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Aphasia

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181. Assessment of Aphasia Across the International Classification of Functioning, Disability and Health Using an iPad-Based Application. (PubMed)

Assessment of Aphasia Across the International Classification of Functioning, Disability and Health Using an iPad-Based Application. Access2Aphasia™ is an iPad™-based aphasia assessment application that enables real-time audiovisual communication between people with aphasia (PWA) and speech-language pathologists (SLPs), and the use of supported conversation techniques. This study aimed to establish the reliability of aphasia assessment across the International Classification of Functioning (...) subtests of the Psycholinguistic Assessment of Language Processing Activities (PALPA) and the Assessment of Living with Aphasia (ALA) to allow for outcomes to be captured across the ICF domains. Consumer perspectives on Access2Aphasia were obtained from both PWA and research SLPs in the online-led group.Kappa statistics indicated moderate to almost perfect agreement between online and FTF SLPs (k = 0.71-1.00). Intrarater and interrater reliability was excellent (ICC = 0.99-1.00) and equivalent

2017 Telemedicine journal and e-health : the official journal of the American Telemedicine Association

182. Predicting clinical decline in progressive agrammatic aphasia and apraxia of speech. (PubMed)

Predicting clinical decline in progressive agrammatic aphasia and apraxia of speech. To determine whether baseline clinical and MRI features predict rate of clinical decline in patients with progressive apraxia of speech (AOS).Thirty-four patients with progressive AOS, with AOS either in isolation or in the presence of agrammatic aphasia, were followed up longitudinally for up to 4 visits, with clinical testing and MRI at each visit. Linear mixed-effects regression models including all visits (...) (n = 94) were used to assess baseline clinical and MRI variables that predict rate of worsening of aphasia, motor speech, parkinsonism, and behavior. Clinical predictors included baseline severity and AOS type. MRI predictors included baseline frontal, premotor, motor, and striatal gray matter volumes.More severe parkinsonism at baseline was associated with faster rate of decline in parkinsonism. Patients with predominant sound distortions (AOS type 1) showed faster rates of decline in aphasia

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2017 Neurology

183. Classical Conditioning Training for Aphasia. A Telemedicine Approach.

Classical Conditioning Training for Aphasia. A Telemedicine Approach. Classical Conditioning Training for Aphasia. A Telemedicine Approach. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Classical (...) Conditioning Training for Aphasia. A Telemedicine Approach. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03381313 Recruitment Status : Completed First Posted : December 22, 2017 Last Update Posted : December 26, 2017 Sponsor: I.R.C.C.S. Fondazione Santa Lucia Information provided by (Responsible Party

2017 Clinical Trials

184. Efficacy of a Combined Linguistic/Communication Therapy in Acute Aphasia After Stroke

Efficacy of a Combined Linguistic/Communication Therapy in Acute Aphasia After Stroke Efficacy of a Combined Linguistic/Communication Therapy in Acute Aphasia After Stroke - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Efficacy of a Combined Linguistic/Communication Therapy in Acute Aphasia After Stroke (ORACLE) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03287544 Recruitment Status : Recruiting First Posted : September

2017 Clinical Trials

185. Frequency of CNKSR2 mutation in the X-linked epilepsy-aphasia spectrum. (PubMed)

Frequency of CNKSR2 mutation in the X-linked epilepsy-aphasia spectrum. Synaptic proteins are critical to neuronal function in the brain, and their deficiency can lead to seizures and cognitive impairments. CNKSR2 (connector enhancer of KSR2) is a synaptic protein involved in Ras signaling-mediated neuronal proliferation, migration and differentiation. Mutations in the X-linked gene CNKSR2 have been described in patients with seizures and neurodevelopmental deficits, especially those affecting (...) language. In this study, we sequenced 112 patients with phenotypes within the epilepsy-aphasia spectrum (EAS) to determine the frequency of CNKSR2 mutation within this complex set of disorders. We detected a novel nonsense mutation (c.2314 C>T; p.Arg712*) in one Ashkenazi Jewish family, the male proband of which had a severe epileptic encephalopathy with continuous spike-waves in sleep (ECSWS). His affected brother also had ECSWS with better outcome, whereas the sister had childhood epilepsy

