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Antithyroid Antibody

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141. Vitamin D in Graves Disease: Levels, Correlation with Laboratory and Clinical Parameters, and Genetics Full Text available with Trip Pro

thyroxine (fT4), free triiodothyronine (fT3), thyrotropin receptor antibodies (TRAb), GO at diagnosis, or relapse after terminating treatment with antithyroid drugs. Two SNPs in VDR were associated with GD: rs10735810 (OR = 1.36, 95% CI: 1.02-1.36, p = 0.02) and rs1544410 (OR = 1.47, 95% CI: 1.03-1.47, p = 0.02). There was no difference in the mean vitamin D level between genotypes in either rs10735810 or rs154410.Patients with GD had lower vitamin D levels compared to the general population; however

2017 European thyroid journal

142. Subclinical Hypothyroidism and Thyroid Autoimmunity Are Not Associated With Fecundity, Pregnancy Loss, or Live Birth. Full Text available with Trip Pro

Subclinical Hypothyroidism and Thyroid Autoimmunity Are Not Associated With Fecundity, Pregnancy Loss, or Live Birth. Prior studies examining associations between subclinical hypothyroidism and antithyroid antibodies with early pregnancy loss and live birth suggest mixed results and time to pregnancy (TTP) has not been studied in this patient population.This study sought to examine associations of prepregnancy TSH concentrations and thyroid autoimmunity with TTP, pregnancy loss, and live birth (...) or the presence of antithyroid antibodies were not associated with fecundity, pregnancy loss, or live birth. Thus, women with subclinical hypothyroidism or thyroid autoimmunity can be reassured that their chances of conceiving and achieving a live birth are likely unaffected by marginal thyroid dysfunction.

2017 The Journal of clinical endocrinology and metabolism Controlled trial quality: predicted high

143. Total Thyroidectomy Versus Thionamides in Patients With Moderate-to-Severe Graves' Ophthalmopathy

the same following the initial decrease in ATD therapy after 6 months. Methods: This prospective randomized clinical trial with observer blinded analysis will analyze 60 patients with moderate-to-severe GO who receive Tx versus ATD without surgery. Main outcome variables include: muscle index measurements via ultrasound and thyroid antibody levels. Additional outcome variables include: CAScore/NOSPECS score, superonasal index measurements via ultrasound and quality of life score. Condition or disease (...) Intervention/treatment Phase Graves Disease Graves Ophthalmopathy Graves' Ophthalmopathy Worsened Drug: Antithyroid Drug Procedure: Total thyroidectomy Phase 3 Detailed Description: Introduction: Graves disease (GD) is characterized by thyrotoxicosis and goiter, arising through circulating autoantibodies that bind to and stimulate the thyroid hormone receptor (TSHR). Graves' ophthalmopathy (GO) is characterized by inflammation, expansion of the extraocular muscles and an increase in retroorbital fat

2017 Clinical Trials

144. Hypothyroidism in Patients With Type 1 Diabetes

of anti-thyroid antibodies at diagnosis of type 1 diabetes predicts the development of future thyroid disease as patients with antithyroid antibodies are 18 times more likely to develop thyroid disease than patients without anti-thyroid antibodies . Therefore, for early detection of hypothyroidism in children with type 1 diabetes, it is suggested to measure anti-thyroid antibodies and thyroid stimulating hormone at disease onset and in yearly intervals after the age of 12 yr. Furthermore (...) ): Romany Safwat, Assiut University Study Details Study Description Go to Brief Summary: Therefore, for early detection of hypothyroidism in children with type 1 diabetes, it is suggested to measure anti-thyroid antibodies and thyroid stimulating hormone at disease onset and in yearly intervals after the age of 12 yr. Furthermore, the International Society for Pediatric and Adolescent Diabetes Consensus Clinical Guidelines recommend the screening of thyroid function by analysing circulating thyroid

2017 Clinical Trials


measurements of thyrotropin, thyroid hormones, and thyroid antibodies. In most cases, thyroid ultrasound and thyroid scintigraphy were performed. Demographic characteristics and the type and the duration of treatment were also reviewed.The incidence of II-Hypo was significantly higher after the increase in iodine supply than it was before (p < 0.001). After the increase in iodine supply, the incidence of II-Hyper was significantly lower than before the increase (p < 0.001). Furthermore, the portion (...) of patients with overt hyperthyroidism decreased, predominantly due to the increased proportion of patients with subclinical hyperthyroidism (p = 0.007 and p = 0.015, respectively). The duration of treatment with antithyroid drugs and perchlorate was significantly shorter after the increase in iodine supply than it was before (p = 0.001 and p = 0.002, respectively). A significantly positive correlation between the year of the occurrence of excessive iodine intake (EII)-induced thyroid disease

