How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

576 results for

Antithyroid Antibody

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

41. Evaluation of thyroid antibodies and benign disease prevalence among young adults exposed to 131I more than 25 years after the accident at the Chernobyl Nuclear Power Plant Full Text available with Trip Pro

Antibodies (TGAb) positive, Antithyroid Peroxidase Antibodies (TPOAb) positive, and TGAb and/or TPOAb positive between the study groups. (11.7% vs 10.3%; p = 0.602, 17.3% vs 13.0%; p = 0.136, 21.0% vs 17.3%; p = 0.254, respectively); after adjusting for age and sex, the prevalence was not associated with the (131)I exposure status in the study groups. The prevalence of subclinical and overt hypothyroidism cases was not significantly different (p = 0.093 and p = 0.320) in the two groups, nor (...) Evaluation of thyroid antibodies and benign disease prevalence among young adults exposed to 131I more than 25 years after the accident at the Chernobyl Nuclear Power Plant Background. The Chernobyl Nuclear Power Plant (CNPP) accident exposed a large number of inhabitants to internal (131)I radiation. The associations between internal (131)I exposure and thyroid autoimmunity and benign thyroid diseases remain controversial in the population living in the contaminated area around the CNNP

2016 PeerJ

42. Antineutrophilic Cytoplasmic Antibody Positive Vasculitis Associated with Methimazole Use Full Text available with Trip Pro

Antineutrophilic Cytoplasmic Antibody Positive Vasculitis Associated with Methimazole Use ANCA-associated vasculitis (AAV) is a rare and potentially life threatening complication associated with antithyroid drug use. It is more commonly reported with propylthiouracil, with fewer cases reported with methimazole use. We present the case of a 55-year-old man with toxic multinodular goiter which was treated with methimazole for 6 months. He developed ANCA positive leukocytoclastic vasculitis

2015 Case reports in endocrinology

43. Hypothyroidism as a Late Sequela in Patients with Graves' Disease Treated with Antithyroid Agents Full Text available with Trip Pro

Hypothyroidism as a Late Sequela in Patients with Graves' Disease Treated with Antithyroid Agents In 1971, thyroid function was evaluated in 15 unselected patients whose only therapy for diffuse toxic goiter was a course of thionamide drug treatment completed 20-27 yr earlier. One patient was frankly hypothyroid by clinical and laboratory criteria. The remaining 14 patients appeared clinically euthyroid and had a normal serum thyroxine (T(4)) concentration and thyroid radioiodine uptake (RAIU (...) responses to TSH. Fluorescent antimicrosomal antibody was found in the serum of 12 of the 15 patients, in contrast to an expected frequency of 7% in normal individuals of the same age. By the time a second major follow-up study was completed in 1978, two additional patients had become frankly hypothyroid. A third subject met accepted criteria for subclinical hypothyroidism. One of these subjects had had a clearly elevated serum TSH concentration in 1972, and the remaining two had exhibited the highest

1979 Journal of Clinical Investigation

44. Specific agglutination of tanned red cells coated with a globulin fraction of an antithyroid serum by saline extracts of thyroid glands Full Text available with Trip Pro

Specific agglutination of tanned red cells coated with a globulin fraction of an antithyroid serum by saline extracts of thyroid glands Experiments are described in which tanned red cells coated with a globulin fraction of human serum with a high titre of antibody to human thyroglobulin were agglutinated by saline extracts of human thyroid gland and thyroglobulin but not by other tissue extracts. It is suggested that the linkage is due to a specific antigen antibody reaction between cell-bound (...) antithyroid antibody and thyroglobulin in solution.

1965 Journal of Clinical Pathology

45. Antithyroid antibodies and parity: further evidence for microchimerism in autoimmune thyroid disease. (Abstract)

Antithyroid antibodies and parity: further evidence for microchimerism in autoimmune thyroid disease. Fetal microchimerism may have a role in development of autoimmune thyroid disorders. Using parity as a surrogate for increasing fetal cell exposure, we analyzed its association with thyroid peroxidase antibody levels.Secondary analysis of serum thyroid analytes determined in 17,298 women from a population-based prospective study between 2001 and 2003. Sera were assayed for thyrotropin, free (...) thyroxine, and antithyroid peroxidase antibodies. We analyzed the relationship between thyroid peroxidase antibodies and increasing parity.The incidence of abnormally elevated thyroid peroxidase antibody levels (>50 IU/mL) increased with advancing parity, but was not significant after adjustment for maternal characteristics. However, at higher thyroid peroxidase antibody levels (>500 IU/mL), a significant relationship with advancing parity persisted after adjustments (P = .002).Advancing parity

