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Antithyroid Drug

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81. Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (Abstract)

Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. We report a prospective study to avaluate the effect of antithyroid drugs containing the sulfhydryl radical on the outcome of I-131 (RAI) therapy. Twenty-four male patients withe toxic diffuse goiter were assigned randomly into tow treatment groups: Group A received RAI treatment while on antighyroid drugs after attainment of euthyroidism; Group B received no antithyroid drugs before, or when

1979 Journal of nuclear medicine : official publication, Society of Nuclear Medicine

82. HLA Association with Drug-Induced Adverse Reactions Full Text available with Trip Pro

with specific alleles of human leukocyte antigen (HLA) genes. For example, hypersensitivity to abacavir, a drug used for treating of human immunodeficiency virus (HIV) infection, has been proposed to be associated with allele 57:01 of HLA-B gene (terms HLA-B∗57:01). The incidences of abacavir hypersensitivity are much higher in Caucasians compared to other populations due to various allele frequencies in different ethnic populations. The antithyroid drug- (ATDs- ) induced agranulocytosis are strongly (...) HLA Association with Drug-Induced Adverse Reactions Adverse drug reactions (ADRs) remain a common and major problem in healthcare. Severe cutaneous adverse drug reactions (SCARs), such as Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with mortality rate ranges from 10% to more than 30%, can be life threatening. A number of recent studies demonstrated that ADRs possess strong genetic predisposition. ADRs induced by several drugs have been shown to have significant associations

2017 Journal of immunology research

83. Idiosyncratic Drug-Induced Severe Neutropenia and Agranulocytosis in Elderly Patients (≥75 years): A Monocentric Cohort Study of 61 Cases Full Text available with Trip Pro

agranulocytosis.Data from 61 patients over 75 years old with idiosyncratic drug-induced agranulocytosis were retrospectively reviewed. All cases were extracted from a cohort study on agranulocytosis (n = 203) in the Strasbourg University Hospitals (Strasbourg, France), a referral center.The mean age was 84.9 years (range 75-95), the gender ratio (F/M) was 2.4. Underlying diseases were present in 74 %. The most frequent causative drugs were antibiotics (43.8 %), antithyroid drugs (15.8 %), neuroleptic and anti (...) septic shock relating to the depth of the neutropenia. Comparison of mortality between <75- and ≥75-year-old patients revealed a statistical difference: 4.2 % versus 14.8 % (p = 0.023).Our study demonstrates that 30 % of idiosyncratic drug-induced agranulocytosis concerned elderly patients. Antibiotic, antithyroid, neuroleptic, anti-epileptic, and antiaggregant platelet agents are the primary causative drug classes. Idiosyncratic drug-induced agranulocytosis is typically serious in this frail

2016 Drugs - real world outcomes

84. History and Outcome of Febrile Neutropenia Outside the Oncology Setting: A Retrospective Study of 76 Cases Related to Non-Chemotherapy Drugs Full Text available with Trip Pro

%), antithyroid drugs (17.2%), neuroleptic and anti-epileptic agents (13.1%), non-steroidal anti-inflammatory agents and analgesics (8%), and platelet aggregation inhibitors (8%). Main clinical presentations upon hospitalization included isolated fever (30%), sore throat, acute tonsillitis and sinusitis (18.4%), documented pneumonia (18.4%), septicemia (14.5%), and septic shock (6.6%). Mean neutrophil count at nadir was 0.13 × 10(9)/L (range: 0-0.48). While in hospital, 22 patients (28.9%) worsened clinically (...) History and Outcome of Febrile Neutropenia Outside the Oncology Setting: A Retrospective Study of 76 Cases Related to Non-Chemotherapy Drugs Despite major advances in its prevention and treatment, febrile neutropenia remains a most concerning complication of cancer chemotherapy. Outside the oncology setting, however, only few data are currently available on febrile neutropenia related to non-chemotherapy drugs. We report here data on 76 patients with febrile neutropenia related to non

