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Antithyroid Antibody

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41. Presence of organ‑specific antibodies in patients with systemic sclerosis. (PubMed)

Presence of organ‑specific antibodies in patients with systemic sclerosis. INTRODUCTION According to the literature, organ‑specific antibodies may be present in the course of systemic sclerosis (SSc). OBJECTIVES The aim of this study was to assess the prevalence of antithyroid antibodies (antithyroid peroxidase antibodies [anti‑TPO] and antithyroglobulin antibodies) and of antimitochondrial antibodies (AMAs), as well as to evaluate their clinical significance in patients with SSc. PATIENTS (...) AND METHODS The study involved 86 consecutive in‑hospital patients with SSc (32 patients with diffuse cutaneous SSc [dcSSc] and 54 with limited cutaneous SSc [lcSSc]). Patients were observed for autoimmune thyroid diseases (ATDs) and primary biliary cirrhosis (PBC). Serum samples were obtained from each patient. RESULTS Positive antithyroid antibody titers were observed in 27 patients (31%) and positive AMA titers-in 11 patients (13%). ATD was diagnosed in 26 patients (30%) and PBC-in 10 patients (12

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2016 Polskie Archiwum Medycyny Wewnetrznej

42. Evaluation of thyroid antibodies and benign disease prevalence among young adults exposed to 131I more than 25 years after the accident at the Chernobyl Nuclear Power Plant (PubMed)

Antibodies (TGAb) positive, Antithyroid Peroxidase Antibodies (TPOAb) positive, and TGAb and/or TPOAb positive between the study groups. (11.7% vs 10.3%; p = 0.602, 17.3% vs 13.0%; p = 0.136, 21.0% vs 17.3%; p = 0.254, respectively); after adjusting for age and sex, the prevalence was not associated with the (131)I exposure status in the study groups. The prevalence of subclinical and overt hypothyroidism cases was not significantly different (p = 0.093 and p = 0.320) in the two groups, nor (...) Evaluation of thyroid antibodies and benign disease prevalence among young adults exposed to 131I more than 25 years after the accident at the Chernobyl Nuclear Power Plant Background. The Chernobyl Nuclear Power Plant (CNPP) accident exposed a large number of inhabitants to internal (131)I radiation. The associations between internal (131)I exposure and thyroid autoimmunity and benign thyroid diseases remain controversial in the population living in the contaminated area around the CNNP

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2016 PeerJ

43. Arthritis Associated With Antithyroid Therapy in a 15-Year-Old Girl (PubMed)

threatening. Arthritis is an uncommon but serious side effect and can develop as a part of the antithyroid arthritis syndrome or as a part of antineutrophil cytoplasmic antibody-associated vasculitis that is induced by antithyroid drugs. Little is known about the exact pathogenesis. Therapy consists of prompt discontinuation of the drug, where upon symptoms rapidly disappear. Because of possible cross-reactivity with alternative thionamides, another form of treatment for hyperthyroidism is recommended (...) Arthritis Associated With Antithyroid Therapy in a 15-Year-Old Girl A 15-year-old white girl with autoimmune thyroiditis developed arthritis 3 weeks after starting therapy with the antithyroid drug thiamazole. Because an adverse drug reaction of thionamide therapy was suspected, thiamazole was withdrawn, and symptoms disappeared rapidly. Thionamide therapy is indicated for hyperthyroidism and has been widely used since 1948. Reported adverse drug reactions range from mild to potentially life

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2011 The Journal of Pediatric Pharmacology and Therapeutics : JPPT

44. Hypothyroidism as a Late Sequela in Patients with Graves' Disease Treated with Antithyroid Agents (PubMed)

Hypothyroidism as a Late Sequela in Patients with Graves' Disease Treated with Antithyroid Agents In 1971, thyroid function was evaluated in 15 unselected patients whose only therapy for diffuse toxic goiter was a course of thionamide drug treatment completed 20-27 yr earlier. One patient was frankly hypothyroid by clinical and laboratory criteria. The remaining 14 patients appeared clinically euthyroid and had a normal serum thyroxine (T(4)) concentration and thyroid radioiodine uptake (RAIU (...) responses to TSH. Fluorescent antimicrosomal antibody was found in the serum of 12 of the 15 patients, in contrast to an expected frequency of 7% in normal individuals of the same age. By the time a second major follow-up study was completed in 1978, two additional patients had become frankly hypothyroid. A third subject met accepted criteria for subclinical hypothyroidism. One of these subjects had had a clearly elevated serum TSH concentration in 1972, and the remaining two had exhibited the highest

