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Antithyroid Drug

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61. Long-term outcome of thyrotoxicosis in childhood and adolescence in the west of Scotland: the case for long-term antithyroid treatment and the importance of initial counselling. Full Text available with Trip Pro

' disease and Hashimoto's thyroiditis.Sixty-six patients (58 females:8 males) comprising 53 with Graves' disease and 13 with Hashimoto's thyroiditis were diagnosed at median 10.4 (2.9-15.8) years and followed up for 11.8 (2.6-30.2) years. Antithyroid drug (ATD) therapy was stopped electively in 35 patients after 4.5 (1.5-8.6) years, resulting in remission in 10/13 Hashimoto's thyroiditis and 10/22 Graves' disease. Side effects occurred in 12 patients receiving carbimazole, six of whom changed (...) Long-term outcome of thyrotoxicosis in childhood and adolescence in the west of Scotland: the case for long-term antithyroid treatment and the importance of initial counselling. Thyrotoxicosis is both rarer and more severe in children than in adults, rendering management difficult and often unsatisfactory.To ascertain outcome in a geographically defined area of Scotland between 1989 and 2014.Retrospective case note review with follow-up questionnaire to family doctors for patients with Graves

2017 Archives of Disease in Childhood

62. Preconceptional antithyroid peroxidase antibodies, but not thyroid-stimulating hormone, are associated with decreased live birth rates in infertile women. Full Text available with Trip Pro

Preconceptional antithyroid peroxidase antibodies, but not thyroid-stimulating hormone, are associated with decreased live birth rates in infertile women. To study whether preconceptual thyroid-stimulating hormone (TSH) and antithyroid peroxidase (TPO) antibodies are associated with poor reproductive outcomes in infertile women.Secondary analysis of data from two multicenter, randomized, controlled trials conducted by the Reproductive Medicine Network of the Eunice Kennedy Shriver National

2017 Fertility and Sterility

63. Steroid-Responsive Chronic Schizophreniform Syndrome in the Context of Mildly Increased Antithyroid Peroxidase Antibodies Full Text available with Trip Pro

and shows a good response to corticosteroids.We present the case of a 41-year-old woman suffering from a schizophreniform syndrome. Starting at the age of 35, she developed psychotic exacerbations with formal thought disorder, acoustic hallucinations, cenesthopathic experiences, and loss of ego boundaries. At the same time, she began to suffer from chronic sexual delusions and olfactory hallucinations, which did not respond to neuroleptic medication. Her levels of antithyroid peroxidase antibodies were (...) Steroid-Responsive Chronic Schizophreniform Syndrome in the Context of Mildly Increased Antithyroid Peroxidase Antibodies Schizophreniform syndromes can be divided into primary forms from polygenic causes or secondary forms due to immunological, epileptiform, monogenic, or degenerative causes. Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) is a secondary immunological form associated with increased thyroid antibodies, such as antithyroid peroxidase antibodies

2017 Frontiers in Psychiatry

64. Nonthionamide Drugs for the Treatment of Hyperthyroidism: From Present to Future Full Text available with Trip Pro

Nonthionamide Drugs for the Treatment of Hyperthyroidism: From Present to Future Hyperthyroidism is a common endocrine disease. Although thionamide antithyroid drugs are the cornerstone of hyperthyroidism treatment, some patients cannot tolerate this drug class because of its serious side effects including agranulocytosis, hepatotoxicity, and vasculitis. Therefore, nonthionamide antithyroid drugs (NTADs) still have an important role in controlling hyperthyroidism in clinical practice (...) . Furthermore, some situations such as thyroid storm or preoperative preparation require a rapid decrease in thyroid hormone by combination treatment with multiple classes of antithyroid drugs. NTADs include iodine-containing compounds, lithium carbonate, perchlorate, glucocorticoid, and cholestyramine. In this narrative review, we summarize the mechanisms of action, indications, dosages, and side effects of currently used NTADs for the treatment of hyperthyroidism. In addition, we also describe the state

2018 International journal of endocrinology

65. A Prospective Comparative Study on Improvement of Hyperthyroid Cardiovascular Dysfunction in Patients Undergoing Total Thyroidectomy Versus Medical Management. (Abstract)

