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Agranulocytosis and AntithyroidDrugs Propylthiouracil and methimazole are used widely in the treatment of hyperthyroid disorders. The most important complication of the use of these drugs is depression of the neutrophilic granulocyte count. Granulocytopenia occurs in about 4 percent and agranulocytosis occurs in about 0.3 percent of treated patients. Although this depression of the granulocyte count is reversible after the drug is discontinued, serious infection frequently accompanies (...) agranulocytosis and accounts for almost all deaths related to the drugs. It is important to be aware of the clinical features of granulocytopenic reactions due to antithyroiddrugs.
Methyl-thiouracil and thiouracil as antithyroiddrugs 19108079 2009 07 29 2009 11 11 0366-0826 1 2 1946 Jun British journal of pharmacology and chemotherapy Br J Pharmacol Chemother Methyl-thiouracil and thiouracil as antithyroiddrugs. 127-34 Glock G E GE eng Journal Article England Br J Pharmacol Chemother 0154627 0366-0826 2008 12 25 9 0 1946 6 1 0 0 1946 6 1 0 1 ppublish 19108079 PMC1509730
ANTITHYROIDDRUGS IN THE TREATMENT OF HYPERTHYROIDISM 20271146 2010 03 18 2018 12 01 0008-4409 57 6 1947 Dec Canadian Medical Association journal Can Med Assoc J Antithyroiddrugs in the treatment of hyperthyroidism. 585-8 KILGOUR J M JM eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 0 Antithyroid Agents OM Antithyroid Agents Humans Hyperthyroidism 4713:1525l1 ANTITHYROIDDRUG HYPERTHYROIDISM/antithyroiddrugs 2010 3 19 6 0 1947 12 1 0 0 1947 12 1 0 1 ppublish 20271146 PMC1590718
Toxic Effects of AntithyroidDrugs 15396321 2004 09 30 2018 12 01 0044-0086 22 2 1949 Dec The Yale journal of biology and medicine Yale J Biol Med Toxic effects of antithyroiddrugs. 139-79 PETERS J P JP MAN E B EB eng Journal Article United States Yale J Biol Med 0417414 0044-0086 0 Antithyroid Agents OM Antithyroid Agents Humans Thyroid Gland 5018:328x:13 THYROID 1949 12 1 1949 12 1 0 1 1949 12 1 0 0 ppublish 15396321 PMC2598806 Nord Med. 1948 Feb 20;37(8):375-80 18862677 Ann Surg. 1947 May
THE USE OF ANTITHYROIDDRUGS The preoperative use of antithyroiddrugs is mandatory if surgical treatment of complicated hyperthyroidism is contemplated. Six months to a year may be required for suitable preparation. The long-term use of antithyroiddrugs is less effective for the "cure" of hyperthyroidism than is operation or the use of radioactive iodine. Propyl and methyl thiouracil are the antithyroiddrugs of choice. Either of these thiouracil derivatives is capable of producing leukopenia (...) . The antithyroiddrugs exert no favorable effect on exophthalmos. The antithyroiddrugs are suitable for the control of hyperthyroidism during pregnancy. The patient probably should not be kept hypothyroid during pregnancy but rather in a state of mild hyperthyroidism.