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2017 Epilepsia

186. Acceptability, reliability, and validity of the Stroke and Aphasia Quality of Life Scale-39 (SAQOL-39) across languages: A systematic review. (PubMed)

Acceptability, reliability, and validity of the Stroke and Aphasia Quality of Life Scale-39 (SAQOL-39) across languages: A systematic review. This systematic review aimed to explore the acceptability, reliability, and validity of the Stroke and Aphasia Quality of Life-39 (SAQOL-39) scale across languages.We employed a systematic search of the online databases including MEDLINE (Pubmed), Science direct, Web of science, Psychinfo, Scopus, ProQuest, Google Scholar, and Cochrane library published

2017 Clinical rehabilitation

187. Generalization and maintenance of treatment gains in primary progressive aphasia (PPA): a systematic review. (PubMed)

Generalization and maintenance of treatment gains in primary progressive aphasia (PPA): a systematic review. Cognitive-linguistic treatments and interventions targeting communication have been developed within the context of primary progressive aphasia (PPA), however knowledge about the scope of generalization and maintenance of therapy gains considering PPA subtypes remains scarce and awaits systematic investigation.To analyse the effects of semantic therapy on generalization and maintenance

2017 International Journal of Language & Communication Disorders

188. Distinct spatiotemporal patterns of neuronal functional connectivity in primary progressive aphasia variants. (PubMed)

Distinct spatiotemporal patterns of neuronal functional connectivity in primary progressive aphasia variants. Primary progressive aphasia is a syndrome characterized by progressive loss of language abilities with three main phenotypic clinical presentations, including logopenic, non-fluent/agrammatic, and semantic variants. Previous imaging studies have shown unique anatomic impacts within language networks in each variant. However, direct measures of spontaneous neuronal activity (...) and functional integrity of these impacted neural networks in primary progressive aphasia are lacking. The aim of this study was to characterize the spatial and temporal patterns of resting state neuronal synchronizations in primary progressive aphasia syndromes. We hypothesized that resting state brain oscillations will show unique deficits within language network in each variant of primary progressive aphasia. We examined 39 patients with primary progressive aphasia including logopenic variant (n = 14, age

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2017 Brain

189. Flortaucipir tau PET imaging in semantic variant primary progressive aphasia. (PubMed)

Flortaucipir tau PET imaging in semantic variant primary progressive aphasia. The semantic variant of primary progressive aphasia (svPPA) is typically associated with frontotemporal lobar degeneration (FTLD) with longTAR DNA-binding protein (TDP)-43-positive neuropil threads and dystrophic neurites (type C), and is only rarely due to a primary tauopathy or Alzheimer's disease. We undertook this study to investigate the localisation and magnitude of the presumed tau Positron Emission Tomography

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2017 Neurosurgery and Psychiatry

190. [<sup>18</sup>F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia. (PubMed)

[18F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia. Semantic dementia, including the semantic variant of primary progressive aphasia (svPPA), is strongly associated with TAR-DNA binding protein 43 (TDP-43) type C pathology. It provides a useful model in which to test the specificity of in vivo binding of the putative tau ligand [18F]AV-1451, which is elevated in frontotemporal lobar degeneration

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2017 Neurosurgery and Psychiatry

191. Constraint and multimodal approaches to therapy for chronic aphasia: A systematic review and meta-analysis. (PubMed)

Constraint and multimodal approaches to therapy for chronic aphasia: A systematic review and meta-analysis. Aphasia is a significant cause of disability and reduced quality of life. Two speech pathology treatment approaches appear efficacious: multimodal and constraint-induced aphasia therapies. In constraint-induced therapies, non-verbal actions (e.g., gesture, drawing) are believed to interfere with treatment and patients are therefore constrained to speech. In contrast, multimodal therapies (...) employ non-verbal modalities to cue word retrieval. Given the clinical and theoretical implications, a comparison of these two divergent treatments was pursued. This systematic review investigated both approaches in chronic aphasia at the levels of impairment, participation and quality of life. After a systematic search, the level of evidence and methodological quality were rated. Meta-analysis was conducted on 14 single case experimental designs using Tau-U, while heterogeneity in the four group