A Prospective Comparative Study on Improvement of Hyperthyroid Cardiovascular Dysfunction in Patients Undergoing Total Thyroidectomy Versus Medical Management. Cardiovascular dysfunction (CVD) is a well-recognized complication in patients with hyperthyroidism and is the major cause of mortality. Very few studies have compared the outcome of CVD following different treatment modalities. In this study we intended to compare treatment modalities (antithyroid drugs vs surgery) for reversal (...) of CVD.Patients with newly detected hyperthyroidism were grouped into, Group I [n = 123, age <60 years, undergoing total thyroidectomy], Group II [n = 42, age <60 years, treated with antithyroid medications] were evaluated with 2D echocardiography, serum N terminal pro brain natriuretic peptide (NT-pro-BNP) at the time of diagnosis (Point A), after achieving euthyroidism (Point B) with antithyroid drugs and 6 months after surgery/continuation of antithyroid medications (Point C). Forty patients (Group III

2018 World Journal of Surgery

66. Antithyroid drugs induced agranulocytosis and multiple myeloma: case report and general considerations Full Text available with Trip Pro

of the severe leucopenia is actually an epiphenomenon of a preexisting hematological disturbance as multiple myeloma is debated. The myeloma may also be correlated with an autoimmune predisposition. We present the case of a 56 years old female patient diagnosed with Graves' disease, who developed agranulocytosis after 8 months of therapy with thiamazole. Two months after antithyroid drug's withdrawal, the granulocytes number increased and she received therapy with radioiodine. Two years later she came back (...) Antithyroid drugs induced agranulocytosis and multiple myeloma: case report and general considerations Antithyroid drugs as thionamides are largely used in the treatment of the thyrotoxicosis. Side effects were reported in less than 10% of the cases, especially hematological, hepatic or skin allergies. One of the most severe manifestations is agranulocytosis, probably based on an immune mechanism that is exacerbated by the presence of the thyroid autoimmune disease itself. If the presence

2013 Journal of medicine and life

67. Genetic Study of Antithyroid Drugs Associated Agranulocytosis

before prescription, we can avoid the happening of severe side effects. Condition or disease Agranulocytosis Study Design Go to Layout table for study information Study Type : Observational Estimated Enrollment : 30 participants Observational Model: Cohort Time Perspective: Prospective Official Title: Genetic Study of Antithyroid Drugs Associated Agranulocytosis Study Start Date : April 2012 Estimated Primary Completion Date : January 2022 Resource links provided by the National Library of Medicine (...) Genetic Study of Antithyroid Drugs Associated Agranulocytosis Genetic Study of Antithyroid Drugs Associated Agranulocytosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Genetic Study of Antithyroid Drugs

2013 Clinical Trials

68. Warfarin Therapy Management

, post-operative, etc.) need lower doses. An effect on the INR generally occurs within 24 hours after drug administration. However, the full anticoagulant effect may be delayed for 5-7 days due to the long half-life of prothrombin. 6 The major challenge in warfarin therapy is its narrow therapeutic range. Over-anticoagulation may lead to hemorrhage while under-anticoagulation can result in thrombosis. Bleeding is the most serious complication of warfarin therapy. 9-12 The average yearly bleeding (...) rates vary widely depending on patient lifestyle, co-morbidities and the concomitant use of antiplatelet drugs. Estimated annual incidences are 0.6% for fatal bleeding, 3.0% for major bleeding, and 9.6% for minor bleeding. 11-12 2 BCGuidelines.ca: Warfarin Therapy Management (2015) A good warfarin management plan, including ongoing patient education, follow-up, dosing tools, and involved caregivers/ other health professionals, can maximize the benefit to harm ratio. The time in therapeutic range

2015 Clinical Practice Guidelines and Protocols in British Columbia

69. Antithyroid Drug

with Methimazole Hepatitis Occurs with both Methimazole and Propylthiouracil (PTU) Methimazole associated hepatitis : 3.17 per 1000 person-years : 0.32 per 1000 person-years Propylthiouracil (PTU) is associated with severe liver injury Adults: 1 in 10,000 Children: 1 in 2,000 -like syndrome Rash or Switch from PTU to Methimazole if severe or Congenital abnormalities possible with Methimazole VI. Monitoring Repeat examination every 3 months before starting therapy Lab Testing while on antithyroid medications (...) SnomedCT 5067008 , 418416001 English Antagonists, Thyroid , Antithyroid Drugs , Drugs, Antithyroid , Thyroid Antagonists , thyroid inhibitor , Agents, Antithyroid , Antithyroid Agents , THYROID ANTAG , ANTITHYROID AGENTS , anti-thyroid agents , anti-thyroid agents (medication) , thyroid antagonists , [HS852] ANTITHYROID AGENTS , antithyroid drug , inhibitors thyroid , antithyroid agents , antithyroid preparations , antithyroid drugs , Thyroid Antagonist , ANTITHYROID PREPARATIONS , Thyroid antagonists

