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Antithyroid Drug

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101. Incidence of neonatal hyperthyroidism among newborns of Graves' disease patients treated with radioiodine therapy. (Abstract)

of NH among newborns of mothers who conceived within two years after RAI therapy, and to identify predictors of NH.GD patients (n = 145) who conceived within two years after RAI therapy were retrospectively reviewed, and information regarding their newborns was collected.Of the 145 pregnant women, 54 (37%) were treated with antithyroid drugs or potassium iodide for maternal hyperthyroidism during the first trimester. There were eight newborns with NH, resulting in an incidence of 5.5%. Seven (...) of the eight mothers whose newborns had NH were treated with antithyroid drugs or potassium iodide during their pregnancy. The incidence of NH among the newborns of mothers who conceived within 6-12 months after RAI therapy was 8.8%, within 12-18 months was 5.5%, and within 18-24 months was 3.6%. Multivariate analysis revealed that the TRAb values in the third trimester were the only risk factor for NH. The cutoff TRAb value in the third trimester for predicting NH was 9.7 IU/L (reference value <2.0 IU/L

2018 Thyroid

102. Longitudinal characterization of autoantibodies to the thyrotropin receptor (TRAb) during alemtuzumab therapy; evidence that TRAb may precede thyroid dysfunction by many years. (Full text)

Longitudinal characterization of autoantibodies to the thyrotropin receptor (TRAb) during alemtuzumab therapy; evidence that TRAb may precede thyroid dysfunction by many years. Thyroid autoimmunity, especially Graves' disease or hypothyroidism with positive autoantibodies (TRAb) to the thyrotropin receptor (TSHR), occurs in 30-40% of patients with relapsing multiple sclerosis following treatment with alemtuzumab (ALTZ). ALTZ therapy therefore provides a unique opportunity to study the evolution (...) of TRAb, antithyroid peroxidase autoantibodies (TPOAb), thyrotropin, free thyroxine, and free triiodothyronine were also collected.Before ALTZ, combined ihTRAb (positive with flow cytometry and/or luciferase bioassay) but not automated TRAb were present in 5/16 (31.2%) TD versus 0/14 (0%) NO-TD (p = 0.017). Detectable ihTRAb preceded TD development in 9/28 (32.1%) and by a median of 1.2 years (range 28 days-7.3 years). Combination testing of ihTRAb and TPOAb at baseline predicted 20% of subsequent

2018 Thyroid PubMed abstract

103. Pattern of presentation of Graves’ disease and response to radioiodine therapy in South African men (Full text)

at a university teaching hospital, in the Western Cape of South Africa.The overall cure rate was 76.4% for these male patients. Cure was observed as euthyroidism in 31 patients (15.3%) and hypothyroidism in 129 (63.5%). Age, thyroid uptake, severity of hyperthyroidism, previous antithyroid drug (ATD) usage, administered quantity of RAI, ethnicity and patients' pulse at presentation were not significant in influencing outcome.Factors which have been evaluated as affecting outcome of RAIT were unimportant (...) Pattern of presentation of Graves’ disease and response to radioiodine therapy in South African men Typically hyperthyroidism has been more often associated with the female gender. There is a large female predilection (male:female sex ratio up to 1:10), with little documentation in the literature about wholly male hyperthyroid populations. A male incidence of 0.7 per 100, 000 has been reported for South African men while the women have a relatively higher rate of 0.02. There is no documented

2018 The Pan African medical journal PubMed abstract

104. Antithyroid Arthritis Syndrome: A Case Report and Review of the Literature (Full text)

Antithyroid Arthritis Syndrome: A Case Report and Review of the Literature We herein report the case of a 38-year-old Japanese woman with antithyroid arthritis syndrome who experienced severe migratory polyarthritis after the initiation of thiamazole therapy. The patient's symptoms promptly disappeared without any sequelae after the withdrawal of the drug. Antithyroid arthritis syndrome is poorly characterized, and the findings from our literature review indicate that this syndrome exhibits (...) serological features that are distinct from those of antithyroid agent-induced vasculitis syndrome. The absence of autoantibodies, especially anti-neutrophil cytoplasmic antibodies, may help characterize and diagnose antithyroid arthritis syndrome. Furthermore, physicians' awareness of this syndrome is essential for its diagnosis in clinical practice.