The mode of action of antithyroiddrugs: further observations on in vitro inhibition of oxidative protein iodination 14351678 2003 05 01 2018 12 01 0366-0826 10 1 1955 Mar British journal of pharmacology and chemotherapy Br J Pharmacol Chemother The mode of action of antithyroiddrugs: further observations on in vitro inhibition of oxidative protein iodination. 1-6 FRASER R R HANNO M G MG PITNEY W R WR eng Journal Article England Br J Pharmacol Chemother 0154627 0366-0826 0 Antithyroid Agents 0 (...) Proteins OM Antithyroid Agents pharmacology Biochemical Phenomena Halogenation Humans In Vitro Techniques Oxidation-Reduction Proteins metabolism 5528:2344:466:562 PROTEINS/metabolism THYROID ANTAGONISTS/effects 1955 3 1 1955 3 1 0 1 1955 3 1 0 0 ppublish 14351678 PMC1509484 Metabolism. 1952 Nov;1(6):533-9 13002073 J Endocrinol. 1953 Apr;9(2):224-31 13052795 Nature. 1954 Feb 13;173(4398):305-7 13144749 Br Med J. 1954 May 29;1(4873):1234-7 13160443 J Clin Endocrinol Metab. 1954 Oct;14(10):1230-44
Metabolism of 35S-labelled AntithyroidDrugs in Man Differences in the metabolic fate of antithyroiddrugs influence the optimal frequency of administration and their therapeutic efficacy. (35)S propylthiouracil differed from the (35)S imidazoles (carbimazole and methimazole) in the more rapid absorption and excretion and the shorter biological half-life in the plasma of the former. Renal function may have a more important influence on the biological half-life of the drugs than thyroid status
The geography of the use of thyroid and antithyroiddrugs in Northern Ireland (preliminary report). 4172539 1968 07 30 2018 11 30 0035-9157 61 4 1968 Apr Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. The geography of the use of thyroid and antithyroiddrugs in Northern Ireland (preliminary report). 389 Wade O L OL eng Journal Article England Proc R Soc Med 7505890 0035-9157 0 Antithyroid Agents 0 Insulin 0 Thyroid Hormones IM Antithyroid Agents therapeutic use Attitude
Results of Treatment of Thyrotoxicosis following Relapse after AntithyroidDrug Therapy One hundred and thirty patients who relapsed after a full course of treatment with antithyroiddrugs have been reviewed. Of 22 patients receiving a second course of antithyroiddrugs, 17 (77%) relapsed. In contrast, only 2 out of 44 patients treated by surgery relapsed and seven became hypothyroid. Nevertheless, local complications, in particular parathyroid insufficiency, were especially common
Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroiddrugs: a prospective study. We report a prospective study to avaluate the effect of antithyroiddrugs containing the sulfhydryl radical on the outcome of I-131 (RAI) therapy. Twenty-four male patients withe toxic diffuse goiter were assigned randomly into tow treatment groups: Group A received RAI treatment while on antighyroid drugs after attainment of euthyroidism; Group B received no antithyroiddrugs before, or when
agranulocytosis.Data from 61 patients over 75 years old with idiosyncratic drug-induced agranulocytosis were retrospectively reviewed. All cases were extracted from a cohort study on agranulocytosis (n = 203) in the Strasbourg University Hospitals (Strasbourg, France), a referral center.The mean age was 84.9 years (range 75-95), the gender ratio (F/M) was 2.4. Underlying diseases were present in 74 %. The most frequent causative drugs were antibiotics (43.8 %), antithyroiddrugs (15.8 %), neuroleptic and anti (...) septic shock relating to the depth of the neutropenia. Comparison of mortality between <75- and ≥75-year-old patients revealed a statistical difference: 4.2 % versus 14.8 % (p = 0.023).Our study demonstrates that 30 % of idiosyncratic drug-induced agranulocytosis concerned elderly patients. Antibiotic, antithyroid, neuroleptic, anti-epileptic, and antiaggregant platelet agents are the primary causative drug classes. Idiosyncratic drug-induced agranulocytosis is typically serious in this frail
Nonthionamide Drugs for the Treatment of Hyperthyroidism: From Present to Future Hyperthyroidism is a common endocrine disease. Although thionamide antithyroiddrugs are the cornerstone of hyperthyroidism treatment, some patients cannot tolerate this drug class because of its serious side effects including agranulocytosis, hepatotoxicity, and vasculitis. Therefore, nonthionamide antithyroiddrugs (NTADs) still have an important role in controlling hyperthyroidism in clinical practice (...) . Furthermore, some situations such as thyroid storm or preoperative preparation require a rapid decrease in thyroid hormone by combination treatment with multiple classes of antithyroiddrugs. NTADs include iodine-containing compounds, lithium carbonate, perchlorate, glucocorticoid, and cholestyramine. In this narrative review, we summarize the mechanisms of action, indications, dosages, and side effects of currently used NTADs for the treatment of hyperthyroidism. In addition, we also describe the state