2015 FP Notebook

70. Hepatotoxicity and cutaneous reactions after antithyroid drug administration. (Abstract)

Hepatotoxicity and cutaneous reactions after antithyroid drug administration. Use of the antithyroid drugs (ATDs) thiamazole (MMI) and propylthiouracil (PTU) is associated with a high frequency of side effects. When patients experience side effects with one (the 1st) ATD, it is usually discontinued and another is administered (the 2nd ATD). We investigated side effects associated with the 1st and 2nd ATDs.Four hundred forty-nine patients with untreated Graves' disease (GD) were randomly

2012 Clinical endocrinology Controlled trial quality: uncertain

71. Antithyroid Antibody

( ) Related Topics in Pathology and Laboratory Medicine About FPnotebook.com is a rapid access, point-of-care medical reference for primary care and emergency clinicians. Started in 1995, this collection now contains 6656 interlinked topic pages divided into a tree of 31 specialty books and 728 chapters. Content is with systematic literature reviews and conferences. Although access to this website is not restricted, the information found here is intended for use by medical providers. Patients should (...) Antithyroid Antibody Antithyroid Antibody Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Antithyroid Antibody Antithyroid Antibody

2018 FP Notebook

72. THE USE OF ANTITHYROID DRUGS Full Text available with Trip Pro

THE USE OF ANTITHYROID DRUGS The preoperative use of antithyroid drugs is mandatory if surgical treatment of complicated hyperthyroidism is contemplated. Six months to a year may be required for suitable preparation. The long-term use of antithyroid drugs is less effective for the "cure" of hyperthyroidism than is operation or the use of radioactive iodine. Propyl and methyl thiouracil are the antithyroid drugs of choice. Either of these thiouracil derivatives is capable of producing leukopenia (...) . The antithyroid drugs exert no favorable effect on exophthalmos. The antithyroid drugs are suitable for the control of hyperthyroidism during pregnancy. The patient probably should not be kept hypothyroid during pregnancy but rather in a state of mild hyperthyroidism.

1951 California Medicine

73. Toxic Effects of Antithyroid Drugs Full Text available with Trip Pro

Toxic Effects of Antithyroid Drugs 15396321 2004 09 30 2018 12 01 0044-0086 22 2 1949 Dec The Yale journal of biology and medicine Yale J Biol Med Toxic effects of antithyroid drugs. 139-79 PETERS J P JP MAN E B EB eng Journal Article United States Yale J Biol Med 0417414 0044-0086 0 Antithyroid Agents OM Antithyroid Agents Humans Thyroid Gland 5018:328x:13 THYROID 1949 12 1 1949 12 1 0 1 1949 12 1 0 0 ppublish 15396321 PMC2598806 Nord Med. 1948 Feb 20;37(8):375-80 18862677 Ann Surg. 1947 May

1949 The Yale journal of biology and medicine

74. Antithyroid Drugs Full Text available with Trip Pro

Antithyroid Drugs 13441488 2002 05 01 2018 12 01 0032-5473 33 381 1957 Jul Postgraduate medical journal Postgrad Med J Antithyroid drugs. 322-6; passim CROOKS J J eng Journal Article England Postgrad Med J 0234135 0032-5473 0 Antithyroid Agents OM Antithyroid Agents Humans 5732:39768 THYROID ANTAGONISTS 1957 7 1 1957 7 1 0 1 1957 7 1 0 0 ppublish 13441488 PMC2501365 Proc R Soc Med. 1950 Dec;43(12):937-46 14808173 Br Med J. 1954 Feb 20;1(4859):422-5 13126530 Lancet. 1954 Apr 10;266(6815):749-51

1957 Postgraduate medical journal

75. The mode of action of antithyroid drugs: further observations on in vitro inhibition of oxidative protein iodination Full Text available with Trip Pro