2017 Journal of clinical medicine

85. Clinical Characteristics of Patients with Drug-induced Liver Injury Full Text available with Trip Pro

(18.47%, 53 patients) of DILI.   Antibiotics (18 patients, 6.27%) and antithyroid (18 patients, 6.27%) drugs also ranked among the major causes of DILI. Chinese herbal medicines are another major cause of DILI, accounting for 36.59% of cases (105 patients). Most of the causative Chinese herbal medicines were those used to treat osteopathy, arthropathy, dermatosis, gastropathy, leukotrichia, alopecia, and gynecologic diseases. Hepatocellular hepatitis was prevalent in DILI, regardless of Chinese (...) Clinical Characteristics of Patients with Drug-induced Liver Injury Drug is an important cause of liver injury and accounts for up to 40% of instances of fulminant hepatic failure. Drug-induced liver injury (DILI) is increasing while the diagnosis becomes more difficult. Though many drugs may cause DILI, Chinese herbal medicines have recently emerged as a major cause due to their extensive use in China. We aimed to provide drug safety information to patients and health carers by analyzing

2017 Chinese medical journal

86. Increased Remission Rates After Long-Term Methimazole Therapy in Patients with Graves' Disease: Results of a Randomized Clinical Trial. (Abstract)

Increased Remission Rates After Long-Term Methimazole Therapy in Patients with Graves' Disease: Results of a Randomized Clinical Trial. Background: Studies differ regarding whether, compared with courses of conventional duration, longer-term antithyroid drug treatment increases frequency of remission in patients with Graves' hyperthyroidism. We prospectively conducted a randomized, parallel-group study comparing relapse rates in patients receiving longer-term versus conventional-length (...) methimazole therapy. We also sought variables associated with relapse following the latter. Methods: We enrolled 302 consecutive patients with untreated first episodes of Graves' hyperthyroidism. After 18-24 months of methimazole, 258 patients (85.4%) were randomized to an additional 36-102-month courses ("long-term group": n = 130; scheduled total time on methimazole: 60-120 months) or discontinuation of methimazole ("conventional group": n = 128). Patients were followed 48 months postmethimazole

2019 Thyroid Controlled trial quality: uncertain

87. Drug-Induced Olfactory Dysfunction

. , , ) (e.g. , ) s s (Lamasil) s s V. Causes: Miscellaneous Antiproliferative drugs (e.g. Cisplatin) Antirheumatic Drugs (e.g. ) Antithyroid Medications s Anticonvulsants Azelastine ( ) Zopiclone (for ) VI. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Drug-Induced Olfactory Dysfunction." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related (...) Olfactory Dysfunction Drug-Induced Olfactory Dysfunction Aka: Drug-Induced Olfactory Dysfunction , Drug-Induced Gustatory Dysfunction , Altered Sensation of Smell due to Medication , Medication Causes of Disordered Sense of Smell , Medication Causes of Disordered Sense of Taste From Related Chapters II. Causes: Cardiovascular -Converting Enzyme Inhibitor ( ) (ARB) s s lowering agents III. Causes: Nasal Preparations Intranasal Nasal Sprays in general IV. Causes: Antimicrobials Antibiotics ( ) s (e.g

2018 FP Notebook

88. Medication Causes of Myositis

of Myositis Medication Causes of Myositis Aka: Medication Causes of Myositis , Toxic Myopathy , Drug Induced Myositis , Muscle Weakness due to Medications II. Causes Antithyroid medications s Chemotherapeutics Emetine s ( agents) Interferon Leuprolide (Lupron) s Niflumic acid Phenylbutazone medications (e.g. ) s III. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Medication Causes of Myositis." Click on the image (or right (...) Medication Causes of Myositis Medication Causes of Myositis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Medication Causes