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1979 Journal of Clinical Investigation

45. Specific agglutination of tanned red cells coated with a globulin fraction of an antithyroid serum by saline extracts of thyroid glands (PubMed)

Specific agglutination of tanned red cells coated with a globulin fraction of an antithyroid serum by saline extracts of thyroid glands Experiments are described in which tanned red cells coated with a globulin fraction of human serum with a high titre of antibody to human thyroglobulin were agglutinated by saline extracts of human thyroid gland and thyroglobulin but not by other tissue extracts. It is suggested that the linkage is due to a specific antigen antibody reaction between cell-bound (...) antithyroid antibody and thyroglobulin in solution.

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1965 Journal of Clinical Pathology

46. There is no association between the presence of anti-thyroid antibodies and increased reproductive loss in pregnant women after ART: a systematic review and meta-analysis. (PubMed)

in pregnancies resulting from ART. MEDLINE via PubMed, LILACS and Embase were searched for studies published in peer-reviewed journals from 1999 to 2017. The studies were summarized using the fixed effects model and the Peto's method to calculate RR in order to flesh out the association between TAI and spontaneous abortion. Only four papers were included in this systematic review and meta-analysis. Thirty-one miscarriages were observed in 210 clinical pregnancies of women with antithyroid antibodies; and 158 (...) miscarriages were seen in 1,371 pregnancies without antithyroid antibodies. The meta-analysis failed to find an association between TAI and higher risk of reproductive loss, RR=0.94 95% confidence interval: 0.71-1.24; p=0.879. In conclusion, the presence of antithyroid antibodies was not associated with increased reproductive loss in patients submitted to ART treatments. It is our opinion that the presence of antithyroid antibodies should be considered as a secondary biomarker of autoimmune disease, rather

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2017 JBRA assisted reproduction

47. Which Thyroid Antibody Assays Should be Checked in Patients with Thyroid Disease?

thyroid Routine Screening No ITD = immune thyroid diseases, AIDs = autoimmune diseases, ATPO = Antithyroid peroxidase antibodies, ATg = Antithyroglobulin antibodies, TSI = Thyroid stimulating immunoglobulin, FNB fine needle biopsy of thyroid nodule, Rx = treat References 1 Adams DD, Fastier FN, Howie JB et al. Stimulation of the human thyroid by infusions of plasma containing LATS protector. J Clin Endocrinol Metab 1974; 39:826. 2 Hadj-Kacem H, Rebuffat S, Mnif-Feki M, Belguith-Maalej S, Ayadi H (...) Which Thyroid Antibody Assays Should be Checked in Patients with Thyroid Disease? Which Thyroid Antibody Assays Should be Checked in Patients with Thyroid Disease? – Clinical Correlations Search Which Thyroid Antibody Assays Should be Checked in Patients with Thyroid Disease? April 14, 2010 7 min read Michael Chu MD Faculty peer reviewed Case: A 44-year old female presented to the emergency room with complaints of a lower extremity rash and swelling. The patient had been in her usual state

2010 Clinical Correlations

48. Antineutrophilic Cytoplasmic Antibody Positive Vasculitis Associated with Methimazole Use (PubMed)

Antineutrophilic Cytoplasmic Antibody Positive Vasculitis Associated with Methimazole Use ANCA-associated vasculitis (AAV) is a rare and potentially life threatening complication associated with antithyroid drug use. It is more commonly reported with propylthiouracil, with fewer cases reported with methimazole use. We present the case of a 55-year-old man with toxic multinodular goiter which was treated with methimazole for 6 months. He developed ANCA positive leukocytoclastic vasculitis

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2015 Case reports in endocrinology

