malayalam version) for early post stroke aphasia: A feasibility study. (Abstract)

Effectiveness of speech language therapy either alone or with add-on computer-based language therapy software (Malayalam version) for early post stroke aphasia: A feasibility study. This study aimed to assess the feasibility of professional based conventional speech language therapy (SLT) either alone (Group A/less intensive) or assisted by novel computer based local language software (Group B/more intensive) for rehabilitation in early post stroke aphasia.Comprehensive Stroke Care Center (...) of a tertiary health care institute situated in South India, with the study design being prospective open randomised controlled trial with blinded endpoint evaluation.This study recruited 24 right handed first ever acute ischemic stroke patients above 15years of age affecting middle cerebral artery territory within 90days of stroke onset with baseline Western Aphasia Battery (WAB) Aphasia Quotient (AQ) score of <93.8 between September 2013 and January 2016.The recruited subjects were block randomised

2018 Journal of the neurological sciences Controlled trial quality: uncertain

195. Can the use of digital devices with specific programs improve the communication of aphasic patients? A systematic review

Can the use of digital devices with specific programs improve the communication of aphasic patients? A systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2020 PROSPERO

196. Therapy-Induced Neuroplasticity in Chronic Aphasia After Phonological Component Analysis: A Matter of Intensity Full Text available with Trip Pro

Therapy-Induced Neuroplasticity in Chronic Aphasia After Phonological Component Analysis: A Matter of Intensity Despite the growing evidence regarding the importance of intensity and dose in aphasia therapy, few well-controlled studies contrasting the effects of intensive and non-intensive treatment have been conducted to date. Phonological components analysis (PCA) treatment for anomia has been associated with improvements in some patients with chronic aphasia; however, the effect of treatment (...) reflects the need to suppress errors to improve naming. Thus, both short-term intensive and standard, non-intensive, PCA treatment can improve word retrieval in chronic aphasia, but neuroimaging data suggest that improved naming is associated with different neural activation patterns in the two treatment conditions.

2018 Frontiers in neurology

197. Thalamic bacterial abscess presenting with hemiparesis and expressive aphasia Full Text available with Trip Pro

Thalamic bacterial abscess presenting with hemiparesis and expressive aphasia Brain abscesses are relative rare in the developing world, with an incidence of 2% of all space occupying lesions. Deep-seated abscesses such as thalamic and basal ganglia abscesses are much rarer than abscesses in other locations of the brain, comprising 1.3-6% of all brain abscesses. These abscesses may present with hemiparesis, and subcortical aphasia has only been reported in a few cases throughout the literature (...) . Here we present and discuss a case of thalamic brain abscess caused by S. anginosus that presented with subcortical aphasia.

2018 IDCases

198. Distinct [18F]THK5351 binding patterns in primary progressive aphasia variants Full Text available with Trip Pro

Distinct [18F]THK5351 binding patterns in primary progressive aphasia variants To assess the binding of the PET tracer [18F]THK5351 in patients with different primary progressive aphasia (PPA) variants and its correlation with clinical deficits. The majority of patients with nonfluent variant (NFV) and logopenic variant (LV) PPA have underlying tauopathy of the frontotemporal lobar or Alzheimer disease type, respectively, while patients with the semantic variant (SV) have predominantly

2018 European Journal of Nuclear Medicine and Molecular Imaging

199. Conduction Aphasia as Initial Manifestation of Tuberculous Meningitis Full Text available with Trip Pro

Conduction Aphasia as Initial Manifestation of Tuberculous Meningitis Conduction aphasia being the arcuate fasciculus of the site of structural injury is a speech disorder characterized by fluent, spontaneous speech and paraphasias, intact auditory comprehension, and limited repetition. One of the causes of stroke in young adults is the Mycobacterium tuberculosis (MTB) infection, which may cause cerebral ischemia secondary to artery obliteration. In this case report, we present a previously (...) healthy 24-year-old woman that presented with a sudden onset of aphasia; MTB was identified as the etiological agent. Tuberculous meningitis (TBM) has a wide range of clinical manifestations with aphasia being one of the rarest forms of initial presentation.

2018 Cureus

200. Electrical brain stimulation in different variants of primary progressive aphasia: A randomized clinical trial Full Text available with Trip Pro

Electrical brain stimulation in different variants of primary progressive aphasia: A randomized clinical trial Transcranial direct current stimulation (tDCS) has been recently shown to improve language outcomes in primary progressive aphasia (PPA) but most studies are small and the influence of PPA variant is unknown.Thirty-six patients with PPA participated in a randomized, sham-controlled, double-blind, within-subject crossover design for 15 daily sessions of stimulation coupled with written

2018 Alzheimer's & dementia : translational research & clinical interventions Controlled trial quality: uncertain

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