(18.47%, 53 patients) of DILI. Antibiotics (18 patients, 6.27%) and antithyroid (18 patients, 6.27%) drugs also ranked among the major causes of DILI. Chinese herbal medicines are another major cause of DILI, accounting for 36.59% of cases (105 patients). Most of the causative Chinese herbal medicines were those used to treat osteopathy, arthropathy, dermatosis, gastropathy, leukotrichia, alopecia, and gynecologic diseases. Hepatocellular hepatitis was prevalent in DILI, regardless of Chinese (...) Clinical Characteristics of Patients with Drug-induced Liver Injury Drug is an important cause of liver injury and accounts for up to 40% of instances of fulminant hepatic failure. Drug-induced liver injury (DILI) is increasing while the diagnosis becomes more difficult. Though many drugs may cause DILI, Chinese herbal medicines have recently emerged as a major cause due to their extensive use in China. We aimed to provide drug safety information to patients and health carers by analyzing
%), antithyroiddrugs (17.2%), neuroleptic and anti-epileptic agents (13.1%), non-steroidal anti-inflammatory agents and analgesics (8%), and platelet aggregation inhibitors (8%). Main clinical presentations upon hospitalization included isolated fever (30%), sore throat, acute tonsillitis and sinusitis (18.4%), documented pneumonia (18.4%), septicemia (14.5%), and septic shock (6.6%). Mean neutrophil count at nadir was 0.13 × 10(9)/L (range: 0-0.48). While in hospital, 22 patients (28.9%) worsened clinically (...) History and Outcome of Febrile Neutropenia Outside the Oncology Setting: A Retrospective Study of 76 Cases Related to Non-Chemotherapy Drugs Despite major advances in its prevention and treatment, febrile neutropenia remains a most concerning complication of cancer chemotherapy. Outside the oncology setting, however, only few data are currently available on febrile neutropenia related to non-chemotherapy drugs. We report here data on 76 patients with febrile neutropenia related to non
with specific alleles of human leukocyte antigen (HLA) genes. For example, hypersensitivity to abacavir, a drug used for treating of human immunodeficiency virus (HIV) infection, has been proposed to be associated with allele 57:01 of HLA-B gene (terms HLA-B∗57:01). The incidences of abacavir hypersensitivity are much higher in Caucasians compared to other populations due to various allele frequencies in different ethnic populations. The antithyroiddrug- (ATDs- ) induced agranulocytosis are strongly (...) HLA Association with Drug-Induced Adverse Reactions Adverse drug reactions (ADRs) remain a common and major problem in healthcare. Severe cutaneous adverse drug reactions (SCARs), such as Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with mortality rate ranges from 10% to more than 30%, can be life threatening. A number of recent studies demonstrated that ADRs possess strong genetic predisposition. ADRs induced by several drugs have been shown to have significant associations
Arthritis Associated With Antithyroid Therapy in a 15-Year-Old Girl A 15-year-old white girl with autoimmune thyroiditis developed arthritis 3 weeks after starting therapy with the antithyroiddrug thiamazole. Because an adverse drug reaction of thionamide therapy was suspected, thiamazole was withdrawn, and symptoms disappeared rapidly. Thionamide therapy is indicated for hyperthyroidism and has been widely used since 1948. Reported adverse drug reactions range from mild to potentially life (...) threatening. Arthritis is an uncommon but serious side effect and can develop as a part of the antithyroid arthritis syndrome or as a part of antineutrophil cytoplasmic antibody-associated vasculitis that is induced by antithyroiddrugs. Little is known about the exact pathogenesis. Therapy consists of prompt discontinuation of the drug, where upon symptoms rapidly disappear. Because of possible cross-reactivity with alternative thionamides, another form of treatment for hyperthyroidism is recommended
Antithyroid treatment: a personal series. 4166808 1967 10 20 2018 11 13 0032-5473 43 497 1967 Mar Postgraduate medical journal Postgrad Med J Antithyroid treatment: a personal series. 146-9 Willcox P H PH eng Journal Article England Postgrad Med J 0234135 0032-5473 0 Antithyroid Agents 0 Imidazoles QW24888U5F Methylthiouracil IM Adolescent Adult Aged Antithyroid Agents therapeutic use Child Female Humans Hyperthyroidism drug therapy Imidazoles therapeutic use Male Methylthiouracil therapeutic
Hypothyroidism as a Late Sequela in Patients with Graves' Disease Treated with Antithyroid Agents In 1971, thyroid function was evaluated in 15 unselected patients whose only therapy for diffuse toxic goiter was a course of thionamide drug treatment completed 20-27 yr earlier. One patient was frankly hypothyroid by clinical and laboratory criteria. The remaining 14 patients appeared clinically euthyroid and had a normal serum thyroxine (T(4)) concentration and thyroid radioiodine uptake (RAIU