49. Decreased CD4+CD152+ T cell subset and its correlation with the level of antithyroid antibodies in children with chronic autoimmune thyroiditis (PubMed)

Decreased CD4+CD152+ T cell subset and its correlation with the level of antithyroid antibodies in children with chronic autoimmune thyroiditis Cytotoxic T lymphocyte antigen-4 (CTLA-4) is one of the basic antigens involved in immune responses regulation associated with autoimmune thyroid diseases. The aim of the study was to evaluate whether the surface expression of CTLA-4(CD152) on T cells is correlated with laboratory autoimmune markers in children with Hashimoto's disease.Blood samples (...) were obtained from 45 children with Hashimoto's thyroiditis of the mean age 14.8 ±2.35 years, and from 55 healthy age-matched children, free of allergic, immune and hematological disorders, and with a normal thyroid function. The anti-thyroid antibodies were measured with Microparticle Enzyme Immunoassay (AxSYM Anti-Tg, AxSYM Anti-TPO). The T cell phenotype was evaluated flow cytometery, with the use of monoclonal antibodies combination: CD4- FITC/ CD28 -PC5/ CD152 -PE and CD8 -FITC/ CD28 -PC5

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2010 European Journal Of Medical Research

50. Differentiation of Postpartum Graves' Thyrotoxicosis from Postpartum Destructive Thyrotoxicosis by Anti-TSH Receptor Antibodies and Thyroid Blood Flow. (PubMed)

-TSH receptor antibodies (TRAb), antithyroglobulin antibodies (TgAb), and antithyroid peroxidase antibodies (TPOAb) were measured by the Elecsys electrochemiluminescence immunoassay. Thyroid volume and blood flow (TBF) were measured quantitatively by color flow Doppler ultrasonography.Onset of thyrotoxicosis was distributed from 2 to 12 months postpartum. Twelve (85.7%) of 14 patients who developed thyrotoxicosis at three months or earlier after delivery had PPDT. On the other hand, all 11 patients (...) Differentiation of Postpartum Graves' Thyrotoxicosis from Postpartum Destructive Thyrotoxicosis by Anti-TSH Receptor Antibodies and Thyroid Blood Flow. Postpartum thyroid dysfunction occurs in approximately 5-10% of women in the general population within one year of delivery. Differentiation of postpartum Graves' thyrotoxicosis (PPGr) from postpartum destructive thyrotoxicosis (PPDT) is essential because of the difference in treatment measures between the two. However, it is sometimes difficult

2014 Thyroid

51. CLINICAL UTILITY OF TSH RECEPTOR ANTIBODIES. (PubMed)

CLINICAL UTILITY OF TSH RECEPTOR ANTIBODIES. TSH receptor antibodies (TRAb) cause Graves' disease (GD) hyperthyroidism. Widely available TRAb measurement methods have been significantly improved recently. However, the role of TRAb measurement in the differential diagnosis of hyperthyroidism, the prediction of remission of GD hyperthyroidism, the prediction of fetal/neonatal thyrotoxicosis, and the clinical assessment of Graves' ophthalmopathy (GO) are controversial.We reviewed and analyzed (...) the literature reporting primary data on the clinical use of TRAb. We focused our analyses on clinical studies analyzing third-generation TRAb assays.The performance of TRAb in the differential diagnosis of overt hyperthyroidism is excellent, with sensitivity and specificity in the upper 90%. TRAb can accurately predict short-term relapses of hyperthyroidism after a course of antithyroid drugs but are less effective in predicting long-term relapses or remissions. Pregnancies in women with GD with negative

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2013 Journal of Clinical Endocrinology and Metabolism

