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Antithyroid Antibody

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161. Clinical and etiologic evaluation of the children with chronic urticaria. (PubMed)

this study, we evaluated the clinical features, laboratory investigations, and provocation tests of children with different subtypes of CU according to a new classification.Two hundred and twenty-two children (59.9% girls) were enrolled in the study. Of the study patients, 59.9% and 40.1% were diagnosed as having CSU and CIndU, respectively. Antithyroid antibody levels were positive in 7.1% of the patients with CSU, 32.8% of the children had positive 14C-urea breath test results, and 6.5% of the patients

2016 Allergy and Asthma Proceedings

162. The natural history of subclinical hyperthyroidism in Graves' disease - the rule of thirds. (PubMed)

regression analysis showed that older age and positive antithyroid peroxidase (TPO) antibody status had a positive association with risk of progression to overt hyperthyroidism, with hazard ratios of 1.06 ([confidence interval (CI) 1.02-1.10], p < 0.01) per year and 10.15 ([CI 1.83-56.23], p < 0.01), respectively, independent of other risk factors including, smoking, TRAb levels at diagnosis, and sex.A third each of patients with SH due to GD progress, normalize, or remain in the SH state. Older people (...) by either a raised TSH receptor antibody (TRAb) level or uniform uptake on Technetium scan.Forty-four patients (89% female, 16% current smokers, and 5% with active Graves' orbitopathy) were diagnosed with SH due to GD. Over the follow-up period (median 32 months), approximately one third (34%) of the cohort progressed to overt hyperthyroidism, one third (34%) normalized their thyroid function, slightly less than one third (30%) remained in the SH state, while one person became hypothyroid. Multivariate

2016 Thyroid

163. Does Immunosuppressive Therapy Improve Outcomes in Graves' disease? A Systematic Review and Meta-analysis. (PubMed)

Does Immunosuppressive Therapy Improve Outcomes in Graves' disease? A Systematic Review and Meta-analysis. Whether the addition of immunosuppressive drugs to standard antithyroid drugs reduces the relapse risk in Graves' disease remains uncertain.The aim of this study was to investigate the effects of immunosuppressive drugs on the relapse rate after a first episode of hyperthyroidism due to Graves' disease.Based on a pre-specified protocol, PubMed (1946-July 2015), EMBASE (1947-July 2015 (...) antibody (TRAb) levels. Seven trials with 862 participants were included. Most trials were small with a moderate to high risk of bias. There were 113 relapses in 481 (23.5%) patients receiving immunosuppressive drugs compared with 225 relapses in 381 (59.1%) control patients (risk ratio for recurrence 0.55; [confidence interval (CI) 0.41-0.75]). Subgroup analyses showed similar effects for randomized trials and controlled trials (I(2) 0%), and for trials using corticosteroid and non-corticosteroid

2016 Thyroid : official journal of the American Thyroid Association

164. Effect of thyroid autoimmunity per se on assisted reproduction treatment outcomes: A meta-analysis. (PubMed)

assisted reproductive technology.Literature searches were conducted on Pubmed, EMBASE, and the Cochrane Controlled Trials Register Database from inception to May 2014.In euthyroid women whose SCH status is unknown, those with positive antithyroid antibodies (ATA) had a higher miscarriage rate [pooled relative risk (RR) = 1.638; 95% confidence interval (CI), 1.228-2.185] and a lower delivery rate (pooled RR = 0.856; 95% CI, 0.759-0.965) than those with negative ATA. Clinical pregnancy rates were similar

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2016 Taiwanese journal of obstetrics & gynecology

165. Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT): Characteristics, treatment and outcome in 251 cases from the literature. (PubMed)

Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT): Characteristics, treatment and outcome in 251 cases from the literature. Steroid-responsive encephalopathy and associated autoimmune thyroiditis (SREAT) is characterized by encephalopathy and the presence of antithyroid antibodies. We describe the clinical presentation, outcome and treatments for SREAT by a systematic review of the literature.MEDLINE via PubMed, Web of Science and the Cochrane Library were (...) searched for articles published until 2015. Inclusion criteria were unexplained encephalopathy with antithyroid antibodies.We found reports of 251 patients (median age 52years [range 18-86], 73% females, 80 [32%] with preexisting thyroiditis). Patients presented encephalitis signs with convulsions (n=117; 47%), confusion (n=115, 46%), speech disorder (n=91, 37%), memory impairment (n=107, 43%), gait disturbance (n=67, 27%) and persecutory delusions (n=61, 25%). Twenty-eight patients (11%) presented

