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Antithyroid Drug

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101. Drugs for Anginal Pain (PubMed)

Drugs for Anginal Pain 14120952 1996 12 01 2018 12 01 0008-4409 90 1964 Feb 15 Canadian Medical Association journal Can Med Assoc J DRUGS FOR ANGINAL PAIN. 491 SEGALL H N HN eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 0 Antithyroid Agents 0 Vasodilator Agents 7C0697DR9I Atropine 8017-89-8 Amyl Nitrite G59M7S0WS3 Nitroglycerin OM Amyl Nitrite Angina Pectoris Antithyroid Agents Atropine Coronary Vessels Humans Nitroglycerin Vasodilator Agents AMYL NITRITE ANGINA PECTORIS ATROPINE

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1964 Canadian Medical Association Journal

102. To-day's Drugs: Treatment of Thyroid Disorders (PubMed)

To-day's Drugs: Treatment of Thyroid Disorders 14161993 1996 12 01 2018 12 01 0007-1447 2 5407 1964 Aug 22 British medical journal Br Med J TO-DAY'S DRUGS. TREATMENT OF THYROID DISORDERS. 493-7 WAYNE E E BLACKBURN G G DAVIS R H RH eng Journal Article England Br Med J 0372673 0007-1447 0 Antithyroid Agents 0 Iodine Isotopes OM Antithyroid Agents Female Goiter Graves Disease Heart Diseases Humans Iodine Isotopes therapeutic use Pregnancy Pregnancy Complications Thyroid Diseases Thyroidectomy

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1964 British medical journal

103. Today's Drugs (PubMed)

Today's Drugs 4181617 1969 07 06 2013 11 21 0007-1447 2 5655 1969 May 24 British medical journal Br Med J Drug treatment of thyrotoxicosis. 496-7 eng Journal Article England Br Med J 0372673 0007-1447 0 Antithyroid Agents 0 Imidazoles 0 Iodides 0 Perchlorates 59X161SCYL Thiouracil 9679TC07X4 Iodine AIM IM Adult Antithyroid Agents therapeutic use Child Exophthalmos drug therapy Female Humans Hyperthyroidism complications drug therapy Imidazoles therapeutic use Iodides therapeutic use Iodine

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1969 British medical journal

104. Fetal and neonatal toxicity of drugs. (PubMed)

Fetal and neonatal toxicity of drugs. 4169817 1968 03 30 2018 11 13 0008-4409 98 6 1968 Feb 10 Canadian Medical Association journal Can Med Assoc J Fetal and neonatal toxicity of drugs. 301-6 Yaffe S J SJ eng Journal Article Review Canada Can Med Assoc J 0414110 0008-4409 0 Analgesics 0 Anesthetics 0 Anti-Infective Agents 0 Antithyroid Agents 0 Hormones 0 Hypnotics and Sedatives 0 Sulfonamides AIM IM Abnormalities, Drug-Induced Analgesics adverse effects Anesthetics adverse effects Anti (...) -Infective Agents adverse effects Antithyroid Agents adverse effects Female Fetus drug effects Hormones adverse effects Humans Hypnotics and Sedatives adverse effects Maternal-Fetal Exchange drug effects Pregnancy Sulfonamides adverse effects 25 1968 2 10 1968 2 10 0 1 1968 2 10 0 0 ppublish 4169817 PMC1923815 J Clin Invest. 1949 Sep;28(5 Pt 2):1144-62 16695787 Pharmacol Rev. 1960 Mar;12:37-90 13796010 J Physiol. 1949 Sep;109(3-4):412-20 15407426 J Pharmacol Exp Ther. 1960 Nov;130:285-93 13723612 J

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1968 Canadian Medical Association Journal

105. Clinical Characteristics of Myeloperoxidase Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Caused by Antithyroid Drugs. (PubMed)

Clinical Characteristics of Myeloperoxidase Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Caused by Antithyroid Drugs. The clinical characteristics of myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis caused by antithyroid drugs are still unclear because most reports describe only a small number of patients.The objective was to analyze a large number of patients with MPO-ANCA-associated vasculitis to determine the time of onset, the drug and dose (...) taken, the clinical symptoms, the relationship between the clinical symptoms and the MPO-ANCA titer, and the incidence.We analyzed 92 patients in whom the adverse reaction of MPO-ANCA-associated vasculitis was reported to Chugai Pharmaceutical, a company that markets antithyroid drugs.Of the 92 patients, 41 (44.6%) had single-organ failure, 32 (34.8%) had two-organ failure, 13 (14.1%), had three-organ failure, and two (2.2%) had four-organ failure. The number of organs involved was unknown

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2009 Journal of Clinical Endocrinology and Metabolism