2017 Neuropsychological rehabilitation

192. Longitudinal structural and molecular neuroimaging in agrammatic primary progressive aphasia. (PubMed)

Longitudinal structural and molecular neuroimaging in agrammatic primary progressive aphasia. The agrammatic variant of primary progressive aphasia affects normal grammatical language production, often occurs with apraxia of speech, and is associated with left frontal abnormalities on cross-sectional neuroimaging studies. We aimed to perform a detailed assessment of longitudinal change on structural and molecular neuroimaging to provide a complete picture of neurodegeneration in these patients (...) , and to determine how patterns of progression compare to patients with isolated apraxia of speech (primary progressive apraxia of speech). We assessed longitudinal structural MRI, diffusion tensor imaging and 18F-fluorodeoxyglucose PET in 11 agrammatic aphasia subjects, 20 primary progressive apraxia of speech subjects, and 62 age and gender-matched controls with two serial assessments. Rates of change in grey matter volume and hypometabolism, and white matter fractional anisotropy, mean diffusivity, radial

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2017 Brain

193. Social participation in working-age adults with aphasia: an updated systematic review. (PubMed)

Social participation in working-age adults with aphasia: an updated systematic review. A previous systematic review found limited data regarding social participation in working-age people with aphasia (PWA). A review of recent studies may reveal more information on challenges in reestablishing social roles.The aim was to provide an updated systematic review on social participation in PWA under 65 years of age. Studies from 2005 to 2017 were searched from Scopus, Pubmed, and Psychinfo. Search (...) terms were derived from the International Classification of Functioning, Disability and Health (ICF) and the Aphasia- Framework for Outcomes Measures (A-FROM). Aspects of domestic life, interpersonal relations and interactions, education and employment, and community, civic, and social life were investigated.From 2864 initial hits, 11 studies were identified, all of which were on the American Speech-Language-Hearing Association (ASHA) Level III of evidence. The studies indicated that participation

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2017 Topics in stroke rehabilitation

194. Structural plasticity of the ventral stream and aphasia recovery. (PubMed)

Structural plasticity of the ventral stream and aphasia recovery. Restrengthening of the residual language network is likely to be crucial for speech recovery in poststroke aphasia. Eight participants with chronic aphasia received intensive speech therapy for 3 weeks, with standardized naming tests and brain magnetic resonance imaging before and after therapy. Kurtosis-based diffusion tensor tractography was used to measure mean kurtosis (MK) along a segment of the inferior longitudinal

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2017 Annals of Neurology

195. Seizure-associated aphasia has good lateralizing but poor localizing significance. (PubMed)

Seizure-associated aphasia has good lateralizing but poor localizing significance. To investigate the occurrence of ictal and postictal aphasia in different focal epilepsy syndromes.We retrospectively analyzed the video-electroencephalographic monitoring data of 1,118 patients with focal epilepsy for seizure-associated aphasia (SAA). Statistical analysis included chi-square analysis and Fisher's exact test.We identified 102 of 1,118 patients (9.1%) in whom ictal or postictal aphasia (SAA (...) ) was part of their recorded seizures (n = 59 of 102; 57.8%) or who reported aphasia by history (n = 43; 42.2% only reported aphasia by history). Postictal aphasia was present in 18 patients (30.5%). Six of the 59 patients had both ictal and postictal aphasia (10.2%). SAA occurred either with left hemisphere seizure onset or with seizures spreading from the right to the left hemisphere. SAA was most common in patients with parieto-occipital epilepsy (10.9%; five of 46 patients), followed by patients

