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Antithyroid Antibody

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21. Do antithyroid antibodies affect hearing outcomes in patients with pediatric euthyroid Hashimoto's thyroiditis? (PubMed)

Do antithyroid antibodies affect hearing outcomes in patients with pediatric euthyroid Hashimoto's thyroiditis? Hashimoto's thyroiditis (HT) is the most common autoimmune thyroid disease in children. HT is a multifaceted disease with a variable clinicopathological presentation, including hearing impairment. It is known that hearing function is negatively affected in patients with thyroid disorders. The literature includes a very limited number of studies on hearing function in euthyroid

2015 International Journal of Pediatric Otorhinolaryngology

22. Characterization of thyroid function and antithyroid antibody tests among Saudis (PubMed)

Characterization of thyroid function and antithyroid antibody tests among Saudis To determine the reference intervals for thyroid function tests and the prevalence of thyroid autoimmunity in the Saudi population.  A cross-sectional prospective study was conducted in King Khalid University Hospital, Riyadh, Saudi Arabia from January to June 2013. History and physical examination were obtained. Thyroid-stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) were measured (...) for antithyroid antibodies.  The TSH reference range was similar to laboratory references. Thyroid antibodies were prevalent in Saudis, necessitating further work in larger scale studies.

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2015 Saudi medical journal

23. Antithyroid peroxidase antibody positivity is associated with lower incidence of metastasis in breast cancer (PubMed)

Antithyroid peroxidase antibody positivity is associated with lower incidence of metastasis in breast cancer Thyroid extracts were first used to treat patients with metastatic breast cancer over a century ago. Since then, a number of studies have investigated the association between thyroid disorders and breast cancer. The presence of antibodies to thyroid peroxidase (TPOab) was recently reported to be associated with improved outcome in these patients. The aim of the present study

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2015 Molecular and clinical oncology

24. Prevalence of antithyroid peroxidase antibodies in pregnant women and the effect on the outcome of pregnancy. (PubMed)

Prevalence of antithyroid peroxidase antibodies in pregnant women and the effect on the outcome of pregnancy.

2014 Obstetrics and Gynecology

25. Antithyroid drug-associated MPO-ANCA-positive tubulointerstitial nephritis in a type 2 diabetes patient: a case report (PubMed)

Antithyroid drug-associated MPO-ANCA-positive tubulointerstitial nephritis in a type 2 diabetes patient: a case report A 54-year-old man diagnosed with type 2 diabetes and hyperthyroidism was prescribed propylthiouracil (PTU) after the patient developed hepatic dysfunction on thiamazole. At 50 mg/day of PTU, he was stable with thyroid-stimulating hormone receptor and thyrotropic antibody titers remaining stable. After four years of taking PTU, he was referred to the Department of Nephrology due (...) to a rapid increase in his serum creatinine (Cr) level. He showed impaired renal function (Cr 2.26 mg/dL; estimated glomerular filtration rate (eGFR), 25 mL/min). In addition, urinary β2-microglobulin (β2 MG) was increased to 71,980 μg/L and was positive for myeloperoxidase (MPO)-anti-neutrophil cytoplasmic antibody (ANCA) (33.9 U/mL). Gallium scintigraphy demonstrated a remarkable accumulation in both kidneys. The patient was diagnosed with tubulointerstitial nephritis based on a renal biopsy

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2016 CEN Case Reports

26. Antithyroid Arthritis Syndrome: A Case Report and Review of the Literature (PubMed)

serological features that are distinct from those of antithyroid agent-induced vasculitis syndrome. The absence of autoantibodies, especially anti-neutrophil cytoplasmic antibodies, may help characterize and diagnose antithyroid arthritis syndrome. Furthermore, physicians' awareness of this syndrome is essential for its diagnosis in clinical practice. (...) Antithyroid Arthritis Syndrome: A Case Report and Review of the Literature We herein report the case of a 38-year-old Japanese woman with antithyroid arthritis syndrome who experienced severe migratory polyarthritis after the initiation of thiamazole therapy. The patient's symptoms promptly disappeared without any sequelae after the withdrawal of the drug. Antithyroid arthritis syndrome is poorly characterized, and the findings from our literature review indicate that this syndrome exhibits

