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Antithyroid Drug

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61. Agranulocytosis and Antithyroid Drugs (PubMed)

Agranulocytosis and Antithyroid Drugs Propylthiouracil and methimazole are used widely in the treatment of hyperthyroid disorders. The most important complication of the use of these drugs is depression of the neutrophilic granulocyte count. Granulocytopenia occurs in about 4 percent and agranulocytosis occurs in about 0.3 percent of treated patients. Although this depression of the granulocyte count is reversible after the drug is discontinued, serious infection frequently accompanies (...) agranulocytosis and accounts for almost all deaths related to the drugs. It is important to be aware of the clinical features of granulocytopenic reactions due to antithyroid drugs.

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1977 Western Journal of Medicine

62. Methyl-thiouracil and thiouracil as antithyroid drugs (PubMed)

Methyl-thiouracil and thiouracil as antithyroid drugs 19108079 2009 07 29 2009 11 11 0366-0826 1 2 1946 Jun British journal of pharmacology and chemotherapy Br J Pharmacol Chemother Methyl-thiouracil and thiouracil as antithyroid drugs. 127-34 Glock G E GE eng Journal Article England Br J Pharmacol Chemother 0154627 0366-0826 2008 12 25 9 0 1946 6 1 0 0 1946 6 1 0 1 ppublish 19108079 PMC1509730

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1946 British journal of pharmacology and chemotherapy

63. ANTITHYROID DRUGS IN THE TREATMENT OF HYPERTHYROIDISM (PubMed)

ANTITHYROID DRUGS IN THE TREATMENT OF HYPERTHYROIDISM 20271146 2010 03 18 2018 12 01 0008-4409 57 6 1947 Dec Canadian Medical Association journal Can Med Assoc J Antithyroid drugs in the treatment of hyperthyroidism. 585-8 KILGOUR J M JM eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 0 Antithyroid Agents OM Antithyroid Agents Humans Hyperthyroidism 4713:1525l1 ANTITHYROID DRUG HYPERTHYROIDISM/antithyroid drugs 2010 3 19 6 0 1947 12 1 0 0 1947 12 1 0 1 ppublish 20271146 PMC1590718

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1947 Canadian Medical Association Journal

64. Toxic Effects of Antithyroid Drugs (PubMed)

Toxic Effects of Antithyroid Drugs 15396321 2004 09 30 2018 12 01 0044-0086 22 2 1949 Dec The Yale journal of biology and medicine Yale J Biol Med Toxic effects of antithyroid drugs. 139-79 PETERS J P JP MAN E B EB eng Journal Article United States Yale J Biol Med 0417414 0044-0086 0 Antithyroid Agents OM Antithyroid Agents Humans Thyroid Gland 5018:328x:13 THYROID 1949 12 1 1949 12 1 0 1 1949 12 1 0 0 ppublish 15396321 PMC2598806 Nord Med. 1948 Feb 20;37(8):375-80 18862677 Ann Surg. 1947 May

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1949 The Yale journal of biology and medicine

65. THE USE OF ANTITHYROID DRUGS (PubMed)

THE USE OF ANTITHYROID DRUGS The preoperative use of antithyroid drugs is mandatory if surgical treatment of complicated hyperthyroidism is contemplated. Six months to a year may be required for suitable preparation. The long-term use of antithyroid drugs is less effective for the "cure" of hyperthyroidism than is operation or the use of radioactive iodine. Propyl and methyl thiouracil are the antithyroid drugs of choice. Either of these thiouracil derivatives is capable of producing leukopenia (...) . The antithyroid drugs exert no favorable effect on exophthalmos. The antithyroid drugs are suitable for the control of hyperthyroidism during pregnancy. The patient probably should not be kept hypothyroid during pregnancy but rather in a state of mild hyperthyroidism.