106. Comparison of the long-term efficacy of low dose 131I versus antithyroid drugs in the treatment of hyperthyroidism. (PubMed)

Comparison of the long-term efficacy of low dose 131I versus antithyroid drugs in the treatment of hyperthyroidism. In China the therapeutic options to treat hyperthyroidism comprise antithyroid drugs (ATDs), radioiodine (131I) therapy and surgery. Physicians in China avoid the risk of hypothyroidism as a consequence of either treatment because patients from rural districts cannot easily comply with long-term medication. Therefore, we prospectively assessed the efficacy and safety of 131I

2009 Nuclear medicine communications Controlled trial quality: uncertain

107. Thyroid-associated ophthalmopathy after treatment for Graves' hyperthyroidism with antithyroid drugs or iodine-131. (PubMed)

Thyroid-associated ophthalmopathy after treatment for Graves' hyperthyroidism with antithyroid drugs or iodine-131. Previous randomized trials have suggested an association between radioiodine treatment for Graves' hyperthyroidism and thyroid-associated ophthalmopathy (TAO).The aim of the study was to compare the occurrence of worsening or development of TAO in patients who were treated with radioiodine or antithyroid drugs.We conducted a randomized trial (TT 96) with a follow-up of 4 yr

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2009 The Journal of clinical endocrinology and metabolism Controlled trial quality: uncertain

108. Comparison of antithyroid drugs efficacy on P wave changes in patients with Graves' disease. (PubMed)

Comparison of antithyroid drugs efficacy on P wave changes in patients with Graves' disease. Some precursor P wave changes on electrocardiogram (ECG) before the atrial fibrillation (AF) episodes occur in the hyperthyroidism. Our aim was to compare the effect of two antithyroid drugs (ATD) on P wave duration and dispersion (PWD) in patients with hyperthyroidism.Fifty patients (13 men, 37 women; mean age 39.2+/-13.2 years) with newly diagnosed overt hyperthyroid patients with Graves' disease (GD

2009 Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology Controlled trial quality: uncertain

109. Graves' disease

of hyperthyroidism. Diagnostic tests are suppressed serum TSH, elevated levels of circulating thyroid hormones, detectable TSH receptor antibodies, and high thyroid uptake of radioactive iodine (or technetium 99). Treatment options are antithyroid drugs, radioactive iodine therapy, and thyroid surgery. Untreated hyperthyroidism, particularly in older people, may result in cardiac arrhythmias, high-output cardiac failure, bone mineral loss, and, rarely, thyroid storm. Unusual complications include vision loss

2018 BMJ Best Practice

110. Urticaria and angio-oedema

in the absence of urticaria and this is separate clinical entity, requiring a different diagnostic approach. Depending on the results of history, physical examination and laboratory investigations, it may be classified as drug-induced angio-oedema, hereditary angio-oedema, or acquired angio-oedema. [Figure caption and citation for the preceding image starts]: Typical lesions seen in acute or chronic urticaria From the collection of Stephen Dreskin, MD, PhD [Citation ends]. [Figure caption and citation (...) for the preceding image starts]: Angio-oedema of the lips in a patient who also has urticaria From the collection of Stephen Dreskin, MD, PhD [Citation ends]. History and exam erythematous oedematous lesions pruritus resolution within 24 hours swelling of face, tongue, or lips blanching lesions stridor positive family history female sex exposure to drug trigger exposure to food trigger recent viral infection recent insect bite Diagnostic investigations FBC with differential complete metabolic panel urinalysis

2018 BMJ Best Practice

111. Subacute granulomatous thyroiditis

therapy is generally necessary. Non-steroidal anti-inflammatory drugs and beta-blockers may be used for symptoms. Some patients with severe symptoms may also require corticosteroids, opioid analgesics, or potassium iodide or iopanoic acid to reduce the conversion of T4 to the more biologically active form of thyroid hormone, T3. Definition Subacute granulomatous thyroiditis is a self-limited inflammation of the thyroid gland. It is associated with a triphasic clinical course that lasts for a few weeks (...) recent viral infection myalgia malaise tremor heat intolerance viral infection HLA-Bw35 and B35 Diagnostic investigations thyroid-stimulating hormone (TSH) total T4, total T3, T3 resin uptake, free thyroxine index T3:T4 ratio radioactive iodine uptake ESR CRP antithyroid antibodies (thyroid peroxidase antibodies) fine needle aspiration biopsy ultrasonography of thyroid salivary CRP Treatment algorithm ACUTE Contributors Authors Associate Chief Director of the Thyroid Health Center Section