2017 Thyroid

146. Diplopia in a patient with Hashimoto's thyroiditis: A case report and literature review. Full Text available with Trip Pro

-associated blood tests were performed; surprisingly, the thyroid function test results were consistent with hypothyroidism and the antibody results such as antithyroglobulin and antithyroid peroxidase were markedly elevated, and the patient was diagnosed with Hashimoto's thyroiditis and treated with corticosteroids. Unfortunately, her diplopia was not relieved with medical management. Subsequently, a 9-mm left inferior rectus recession was performed.Clinicians should be aware of the atypical signs

2017 Medicine

147. Thyroid dysfunction and autoimmune thyroid diseases among atomic-bomb survivors exposed in childhood. Full Text available with Trip Pro

atomic bomb radiation dose and the prevalence of hypothyroidism, hyperthyroidism (Graves' disease), and positive for antithyroid antibodies.Prevalences were determined for hypothyroidism (129 cases, 7.8%), hyperthyroidism (32 cases of Graves' disease, 1.2%), and positive for antithyroid antibodies (573 cases, 21.5%). None of these was associated with thyroid radiation dose. Neither thyroid antibody-positive nor -negative hypothyroidism was associated with thyroid radiation dose. Additional analyses

2017 Journal of Clinical Endocrinology and Metabolism

148. Hyperthyroidism in Pregnancy

Antithyroid medication use Poorly controlled High Receptor Perform monthly after 20 weeks Evaluate for fetal dysfunction Cardiac failure Antepartum testing Start testing at 32-34 weeks gestation (earlier if indicated by risk) VI. Imaging: Contraindicated Studies Absolutely contraindicated in pregnancy VII. Management is not typically treated in pregnancy Antithyroid medications (lowest effective dose that keeps <1.8 ng/dl) First trimester (and if trying to conceive) (risk of liver failure, hence (...) then change to after first trimester) Second and third trimester (and in ) (risk of in the first trimester) Symptomatic management Consider ( or ) for first 2-6 weeks while initiating antithyroid medication VIII. Course: Grave's Disease Fluctuating course during pregnancy symptoms increase in first trimester Results from HCG cross reactive stimulatory effect on the symptoms improve in second trimester symptoms worsen in third trimester IX. Complications Maternal Preterm delivery Fetal (and birth

2018 FP Notebook

149. Riedel's Thyroiditis

. Labs s (T4 Free and TSH) Most patients are euthyroid (70%) (Increased and decreased T4 Free) in up to 30% of cases Antithyroid peroxidase antibodies (>60%) occurs if fibrosis affects the adjacent s VII. Imaging ( uptake and scan) Low uptake (contrast with ) VIII. Diagnosis biopsy IX. Management: Tracheal or esophageal compression First-line Surgical decompression Other agents s ( ) (suppresses fibroblast proliferation) X. References Images: Related links to external sites (from Bing) These images

2018 FP Notebook

150. Thyroid Cancer Treatment (PDQ®): Patient Version

in the body. An unusual (higher or lower than normal) amount of a substance can be a sign of disease in the organ or tissue that makes it. The blood may be checked for abnormal levels of (TSH). TSH is made by the in the brain. It stimulates the release of thyroid hormone and controls how fast follicular thyroid cells grow. The blood may also be checked for high levels of the hormone and antithyroid antibodies. : A procedure in which a blood sample is checked to measure the amounts of certain substances (...) are not cancer. Your doctor may find a lump ( ) in your thyroid during a routine medical exam. A thyroid nodule is an growth of thyroid in the thyroid. Nodules may be solid or -filled. When a thyroid nodule is found, an of the thyroid and a are often done to check for of . to check thyroid hormone levels and for antithyroid in the may also be done to check for other types of thyroid disease. Thyroid nodules usually don't cause or need treatment. Sometimes the thyroid nodules become large enough

