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Antithyroid Drug

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181. A Somewhat Bizarre Case of Graves Disease Due to Vitamin Treatment Full Text available with Trip Pro

with X-linked adrenomyeloneuropathy recently diagnosed with Graves disease, was referred to our department to evaluate his response to antithyroid drugs. His thyroid function tests were still consistent with hyperthyroidism while he had been receiving carbimazole 40 mg/d for 6 weeks. We found no signs of thyrotoxicosis on physical examination despite the "frank and severe" biochemical hyperthyroidism. Noticing that all the patient's assays had been done at the same laboratory, we suspected assay (...) interference. We therefore repeated the thyroid function tests at our hospital laboratory, which uses a different assay platform. Surprisingly, all the results were normal, confirming assay interference. The patient was taking an investigational "vitamin" therapy, which turned out to be biotin, prescribed at a dose of 100 mg tid as part of a trial of high-dose biotin in X-linked adrenomyeloneuropathy.This case should encourage physicians to ask their patients about possible biotin intake, especially when

2017 Journal of the Endocrine Society

182. An association of myasthenia gravis with Hashimoto's thyroiditis in a patient with a multinodular goitre Full Text available with Trip Pro

hyperthyroidism secondary to Hashimoto's thyroiditis in multinodular goitre was diagnosed with generalised MG after 2 years. She presented with right eye ptosis (ocular) and difficulty in swallowing and chewing (bulbar). The diagnosis of MG was confirmed by fatigability testing, electromyography and the presence of AChR antibodies. Her symptoms showed improvement with pyridostigmine (Mestinon) 60 mg 6-hourly. Her antithyroid drug was tapered down according to her thyroid function test. Throughout a year

2017 Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia

183. Study of the Factors Leading to Fetal and Neonatal Dysthyroidism in Children of Patients With Graves Disease Full Text available with Trip Pro

of 100% and specificity of 64%. Using the newborn TRAb levels, the cutoff value of 6.8 IU/L best predicted for ND, with a sensitivity of 100% and a specificity of 94%. In our study, 65% of women with a history of Graves disease did not receive antithyroid drugs during pregnancy but still had infants at risk of ND.In pregnant women with TRAb levels ≥2.5 IU/L, fetal ultrasound monitoring is essential until delivery. All newborns with TRAb levels ≥6.8 IU/L should be examined by a pediatrician (...) -thyrotropin receptor antibodies (TRAbs) circulating in the mother and child.This was a retrospective multicenter study of data from the medical records of all patients monitored for pregnancy from 2007 to 2014.Among 280,000 births, the medical records of 2288 women with thyroid dysfunction were selected and screened, and 417 women with Graves disease and positive for TRAbs during pregnancy were included.Using the maternal TRAb levels, the cutoff value of 2.5 IU/L best predicted for FD, with a sensitivity

2017 Journal of the Endocrine Society

184. Current Diagnostic and Treatment Strategies for Specific Dilated Cardiomyopathies: A Scientific Statement From the American Heart Association Full Text available with Trip Pro

hypertension usually precedes the development of HF with anti–vascular en- dothelial growth factor medications; it is also generally acknowledged that if blood pressure is well controlled with antihypertensive drugs, the risk of HF is low with anti–vascular endothelial growth factor therapy. Several other newer classes of medications for the treatment of cancer are in development; at this time, there are not enough data to clearly implicate them as causing cardiomyopathy, but with expanded clinical use (...) there is truly a difference in re- sponse to treatment according to pathogenesis of HF. Currently, it is accepted that guideline-directed medical and device therapies, including implantable cardioverter- defibrillator (ICD) and cardiac resynchronization therapy (CRT) for HF, are beneficial in DCM. 1 DIAGNoSTIC AND TrEATMENT STrATEGIES for SpECIfIC C ArDIoMyop AThIES In the following sections, diagnostic and treatment strat- egies for specific cardiomyopathies such as cardiac amyloidosis, cardiotoxins

2016 American Heart Association

185. Classification of Anemias

deficiency high RDW, low-normal reticulocyte , Hemolytic anemia Drug induced Aplastic anemia: allopurinol, antithyroid meds , chemo, chloramphenicol, chlorpromazine, clopidogrel, corticosteroids, furosemide, gold, indomethacin, interferon a2a&2b , isoniazid, methyldopa, NSAIDs, penicillamine, phenothiazines, procainamide, sulfonamides & ticlopidine. Drug induced Hemolysis in G6PD Deficiency: ascorbic acid, benzocaine, chloroquine, dapsone, hydroxychloroqine, nitrofurantoin, phenazopyridine, primaquine (...) , sulfacetamide, sulfamethoxazole, sulfanilamide & sulfapyridine. Drug induced Hemolytic anemia: ACEI, acetaminophen, ASA/NSAIDs, cephalosporins, chlorpromazine, chlorpropamide, diclofenac, hydrochlorothiazide, interferon a2a&2b , isoniazid, levodopa, levofloxacin, mefenamic acid, methadone, methyldopa, penicillins, probenecid, procainamide, quinine, quinidine, ribavirin, rifampin, sulfonamides, & tetracycline. (Direct antiglobulin test-DAT or Coomb’s test is used to detect cause of hemolytic anemia) Drug