2016 Autoimmunity reviews

166. Thyroid Stimulating Hormone Levels are Associated with Cardiometabolic Risk Factors in Euthyroid Adolescents. (PubMed)

the United States National Health and Nutrition Examination Survey, 2007-2010, for univariate and multivariate analyses of TSH, thyroid hormones, body mass index (BMI), blood pressure, lipids, and glucose metabolism. Subjects aged 12-18 years, with normal TSH and antithyroid peroxidase antibody levels, and without a history of thyroid disease, diabetes, or treatment of hypertension/dyslipidemia (n = 1167) were included. TSH and thyroid hormones were assessed for impact on BMI Z-score, systolic blood

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2016 Thyroid

167. The Effect of Subclinical Maternal Thyroid Dysfunction and Autoimmunity on Intrauterine Growth Restriction: A Systematic Review and Meta-Analysis. (PubMed)

to search for the eligible studies: one indexed thyroid dysfunction or antithyroid antibodies; and the other one indexed the adverse neonatal outcomes of pregnancy, such as IUGR, small for gestational age, fetal growth restriction, or low birth weight.Two reviewers selected the studies, and eligible studies met the following criteria: prospective cohort studies or case control studies, studies of maternal thyroid dysfunction and positive antithyroid antibodies as the exposure of interest, and studies (...) of IUGR or small for gestational age as the outcome of interest.Data were recorded, including data from maternal thyroid disorders and IUGR, and compared with a reference group.There were 22 individual data from the 13 cohort articles. Among these, 7 were focused on subclinical hypothyroidism (SCH), 4 on subclinical hyperthyroidism, 7 on positivity for thyroid peroxidase antibody (TPOAb), and 4 on isolated hypothyroxinemia. Meta-analysis showed that there was no effect of subclinical hyperthyroidism

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2016 Medicine

168. Hashimoto Thyroiditis and Nephrocalcinosis in a Child with Down Syndrome (PubMed)

acidosis and alkaline urine consistent with dTRA. Abdominal ultrasound found nephrocalcinosis. In addition, Antithyroid peroxidase antibodies were positive, suggesting an autoimmune background for the pathogenesis of the tubular dysfunction. Treatment for dRTA and hypothyroidism was started and symptomatic improve was noticed.dRTA should be excluded in children with autoimmune disorders who develop weakness, polyuria, polydipsia or growth failure. Early diagnosis would reduce long-term complications.

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2016 Acta Informatica Medica

169. An unusual cause of cerebellovestibular symptoms (PubMed)

. She had a history of similar, but milder, symptoms and was misdiagnosed several times. She had subclinical hypothyroidism, and high levels of antithyroid antibodies. There were abnormal MRI and visual evoked potential findings. After excluding other more common causes, we diagnosed her as having 'Hashimoto Encephalopathy', and started treatment with corticosteroids, on which she showed dramatic improvement. After about 2 years of presentation, the patient is able to continue her life independently

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2016 BMJ case reports

170. Correlation of thyroid dysfunction and cognitive impairments induced by subcortical ischemic vascular disease (PubMed)

). Serum thyroid-stimulating hormone (TSH), total triiodothyronine (TT3), free triiodothyronine (FT3), total thyroxine (TT4) and free thyroxine (FT4), thyroglobulin antibody (TGA), and antithyroid peroxidase antibody (TPO-Abs) were quantified by radioimmunoassay or ELISA.A close correlation between thyroid status and cognitive dysfunction in SIVD was observed. Serum TT3 and FT3 levels decreased, whereas serum TSH level increased, with the decline in cognitive functions. Furthermore, TT3 levels showed

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2016 Brain and behavior

171. Kidney, thyroid and other organ functions after 40 years or more of lithium therapy: a case series of five patients (PubMed)