The mode of action of antithyroid drugs: further observations on in vitro inhibition of oxidative protein iodination 14351678 2003 05 01 2018 12 01 0366-0826 10 1 1955 Mar British journal of pharmacology and chemotherapy Br J Pharmacol Chemother The mode of action of antithyroid drugs: further observations on in vitro inhibition of oxidative protein iodination. 1-6 FRASER R R HANNO M G MG PITNEY W R WR eng Journal Article England Br J Pharmacol Chemother 0154627 0366-0826 0 Antithyroid Agents 0 (...) Proteins OM Antithyroid Agents pharmacology Biochemical Phenomena Halogenation Humans In Vitro Techniques Oxidation-Reduction Proteins metabolism 5528:2344:466:562 PROTEINS/metabolism THYROID ANTAGONISTS/effects 1955 3 1 1955 3 1 0 1 1955 3 1 0 0 ppublish 14351678 PMC1509484 Metabolism. 1952 Nov;1(6):533-9 13002073 J Endocrinol. 1953 Apr;9(2):224-31 13052795 Nature. 1954 Feb 13;173(4398):305-7 13144749 Br Med J. 1954 May 29;1(4873):1234-7 13160443 J Clin Endocrinol Metab. 1954 Oct;14(10):1230-44

1955 British journal of pharmacology and chemotherapy

76. Methyl-thiouracil and thiouracil as antithyroid drugs Full Text available with Trip Pro

Methyl-thiouracil and thiouracil as antithyroid drugs 19108079 2009 07 29 2009 11 11 0366-0826 1 2 1946 Jun British journal of pharmacology and chemotherapy Br J Pharmacol Chemother Methyl-thiouracil and thiouracil as antithyroid drugs. 127-34 Glock G E GE eng Journal Article England Br J Pharmacol Chemother 0154627 0366-0826 2008 12 25 9 0 1946 6 1 0 0 1946 6 1 0 1 ppublish 19108079 PMC1509730

1946 British journal of pharmacology and chemotherapy

77. ANTITHYROID DRUGS IN THE TREATMENT OF HYPERTHYROIDISM Full Text available with Trip Pro

ANTITHYROID DRUGS IN THE TREATMENT OF HYPERTHYROIDISM 20271146 2010 03 18 2018 12 01 0008-4409 57 6 1947 Dec Canadian Medical Association journal Can Med Assoc J Antithyroid drugs in the treatment of hyperthyroidism. 585-8 KILGOUR J M JM eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 0 Antithyroid Agents OM Antithyroid Agents Humans Hyperthyroidism 4713:1525l1 ANTITHYROID DRUG HYPERTHYROIDISM/antithyroid drugs 2010 3 19 6 0 1947 12 1 0 0 1947 12 1 0 1 ppublish 20271146 PMC1590718

1947 Canadian Medical Association Journal

78. Metabolism of 35S-labelled Antithyroid Drugs in Man Full Text available with Trip Pro

Metabolism of 35S-labelled Antithyroid Drugs in Man Differences in the metabolic fate of antithyroid drugs influence the optimal frequency of administration and their therapeutic efficacy. (35)S propylthiouracil differed from the (35)S imidazoles (carbimazole and methimazole) in the more rapid absorption and excretion and the shorter biological half-life in the plasma of the former. Renal function may have a more important influence on the biological half-life of the drugs than thyroid status

1969 British medical journal

79. Agranulocytosis and Antithyroid Drugs Full Text available with Trip Pro

Agranulocytosis and Antithyroid Drugs Propylthiouracil and methimazole are used widely in the treatment of hyperthyroid disorders. The most important complication of the use of these drugs is depression of the neutrophilic granulocyte count. Granulocytopenia occurs in about 4 percent and agranulocytosis occurs in about 0.3 percent of treated patients. Although this depression of the granulocyte count is reversible after the drug is discontinued, serious infection frequently accompanies (...) agranulocytosis and accounts for almost all deaths related to the drugs. It is important to be aware of the clinical features of granulocytopenic reactions due to antithyroid drugs.

1977 Western Journal of Medicine

80. The geography of the use of thyroid and antithyroid drugs in Northern Ireland (preliminary report). Full Text available with Trip Pro

The geography of the use of thyroid and antithyroid drugs in Northern Ireland (preliminary report). 4172539 1968 07 30 2018 11 30 0035-9157 61 4 1968 Apr Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. The geography of the use of thyroid and antithyroid drugs in Northern Ireland (preliminary report). 389 Wade O L OL eng Journal Article England Proc R Soc Med 7505890 0035-9157 0 Antithyroid Agents 0 Insulin 0 Thyroid Hormones IM Antithyroid Agents therapeutic use Attitude

1968 Proceedings of the Royal Society of Medicine

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