2014 RxFiles

186. Subclinical hypothyroidism in the infertile female population: a guideline

Subclinical hypothyroidism in the infertile female population: a guideline Subclinical hypothyroidism in the infertile female population: a guideline Practice Committee of the American Society for Reproductive Medicine American Society for Reproductive Medicine, Birmingham, Alabama Thereiscontroversyregardingwhethertotreatsubtleabnormalitiesofthyroiddysfunctionintheinfertilefemalepatient.Thisguideline document reviews the risks and bene?ts of treating subclinical hypothyroidism in female (...) patients with a history of infertility and miscarriage,aswellasobstetricalandneonataloutcomesinthispopulation.(FertilSteril 2015;104:545–53.2015byAmericanSo- ciety for Reproductive Medicine.) Key Words: Thyroid-stimulating hormone, levothyroxine treatment, infertility, fertility treatment, screening Earn online CME credit related to this document at www.asrm.org/elearn Discuss: You candiscuss thisarticlewith its authorsand with otherASRM membersathttp:// fertstertforum.com/asrmpraccom-subclinical

2015 Society for Assisted Reproductive Technology

187. Management of primary hypothyroidism: statement by the British Thyroid Association Executive Committee

of such individuals has been the subject of controversy and of con- siderable public interest. The American Thyroid Association (ATA) and the European Thyroid Association (ETA) have recently published guidelines on the diagnosis and management of hypothyroidism. These guidelines have been based on exten- sive reviews of the medical literature and include sections on the role of combination therapy with L-T4 and liothyronine (L-T3) in individuals who are persistently dissatis?ed with L-T4 ther- apy. This position (...) in the management of hypothyroidism as the value of this approach is unproven (1/+00). 10 L-T4/L-T3 combination therapy in patients with hypothy- roidism should not be used routinely, as there is insuf?cient evi- dence to show that combination therapy is superior to L-T4 monotherapy (1/++0). 11 Clinicians have an ethical responsibility to adhere to the highest professional standards of good medical practice rooted in sound evidence. This includes not prescribing potentially harmful therapies without proven

2015 British Thyroid Association

188. Interventions for hyperthyroidism pre-pregnancy and during pregnancy. (Abstract)

included in the review.As we did not identify any eligible trials, we are unable to comment on implications for practice, although early identification of hyperthyroidism before pregnancy may allow a woman to choose radioactive iodine therapy or surgery before planning to have a child. Designing and conducting a trial of antithyroid interventions for pregnant women with hyperthyroidism presents formidable challenges. Not only is hyperthyroidism a relatively rare condition, both of the two main drugs (...) searched the Cochrane Pregnancy and Childbirth Group's Trials Register (30 September 2013).We planned to include randomised controlled trials, quasi-randomised controlled trials, and cluster-randomised trials comparing antithyroid interventions for hyperthyroidism pre-pregnancy or during pregnancy with another intervention or no intervention (placebo or no treatment).Two review authors assessed trial eligibility and planned to assess trial quality and extract the data independently.No trials were

2013 Cochrane

189. Thyroid Dysfunction: Screening

of Medicines in the United States: Review of 2010. Parsippany, NJ: IMS Institute for Healthcare Informatics; 2011. Accessed at on 12 February 2015. 19. Brooks M. Top 100 selling drugs of 2013. Medscape Medical News . 30 January 2014. 20. Fatourechi V, Lankarani M, Schryver PG, Vanness DJ, Long KH, Klee GG. Factors influencing clinical decisions to initiate thyroxine therapy for patients with mildly increased serum thyrotropin (5.1-10.0 mIU/L). Mayo Clin Proc . 2003;78:554-60. 21. Somwaru LL, Arnold AM (...) is lacking on the appropriate point for clinical intervention, especially for TSH levels <10.0 mIU/L. Hyperthyroidism is treated with antithyroid medications (e.g., methimazole) or nonreversible thyroid ablation therapy (e.g., radioactive iodine or surgery). Treatment is generally recommended for patients with a TSH level that is undetectable or <0.1 mIU/L, particularly those with overt Graves disease or nodular thyroid disease. Balance of Benefits and Harms The current evidence is insufficient to assess