2018 FP Notebook

89. Medications Affecting Thyroid Function

Medications Affecting Thyroid Function Medications Affecting Thyroid Function Aka: Medications Affecting Thyroid Function , Drug-Induced Thyroiditis From Related Chapters II. Causes: Medications associated with Hypothyroidism Inorganic Iodide Cyanates Interleukin-2 inhibitors III. Causes: Medications associated with Hyperthyroidism Excess hormone intake Excess exposure Dietary (contains ) (contains 37% ) IV. Causes: Medications causing Thyroiditis Type 1 -induced Increased hormone synthesis (pre-existing (...) ) Treated with antithyroid medications (and s as needed for symptom control) Type 2 -induced Destructive results in increased T4 and T3 release into circulation Treated with glucocorticoids (and s as needed for symptom control) Denileukin (Ontak) CD25 cytotoxin used in CTCL, CLL, causes Autoimmune mechanism causes with or Interleukin-2 Autoimmune mechanism causes with more often than Autoimmune mechanism causes with more often than inhibitors uptake inhibition results in V. References Images: Related

2018 FP Notebook

90. Triiodothyronine and Thyroxine in Hyperthyroidism COMPARISON OF THE ACUTE CHANGES DURING THERAPY WITH ANTITHYROID AGENTS Full Text available with Trip Pro

Triiodothyronine and Thyroxine in Hyperthyroidism COMPARISON OF THE ACUTE CHANGES DURING THERAPY WITH ANTITHYROID AGENTS In 66 untreated patients with hyperthyroidism, serum triiodothyronine (T(3)) and thyroxine (T(4)) concentrations were measured by immunoassay. The mean T(3) level was 478+/-28 ng/100 ml (all values mean+/-SEM) and the T(4) was 20.6+/-0.6 mug/100 ml. The serum T(4)/T(3) ratio by weight was 48+/-2 as opposed to a value of 71+/-3 in euthyroid adults. There was a significant (...) inverse correlation of the T(4)/T(3) ratios with serum T(3) (r=0.77; P<0.01) but not with serum T(4)(r=0.21). These results suggested that relative overproduction of T(3) is consistently present in patients with hyperthyroidism. To examine the acute effects of various antithyroid agents on serum T(3) and T(4) concentrations, iodide, propylthiouracil (PTU), and methylmercaptoimidazole (MMI) were given alone to mine patients, and serial T(3) and T(4) measurements were made. There was an acute decrease

1974 Journal of Clinical Investigation

91. Therapy with propylthiouracil for T3-predominant neonatal Graves’ disease: a case report Full Text available with Trip Pro

Therapy with propylthiouracil for T3-predominant neonatal Graves’ disease: a case report This case report describes a male neonate with Graves' disease. The mother's pregnancy was complicated by poorly controlled Graves' disease. The neonate was diagnosed with thyroxine (T3)-predominant Graves' disease with low free triiodothyronine (T4) and high free T3 during antithyroid drug therapy. The patient also presented with persistent pulmonary hypertension of the newborn due to hyperthyroidism (...) . We ceased administration of antithyroid drugs on day 85 of life. Subsequently, as the TRH loading test revealed central hypothyroidism, oral administration of levothyroxine sodium hydrate was continued. Its administration was discontinued at the age of 1 yr. Thyroid-stimulating hormone recovered to normal values, and his development had progressed without complications by the age of 2 yr.

2018 Clinical Pediatric Endocrinology

92. Hepatotoxicity in hyperthyroid patient after consecutive methimazole and propylthiouracil therapies Full Text available with Trip Pro

Hepatotoxicity in hyperthyroid patient after consecutive methimazole and propylthiouracil therapies Methimazole (MMI) and propylthiouracil (PTU) are widely used antithyroid drugs (ATD) that have been approved for the treatment of hyperthyroidism. Hepatotoxicity may be induced by these drugs, though they exert dissimilar incidence rates of hepatotoxicity and, possibly, with different underlying pathogenic mechanisms. We report the case of a 55-year-old woman with no relevant medical history