(in three patients within the first 2 years). In four patients, lithium concentration was between 0.60 and 0.65 mmol/l and in one patient, between 0.7 and 0.8 mmol/l. Four were very good lithium responders. One man had stage 3 chronic kidney disease, and the other stage 2/3 chronic kidney disease. All three women had asymptomatic stage 2 chronic kidney disease. One woman had severe thyroid dysfunction (Hashimoto's disease) with extremely high levels of antithyroid peroxidase antibodies (...) and antithyroglobulin antibodies and was receiving thyroxine. Serum calcium levels were normal or borderline in all five patients, and most cognitive functions were comparable to healthy persons of similar gender, age and years of education. All the patients were professionally active until 55-65 years and their family and social functioning were satisfactory. It was concluded that, in good lithium responders, ultra-long-term treatment with lithium enables good professional and psychosocial functioning

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2016 Therapeutic Advances in Psychopharmacology

172. Riedel's Thyroiditis

. Labs s (T4 Free and TSH) Most patients are euthyroid (70%) (Increased and decreased T4 Free) in up to 30% of cases Antithyroid peroxidase antibodies (>60%) occurs if fibrosis affects the adjacent s VII. Imaging ( uptake and scan) Low uptake (contrast with ) VIII. Diagnosis biopsy IX. Management: Tracheal or esophageal compression First-line Surgical decompression Other agents s ( ) (suppresses fibroblast proliferation) X. References Images: Related links to external sites (from Bing) These images

2018 FP Notebook

173. Hyperthyroidism in Pregnancy

Antithyroid medication use Poorly controlled High Receptor Perform monthly after 20 weeks Evaluate for fetal dysfunction Cardiac failure Antepartum testing Start testing at 32-34 weeks gestation (earlier if indicated by risk) VI. Imaging: Contraindicated Studies Absolutely contraindicated in pregnancy VII. Management is not typically treated in pregnancy Antithyroid medications (lowest effective dose that keeps <1.8 ng/dl) First trimester (and if trying to conceive) (risk of liver failure, hence (...) then change to after first trimester) Second and third trimester (and in ) (risk of in the first trimester) Symptomatic management Consider ( or ) for first 2-6 weeks while initiating antithyroid medication VIII. Course: Grave's Disease Fluctuating course during pregnancy symptoms increase in first trimester Results from HCG cross reactive stimulatory effect on the symptoms improve in second trimester symptoms worsen in third trimester IX. Complications Maternal Preterm delivery Fetal (and birth

2018 FP Notebook

174. Serum 25-Hydroxyvitamin D Level Does Not Affect the Aggressiveness and Prognosis of Papillary Thyroid Cancer. (PubMed)

, pathologic, and recurrence data were accessed to examine the prognostic effects of vitamin D. Patients were categorized into four quartiles by preoperative serum vitamin D levels.Of the enrolled patients, 795 (97%) had insufficient vitamin D levels (<30 ng/mL). Vitamin D levels showed positive correlations with age and body mass index (BMI), and negative correlations with serum thyrotropin levels and antithyroid peroxidase antibody titers. The association between vitamin D quartile and the risks

2016 Thyroid

175. Thyroid dysfunction among type 2 diabetic female Egyptian subjects (PubMed)

versus 7.4% (32.89±33.26 IU/mL) of controls (P<0.001). Anti-Tg was found in 61.3% (508.03±369.16 IU/mL) of patients versus 0 (51.26±35.53 IU/mL) controls (P<0.001). A significant positive correlation was found between TSH and antithyroid antibodies (anti-Tg, anti-TPO; P=0.002 and P=0.043, respectively) and between TSH and thyroid-gland volume (P=0.002) in diabetic patients. No correlation was found between any components of metabolic syndrome and thyroid antibodies in diabetic patients.Autoimmune

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2016 Therapeutics and clinical risk management

176. Fatal outcome in a Hispanic woman with moyamoya syndrome and Graves’ disease (PubMed)

Fatal outcome in a Hispanic woman with moyamoya syndrome and Graves’ disease We describe the case of a young Hispanic female who presented with thyrotoxicosis with seizures and ischemic stroke. She was diagnosed with a rare vasculopathy - moyamoya syndrome. After starting antithyroid therapy, her neurologic symptoms did not improve. Acute neurosurgical intervention had relieved her symptoms in the immediate post-operative period after re-anastomosis surgery. However, 2 post-operative days (...) revascularization surgery may protect the patient from perioperative mortality and morbidity.Although moyamoya disease is usually thought to be genetically associated, there are reports that thyroid antibodies may play a role in its pathogenesis and have an autoimmune link.Fluctuations in baseline thyroid function for patients with known Graves' disease may be a potentiating factor in exacerbating moyamoya vasculopathy.