2016 PDQ - NCI's Comprehensive Cancer Database

151. Hyperthyroidism and Other Causes of Thyrotoxicosis

of antithyroid peroxidase antibodies (38). Thyroglobulin is released along with thyroid hormone in subacute, painless, and palpation thyroiditis, whereas its release is suppressed in the setting of exogenous thyroid hormone administration. Therefore, if not elucidated by the history, factitious ingestion of thyroid hormone can be distinguished from other causes of thyrotoxicosis by a low serum thyroglobulin level and a near-zero RAIU (39). In patients with antithyroglobulin antibodies, which interfere (...) than one treatment (150). The prevalence of hypothyroidism following 131 I therapy is increased by normalization or elevation of TSH at the time of treatment resulting from ATD pretreatment and by the presence of antithyroid antibodies (166). The activity of radioiodine used to treat TMNG, cal- culated on the basis of goiter size to deliver 150–200 µCi per gram of tissue corrected for 24-hour RAIU, is usu- ally higher than that needed to treat GD. In addition, the RAIU values for TMNG may be lower

2011 American Association of Clinical Endocrinologists

152. Hyperthyroidism secondary to hysterosalpingography: an extremely rare complication: A case report. Full Text available with Trip Pro

euthyroid woman who presented to our hospital with palpitation, hand tremor, fatigue, and excessive sweating after HSG. Thyroid function tests revealed a thyroid stimulating hormone (TSH) level of 0.012 μIU/mL (range 0.38-4.34 μIU/mL), free T4 of 2.886 ng/dL (range 0.81-1.89 ng/dL), and free T3 levels of 9.4 pg/mL (range 1.80-4.10 pg/mL), and antithyroglobulin antibody of 31.78 IU/mL (range <115 IU/mL). The triiodothyronine uptake was 3.057 ng/mL (range 0.66-1.92 ng/mL). Serum iodine (SI) and urinary (...) iodine (UI) levels: SI of 4717.748 μg/L (range 45-90 μg/L) and UI of 18069.336 μg/L (range 26-705 μg/L).The patient was diagnosed with iodine-induced hyperthyroidism (IIH), but was not treated with antithyroid drugs. She has spontaneously recovered and is pregnant currently.This is the first reported case of overt IIH caused by HSG in a euthyroid patient without risk factors. It suggests that HSG also leads to excessive iodine absorption, which induces secondary hyperthyroidism.

2016 Medicine

153. Clinical and etiologic evaluation of the children with chronic urticaria. (Abstract)

this study, we evaluated the clinical features, laboratory investigations, and provocation tests of children with different subtypes of CU according to a new classification.Two hundred and twenty-two children (59.9% girls) were enrolled in the study. Of the study patients, 59.9% and 40.1% were diagnosed as having CSU and CIndU, respectively. Antithyroid antibody levels were positive in 7.1% of the patients with CSU, 32.8% of the children had positive 14C-urea breath test results, and 6.5% of the patients

2016 Allergy and Asthma Proceedings

154. The natural history of subclinical hyperthyroidism in Graves' disease - the rule of thirds. (Abstract)

regression analysis showed that older age and positive antithyroid peroxidase (TPO) antibody status had a positive association with risk of progression to overt hyperthyroidism, with hazard ratios of 1.06 ([confidence interval (CI) 1.02-1.10], p < 0.01) per year and 10.15 ([CI 1.83-56.23], p < 0.01), respectively, independent of other risk factors including, smoking, TRAb levels at diagnosis, and sex.A third each of patients with SH due to GD progress, normalize, or remain in the SH state. Older people (...) by either a raised TSH receptor antibody (TRAb) level or uniform uptake on Technetium scan.Forty-four patients (89% female, 16% current smokers, and 5% with active Graves' orbitopathy) were diagnosed with SH due to GD. Over the follow-up period (median 32 months), approximately one third (34%) of the cohort progressed to overt hyperthyroidism, one third (34%) normalized their thyroid function, slightly less than one third (30%) remained in the SH state, while one person became hypothyroid. Multivariate

2016 Thyroid

155. Serum 25-Hydroxyvitamin D Level Does Not Affect the Aggressiveness and Prognosis of Papillary Thyroid Cancer. (Abstract)