2018 Endocrinology, diabetes & metabolism case reports

93. Incidence of neonatal hyperthyroidism among newborns of Graves' disease patients treated with radioiodine therapy. (Abstract)

of NH among newborns of mothers who conceived within two years after RAI therapy, and to identify predictors of NH.GD patients (n = 145) who conceived within two years after RAI therapy were retrospectively reviewed, and information regarding their newborns was collected.Of the 145 pregnant women, 54 (37%) were treated with antithyroid drugs or potassium iodide for maternal hyperthyroidism during the first trimester. There were eight newborns with NH, resulting in an incidence of 5.5%. Seven (...) of the eight mothers whose newborns had NH were treated with antithyroid drugs or potassium iodide during their pregnancy. The incidence of NH among the newborns of mothers who conceived within 6-12 months after RAI therapy was 8.8%, within 12-18 months was 5.5%, and within 18-24 months was 3.6%. Multivariate analysis revealed that the TRAb values in the third trimester were the only risk factor for NH. The cutoff TRAb value in the third trimester for predicting NH was 9.7 IU/L (reference value <2.0 IU/L

2018 Thyroid

94. Longitudinal characterization of autoantibodies to the thyrotropin receptor (TRAb) during alemtuzumab therapy; evidence that TRAb may precede thyroid dysfunction by many years. Full Text available with Trip Pro

Longitudinal characterization of autoantibodies to the thyrotropin receptor (TRAb) during alemtuzumab therapy; evidence that TRAb may precede thyroid dysfunction by many years. Thyroid autoimmunity, especially Graves' disease or hypothyroidism with positive autoantibodies (TRAb) to the thyrotropin receptor (TSHR), occurs in 30-40% of patients with relapsing multiple sclerosis following treatment with alemtuzumab (ALTZ). ALTZ therapy therefore provides a unique opportunity to study the evolution (...) of TRAb, antithyroid peroxidase autoantibodies (TPOAb), thyrotropin, free thyroxine, and free triiodothyronine were also collected.Before ALTZ, combined ihTRAb (positive with flow cytometry and/or luciferase bioassay) but not automated TRAb were present in 5/16 (31.2%) TD versus 0/14 (0%) NO-TD (p = 0.017). Detectable ihTRAb preceded TD development in 9/28 (32.1%) and by a median of 1.2 years (range 28 days-7.3 years). Combination testing of ihTRAb and TPOAb at baseline predicted 20% of subsequent

2018 Thyroid

95. Pattern of presentation of Graves’ disease and response to radioiodine therapy in South African men Full Text available with Trip Pro

at a university teaching hospital, in the Western Cape of South Africa.The overall cure rate was 76.4% for these male patients. Cure was observed as euthyroidism in 31 patients (15.3%) and hypothyroidism in 129 (63.5%). Age, thyroid uptake, severity of hyperthyroidism, previous antithyroid drug (ATD) usage, administered quantity of RAI, ethnicity and patients' pulse at presentation were not significant in influencing outcome.Factors which have been evaluated as affecting outcome of RAIT were unimportant (...) Pattern of presentation of Graves’ disease and response to radioiodine therapy in South African men Typically hyperthyroidism has been more often associated with the female gender. There is a large female predilection (male:female sex ratio up to 1:10), with little documentation in the literature about wholly male hyperthyroid populations. A male incidence of 0.7 per 100, 000 has been reported for South African men while the women have a relatively higher rate of 0.02. There is no documented

2018 The Pan African medical journal

96. Antithyroid Arthritis Syndrome: A Case Report and Review of the Literature Full Text available with Trip Pro

Antithyroid Arthritis Syndrome: A Case Report and Review of the Literature We herein report the case of a 38-year-old Japanese woman with antithyroid arthritis syndrome who experienced severe migratory polyarthritis after the initiation of thiamazole therapy. The patient's symptoms promptly disappeared without any sequelae after the withdrawal of the drug. Antithyroid arthritis syndrome is poorly characterized, and the findings from our literature review indicate that this syndrome exhibits (...) serological features that are distinct from those of antithyroid agent-induced vasculitis syndrome. The absence of autoantibodies, especially anti-neutrophil cytoplasmic antibodies, may help characterize and diagnose antithyroid arthritis syndrome. Furthermore, physicians' awareness of this syndrome is essential for its diagnosis in clinical practice.