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1951 California Medicine

66. Antithyroid Drugs (PubMed)

Antithyroid Drugs 13441488 2002 05 01 2018 12 01 0032-5473 33 381 1957 Jul Postgraduate medical journal Postgrad Med J Antithyroid drugs. 322-6; passim CROOKS J J eng Journal Article England Postgrad Med J 0234135 0032-5473 0 Antithyroid Agents OM Antithyroid Agents Humans 5732:39768 THYROID ANTAGONISTS 1957 7 1 1957 7 1 0 1 1957 7 1 0 0 ppublish 13441488 PMC2501365 Proc R Soc Med. 1950 Dec;43(12):937-46 14808173 Br Med J. 1954 Feb 20;1(4859):422-5 13126530 Lancet. 1954 Apr 10;266(6815):749-51

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1957 Postgraduate medical journal

67. The mode of action of antithyroid drugs: further observations on in vitro inhibition of oxidative protein iodination (PubMed)

The mode of action of antithyroid drugs: further observations on in vitro inhibition of oxidative protein iodination 14351678 2003 05 01 2018 12 01 0366-0826 10 1 1955 Mar British journal of pharmacology and chemotherapy Br J Pharmacol Chemother The mode of action of antithyroid drugs: further observations on in vitro inhibition of oxidative protein iodination. 1-6 FRASER R R HANNO M G MG PITNEY W R WR eng Journal Article England Br J Pharmacol Chemother 0154627 0366-0826 0 Antithyroid Agents 0 (...) Proteins OM Antithyroid Agents pharmacology Biochemical Phenomena Halogenation Humans In Vitro Techniques Oxidation-Reduction Proteins metabolism 5528:2344:466:562 PROTEINS/metabolism THYROID ANTAGONISTS/effects 1955 3 1 1955 3 1 0 1 1955 3 1 0 0 ppublish 14351678 PMC1509484 Metabolism. 1952 Nov;1(6):533-9 13002073 J Endocrinol. 1953 Apr;9(2):224-31 13052795 Nature. 1954 Feb 13;173(4398):305-7 13144749 Br Med J. 1954 May 29;1(4873):1234-7 13160443 J Clin Endocrinol Metab. 1954 Oct;14(10):1230-44

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1955 British journal of pharmacology and chemotherapy

68. Psychosis and antithyroid drug therapy. (PubMed)

Psychosis and antithyroid drug therapy. 4184813 1969 10 05 2013 11 21 0007-1447 3 5670 1969 Sep 06 British medical journal Br Med J Psychosis and antithyroid drug therapy. 596-7 Hedley A J AJ Bewsher P D PD eng Journal Article England Br Med J 0372673 0007-1447 0 Antithyroid Agents 0 Imidazoles 8KQ660G60G Carbimazole AIM IM Adult Antithyroid Agents adverse effects Carbimazole adverse effects Female Humans Imidazoles adverse effects Psychoses, Substance-Induced etiology 1969 9 6 1969 9 6 0 1

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1969 British medical journal

69. Metabolism of 35S-labelled Antithyroid Drugs in Man (PubMed)

Metabolism of 35S-labelled Antithyroid Drugs in Man Differences in the metabolic fate of antithyroid drugs influence the optimal frequency of administration and their therapeutic efficacy. (35)S propylthiouracil differed from the (35)S imidazoles (carbimazole and methimazole) in the more rapid absorption and excretion and the shorter biological half-life in the plasma of the former. Renal function may have a more important influence on the biological half-life of the drugs than thyroid status

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1969 British medical journal

70. The geography of the use of thyroid and antithyroid drugs in Northern Ireland (preliminary report). (PubMed)

The geography of the use of thyroid and antithyroid drugs in Northern Ireland (preliminary report). 4172539 1968 07 30 2018 11 30 0035-9157 61 4 1968 Apr Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. The geography of the use of thyroid and antithyroid drugs in Northern Ireland (preliminary report). 389 Wade O L OL eng Journal Article England Proc R Soc Med 7505890 0035-9157 0 Antithyroid Agents 0 Insulin 0 Thyroid Hormones IM Antithyroid Agents therapeutic use Attitude

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1968 Proceedings of the Royal Society of Medicine

71. Results of Treatment of Thyrotoxicosis following Relapse after Antithyroid Drug Therapy (PubMed)

Results of Treatment of Thyrotoxicosis following Relapse after Antithyroid Drug Therapy One hundred and thirty patients who relapsed after a full course of treatment with antithyroid drugs have been reviewed. Of 22 patients receiving a second course of antithyroid drugs, 17 (77%) relapsed. In contrast, only 2 out of 44 patients treated by surgery relapsed and seven became hypothyroid. Nevertheless, local complications, in particular parathyroid insufficiency, were especially common