2016 Internal Medicine PubMed abstract

105. Comparison of Early Total Thyroidectomy with Antithyroid Treatment in Patients with Moderate-Severe Graves' Orbitopathy: A Randomized Prospective Trial. (Full text)

Comparison of Early Total Thyroidectomy with Antithyroid Treatment in Patients with Moderate-Severe Graves' Orbitopathy: A Randomized Prospective Trial. The optimal therapeutic choice for Graves' hyperthyroidism in the presence of moderate-severe Graves' orbitopathy (GO) remains controversial.We aimed to compare GO course in patients with moderate-severe GO treated with early total thyroidectomy (TTx) versus antithyroid drug (ATD) regimens, in a prospective, randomized manner.Forty-two patients (...) , and diplopia between the two groups during a median (min.-max.) follow-up period of 60 months (36-72).Although no definitive conclusions could be drawn from the study, mainly due to limited power, early TTx and the ATD treatment regimens, followed by intravenous pulse corticosteroid therapy, seemed to be equally effective on the course of GO in this relatively small group of patients with moderate-severe GO during a median (min.-max.) follow-up period of 60 months (36-72).

2016 European thyroid journal Controlled trial quality: uncertain PubMed abstract

106. Characterization of thyroid function and antithyroid antibody tests among Saudis (Full text)

Characterization of thyroid function and antithyroid antibody tests among Saudis To determine the reference intervals for thyroid function tests and the prevalence of thyroid autoimmunity in the Saudi population.  A cross-sectional prospective study was conducted in King Khalid University Hospital, Riyadh, Saudi Arabia from January to June 2013. History and physical examination were obtained. Thyroid-stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) were measured (...) by Electro-chemiluminescence Immunoassay system-assay. Anti-thyroperoxidase, and anti-thyroglobulin antibodies were measured using enzyme-linked immunosorbent-assay. Subjects with previous or a family history of thyroid disorders, those taking medications affecting thyroid function, pregnant or lactating women, and those with goiter were excluded. Individuals with positive antibodies were excluded from the final analysis of the TSH reference range, but were used to determine the prevalence of thyroid

2015 Saudi medical journal PubMed abstract

107. Successful treatment of thyroid storm presenting as recurrent cardiac arrest and subsequent multiorgan failure by continuous renal replacement therapy (Full text)

hypotension, we reduced the patient's dose of beta-blocker and antithyroid drug, and she was started on continuous veno-venous renal replacement therapy (CRRT) with intravenous albumin and plasma supplementation. Subsequently, her body temperature and pulse rate began to stabilize within 1 h, and her blood pressure reached 120/60 mmHg after 6 h. We discontinued antithyroid drug 3 days after admission because of aggravated hyperbilirubinemia. The patient exhibited progressive improvement in thyroid (...) function even after cessation of antithyroid drug, and she successfully recovered from thyroid storm and MOF. This is the first case of thyroid storm successfully treated by CRRT in a patient considered unfit for antithyroid drug treatment.The presenting manifestations of thyroid storm vary and can include cardiac arrest with multiorgan failure in rare cases.In some patients with thyroid storm, especially those with severe complications, conventional medical treatment may be ineffective

2017 Endocrinology, diabetes & metabolism case reports PubMed abstract

108. Prognostic factor analysis in 325 patients with Graves’ disease treated with radioiodine therapy (Full text)

with I in the First Affiliated Hospital of Xi'an Jiaotong University between 2010 and 2016. We collected the potential influencing factors, including demographic data (age, sex, family history), iodine intake state, antithyroid drugs (ATD) taking, thyroid texture, complications of hyperthyroidism, physical and laboratory examinations [thyroid weight, effective I half-life time (Teff), 24-h iodine uptake rate, tri-iodothyronine, thyroxine, free tri-iodothyronine (FT3), free thyroxine, thyroid (...) Prognostic factor analysis in 325 patients with Graves’ disease treated with radioiodine therapy I therapy is a choice for Graves' hyperthyroidism. Several factors that affect the success of I treatment in Graves' disease (GD) patients have been put forward. The aim of this retrospective study was to evaluate the factors influencing the success of I therapy and the occurrence of hypothyroidism after I therapy.We reviewed 325 GD patients, who were well documented out of 779 cases, treated