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2016 Endocrinology, diabetes & metabolism case reports

177. Successful Re-administration of Low-dose of Methimazole (MMI) in Graves' Disease Patients Who Experienced Allergic Cutaneous Reactions to MMI at Initial Treatment and Had Received Long-term Propylthiouracil (PTU) (PubMed)

Successful Re-administration of Low-dose of Methimazole (MMI) in Graves' Disease Patients Who Experienced Allergic Cutaneous Reactions to MMI at Initial Treatment and Had Received Long-term Propylthiouracil (PTU) Objective When patients with Graves' disease show severe allergic cutaneous reactions, physicians often suggest that they undergo radioiodine therapy instead of receiving propylthiouracil (PTU), another antithyroid drug, because anti-neutrophil cytoplasmic antibody (ANCA) -related

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2016 Internal Medicine

178. Hyperthyroidism due to struma ovarii: Diagnostic pitfalls and preventing thyroid storm (PubMed)

Hyperthyroidism due to struma ovarii: Diagnostic pitfalls and preventing thyroid storm We report struma ovarii in a case that had hyperthyroidism and was treated with laparoscopic tumor resection. A 40-year-old Japanese woman presented with tachycardia, finger tremor, and weight loss. Although blood examination showed hyperthyroidism, test results for thyroid stimulating hormone receptor antibody and thyroid stimulating antibody were negative, and thyroid scintigraphy showed no abnormal (...) hyperthyroidism. Controlling the thyroid hormone level preoperatively by using antithyroid drugs and performing minimally invasive laparoscopic surgery is considered useful for preventing thyroid storm.

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2016 Gynecology and Minimally Invasive Therapy

179. Early pregnancy thyroid hormone reference ranges in Chilean women: The influence of body mass index (PubMed)

is a prospective observational study of 720 healthy Chilean women attending their first prenatal consultation at an outpatient clinic. Thyroid function [TSH, Free T4, Total T4 and antithyroid peroxidase antibodies (TPOAb)] and BMI were assessed at 8·8 ± 2·4 weeks of gestational age.Median, 2·5th percentile (p2·5), and 97·5th percentile (p97·5) TSH values were higher, while median, p2·5, and p97·5 free T4 values were lower in obese patients compared with normal weight patients. Obesity was associated (...) with a median TSH 16% higher (P = 0·035) and a median free T4 6·5% lower (P < 0·01) than values from patients with normal weight. BMI had a small, but statistically significant effect on TSH (P = 0·04) and free T4 (P < 0·01) when adjusted by maternal age, TPO antibodies, parity, sex of the newborn, gestational age and smoking. In all TPOAb (-) patients, median (p2·5-p.97·5) TSH was 1·96 mIU/l (0·11-5·96 mIU/l) and median (p2·5-p.97·5) free T4 was 14·54 pmol/l (11·1 - 19·02 pmol/l). Applying these reference

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2016 Clinical endocrinology

180. A patient has thyroid peroxidase antibodies, are there any interventions to prevent the development of hypothyroidism?

-2 or lithium. - As a risk factor for thyroid dysfunction during lithium or amiodarone therapy.” The same guideline discusses monitoring of patients who have TPOAb (see URL below for further details). An American Family Physician article on subclinical thyroid disease [2] reports: “Although the presence of antithyroid peroxidase antibodies increases the chance of progression to overt hypothyroidism, the panel found insufficient evidence to recommend for or against obtaining titers because (...) A patient has thyroid peroxidase antibodies, are there any interventions to prevent the development of hypothyroidism? A patient has thyroid peroxidase antibodies, are there any interventions to prevent the development of hypothyroidism? - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only

2008 TRIP Answers

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