2018 BMJ Best Practice

112. Side effects

on getting some today, under the headline “Statins ‘have no side effects '”. That’s not what found. But it was an interesting piece of work, with an odd result, looking 2014 7. Antithyroid Drug Side Effects in the Population and in Pregnancy. In a Danish population study using health registers, agranulocytosis caused by antithyroid drugs was 4 times more frequent than liver failure. Both were very rare in pregnancy, where birth defects were the dominant side effect . 2016 8. Management of opioid side (...) pain relief for patients with hand or knee osteoarthritis with similar efficacy, and fewer side effects , than oral NSAIDS Article Text 2013 2. Domperidone: risks of cardiac side effects Domperidone: risks of cardiac side effects Drug Safety Update - GOV.UK GOV.UK uses cookies to make the site simpler. Search Domperidone: risks of cardiac side effects From: Published: 30 May 2014 Therapeutic area: and Indication restricted to nausea and vomiting, new contraindications, and reduced dose and duration

2018 Trip Latest and Greatest

113. Pregnancy and Graves' disease: opt for treatments posing the lowest maternal and fetal risks

|   |   |   |  Spotlight Pregnancy and Graves' disease: opt for treatments posing the lowest maternal and fetal risks Treatment of pregnant women with Graves' disease (hyperthyroidism) is problematic since all drug therapies carry significant risks. Some synthetic antithyroid drugs are the treatment of choice. Graves' disease is one of the major causes of hyperthyroidism, which is due to an overactive thyroid gland. In cases of Graves' disease in pregnancy, poorly (...) for pregnant women. During pregnancy, synthetic antithyroid drugs are the treatment of choice, but they cross the placenta and hinder the functioning of the fetal thyroid, which means the minimum effective dose should be used. In the first trimester, propylthiouracil is the drug of choice because malformations appeared to be less severe and less common than with carbimazole or thiamazol. In the second and third trimesters, if it is not possible to halt antithyroid treatment, the risk of hepatic damage

2017 Prescrire

114. The role of immunotherapy in IVF: a guideline

; anti-nuclear antibodies; anti-nuclear antibody; antinuclear antibodies; antinuclear antibody; antiphospholipid antibody; antiphospholipid antibodies; antithyroid antibody; antithyroid antibodies; aspirin; assisted reproduction; autoantibodies; corticosteroid/s; corticotropin-releasinghormone;cost;cytokine;cytokines; dexamethasone; drug costs; embryo implantation; embryo transfer; Enbrel; estrogen/s; etanercept; fertility agents, fe- male/adverseeffects;fertilizationinvitro/methods;?lgras- tim; G (...) treatment Aspirin as monotherapy for IVF outcomes Agents that are both immunomodulating and have other progestational effects Corticosteroids during ovarian stimulation Anticardiolipin studies that focus on recurrent pregnancy loss Peri-implantation corticosteroids Anticoagulants G-CSF and GM-CSF and embryo development, aneuploidy, endometrial thickness, or IVF outcomes Antithyroid antibodies DHEA Intravenous fat emulsions and IVF outcomes IUI IVIG and IVF outcomes Metformin Adalimumab and IVF outcomes

2018 Society for Assisted Reproductive Technology

115. DRY EYE (Tear deficiency (KCS)

Versus Host Disease (GVHD) Stevens-Johnson syndrome (SJS) cicatricial pemphigoid trachoma chemical injury hyposecretory states reflex afferent block topical anaesthesia trigeminal nerve injury refractive surgery neurotrophic keratitis secretomotor block parasympathetic damage pharmacological inhibition (wide range of systemic drugs, including antidepressants, anticholinergics, antipsychotics, antihistamines, chemotherapeutic agents, antihypertensives, anti-arrhythmics, antithyroid agents and opioid (...) or function is abnormal, refer. If the condition is not idiopathic, for example if Sjögren’s syndrome or an unidentified underlying disease are suspected, refer. A3: if SJS or OCP are suspected, refer urgently (within one week) to ophthalmologist Possible management by ophthalmologist drug treatment for underlying disease (eg SJS, OCP) ciclosporin eye drops (Ikervis) autologous serum eye drops electrolysis, cryotherapy protection with therapeutic contact lenses of all types permanent (surgical) occlusion