2017 Nuclear medicine communications PubMed abstract

109. Intraorbital Electroacupuncture Therapy for Thyroid-associated Ophthalmopathy (Full text)

University, Harbin, Heilongjiang 150001, China. eng Case Reports Letter China Chin Med J (Engl) 7513795 0366-6999 0 Antithyroid Agents IM Antithyroid Agents therapeutic use Electroacupuncture methods Graves Ophthalmopathy diagnostic imaging drug therapy therapy Humans Male Middle Aged 2017 7 28 6 0 2017 7 28 6 0 2018 10 10 6 0 ppublish 28748866 ChinMedJ_2017_130_15_1884_211546 10.4103/0366-6999.211546 PMC5547845 Urology. 2009 May;73(5):1036-41 19394499 Eur J Endocrinol. 2008 Mar;158(3):273-85 18299459 N (...) Intraorbital Electroacupuncture Therapy for Thyroid-associated Ophthalmopathy 28748866 2018 10 09 2018 11 13 2542-5641 130 15 2017 08 05 Chinese medical journal Chin. Med. J. Intraorbital Electroacupuncture Therapy for Thyroid-associated Ophthalmopathy. 1884-1885 10.4103/0366-6999.211546 Zhou Ling-Yun LY Department of Acupuncture and Moxibustion, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China. Su Chang C Department of Acupuncture and Moxibustion

2017 Chinese medical journal PubMed abstract

110. Five cases of childhood-onset Graves’ disease treated with either surgery or radio-iodine therapy (Full text)

Five cases of childhood-onset Graves’ disease treated with either surgery or radio-iodine therapy There are three major therapeutic options for the treatment of Graves' disease (GD): antithyroid drugs (ATDs), thyroidectomy, and radio-iodine (RAI) therapy. ATDs are the initial treatment option for children. However, some pediatric GD patients who are initially treated with ATDs require other type of treatments later on. We reviewed the medical records of childhood-onset GD cases (...) retrospectively to report the clinical course of patients who received either surgery or RAI therapy subsequent to treatment with ATDs. Childhood-onset GD was successfully managed in five girls with non-ATD treatments at the age of 7-14 yr following an unfavorable outcome of initial ATD treatment. Four cases had surgery and one case was managed with RAI therapy. The reasons for switching to non-ATD treatment included poor compliance, failure to maintain remission, serious adverse events resulting from ATDs

2017 Clinical Pediatric Endocrinology PubMed abstract

111. Rapid Improvement of thyroid storm-related hemodynamic collapse by aggressive anti-thyroid therapy including steroid pulse: A case report. (Full text)

cardiomyopathy.Aggressive antithyroid therapy, including steroid pulse to hyperthyroidism, leads to the dramatic improvement of cardiac function and she was successfully weaned from ECMO.The most outstanding feature of the current case was the rapid decrease of cardiac injury and improvement of cardiac function by strengthening antithyroid therapy, including steroid pulse, without thyroid hormone level normalization. In thyroid storm, various systemic inflammatory reactions have different time courses and among them (...) Rapid Improvement of thyroid storm-related hemodynamic collapse by aggressive anti-thyroid therapy including steroid pulse: A case report. Heart failure is relatively common in patients with hyperthyroidism, but thyrotoxic cardiomyopathy with poor left ventricular (LV) systolic function is very rare.We experienced a representative case of a patient who presented with severe LV dysfunction related to thyroid storm and needed extracorporeal membrane oxygenation (ECMO) temporally.Thyrotoxic

2017 Medicine PubMed abstract

112. MANAGEMENT OF ENDOCRINE DISEASE: Subclinical Thyrotoxicosis: Prevalence, Causes and Choice of Therapy. (Full text)

of subclinical thyrotoxicosis, and how treatment should be tailored to the specific cause. We advocate radioactive iodine treatment to be the first-line treatment in majority of patients suffering from subclinical thyrotoxicosis due to multinodular toxic goitre and solitary toxic adenoma, but we do generally not recommend it as the first-line treatment in patients suffering from subclinical Graves' hyperthyroidism. Such patients may benefit mostly from antithyroid drug therapy. Subclinical thyrotoxicosis (...) MANAGEMENT OF ENDOCRINE DISEASE: Subclinical Thyrotoxicosis: Prevalence, Causes and Choice of Therapy. Subclinical thyrotoxicosis is a condition affecting up to 10% of the population in some studies. We have reviewed literature and identified studies describing prevalences, causes and outcomes of this condition. Treatment should be considered in all subjects if this biochemical abnormality is persistent, especially in case of symptoms of thyrotoxicosis or in the presence of any complication