2016 Internal Medicine

97. Comparison of Early Total Thyroidectomy with Antithyroid Treatment in Patients with Moderate-Severe Graves' Orbitopathy: A Randomized Prospective Trial. Full Text available with Trip Pro

Comparison of Early Total Thyroidectomy with Antithyroid Treatment in Patients with Moderate-Severe Graves' Orbitopathy: A Randomized Prospective Trial. The optimal therapeutic choice for Graves' hyperthyroidism in the presence of moderate-severe Graves' orbitopathy (GO) remains controversial.We aimed to compare GO course in patients with moderate-severe GO treated with early total thyroidectomy (TTx) versus antithyroid drug (ATD) regimens, in a prospective, randomized manner.Forty-two patients (...) , and diplopia between the two groups during a median (min.-max.) follow-up period of 60 months (36-72).Although no definitive conclusions could be drawn from the study, mainly due to limited power, early TTx and the ATD treatment regimens, followed by intravenous pulse corticosteroid therapy, seemed to be equally effective on the course of GO in this relatively small group of patients with moderate-severe GO during a median (min.-max.) follow-up period of 60 months (36-72).

2016 European thyroid journal Controlled trial quality: uncertain

98. Characterization of thyroid function and antithyroid antibody tests among Saudis Full Text available with Trip Pro

Characterization of thyroid function and antithyroid antibody tests among Saudis To determine the reference intervals for thyroid function tests and the prevalence of thyroid autoimmunity in the Saudi population.  A cross-sectional prospective study was conducted in King Khalid University Hospital, Riyadh, Saudi Arabia from January to June 2013. History and physical examination were obtained. Thyroid-stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) were measured (...) by Electro-chemiluminescence Immunoassay system-assay. Anti-thyroperoxidase, and anti-thyroglobulin antibodies were measured using enzyme-linked immunosorbent-assay. Subjects with previous or a family history of thyroid disorders, those taking medications affecting thyroid function, pregnant or lactating women, and those with goiter were excluded. Individuals with positive antibodies were excluded from the final analysis of the TSH reference range, but were used to determine the prevalence of thyroid

2015 Saudi medical journal

99. Successful treatment of thyroid storm presenting as recurrent cardiac arrest and subsequent multiorgan failure by continuous renal replacement therapy Full Text available with Trip Pro

hypotension, we reduced the patient's dose of beta-blocker and antithyroid drug, and she was started on continuous veno-venous renal replacement therapy (CRRT) with intravenous albumin and plasma supplementation. Subsequently, her body temperature and pulse rate began to stabilize within 1 h, and her blood pressure reached 120/60 mmHg after 6 h. We discontinued antithyroid drug 3 days after admission because of aggravated hyperbilirubinemia. The patient exhibited progressive improvement in thyroid (...) function even after cessation of antithyroid drug, and she successfully recovered from thyroid storm and MOF. This is the first case of thyroid storm successfully treated by CRRT in a patient considered unfit for antithyroid drug treatment.The presenting manifestations of thyroid storm vary and can include cardiac arrest with multiorgan failure in rare cases.In some patients with thyroid storm, especially those with severe complications, conventional medical treatment may be ineffective

2017 Endocrinology, diabetes & metabolism case reports

100. Prognostic factor analysis in 325 patients with Graves’ disease treated with radioiodine therapy Full Text available with Trip Pro

with I in the First Affiliated Hospital of Xi'an Jiaotong University between 2010 and 2016. We collected the potential influencing factors, including demographic data (age, sex, family history), iodine intake state, antithyroid drugs (ATD) taking, thyroid texture, complications of hyperthyroidism, physical and laboratory examinations [thyroid weight, effective I half-life time (Teff), 24-h iodine uptake rate, tri-iodothyronine, thyroxine, free tri-iodothyronine (FT3), free thyroxine, thyroid (...) Prognostic factor analysis in 325 patients with Graves’ disease treated with radioiodine therapy I therapy is a choice for Graves' hyperthyroidism. Several factors that affect the success of I treatment in Graves' disease (GD) patients have been put forward. The aim of this retrospective study was to evaluate the factors influencing the success of I therapy and the occurrence of hypothyroidism after I therapy.We reviewed 325 GD patients, who were well documented out of 779 cases, treated

2017 Nuclear medicine communications

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