52. Metastatic melanoma: spontaneous occurrence of auto antibodies is a good prognosis factor in a prospective cohort. (PubMed)

melanoma.From 2007 to 2008, 103 patients were studied with antithyroid and antinuclear auto antibody assays performed every 6 months. Any detectable occurrence of a spontaneous self antibody (SpSA) at the upper detection limit, at least for one assay, was considered to be a biological marker of autoimmunity.Univariate and multivariate analyses confirmed significantly longer survival in the absence of known primary melanoma (P = 0.044) and in the presence of marker of biologic autoimmunity, independently (...) Metastatic melanoma: spontaneous occurrence of auto antibodies is a good prognosis factor in a prospective cohort. Melanoma is an immunogenic tumour type frequently associated with spontaneous auto-immune manifestations such as spontaneous regression, vitiligo-like reactions or auto-immune retinopathy, which seem to be associated with better prognosis.The aim of this prospective study was to evaluate the correlation between spontaneous autoimmunity and survival in patients with stage IV

2013 Journal of the European Academy of Dermatology and Venereology

53. LATE PRIMARY AUTOIMMUNE HYPOTHYROIDISM IN A PATIENT WITH POST-DELIVERY AUTOIMMUNE HYPOPITUITARISM ASSOCIATED WITH ANTIBODIES TO GROWTH HORMONE- AND PROLACTIN-SECRETING CELLS. (PubMed)

and insulin-like growth factor-1 concentrations. Thyroid function was normal when initially investigated three months after delivery, but five months later, marked primary hypothyroidism (thyrotropin levels >100 mIU/L) occurred. Immunological investigation revealed the presence of antipituitary antibodies, identified by double immunofluorescence and targeting GH- and prolactin-secreting cells. Antithyroid antibodies, in the normal range three months postpartum, became significantly elevated when (...) LATE PRIMARY AUTOIMMUNE HYPOTHYROIDISM IN A PATIENT WITH POST-DELIVERY AUTOIMMUNE HYPOPITUITARISM ASSOCIATED WITH ANTIBODIES TO GROWTH HORMONE- AND PROLACTIN-SECRETING CELLS. Pituitary and thyroid autoimmunity can be triggered by pregnancy. We report the first association of combined growth hormone (GH) and prolactin secretion deficiency due to autoimmune damage to GH- and prolactin-secreting cells in a patient with postdelivery lactation failure, presenting subsequently with primary autoimmune

2013 Thyroid

54. Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis. (PubMed)

Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis. Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) refers to a group of potentially life-threatening autoimmune diseases. A recent development in this field is the recognition that certain drugs can induce AAV. Among these agents, the drug most often implicated in causing disease is the commonly used antithyroid agent propylthiouracil (PTU). This Review provides an update on PTU-induced AAV

2012 Nature reviews. Nephrology

55. The role of TSH receptor antibodies in the management of Graves' disease. (PubMed)

clinical scenarios such as in the differential diagnosis of unilateral exophthalmos, euthyroid Graves' ophthalmopathy, subclinical hyperthyroidism, thyrotoxicosis associated with hyperemesis gravidarum, amiodarone-induced thyrotoxicosis and painless thyroiditis. It may also have a role in predicting the risk of a recurrence of Graves' disease following a course of antithyroid drug treatment. One further clinical utility of the TRAb test is in pregnancy where antibody titre measured during the third (...) The role of TSH receptor antibodies in the management of Graves' disease. The central role of thyrotropin receptor antibodies (TRAbs) in the pathogenesis of Graves' disease has been recognised for several decades. However, the practical application of testing for TRAbs in clinical decision making remains the subject of controversy. The diagnosis of Graves' disease can be made in most cases simply based on a patient's clinical presentation. The TRAb test is therefore of most value in ambiguous

2011 European journal of internal medicine

56. Preconception steroid treatment in infertile women with antithyroid autoimmunity undergoing ovarian stimulation and intrauterine insemination: a double-blind, randomized, prospective cohort study. (PubMed)

Preconception steroid treatment in infertile women with antithyroid autoimmunity undergoing ovarian stimulation and intrauterine insemination: a double-blind, randomized, prospective cohort study. This study investigated the role of a steroid pretreatment on the pregnancy rate and pregnancy outcomes in patients positive for antithyroid antibodies who were undergoing induction of ovulation and intrauterine insemination (IUI).A double-blind, randomized, prospective cohort study was conducted (...) autoimmunity. The patients with antithyroid autoimmunity were randomly assigned in a blinded manner to an intervention group treated with prednisone (administered orally for 4 weeks before IUI) or a group given matching placebo. The primary objective was to compare the pregnancy and miscarriage rates among all 3 the groups.The study included 98 infertile women: 48 with antithyroid autoimmunity (antibody positive) and 50 without antithyroid autoimmunity (antibody negative). The study groups were comparable

