How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

849 results for

Antithyroid Drug

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

141. The Diagnosis and Management of Primary Hypothyroidism

to one-third of cases of hypothyroidism in the community. 6 Less frequent causes include surgery and radioiodine ablation for benign nodular thy- roid disease and thyroid cancer, external beam irradiation of malignant tumours of the head and neck and drugs including lithium, amiodarone and interferon. 1 Congenital hypothyroidism affects about one newborn in 3500–4000 births. 7 The term subclinical hypothyroidism describes the ?nding of a raised serum TSH but a normal free T4. 3,8,9 It represents (...) :10.1111/cen.12824in 5–10% of the population, being more common in women and increasing with age. 9 It can progress to overt hypothyroidism, par- ticularly if antithyroid antibody positive. 10 In the community, the mostcommon aetiology ischronic autoimmune thyroiditis. 6 There has been a growing controversy about the upper limit of the reference range for serum TSH. 11,12 Reference ranges are derived from a reference population that comprises a large group of subjects who do not have thyroid disease

2015 British Thyroid Association

142. Atezolizumab (Tecentriq) - Non-Small-Cell Lung Carcinoma or Transitional Cell Carcinoma

-response Assessment report EMA/153102/2018 Page 5/205 ES exposure-safety ESMO European Society of Medical Oncology HR hazard ratio IC tumor-infiltrating immune cell Ig immunoglobulin IHC immunohistochemistry IND Investigational New Drug (application) IRF Independent Review Facility IUO Investigational Use Only IV intravenous LFT liver function test LOQ limit of quantification MAA Marketing Authorization Application MedDRA Medical Dictionary for Regulatory Activities NCA noncompartmental analysis NCCN (...) are not recommended. Table 1 - Dose modification advice for specified adverse drug reactions Adverse reaction Severity Treatment modification Pneumonitis Grade 2 Withhold Tecentriq Treatment may be resumed when the event improves to Grade 0 or Grade 1 within 12 weeks, and corticosteroids have been reduced to = 10 mg prednisone or equivalent per day Grade 3 or 4 Permanently discontinue Tecentriq Assessment report EMA/153102/2018 Page 13/205 Adverse reaction Severity Treatment modification Hepatitis Grade 2: (ALT

2017 European Medicines Agency - EPARs

143. Therapy with propylthiouracil for T3-predominant neonatal Graves’ disease: a case report (PubMed)

Therapy with propylthiouracil for T3-predominant neonatal Graves’ disease: a case report This case report describes a male neonate with Graves' disease. The mother's pregnancy was complicated by poorly controlled Graves' disease. The neonate was diagnosed with thyroxine (T3)-predominant Graves' disease with low free triiodothyronine (T4) and high free T3 during antithyroid drug therapy. The patient also presented with persistent pulmonary hypertension of the newborn due to hyperthyroidism (...) . We ceased administration of antithyroid drugs on day 85 of life. Subsequently, as the TRH loading test revealed central hypothyroidism, oral administration of levothyroxine sodium hydrate was continued. Its administration was discontinued at the age of 1 yr. Thyroid-stimulating hormone recovered to normal values, and his development had progressed without complications by the age of 2 yr.

Full Text available with Trip Pro

2018 Clinical Pediatric Endocrinology

144. A Prospective Comparative Study on Improvement of Hyperthyroid Cardiovascular Dysfunction in Patients Undergoing Total Thyroidectomy Versus Medical Management. (PubMed)

A Prospective Comparative Study on Improvement of Hyperthyroid Cardiovascular Dysfunction in Patients Undergoing Total Thyroidectomy Versus Medical Management. Cardiovascular dysfunction (CVD) is a well-recognized complication in patients with hyperthyroidism and is the major cause of mortality. Very few studies have compared the outcome of CVD following different treatment modalities. In this study we intended to compare treatment modalities (antithyroid drugs vs surgery) for reversal (...) of CVD.Patients with newly detected hyperthyroidism were grouped into, Group I [n = 123, age <60 years, undergoing total thyroidectomy], Group II [n = 42, age <60 years, treated with antithyroid medications] were evaluated with 2D echocardiography, serum N terminal pro brain natriuretic peptide (NT-pro-BNP) at the time of diagnosis (Point A), after achieving euthyroidism (Point B) with antithyroid drugs and 6 months after surgery/continuation of antithyroid medications (Point C). Forty patients (Group III