2015 U.S. Preventive Services Task Force

190. The Diagnosis and Management of Primary Hypothyroidism

and of con- siderable public interest. The American Thyroid Association (ATA) and the European Thyroid Association (ETA) have recently published guidelines on the diagnosis and management of hypothyroidism. These guidelines have been based on exten- sive reviews of the medical literature and include sections on the role of combination therapy with L-T4 and liothyronine (L-T3) in individuals who are persistently dissatis?ed with L-T4 ther- apy. This position statement by the British Thyroid Association (...) is unproven (1/+00). 10 L-T4/L-T3 combination therapy in patients with hypothy- roidism should not be used routinely, as there is insuf?cient evi- dence to show that combination therapy is superior to L-T4 monotherapy (1/++0). 11 Clinicians have an ethical responsibility to adhere to the highest professional standards of good medical practice rooted in sound evidence. This includes not prescribing potentially harmful therapies without proven advantages over existing treat- ments. 12 If a decision is made

2015 British Thyroid Association

191. Preoperative Thyroid Autoimmune Status and Changes in Thyroid Function and Body Weight After Bariatric Surgery. (Abstract)

recruited 101 patients with morbid obesity (44 men and 57 women) who received bariatric surgery at Zhongshan Hospital, Fudan University. Those who had used thyroid hormone replacement or antithyroid drugs were excluded. General linear models were used to compare the changes in body weight and thyroid function in participants with different thyroid autoimmune statuses.After bariatric surgery, serum-free triiodothyronine (FT3) (4.94 ± 0.73 vs 4.33 ± 0.59 pmol/L, P < 0.001) and thyroid-stimulating hormone (...) Preoperative Thyroid Autoimmune Status and Changes in Thyroid Function and Body Weight After Bariatric Surgery. Bariatric surgery has emerged as the most effective therapy for morbid obesity. There is increasing evidence that bariatric surgery could alleviate systemic inflammation and influence thyroid function. The current study aimed to investigate the associations of preoperative thyroid autoimmune status with the changes in body weight and thyroid function after bariatric surgery.We

2019 Obesity Surgery

192. MANAGEMENT OF ENDOCRINE DISEASE: Predictive scores in Autoimmune Thyroid Disease. Are they useful? Full Text available with Trip Pro

of the development of overt AITD, the Graves' Events After Therapy-GREAT score: a prediction score for the risk of recurrence after antithyroid drugs withdrawal and the Prediction Graves' Orbitopathy-PREDIGO score: a prediction score for the development of Graves' Orbitopathy in newly diagnosed patients with Graves' hyperthyroidism. Their construction, clinical applicability, the possible preventative measurements which can be taken to diminish the risks and the potential future developments which can improve

2019 European Journal of Endocrinology

193. Propylthiouracil-induced organizing pneumonia: A case report. Full Text available with Trip Pro

Propylthiouracil-induced organizing pneumonia: A case report. Propylthiouracil (PTU) is a common antithyroid drug which can treat hyperthyroidism effectively. PTU is, however, associated to multiple adverse effects. In rare case, PTU can cause interstitial pneumonia.A 40-year-old woman presented with dyspnea and was diagnosed with pulmonary infection at the first time. After the treatment with moxifloxacin, her symptoms still got worse.The lung tissues biopsy confirmed the diagnosis

2019 Medicine

194. Relationship between Chronic urticaria and autoimmune thyroid disease. Full Text available with Trip Pro

Relationship between Chronic urticaria and autoimmune thyroid disease. Hives is an erythematous and itchy disease that commonly affects the trunk and the organs. Acute urticaria is a common disease and affects about 10%-20% of the population during its lifetime. In patients with chronic urticaria, about 25%-30% of cases, antithyroid peroxidase (TPO) was detected and Hashimoto's disease was diagnosed. This study aimed to evaluate the anti-TPO antibody in patients with chronic urticaria (...) and the effect of treatment of levothyroxine on its recovery. In this study, 72 people with chronic urticaria and positive anti-TPO antibody were randomly divided into two groups. Low-dose antihistamine was administered to both groups, and the first group received levothyroxine at a dose of 50 μg/day. The severity of itching was evaluated according to the visual analog scale before and after therapy. There was no significant difference in the age, sex, thyroid-stimulating hormone (TSH), and anti-TPO between