2011 American Journal of Obstetrics and Gynecology

46. Which Thyroid Antibody Assays Should be Checked in Patients with Thyroid Disease?

thyroid Routine Screening No ITD = immune thyroid diseases, AIDs = autoimmune diseases, ATPO = Antithyroid peroxidase antibodies, ATg = Antithyroglobulin antibodies, TSI = Thyroid stimulating immunoglobulin, FNB fine needle biopsy of thyroid nodule, Rx = treat References 1 Adams DD, Fastier FN, Howie JB et al. Stimulation of the human thyroid by infusions of plasma containing LATS protector. J Clin Endocrinol Metab 1974; 39:826. 2 Hadj-Kacem H, Rebuffat S, Mnif-Feki M, Belguith-Maalej S, Ayadi H (...) Which Thyroid Antibody Assays Should be Checked in Patients with Thyroid Disease? Which Thyroid Antibody Assays Should be Checked in Patients with Thyroid Disease? – Clinical Correlations Search Which Thyroid Antibody Assays Should be Checked in Patients with Thyroid Disease? April 14, 2010 7 min read Michael Chu MD Faculty peer reviewed Case: A 44-year old female presented to the emergency room with complaints of a lower extremity rash and swelling. The patient had been in her usual state

2010 Clinical Correlations

47. Differentiation of Postpartum Graves' Thyrotoxicosis from Postpartum Destructive Thyrotoxicosis by Anti-TSH Receptor Antibodies and Thyroid Blood Flow. (Abstract)

-TSH receptor antibodies (TRAb), antithyroglobulin antibodies (TgAb), and antithyroid peroxidase antibodies (TPOAb) were measured by the Elecsys electrochemiluminescence immunoassay. Thyroid volume and blood flow (TBF) were measured quantitatively by color flow Doppler ultrasonography.Onset of thyrotoxicosis was distributed from 2 to 12 months postpartum. Twelve (85.7%) of 14 patients who developed thyrotoxicosis at three months or earlier after delivery had PPDT. On the other hand, all 11 patients (...) Differentiation of Postpartum Graves' Thyrotoxicosis from Postpartum Destructive Thyrotoxicosis by Anti-TSH Receptor Antibodies and Thyroid Blood Flow. Postpartum thyroid dysfunction occurs in approximately 5-10% of women in the general population within one year of delivery. Differentiation of postpartum Graves' thyrotoxicosis (PPGr) from postpartum destructive thyrotoxicosis (PPDT) is essential because of the difference in treatment measures between the two. However, it is sometimes difficult

2014 Thyroid

48. CLINICAL UTILITY OF TSH RECEPTOR ANTIBODIES. Full Text available with Trip Pro

CLINICAL UTILITY OF TSH RECEPTOR ANTIBODIES. TSH receptor antibodies (TRAb) cause Graves' disease (GD) hyperthyroidism. Widely available TRAb measurement methods have been significantly improved recently. However, the role of TRAb measurement in the differential diagnosis of hyperthyroidism, the prediction of remission of GD hyperthyroidism, the prediction of fetal/neonatal thyrotoxicosis, and the clinical assessment of Graves' ophthalmopathy (GO) are controversial.We reviewed and analyzed (...) the literature reporting primary data on the clinical use of TRAb. We focused our analyses on clinical studies analyzing third-generation TRAb assays.The performance of TRAb in the differential diagnosis of overt hyperthyroidism is excellent, with sensitivity and specificity in the upper 90%. TRAb can accurately predict short-term relapses of hyperthyroidism after a course of antithyroid drugs but are less effective in predicting long-term relapses or remissions. Pregnancies in women with GD with negative

2013 Journal of Clinical Endocrinology and Metabolism

49. Metastatic melanoma: spontaneous occurrence of auto antibodies is a good prognosis factor in a prospective cohort. (Abstract)

melanoma.From 2007 to 2008, 103 patients were studied with antithyroid and antinuclear auto antibody assays performed every 6 months. Any detectable occurrence of a spontaneous self antibody (SpSA) at the upper detection limit, at least for one assay, was considered to be a biological marker of autoimmunity.Univariate and multivariate analyses confirmed significantly longer survival in the absence of known primary melanoma (P = 0.044) and in the presence of marker of biologic autoimmunity, independently (...) Metastatic melanoma: spontaneous occurrence of auto antibodies is a good prognosis factor in a prospective cohort. Melanoma is an immunogenic tumour type frequently associated with spontaneous auto-immune manifestations such as spontaneous regression, vitiligo-like reactions or auto-immune retinopathy, which seem to be associated with better prognosis.The aim of this prospective study was to evaluate the correlation between spontaneous autoimmunity and survival in patients with stage IV