2018 World Journal of Surgery

145. Alterations of global DNA methylation and DNMT expression in T and B lymphocytes from patients with newly diagnosed AITD after treatment: A follow-up study. (PubMed)

patients: 51 with newly diagnosed Graves' disease (GD), 28 with autoimmune hypothyroidism (AIT), 29 with positive thyroid autoantibodies, and 39 matched healthy volunteers. Forty GD patients treated with radioiodine or antithyroid drugs and 28 AIT patients treated with L-thyroxine were followed for three months. Serum free triiodothyronine, free thyroxine, thyrotropin, thyroid peroxidase antibodies, thyroglobulin antibodies, and thyrotropin receptor antibodies were assayed using electrochemiluminescent (...) exhibited differences in their global DNA methylation status or DNMT mRNA levels compared with healthy controls. Antithyroid drugs restored global methylation and DNMT1 expression in both T and B lymphocytes, whereas radioiodine therapy affected only T cells. L-thyroxine replacement did not alter the methylation or DNMT expression levels in lymphocytes. The global methylation levels of B cells were negatively correlated with the serum thyroid peroxidase antibodies in patients with autoimmune thyroid

2018 Thyroid

146. Rapid remission of Graves' hyperthyroidism without thionamides under immunosuppressive treatment for concomitant autoimmune hepatitis. (PubMed)

, Lausanne University Hospital , Lausanne, Switzerland . eng Case Reports Letter Research Support, Non-U.S. Gov't United States Thyroid 9104317 1050-7256 0 Antithyroid Agents 0 Immunosuppressive Agents IM Adult Antithyroid Agents therapeutic use Female Graves Disease complications drug therapy Hepatitis, Autoimmune complications drug therapy Humans Immunosuppressive Agents therapeutic use Remission Induction Treatment Outcome 2018 1 18 6 0 2018 12 12 6 0 2018 1 17 6 0 ppublish 29336235 10.1089/thy

2018 Thyroid

147. A Trial for the Evaluation of the Treatment and Outcome of Hyperthyroidism With Iodized Salt and Non Iodized Salt

: Iodine free diet group The arm with non iodized salt,the subject in the non iodized salt group used the iodized salt for the first three months, and the iodized salt was changed after three months. Dietary Supplement: Iodine free diet group 120 patients with hyperthyroidism relapsed after new diagnosis or treatment were enrolled. They were randomly divided into iodine free diet group and normal iodine diet group. The two groups were treated with routine antithyroid drugs, followed up for 6 months (...) . Dietary Supplement: Normal iodine diet group 120 patients with hyperthyroidism relapsed after new diagnosis or treatment were enrolled. They were randomly divided into iodine free diet group and normal iodine diet group. The two groups were treated with routine antithyroid drugs, followed up for 6 months. Active Comparator: Normal iodine diet group The arm with iodized salt,the subject in the control group were consumed with iodized salt within six months. Dietary Supplement: Normal iodine diet group

2018 Clinical Trials

148. The Oral Microbiota is Associated With Autoimmune Thyroiditis

Action Antithyroid Agents Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists Physiological Effects of Drugs (...) . Therefore, our group will study the correlation between oral microbiota and AITD. Condition or disease Intervention/treatment Microbiota Drug: Methimazole Pill Drug: Propylthiouracil Pill Detailed Description: Autoimmune thyroiditis (AITD) mainly includes Hashimoto's thyroiditis (HT) and Grave's disease (GD). Studies have shown that autoimmune thyroiditis is closely related to microbiological disorders. Intestinal microelements Both ecology and oral microecology belong to the category of microorganisms

2018 Clinical Trials

149. Intestinal Microbiota and Treatment of GD

Molecular Mechanisms of Pharmacological Action Antithyroid Agents Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists Physiological Effects of Drugs (...) microbiota in GD patients and healthy controls and analyse the relationship between intestinal microbiota and GD drug therapy. Condition or disease Intervention/treatment Microbiota Drug: Methimazole Pill Drug: Propylthiouracil Pill Detailed Description: Graves' disease is an organ-specific autoimmune disease in which both genetic predisposition and environmental factors serve as disease triggers. Many studies have indicated that alterations in the gut microbiota are important environmental factors