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1969 British medical journal

72. Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (PubMed)

Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. We report a prospective study to avaluate the effect of antithyroid drugs containing the sulfhydryl radical on the outcome of I-131 (RAI) therapy. Twenty-four male patients withe toxic diffuse goiter were assigned randomly into tow treatment groups: Group A received RAI treatment while on antighyroid drugs after attainment of euthyroidism; Group B received no antithyroid drugs before, or when

1979 Journal of nuclear medicine : official publication, Society of Nuclear Medicine

73. Idiosyncratic Drug-Induced Severe Neutropenia and Agranulocytosis in Elderly Patients (≥75 years): A Monocentric Cohort Study of 61 Cases (PubMed)

agranulocytosis.Data from 61 patients over 75 years old with idiosyncratic drug-induced agranulocytosis were retrospectively reviewed. All cases were extracted from a cohort study on agranulocytosis (n = 203) in the Strasbourg University Hospitals (Strasbourg, France), a referral center.The mean age was 84.9 years (range 75-95), the gender ratio (F/M) was 2.4. Underlying diseases were present in 74 %. The most frequent causative drugs were antibiotics (43.8 %), antithyroid drugs (15.8 %), neuroleptic and anti (...) septic shock relating to the depth of the neutropenia. Comparison of mortality between <75- and ≥75-year-old patients revealed a statistical difference: 4.2 % versus 14.8 % (p = 0.023).Our study demonstrates that 30 % of idiosyncratic drug-induced agranulocytosis concerned elderly patients. Antibiotic, antithyroid, neuroleptic, anti-epileptic, and antiaggregant platelet agents are the primary causative drug classes. Idiosyncratic drug-induced agranulocytosis is typically serious in this frail

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2016 Drugs - real world outcomes

74. Nonthionamide Drugs for the Treatment of Hyperthyroidism: From Present to Future (PubMed)

Nonthionamide Drugs for the Treatment of Hyperthyroidism: From Present to Future Hyperthyroidism is a common endocrine disease. Although thionamide antithyroid drugs are the cornerstone of hyperthyroidism treatment, some patients cannot tolerate this drug class because of its serious side effects including agranulocytosis, hepatotoxicity, and vasculitis. Therefore, nonthionamide antithyroid drugs (NTADs) still have an important role in controlling hyperthyroidism in clinical practice (...) . Furthermore, some situations such as thyroid storm or preoperative preparation require a rapid decrease in thyroid hormone by combination treatment with multiple classes of antithyroid drugs. NTADs include iodine-containing compounds, lithium carbonate, perchlorate, glucocorticoid, and cholestyramine. In this narrative review, we summarize the mechanisms of action, indications, dosages, and side effects of currently used NTADs for the treatment of hyperthyroidism. In addition, we also describe the state

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2018 International journal of endocrinology

75. Clinical Characteristics of Patients with Drug-induced Liver Injury (PubMed)

(18.47%, 53 patients) of DILI.   Antibiotics (18 patients, 6.27%) and antithyroid (18 patients, 6.27%) drugs also ranked among the major causes of DILI. Chinese herbal medicines are another major cause of DILI, accounting for 36.59% of cases (105 patients). Most of the causative Chinese herbal medicines were those used to treat osteopathy, arthropathy, dermatosis, gastropathy, leukotrichia, alopecia, and gynecologic diseases. Hepatocellular hepatitis was prevalent in DILI, regardless of Chinese (...) Clinical Characteristics of Patients with Drug-induced Liver Injury Drug is an important cause of liver injury and accounts for up to 40% of instances of fulminant hepatic failure. Drug-induced liver injury (DILI) is increasing while the diagnosis becomes more difficult. Though many drugs may cause DILI, Chinese herbal medicines have recently emerged as a major cause due to their extensive use in China. We aimed to provide drug safety information to patients and health carers by analyzing

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2017 Chinese medical journal

76. History and Outcome of Febrile Neutropenia Outside the Oncology Setting: A Retrospective Study of 76 Cases Related to Non-Chemotherapy Drugs (PubMed)