2017 European Journal of Endocrinology PubMed abstract

113. Anti-thyroid drug use in pregnancy and birth defects: Why some studies find clear associations, and some studies report none. (Full text)

defects observed in one study were in general milder and tended to be diagnosed and registered only when they resulted in complications and led to surgery after one year of age. None of the negative studies has investigated outcomes after one year of age.Studies finding no associations between early pregnancy exposure to antithyroid drugs and birth defects were either not sufficiently powered or did not study outcomes at optimal ages. (...) Anti-thyroid drug use in pregnancy and birth defects: Why some studies find clear associations, and some studies report none. Rare cases of birth defects after the use of methimazole (MMI) or carbimazole to treat hyperthyroidism in early pregnancy have been reported since 1972, whereas propylthiouracil (PTU) has not been considered teratogenic. Recently, two studies reported birth defects after the use of MMI in early pregnancy to affect 2-4% of exposed children, and one study also found birth

2015 Thyroid PubMed abstract

114. Substituting potassium iodide for methimazole as the treatment for Graves' disease during the first trimester may reduce the incidence of congenital anomalies: a retrospective study at a single medical institution in Japan. (Abstract)

Substituting potassium iodide for methimazole as the treatment for Graves' disease during the first trimester may reduce the incidence of congenital anomalies: a retrospective study at a single medical institution in Japan. To control hyperthyroidism due to Graves' disease, antithyroid drugs should be administered. Several studies have shown that exposure to methimazole (MMI) during the first trimester of pregnancy increases the incidence of specific congenital anomalies that are collectively

2015 Thyroid

115. Antithyroid peroxidase antibodies in women with polycystic ovary syndrome (Full text)

Antithyroid peroxidase antibodies in women with polycystic ovary syndrome 24639731 2014 03 18 2018 11 13 1680-6433 11 12 2013 Dec Iranian journal of reproductive medicine Iran J Reprod Med Antithyroid peroxidase antibodies in women with polycystic ovary syndrome. 1031-2 Salehpour Saghar S Department of Obstetrics and Gynecology, Infertility and Reproductive Health Research Center, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Saharkhiz Nasrin N Department (...) of Obstetrics and Gynecology, Infertility and Reproductive Health Research Center, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Moeini Aida A Department of Obstetrics and Gynecology, Infertility and Reproductive Health Research Center, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Enzevaei Anahita A Department of Obstetrics and Gynecology, Infertility and Reproductive Health Research Center, Taleghani Hospital, Shahid Beheshti

2013 Iranian Journal of Reproductive Medicine PubMed abstract

116. Effects of low-carbohydrate diet therapy in overweight subjects with autoimmune thyroiditis: possible synergism with ChREBP (Full text)

Effects of low-carbohydrate diet therapy in overweight subjects with autoimmune thyroiditis: possible synergism with ChREBP The thyroid is one of the metabolism regulating glands. Its function is to determine the amount of calories that the body has to burn to maintain normal weight. Thyroiditides are inflammatory processes that mainly result in autoimmune diseases. We have conducted the present study in order to have a clear picture of both autoimmune status and the control of body weight. We (...) have evaluated the amount of either thyroid hormones, or antithyroid, or anti-microsomal, or anti-peroxidase antibodies (Abs) in patients with high amounts of Abs. In a diet devoid of carbohydrates (bread, pasta, fruit, and rice), free from goitrogenic food, and based on body mass index, the distribution of body mass and intracellular and extracellular water conducted for 3 weeks gives the following results: patients treated as above showed a significant reduction of antithyroid (-40%, P<0.013