2018 Clinical Trials

150. Fine mapping MHC associations in Graves' disease and its clinical subtypes in Han Chinese. (PubMed)

of the MHC association to GD risk. We further evaluated risk of two clinical subtypes of GD, namely persistent thyroid stimulating hormone receptor antibody -positive (pTRAb+) group and 'non-persistent TRAb positive' (pTRAb-) group after antithyroid drug therapy. We found that HLA-B residues Lys66-Arg69-Val76 could drive pTRAb- GD risk alone, while HLA-DPβ1 position 205, HLA-B position 69 and 199 and HLA-DRβ1 position 28 drive pTRAb+ GD risk. The risk heterogeneity between pTRAb+ and pTRAb- GD might

Full Text available with Trip Pro

2018 Journal of Medical Genetics

151. PREDICTIVE SCORE FOR THE DEVELOPMENT OR PROGRESSION OF GRAVES' ORBITOPATHY IN PATIENTS WITH NEWLY DIAGNOSED GRAVES' HYPERTHYROIDISM. (PubMed)

PREDICTIVE SCORE FOR THE DEVELOPMENT OR PROGRESSION OF GRAVES' ORBITOPATHY IN PATIENTS WITH NEWLY DIAGNOSED GRAVES' HYPERTHYROIDISM. To construct a predictive score for the development or progression of Graves' orbitopathy (GO) in Graves' hyperthyroidism (GH).Prospective observational study in patients with newly diagnosed GH, treated with antithyroid drugs (ATD) for 18 months at ten participating centers from EUGOGO in 8 European countries.348 patients were included with untreated GH

2018 European Journal of Endocrinology

152. Multiple intracranial lesions as the unusual imaging features of Hashimoto's encephalopathy: A case report. (PubMed)

resonance imaging (MRI) findings.After suffering for almost 8 years, the patient was diagnosed with HE based on clinical manifestation, abnormal electroencephalogram, unusual MRI findings, sensitivity to cortisol treatment, and characteristic high antithyroid peroxidase antibody (TpoAb) titer.The patient continued regular glucocorticoids therapy after intravenous methylprednisolone pulse therapy, neurotrophic drugs, traditional Chinese medicine and rehabilitation to relieve hypermyotonia and cognitive

2018 Medicine

153. Epidemiology of childhood hyperthyroidism in France: a nationwide population-based study. (PubMed)

Epidemiology of childhood hyperthyroidism in France: a nationwide population-based study. Hyperthyroidism affects all age groups, but epidemiological data for children are scarce.To perform a nationwide epidemiological survey of hyperthyroidism in children and adolescents.A cross-sectional descriptive study.Identification of entries corresponding to reimbursements for antithyroid drugs in the French national insurance database.All cases of childhood hyperthyroidism (6 months to 17 years of age

2018 Journal of Clinical Endocrinology and Metabolism

154. Alemtuzumab-induced thyroid dysfunction exhibits distinctive clinical and immunological features. (PubMed)

female and 22 male) of patients developed TD, principally GD (71.6%). Median onset was 17 months (range 2 to 107) following the last dose, with the majority (89%) within 3 years. Follow-up data (range 6 to 251 months) were available in 71 case subjects, of whom 52 (73.2%) developed GD: 10 of these (19.2%) had fluctuating TD. All 52 patients with GD commenced antithyroid drugs (ATDs): 3 required radioiodine (RAI) due to ATD side effects, and drug therapy is ongoing in 2; of those who completed (...) a course, 16 are in remission, 1 developed spontaneous hypothyroidism, and 30 (64%) required definitive or long-term treatment (RAI, n = 17; thyroidectomy, n = 5; and long-term ATDs, n = 8). Three cases of thyroiditis and 16 cases of hypothyroidism were documented: 5 with antithyroid peroxidase antibody positivity only, 10 with positive TSH receptor antibody (TRAb), and 1 of uncertain etiology. Bioassay confirmed both stimulating and blocking TRAb in a subset of fluctuating GD cases.Contrary