, pathologic, and recurrence data were accessed to examine the prognostic effects of vitamin D. Patients were categorized into four quartiles by preoperative serum vitamin D levels.Of the enrolled patients, 795 (97%) had insufficient vitamin D levels (<30 ng/mL). Vitamin D levels showed positive correlations with age and body mass index (BMI), and negative correlations with serum thyrotropin levels and antithyroid peroxidase antibody titers. The association between vitamin D quartile and the risks

2016 Thyroid

156. Effects of low-carbohydrate diet therapy in overweight subjects with autoimmune thyroiditis: possible synergism with ChREBP Full Text available with Trip Pro

have evaluated the amount of either thyroid hormones, or antithyroid, or anti-microsomal, or anti-peroxidase antibodies (Abs) in patients with high amounts of Abs. In a diet devoid of carbohydrates (bread, pasta, fruit, and rice), free from goitrogenic food, and based on body mass index, the distribution of body mass and intracellular and extracellular water conducted for 3 weeks gives the following results: patients treated as above showed a significant reduction of antithyroid (-40%, P<0.013 (...) ), anti-microsomal (-57%, P<0.003), and anti-peroxidase (-44%, P<0,029) Abs. Untreated patients had a significant increase in antithyroid (+9%, P<0.017) and anti-microsomal (+30%, P<0.028) Abs. Even the level of anti-peroxidase Abs increased without reaching statistical significance (+16%, P>0064). With regard to the body parameters measured in patients who followed this diet, reduction in body weight (-5%, P<0.000) and body mass index (-4%, P<0.000) were observed. Since 83% of patients with high

2016 Drug design, development and therapy

157. Fatal outcome in a Hispanic woman with moyamoya syndrome and Graves’ disease Full Text available with Trip Pro

Fatal outcome in a Hispanic woman with moyamoya syndrome and Graves’ disease We describe the case of a young Hispanic female who presented with thyrotoxicosis with seizures and ischemic stroke. She was diagnosed with a rare vasculopathy - moyamoya syndrome. After starting antithyroid therapy, her neurologic symptoms did not improve. Acute neurosurgical intervention had relieved her symptoms in the immediate post-operative period after re-anastomosis surgery. However, 2 post-operative days (...) revascularization surgery may protect the patient from perioperative mortality and morbidity.Although moyamoya disease is usually thought to be genetically associated, there are reports that thyroid antibodies may play a role in its pathogenesis and have an autoimmune link.Fluctuations in baseline thyroid function for patients with known Graves' disease may be a potentiating factor in exacerbating moyamoya vasculopathy.

2016 Endocrinology, diabetes & metabolism case reports

158. An unusual cause of cerebellovestibular symptoms Full Text available with Trip Pro

. She had a history of similar, but milder, symptoms and was misdiagnosed several times. She had subclinical hypothyroidism, and high levels of antithyroid antibodies. There were abnormal MRI and visual evoked potential findings. After excluding other more common causes, we diagnosed her as having 'Hashimoto Encephalopathy', and started treatment with corticosteroids, on which she showed dramatic improvement. After about 2 years of presentation, the patient is able to continue her life independently

2016 BMJ case reports

159. Hashimoto Thyroiditis and Nephrocalcinosis in a Child with Down Syndrome Full Text available with Trip Pro

acidosis and alkaline urine consistent with dTRA. Abdominal ultrasound found nephrocalcinosis. In addition, Antithyroid peroxidase antibodies were positive, suggesting an autoimmune background for the pathogenesis of the tubular dysfunction. Treatment for dRTA and hypothyroidism was started and symptomatic improve was noticed.dRTA should be excluded in children with autoimmune disorders who develop weakness, polyuria, polydipsia or growth failure. Early diagnosis would reduce long-term complications.

2016 Acta Informatica Medica

160. Correlation of thyroid dysfunction and cognitive impairments induced by subcortical ischemic vascular disease Full Text available with Trip Pro

). Serum thyroid-stimulating hormone (TSH), total triiodothyronine (TT3), free triiodothyronine (FT3), total thyroxine (TT4) and free thyroxine (FT4), thyroglobulin antibody (TGA), and antithyroid peroxidase antibody (TPO-Abs) were quantified by radioimmunoassay or ELISA.A close correlation between thyroid status and cognitive dysfunction in SIVD was observed. Serum TT3 and FT3 levels decreased, whereas serum TSH level increased, with the decline in cognitive functions. Furthermore, TT3 levels showed

2016 Brain and behavior

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