%), antithyroid drugs (17.2%), neuroleptic and anti-epileptic agents (13.1%), non-steroidal anti-inflammatory agents and analgesics (8%), and platelet aggregation inhibitors (8%). Main clinical presentations upon hospitalization included isolated fever (30%), sore throat, acute tonsillitis and sinusitis (18.4%), documented pneumonia (18.4%), septicemia (14.5%), and septic shock (6.6%). Mean neutrophil count at nadir was 0.13 × 10(9)/L (range: 0-0.48). While in hospital, 22 patients (28.9%) worsened clinically (...) History and Outcome of Febrile Neutropenia Outside the Oncology Setting: A Retrospective Study of 76 Cases Related to Non-Chemotherapy Drugs Despite major advances in its prevention and treatment, febrile neutropenia remains a most concerning complication of cancer chemotherapy. Outside the oncology setting, however, only few data are currently available on febrile neutropenia related to non-chemotherapy drugs. We report here data on 76 patients with febrile neutropenia related to non

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2017 Journal of clinical medicine

77. HLA Association with Drug-Induced Adverse Reactions (PubMed)

with specific alleles of human leukocyte antigen (HLA) genes. For example, hypersensitivity to abacavir, a drug used for treating of human immunodeficiency virus (HIV) infection, has been proposed to be associated with allele 57:01 of HLA-B gene (terms HLA-B∗57:01). The incidences of abacavir hypersensitivity are much higher in Caucasians compared to other populations due to various allele frequencies in different ethnic populations. The antithyroid drug- (ATDs- ) induced agranulocytosis are strongly (...) HLA Association with Drug-Induced Adverse Reactions Adverse drug reactions (ADRs) remain a common and major problem in healthcare. Severe cutaneous adverse drug reactions (SCARs), such as Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with mortality rate ranges from 10% to more than 30%, can be life threatening. A number of recent studies demonstrated that ADRs possess strong genetic predisposition. ADRs induced by several drugs have been shown to have significant associations

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2017 Journal of immunology research

78. Arthritis Associated With Antithyroid Therapy in a 15-Year-Old Girl (PubMed)

Arthritis Associated With Antithyroid Therapy in a 15-Year-Old Girl A 15-year-old white girl with autoimmune thyroiditis developed arthritis 3 weeks after starting therapy with the antithyroid drug thiamazole. Because an adverse drug reaction of thionamide therapy was suspected, thiamazole was withdrawn, and symptoms disappeared rapidly. Thionamide therapy is indicated for hyperthyroidism and has been widely used since 1948. Reported adverse drug reactions range from mild to potentially life (...) threatening. Arthritis is an uncommon but serious side effect and can develop as a part of the antithyroid arthritis syndrome or as a part of antineutrophil cytoplasmic antibody-associated vasculitis that is induced by antithyroid drugs. Little is known about the exact pathogenesis. Therapy consists of prompt discontinuation of the drug, where upon symptoms rapidly disappear. Because of possible cross-reactivity with alternative thionamides, another form of treatment for hyperthyroidism is recommended

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2011 The Journal of Pediatric Pharmacology and Therapeutics : JPPT

79. Antithyroid treatment: a personal series. (PubMed)

Antithyroid treatment: a personal series. 4166808 1967 10 20 2018 11 13 0032-5473 43 497 1967 Mar Postgraduate medical journal Postgrad Med J Antithyroid treatment: a personal series. 146-9 Willcox P H PH eng Journal Article England Postgrad Med J 0234135 0032-5473 0 Antithyroid Agents 0 Imidazoles QW24888U5F Methylthiouracil IM Adolescent Adult Aged Antithyroid Agents therapeutic use Child Female Humans Hyperthyroidism drug therapy Imidazoles therapeutic use Male Methylthiouracil therapeutic

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1967 Postgraduate medical journal

80. Hypothyroidism as a Late Sequela in Patients with Graves' Disease Treated with Antithyroid Agents (PubMed)

Hypothyroidism as a Late Sequela in Patients with Graves' Disease Treated with Antithyroid Agents In 1971, thyroid function was evaluated in 15 unselected patients whose only therapy for diffuse toxic goiter was a course of thionamide drug treatment completed 20-27 yr earlier. One patient was frankly hypothyroid by clinical and laboratory criteria. The remaining 14 patients appeared clinically euthyroid and had a normal serum thyroxine (T(4)) concentration and thyroid radioiodine uptake (RAIU

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1979 Journal of Clinical Investigation

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