Full Text available with Trip Pro

2018 Journal of Clinical Endocrinology and Metabolism

155. Increased Prevalence of Thyroid Disease in Patients with Antineutrophil Cytoplasmic Antibodies-associated Vasculitis. (PubMed)

previously received propylthiouracil. There was a greater proportion of female patients, patients with antimyeloperoxidase antibodies, and patients with renal disease in the group with thyroid disease.Our data show a higher prevalence of thyroid disease in patients with AAV than the general population. This was not attributable to antithyroid drugs. (...) Increased Prevalence of Thyroid Disease in Patients with Antineutrophil Cytoplasmic Antibodies-associated Vasculitis. Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) has been linked with thyroid disease as a result of antithyroid medications. We assessed the prevalence of thyroid disease in our patients with AAV.Clinical records of 279 patients with AAV diagnosed between 1991 and 2014 were analyzed.Thyroid disease was identified in 21.5% of patients, but only 2 had

2018 Journal of Rheumatology

156. Methodological Quality Assessment of Meta-Analyses of Hyperthyroidism Treatment.

Methodological Quality Assessment of Meta-Analyses of Hyperthyroidism Treatment. Hyperthyroidism is a common condition that is associated with increased morbidity and mortality. A number of meta-analyses (MAs) have assessed the therapeutic measures for hyperthyroidism, including antithyroid drugs, surgery, and radioiodine, however, the methodological quality has not been evaluated. This study evaluated the methodological quality and summarized the evidence obtained from MAs of hyperthyroidism (...) treatments for radioiodine, antithyroid drugs, and surgery. We searched the PubMed, EMBASE, Cochrane Library, Web of Science, and Chinese Biomedical Literature Database databases. Two investigators independently assessed the meta-analyses titles and abstracts for inclusion. Methodological quality was assessed using the validated AMSTAR (Assessing the Methodological Quality of Systematic Reviews) tool. A total of 26 MAs fulfilled the inclusion criteria. Based on the AMSTAR scores, the average

2018 Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

157. Thyrotoxic Hypokalemic Periodic Paralysis (PubMed)

was administered with regular monitoring of vitals and electrolytes. Patient's symptoms improved. Thyroid function testing showed high free T3 (tri-iodothyronine) and free T4 (thyroxine) with low thyroid-stimulating hormone concentration in the serum, indicating thyrotoxic hypokalemic periodic paralysis. Treatment with antithyroid drug carbimazole resulted in an improvement during the follow-up visit. Hypokalemia is believed to be a consequence of a massive shift due to increased sodium-potassium-adenosine

Full Text available with Trip Pro

2018 Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

158. Hepatotoxicity in hyperthyroid patient after consecutive methimazole and propylthiouracil therapies (PubMed)

Hepatotoxicity in hyperthyroid patient after consecutive methimazole and propylthiouracil therapies Methimazole (MMI) and propylthiouracil (PTU) are widely used antithyroid drugs (ATD) that have been approved for the treatment of hyperthyroidism. Hepatotoxicity may be induced by these drugs, though they exert dissimilar incidence rates of hepatotoxicity and, possibly, with different underlying pathogenic mechanisms. We report the case of a 55-year-old woman with no relevant medical history

Full Text available with Trip Pro

2018 Endocrinology, diabetes & metabolism case reports

159. Pattern of presentation of Graves’ disease and response to radioiodine therapy in South African men (PubMed)

at a university teaching hospital, in the Western Cape of South Africa.The overall cure rate was 76.4% for these male patients. Cure was observed as euthyroidism in 31 patients (15.3%) and hypothyroidism in 129 (63.5%). Age, thyroid uptake, severity of hyperthyroidism, previous antithyroid drug (ATD) usage, administered quantity of RAI, ethnicity and patients' pulse at presentation were not significant in influencing outcome.Factors which have been evaluated as affecting outcome of RAIT were unimportant

Full Text available with Trip Pro

2018 The Pan African medical journal

160. Plasma 3,3’,5-Triiodo-L-thyronine [T3] level mirrors changes in tumor markers in two cases of metastatic cancer of the breast and pancreas treated with exogenous L-T3 (PubMed)

and neoangiogenesis, therefore lowering endogenous T4 reduces tumor growth rate. We present the case of two patients with metastatic triple negative breast cancer and metastatic pancreatic cancer respectively, who benefit of the sole treatment with antithyroid drugs and exogenous administration of T3 (liothyronine). In these cases tumor growth was accompanied by T3 depletion in plasma, which may represent a novel marker for progression.

Full Text available with Trip Pro

2018 Cancer Biomarkers

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>