2010 Clinical therapeutics Controlled trial quality: predicted high

57. Benefit of short-term iodide supplementation to antithyroid drug treatment of thyrotoxicosis due to Graves' disease. (PubMed)

Benefit of short-term iodide supplementation to antithyroid drug treatment of thyrotoxicosis due to Graves' disease. Combined treatment with anti-thyroid drugs (ATDs) and potassium iodide (KI) has been used only for severe thyrotoxicosis or as a pretreatment before urgent thyroidectomy in patients with Graves' disease. We compared methimazole (MMI) treatment with MMI + KI treatment in terms of rapid normalization of thyroid hormones during the early phase and examined the later induction (...) and TSH were measured by chemiluminescent immunoassays. TSH receptor antibody (TRAb) was assayed with TRAb-ELISA. Goitre size was estimated by ultrasonography.After 2 weeks of treatment, normal FT4 was observed in 29% of patients in Group 1 and 59% (P < 0.05) of patients in Group 2. Furthermore, normal FT4 after 2 weeks of treatment was observed in 27% of patients in Group 3 and 54% (P < 0.05) of patients in Group 4. Similarly, FT3 normalized more rapidly in Groups 2 and 4 than in Groups 1 and 3. None

2010 Clinical endocrinology Controlled trial quality: uncertain

58. Clinical Characteristics of Myeloperoxidase Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Caused by Antithyroid Drugs. (PubMed)

Clinical Characteristics of Myeloperoxidase Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Caused by Antithyroid Drugs. The clinical characteristics of myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis caused by antithyroid drugs are still unclear because most reports describe only a small number of patients.The objective was to analyze a large number of patients with MPO-ANCA-associated vasculitis to determine the time of onset, the drug and dose (...) taken, the clinical symptoms, the relationship between the clinical symptoms and the MPO-ANCA titer, and the incidence.We analyzed 92 patients in whom the adverse reaction of MPO-ANCA-associated vasculitis was reported to Chugai Pharmaceutical, a company that markets antithyroid drugs.Of the 92 patients, 41 (44.6%) had single-organ failure, 32 (34.8%) had two-organ failure, 13 (14.1%), had three-organ failure, and two (2.2%) had four-organ failure. The number of organs involved was unknown

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2009 Journal of Clinical Endocrinology and Metabolism

59. Graves' disease

of hyperthyroidism. Diagnostic tests are suppressed serum TSH, elevated levels of circulating thyroid hormones, detectable TSH receptor antibodies, and high thyroid uptake of radioactive iodine (or technetium 99). Treatment options are antithyroid drugs, radioactive iodine therapy, and thyroid surgery. Untreated hyperthyroidism, particularly in older people, may result in cardiac arrhythmias, high-output cardiac failure, bone mineral loss, and, rarely, thyroid storm. Unusual complications include vision loss (...) Graves' disease Graves' disease - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Graves' disease Last reviewed: February 2019 Last updated: April 2018 Summary Most common cause of hyperthyroidism in countries with sufficient iodine intake. Caused by TSH receptor antibodies. Extrathyroidal manifestations include orbitopathy, pretibial myxoedema (thyroid dermopathy), or acropachy, which do not occur with other causes

2018 BMJ Best Practice

60. Turner's syndrome

karyotype audiology testing bone age echocardiogram cardiac MRI serum FSH and anti-Müllerian hormone (AMH) skeletal survey pelvic ultrasound renal ultrasound TFTs antithyroid antibodies LFTs/gamma GT fasting glucose and HbA1c serum lipids IgA level and tissue transglutaminase IgA Treatment algorithm ACUTE ONGOING Contributors Authors Medical Director Disorders of Sex Development Program Seattle Children’s Hospital Associate Professor of Pediatrics University of Washington Seattle WA Disclosures PYF

2018 BMJ Best Practice

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