2019 Journal of advanced pharmaceutical technology & research Controlled trial quality: uncertain

195. Patients Treated for Hyperthyroidism Are at Increased Risk of Becoming Obese: Findings from a Large Prospective Secondary Care Cohort. Full Text available with Trip Pro

population (Health Survey for England, 2007-2009). Next, we investigated the effect of treatment with an antithyroid drug (ATD) alone in regard to ATD with radioactive iodine (131I) therapy. We modeled the longitudinal weight data in relation to the treatment pathway to thyroid function and the need for long-term thyroxine replacement. Results: During treatment of hyperthyroidism, men gained 8.0 kg (standard deviation ±7.5) and women 5.5 kg (±6.8). At discharge, there was a significantly increased risk

2019 Thyroid

196. The long-term outcome of treatment for Graves' hyperthyroidism. Full Text available with Trip Pro

The long-term outcome of treatment for Graves' hyperthyroidism. The treatment efficacy of antithyroid drug therapy(ATD), radioactive iodine(I131) or surgery for Graves' hyperthyroidism is well described. However, there are few reports on the long-term total outcome of each treatment modality as how many require levothyroxine supplementation, the need of thyroid ablation or the individual patient's estimation of their recovery.We conducted a pragmatic trial to determine the effectiveness (...) initially treated with ATD. The proportion of patients that did not feel fully recovered at follow-up was25.3%.A patient selecting ATD therapy as the initial approach in the treatment of Graves' hyperthyroidism should be informed that they have only a 50.3%chance of ultimately avoiding ablative treatment and only a 40%chance of eventually being euthyroid without thyroid medication. Surprisingly, 1in4 patients did not feel fully recovered after 6-10 years. The treatment for Graves' hyperthyroidism, thus

2019 Thyroid

197. Serum levels of insulin-like growth factor 1 are negatively associated with log transformation of thyroid-stimulating hormone in Graves' disease patients with hyperthyroidism or subjects with euthyroidism: A prospective observational study. Full Text available with Trip Pro

in patients with hyperthyroidism or euthyroidism.In this study, 30 patients each of Graves' disease with hyperthyroidism (HY group) and euthyroid individuals (EU group) were recruited. The HY patients were treated with antithyroid regimens as clinically indicated. No medications were given to EU patients. The demographic characteristics and anthropometric and laboratory data of both groups at baseline and 6 months were compared. Associations between levels of IGF-1 and free thyroxine (fT4), thyroid

2019 Medicine

198. THE PRIMARY CILIUM IN THE HUMAN THYROCYTE: CHANGES IN FREQUENCY AND LENGTH IN RELATION TO THE FUNCTIONAL PATHOLOGY OF THE THYROID GLAND. (Abstract)

biosynthetic hyperactivity after long-term antithyroid drug treatment.Our results suggest a direct relationship between ciliogenesis and both follicle activity and tissue heterogeneity in the functional pathology of the thyroid gland.

2019 Thyroid

199. Thyroid function reference values in healthy iodine-sufficient pregnant women and influence of thyroid nodules on thyroid-stimulating hormone and free thyroxine values. (Abstract)

) in the three pregnancy trimesters in iodine-sufficient pregnant women, and to analyze the influence of thyroid nodules on thyroid function during pregnancy.This was a prospective, longitudinal study comprising 400 pregnant women with no history of thyroid disease and no medication influencing thyroid function. TSH, fT4, antithyroglobulin, and antithyroid peroxidase antibodies were measured each trimester by chemiluminescent immunoassays. Urinary iodine concentration was measured in the first trimester when

2019 Thyroid

200. Adjuvant rituximab, a potential treatment for the young patient with Graves' hyperthyroidism (RiGD): study protocol for a single-arm, single-stage, phase II trial. Full Text available with Trip Pro

will determine whether the immunomodulatory medication, rituximab, will facilitate remission above and beyond that observed with antithyroid drug alone. A meaningful increase in the expected proportion of young patients entering remission when managed according to the trial protocol will justify consideration of a phase III trial.Ethics and dissemination The trial has received a favourable ethical opinion (North East - Tyne and Wear South Research Ethics Committee, reference 16/NE/0253, EudraCT number 2016 (...) of rituximab (500 mg) and a 12-month course of antithyroid drug (usually carbimazole) can result in a meaningful increase in the proportion of patients in remission at 2 years, the primary endpoint. A single-stage, phase II A'Hern design is used. 27 patients aged 12-20 years with newly presenting Graves' hyperthyroidism will be recruited. Markers of immune function, including lymphocyte numbers and antibody levels (total and specific), will be collected regularly throughout the trial.The trial

2019 BMJ open Controlled trial quality: uncertain

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