2013 Journal of the European Academy of Dermatology and Venereology

50. LATE PRIMARY AUTOIMMUNE HYPOTHYROIDISM IN A PATIENT WITH POST-DELIVERY AUTOIMMUNE HYPOPITUITARISM ASSOCIATED WITH ANTIBODIES TO GROWTH HORMONE- AND PROLACTIN-SECRETING CELLS. (Abstract)

and insulin-like growth factor-1 concentrations. Thyroid function was normal when initially investigated three months after delivery, but five months later, marked primary hypothyroidism (thyrotropin levels >100 mIU/L) occurred. Immunological investigation revealed the presence of antipituitary antibodies, identified by double immunofluorescence and targeting GH- and prolactin-secreting cells. Antithyroid antibodies, in the normal range three months postpartum, became significantly elevated when (...) LATE PRIMARY AUTOIMMUNE HYPOTHYROIDISM IN A PATIENT WITH POST-DELIVERY AUTOIMMUNE HYPOPITUITARISM ASSOCIATED WITH ANTIBODIES TO GROWTH HORMONE- AND PROLACTIN-SECRETING CELLS. Pituitary and thyroid autoimmunity can be triggered by pregnancy. We report the first association of combined growth hormone (GH) and prolactin secretion deficiency due to autoimmune damage to GH- and prolactin-secreting cells in a patient with postdelivery lactation failure, presenting subsequently with primary autoimmune

2013 Thyroid

51. Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis. (Abstract)

Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis. Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) refers to a group of potentially life-threatening autoimmune diseases. A recent development in this field is the recognition that certain drugs can induce AAV. Among these agents, the drug most often implicated in causing disease is the commonly used antithyroid agent propylthiouracil (PTU). This Review provides an update on PTU-induced AAV

2012 Nature reviews. Nephrology

52. Anti‑livin antibodies in Hashimoto thyroiditis. (Abstract)

apoptosis.The study comprised 65 women with Hashimoto thyroiditis and the control group of 40 healthy women. In the majority of the patients, clinical manifestations of hypothyroidism were observed; all patients had high levels of serum antithyroid peroxidase antibodies. A solid‑phase radioimmunoassay in livin‑coated polyethylene tubes using 125I-labeled protein A was used to determine anti-livin antibodies.Significant amounts of anti-livin antibodies were reported in 18 patients (26.8%); 3 patients (4.6 (...) Anti‑livin antibodies in Hashimoto thyroiditis. Livin belongs to the family of apoptosis inhibitors. High livin expression is observed in malignancies of the gastrointestinal tract, lungs, breast, and kidneys, but it is not present in differentiated adult tissues. In some malignant processes, anti‑livin antibodies are present.The aim of the study was to evaluate the prevalence of anti‑livin antibodies in Hashimoto thyroiditis, a disease characterized by rapid and widespread thyrocyte

2012 Polskie Archiwum Medycyny Wewnetrznej

53. Arthritis Associated With Antithyroid Therapy in a 15-Year-Old Girl Full Text available with Trip Pro

threatening. Arthritis is an uncommon but serious side effect and can develop as a part of the antithyroid arthritis syndrome or as a part of antineutrophil cytoplasmic antibody-associated vasculitis that is induced by antithyroid drugs. Little is known about the exact pathogenesis. Therapy consists of prompt discontinuation of the drug, where upon symptoms rapidly disappear. Because of possible cross-reactivity with alternative thionamides, another form of treatment for hyperthyroidism is recommended (...) Arthritis Associated With Antithyroid Therapy in a 15-Year-Old Girl A 15-year-old white girl with autoimmune thyroiditis developed arthritis 3 weeks after starting therapy with the antithyroid drug thiamazole. Because an adverse drug reaction of thionamide therapy was suspected, thiamazole was withdrawn, and symptoms disappeared rapidly. Thionamide therapy is indicated for hyperthyroidism and has been widely used since 1948. Reported adverse drug reactions range from mild to potentially life

2011 The Journal of Pediatric Pharmacology and Therapeutics : JPPT

54. The role of TSH receptor antibodies in the management of Graves' disease. (Abstract)

clinical scenarios such as in the differential diagnosis of unilateral exophthalmos, euthyroid Graves' ophthalmopathy, subclinical hyperthyroidism, thyrotoxicosis associated with hyperemesis gravidarum, amiodarone-induced thyrotoxicosis and painless thyroiditis. It may also have a role in predicting the risk of a recurrence of Graves' disease following a course of antithyroid drug treatment. One further clinical utility of the TRAb test is in pregnancy where antibody titre measured during the third (...) The role of TSH receptor antibodies in the management of Graves' disease. The central role of thyrotropin receptor antibodies (TRAbs) in the pathogenesis of Graves' disease has been recognised for several decades. However, the practical application of testing for TRAbs in clinical decision making remains the subject of controversy. The diagnosis of Graves' disease can be made in most cases simply based on a patient's clinical presentation. The TRAb test is therefore of most value in ambiguous