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2017 Epilepsia

196. rTMS treatments combined with speech training for a conduction aphasia patient: A case report with MRI study. (PubMed)

rTMS treatments combined with speech training for a conduction aphasia patient: A case report with MRI study. To date, little is known regarding the neural mechanisms of the functional recovery of language after repetitive transcranial magnetic stimulation (rTMS) in aphasia. Our aim was to investigate the mechanism that underlies rTMS and speech training in a case report.We report the case of a 39-year-old woman who was initially diagnosed with conduction aphasia following a left hemisphere (...) stroke.The rTMS location comprised the left Broca area, and a frequency of 5 Hz for 20 min/d for 10 days during a 2-week period was used. She had received speech rehabilitation training 1 month after stroke. Functional magnetic resonance imaging (fMRI) and diffusion tensor imaging were used to investigate the functional and microstructural changes before and after rTMS treatment.The results demonstrated that the Western Aphasia Battery scores significantly improved for language ability at 2 weeks post

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2017 Medicine

197. Characterisation of "Positive" Behaviours in Primary Progressive Aphasias. (PubMed)

Characterisation of "Positive" Behaviours in Primary Progressive Aphasias. Although some patients with primary progressive aphasia (PPA) exhibit novel or improved skills after the onset of dementia, these changes have yet to be quantified. Therefore, this study systematically explored and identified the emergence of positive behaviours after dementia onset.This study included 48 carers of patients with PPA: 12 nonfluent/agrammatic PPA (nfvPPA), 22 semantic variant PPA (svPPA), and 14 logopenic

2017 Dementia and Geriatric Cognitive Disorders

198. Functional neuroanatomy of speech signal decoding in primary progressive aphasias. (PubMed)

Functional neuroanatomy of speech signal decoding in primary progressive aphasias. The pathophysiology of primary progressive aphasias remains poorly understood. Here, we addressed this issue using activation fMRI in a cohort of 27 patients with primary progressive aphasia (nonfluent, semantic, and logopenic variants) versus 15 healthy controls. Participants listened passively to sequences of spoken syllables in which we manipulated 3-key auditory speech signal characteristics: temporal (...) to phonemic spectral structure. Taken together, our findings suggest that impaired processing of core speech signal attributes may drive particular progressive aphasia syndromes and could index a generic physiological mechanism of reduced computational efficiency relevant to all these syndromes, with implications for development of new biomarkers and therapeutic interventions.Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

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2017 Neurobiology of Aging

199. Clinical marker for Alzheimer disease pathology in logopenic primary progressive aphasia. (PubMed)

Clinical marker for Alzheimer disease pathology in logopenic primary progressive aphasia. To determine whether logopenic features of phonologic loop dysfunction reflect Alzheimer disease (AD) neuropathology in primary progressive aphasia (PPA).We performed a retrospective case-control study of 34 patients with PPA with available autopsy tissue. We compared baseline and longitudinal clinical features in patients with primary AD neuropathology to those with primary non-AD pathologies. We analyzed

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2017 Neurology

200. Baseline executive control ability and its relationship to language therapy improvements in post-stroke aphasia: a systematic review. (PubMed)

Baseline executive control ability and its relationship to language therapy improvements in post-stroke aphasia: a systematic review. To review current evidence on the relationship between executive control (EC) and post-treatment language gains in adults with post-stroke aphasia.Electronic databases (CINAHL, Cochrane Trials, Embase, MEDLINE, MEDLINE-in-Process and PsycINFO) were systematically searched (year 2000 - present). Abstracts and full-text articles were reviewed by two independent (...) raters against pre-specified criteria: original research with N > 2; at least 90% adults with stroke, all undergoing treatment for acquired aphasia; pre-treatment EC abilities were compared to language gains post-treatment across studies. Critical appraisal was conducted using the Cochrane group and Single-Case Experimental Design (SCED) methods. Data were extracted and summarised descriptively.Search results yielded 2272 unique citations; ultimately 15 studies were accepted for review. Both pre

2017 Neuropsychological rehabilitation

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