2016 Drug design, development and therapy PubMed abstract

117. Response to Radioiodine Therapy for Thyrotoxicosis: Disparate Outcomes for an Indigenous Population (Full text)

for thyrotoxicosis from 1 January 2008 to 31 December 2010 and had follow-up available of a minimum of 12 months. 224 patients were included, 82.4% female, and 63.7% had Graves's disease. Radioiodine failed in 21.5% of patients overall, with a higher failure rate in the indigenous population (35.2%). When controlling for other influencing factors by logistic regression, there continued to be an increased risk for the indigenous group (OR 2.82) and those treated with antithyroid drugs following radioiodine (...) Response to Radioiodine Therapy for Thyrotoxicosis: Disparate Outcomes for an Indigenous Population Despite 70 years of experience treating thyrotoxic patients with radioiodine not all patients are successfully treated by a single dose. Multiple factors predicting radioiodine efficacy have been reported. The aim of this study was to assess whether ethnicity was associated with radioiodine response. A retrospective review was performed of patients who received radioiodine therapy

2016 International journal of endocrinology PubMed abstract

118. Kidney, thyroid and other organ functions after 40 years or more of lithium therapy: a case series of five patients (Full text)

Kidney, thyroid and other organ functions after 40 years or more of lithium therapy: a case series of five patients We present the cases of five patients (two men aged 64 years and 79 years) and three women (aged 64 years, 65 years and 75 years) who have received lithium treatment for 40-45 years, with particular regard to kidney and thyroid functions, hypercalcaemia and cognition, in the context of disease course and overall functioning. Lithium was initiated in the early phase of the illness (...) (in three patients within the first 2 years). In four patients, lithium concentration was between 0.60 and 0.65 mmol/l and in one patient, between 0.7 and 0.8 mmol/l. Four were very good lithium responders. One man had stage 3 chronic kidney disease, and the other stage 2/3 chronic kidney disease. All three women had asymptomatic stage 2 chronic kidney disease. One woman had severe thyroid dysfunction (Hashimoto's disease) with extremely high levels of antithyroid peroxidase antibodies

2016 Therapeutic Advances in Psychopharmacology PubMed abstract

119. Relation between therapy options for Graves' disease and the course of Graves' ophthalmopathy: a systematic review and meta-analysis. (Abstract)

Relation between therapy options for Graves' disease and the course of Graves' ophthalmopathy: a systematic review and meta-analysis. The relation between therapy options for Graves' disease (GD) and the course of Graves' ophthalmopathy (GO) are still controversial. Our aim was to compare the occurrence of development or worsening of GO in patients who were treated with antithyroid drugs (ATDs) or radioactive iodine (RAI) or thyroidectomy (TX).We conducted a comprehensive search of the Embase (...) and PubMed database. Odds ratio (OR) was used as a measure of the effect of therapy options for GD on the risk of development or worsening of GO. The analysis was further stratified by factors that could affect the treatment effects.Nine trials involving 1773 patients were included. RAI therapy showed a significant effect on the risk of development or worsening GO compared with ATD (OR 2.25; 95 % CI 1.61-3.14; P < 0.00001). Glucocorticoid prophylaxis was effective in preventing GO development

2016 Journal of endocrinological investigation

120. Does Immunosuppressive Therapy Improve Outcomes in Graves' disease? A Systematic Review and Meta-analysis. (Abstract)

Does Immunosuppressive Therapy Improve Outcomes in Graves' disease? A Systematic Review and Meta-analysis. Whether the addition of immunosuppressive drugs to standard antithyroid drugs reduces the relapse risk in Graves' disease remains uncertain.The aim of this study was to investigate the effects of immunosuppressive drugs on the relapse rate after a first episode of hyperthyroidism due to Graves' disease.Based on a pre-specified protocol, PubMed (1946-July 2015), EMBASE (1947-July 2015 (...) ), and Cochrane (1992-July 2015) databases were searched. The search was for (randomized) controlled trials comparing immunosuppressive drugs with a control group. PRISMA and SIGN statements were used for assessing data quality. Two reviewers extracted data, with any disagreement being resolved by consensus. Data were pooled using a random-effects model.The primary endpoint was relapse of disease until follow-up. Secondary endpoints included reduction of thyroid volume and decrease in thyrotropin-receptor

2016 Thyroid : official journal of the American Thyroid Association

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