2018 College of Optometrists

116. National minimum retesting intervals in pathology: A final report detailing consensus recommendations for minimum retesting intervals for use in pathology

interval? 4 1.2 Establishing MRIs 4 1.3 Using minimum retesting intervals in practice 5 1.4 Terms and conditions for use 6 1.5 References 6 2 Abbreviations 7 3 Biochemistry recommendations 9 3.1 Renal 9 3.2 Bone 11 3.3 Liver 12 3.4 Lipids 13 3.5 Endocrine related 13 3.6 Cardiac 20 3.7 Gastrointestinal 21 3.8 Specific proteins 23 3.9 Tumour markers 24 3.10 Therapeutic drug monitoring 26 3.11 Occupational/toxicology 28 3.12 Pregnancy related 29 3.13 Paediatric related 32 4 Haematology recommendations 33 (...) more frequently because of impaired renal function) Clinical Knowledge Summary. Hypertension – not diabetic. NICE, 2014. cks.nice.org.uk/hypertension-not- diabetic B-R7 Diuretic therapy Before the initiation of therapy and after 4 weeks, and then 6 monthly/yearly or more frequently in the elderly or in patients with renal disease, disorders affecting electrolyte status or those patients taking other drugs, e.g. corticosteroids, digoxin Clinical Knowledge Summary. Hypertension – not diabetic. NICE

2016 Royal College of Pathologists

117. The Management of Nausea and Vomiting of Pregnancy and Hyperemesis Gravidarum

and raised free thyroxine levels with or without a suppressed thyroid stimulating hormone level. These patients rarely have thyroid antibodies and are euthyroid clinically. The biochemical thyrotoxicosis resolves as the HG improves 22 and treatment with antithyroid drugs is inappropriate. Liver function tests are abnormal in up to 40% of women with HG, 23 with the most likely abnormality being a rise in transaminases. Bilirubin levels can be slightly raised but without jaundice, and amylase levels can (...) and HG (Appendix III). Combinations of different drugs should be used in women who do not respond to a single antiemetic. For women with persistent or severe HG, the parenteral or rectal route may be necessary and more effective than an oral regimen. Women should be asked about previous adverse reactions to antiemetic therapies. Drug-induced extrapyramidal symptoms and oculogyric crises can occur with the use of phenothiazines and metoclopramide. If this occurs, there should be prompt cessation

2016 Royal College of Obstetricians and Gynaecologists

118. Long-term Methimazole Therapy in Juvenile Graves' Disease: A Randomized Trial

Long-term Methimazole Therapy in Juvenile Graves' Disease: A Randomized Trial Recent studies show that long-term (LT) antithyroid drugs reduce relapse of hyperthyroidism in patients with Graves' disease. Our objective was to evaluate the effectiveness and safety of LT methimazole treatment and to compare remission rates in Graves' disease patients after LT and short-term (ST) therapy.In this randomized, parallel group trial, 66 consecutive patients with untreated juvenile Graves

2019 EvidenceUpdates

119. AACE/ACE/AME Medical Guidelines for Clinical Practice for the Diagnosis and Management of Thyroid Nodules

antithyroid drugs 4 to 7 days before treatment and consider resumption 1 week after radioiodine ther- apy [BEL 2, GRADE B]. 7.2.6.2. Contraindications • Radioiodine is contraindicated in preg- nant and breastfeeding subjects [BEL 2, GRADE A].12 Thyroid Nodule Management, Endocr Pract. 2016;22(Suppl 1) • In females of childbearing potential, per- form a pregnancy test before administra- tion of radioiodine [BEL 2, GRADE A]. 7.2.6.3. Follow-up after radioiodine therapy • Regular thyroid function monitoring (...) of iodine-containing drugs or supplements [BEL 2, GRADE A] • Most nodules are asymptomatic and benign, but the absence of symptoms does not rule out malignancy [BEL 2, GRADE A]. 2.2. Physical Examination • We recommend a careful, focused examination of the thyroid gland and cervical lymph nodes [BEL 3, GRADE B]. • Record the following data: Thyroid volume and consistency Location, consistency, size, and number of nodule(s) Neck tenderness or pain Cervical adenopathy [BEL 3, GRADE B] • The risk of cancer

2016 American Association of Clinical Endocrinologists

120. Current Diagnostic and Treatment Strategies for Specific Dilated Cardiomyopathies: A Scientific Statement From the American Heart Association

ag- gregation, and deceased fibrinolysis by cocaine predis- pose to coronary and microvascular disease. 97 Treatment Other than abstinence, very little is known about treat- ment of cocaine-induced cardiac dysfunction. Indeed, there are case reports of reversibility of cardiac function after cessation of drug use. 99 Early reports of cocaine- induced hypertension and myocardial ischemia caused by unopposed a-effects of ß 1 -adrenergic blocking agents in cocaine-related chest pain resulted (...) related to Methamphetamines and other Stimulant Drugs In the past decade, methamphetamine abuse has been associated with increasing numbers of reports of MI, pulmonary edema, aortic dissection, and DCM. 101 Espe- cially among adult patients 40 years. By far the most commonly implicated direct cardio- toxins are the anthracycline-based therapeutic agents. These medications are still an integral part of the treat- ment for cancer, although their toxicity is known. There are many formulations

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2016 American Heart Association

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