2011 European journal of internal medicine

55. Decreased CD4+CD152+ T cell subset and its correlation with the level of antithyroid antibodies in children with chronic autoimmune thyroiditis Full Text available with Trip Pro

Decreased CD4+CD152+ T cell subset and its correlation with the level of antithyroid antibodies in children with chronic autoimmune thyroiditis Cytotoxic T lymphocyte antigen-4 (CTLA-4) is one of the basic antigens involved in immune responses regulation associated with autoimmune thyroid diseases. The aim of the study was to evaluate whether the surface expression of CTLA-4(CD152) on T cells is correlated with laboratory autoimmune markers in children with Hashimoto's disease.Blood samples (...) were obtained from 45 children with Hashimoto's thyroiditis of the mean age 14.8 ±2.35 years, and from 55 healthy age-matched children, free of allergic, immune and hematological disorders, and with a normal thyroid function. The anti-thyroid antibodies were measured with Microparticle Enzyme Immunoassay (AxSYM Anti-Tg, AxSYM Anti-TPO). The T cell phenotype was evaluated flow cytometery, with the use of monoclonal antibodies combination: CD4- FITC/ CD28 -PC5/ CD152 -PE and CD8 -FITC/ CD28 -PC5

2010 European Journal Of Medical Research

56. Thyroid disease: assessment and management

with Graves' disease or toxic nodular goitre 42 Antithyroid drugs for people with hyperthyroidism 43 Follow-up and monitoring of hyperthyroidism 45 Managing and monitoring subclinical hyperthyroidism 46 Investigating non-malignant thyroid enlargement with normal thyroid function 47 Managing non-malignant thyroid enlargement 49 Context 51 Key facts and figures 51 Current practice 52 Finding more information and resources 53 Thyroid disease: assessment and management (NG145) © NICE 2019. All rights reserved (...) treatment options (for example, antithyroid drugs may be Thyroid disease: assessment and management (NG145) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 7 of 53more suitable for mild uncomplicated Graves' disease, surgery may be best for an enlarged thyroid causing compression, radioactive iodine is not usually suitable before puberty) the possible benefits/advantages of the treatment options (for example

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

57. Turner's syndrome

karyotype audiology testing bone age echocardiogram cardiac MRI serum FSH and anti-Müllerian hormone (AMH) skeletal survey pelvic ultrasound renal ultrasound TFTs antithyroid antibodies LFTs/gamma GT fasting glucose and HbA1c serum lipids IgA level and tissue transglutaminase IgA Treatment algorithm ACUTE ONGOING Contributors Authors Medical Director Disorders of Sex Development Program Seattle Children’s Hospital Associate Professor of Pediatrics University of Washington Seattle WA Disclosures PYF

2018 BMJ Best Practice

58. Urticaria and angio-oedema

ESR C-reactive protein anti-IgE receptor antibody and related tests thyroid-stimulating hormone (TSH) antithyroid antibodies antinuclear antibodies (ANA) skin biopsy C4 level C1-esterase inhibitor level C1-esterase inhibitor function C1q levels Treatment algorithm ACUTE ONGOING Contributors Authors Allergy and Clinical Immunology Rochester Regional Health Clinical Assistant Professor of Medicine University of Rochester School of Medicine & Dentistry Rochester NY Disclosures SSM is on the speakers

2018 BMJ Best Practice

59. Subacute granulomatous thyroiditis

recent viral infection myalgia malaise tremor heat intolerance viral infection HLA-Bw35 and B35 Diagnostic investigations thyroid-stimulating hormone (TSH) total T4, total T3, T3 resin uptake, free thyroxine index T3:T4 ratio radioactive iodine uptake ESR CRP antithyroid antibodies (thyroid peroxidase antibodies) fine needle aspiration biopsy ultrasonography of thyroid salivary CRP Treatment algorithm ACUTE Contributors Authors Associate Chief Director of the Thyroid Health Center Section

2018 BMJ Best Practice

60. Primary hypothyroidism

antithyroid peroxidase antibodies Treatment algorithm ONGOING Contributors Authors Adjunct Clinical Professor Department of Family Medicine University of North Carolina Chapel Hill NC Disclosures WM declares that he has no competing interests. Peer reviewers Professor of Medicine Chair of Family Medicine University of Chicago Medical Center Chicago IL Disclosures BE declares that he has no competing interests. Consultant Endocrinologist Queen Elizabeth Hospital Gateshead UK Disclosures SR declares that he

2018 BMJ Best Practice

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>