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2016 Internal Medicine

27. Predicting relapse of Graves' disease following treatment with antithyroid drugs (PubMed)

Predicting relapse of Graves' disease following treatment with antithyroid drugs The aim of the present study was to monitor long term antithyroid drug treatments and to identify prognostic factors for Graves' disease (GD). A total of 306 patients with GD who were referred to the Endocrinology Clinic at Weifang People's Hospital (Weifang, China) between August 2005 and June 2009 and treated with methimazole were included in the present study. Following treatment, patients were divided into non (...) and thyrotrophin receptor antibody (TRAb) levels were both significantly higher in the non-remission group (t=3.331, 3.389, P=0.001), as compared with the remission group. Logistic regression analysis demonstrated that elevated thyroid size, FT3/FT4 ratio and TRAb at diagnosis were associated with poor outcomes. The ratio of continued thyrotropin suppression in the recurrent subgroup was significantly increased, as compared with the remission group (P=0.001), as thyroid function reached euthyroid state at 3, 6

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2016 Experimental and therapeutic medicine

28. Comparison of Early Total Thyroidectomy with Antithyroid Treatment in Patients with Moderate-Severe Graves' Orbitopathy: A Randomized Prospective Trial. (PubMed)

Comparison of Early Total Thyroidectomy with Antithyroid Treatment in Patients with Moderate-Severe Graves' Orbitopathy: A Randomized Prospective Trial. The optimal therapeutic choice for Graves' hyperthyroidism in the presence of moderate-severe Graves' orbitopathy (GO) remains controversial.We aimed to compare GO course in patients with moderate-severe GO treated with early total thyroidectomy (TTx) versus antithyroid drug (ATD) regimens, in a prospective, randomized manner.Forty-two patients (...) decreased significantly, and there were significant improvements in proptosis, lid aperture, and CAS in the TTx group. While in the ATD group the decrement in thyroid autoantibodies was not significant, there were significant improvements in proptosis and CAS. When the TTx group was compared with the ATD group, anti-TPO, anti-Tg, and TSH-receptor antibodies were significantly decreased in the TTx group (p < 0.01), but there was no significant difference with respect to proptosis, lid aperture, CAS

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2016 European thyroid journal Controlled trial quality: uncertain

29. Relationship between rheumatoid arthritis activity and antithyroid antibodies. (PubMed)

Relationship between rheumatoid arthritis activity and antithyroid antibodies. Rheumatoid arthritis (RA) is known to be associated with a higher prevalence of antithyroid antibodies and autoimmune thyroid disease, but there have been few studies regarding the correlations between the presence of these antibodies and RA activity.The aim of this study was to analyze the relationship between antithyroid antibody titers and selected parameters of RA activity.A total of 75 consecutive hospitalized (...) patients with RA were enrolled into the study. Levels of antithyroid peroxidase antibodies (aTPO), antithyroglobulin antibodies (aTG), and antithyrotropin receptor antibodies (aTSH-R) were measured. The analysis of disease activity was based on the disease activity score with 28-joint count (DAS28), duration of morning stiffness, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) and hemoglobin levels.Antithyroid antibodies were present in 13.3% of the patients (n = 10), aTPO in 9.3% (n

2013 Polskie Archiwum Medycyny Wewnetrznej

30. Antithyroid peroxidase antibodies in women with polycystic ovary syndrome (PubMed)

Antithyroid peroxidase antibodies in women with polycystic ovary syndrome 24639731 2014 03 18 2018 11 13 1680-6433 11 12 2013 Dec Iranian journal of reproductive medicine Iran J Reprod Med Antithyroid peroxidase antibodies in women with polycystic ovary syndrome. 1031-2 Salehpour Saghar S Department of Obstetrics and Gynecology, Infertility and Reproductive Health Research Center, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Saharkhiz Nasrin N Department

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2013 Iranian Journal of Reproductive Medicine

31. Antithyroid Antibody

Antithyroid Antibody Antithyroid Antibody Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Antithyroid Antibody Antithyroid Antibody (...) Aka: Antithyroid Antibody , Thyroid Autoantibody , TSH Receptor Antibody , Thyroid Stimulating Immunoglobulin , Antithyroid Microsomal Antibody , Antithyroid Peroxidase Antibody , Antithyroglobulin Antibody , Thyroglobulin Antibody , TPO Antibody II. Measurement Bioassay III. Labs: Thyroid Stimulating Immunoglobulin (TSH receptor ab) Binds and activates TSH receptor in Seen in : Linked with ophthalmopathy IV. Labs: Antithyroid Microsomal Antibody (TMAb) or Antithyroid Peroxidase Antibody (TPO

2015 FP Notebook

32. Antithyroid antibodies and parity: further evidence for microchimerism in autoimmune thyroid disease. (PubMed)

Antithyroid antibodies and parity: further evidence for microchimerism in autoimmune thyroid disease. Fetal microchimerism may have a role in development of autoimmune thyroid disorders. Using parity as a surrogate for increasing fetal cell exposure, we analyzed its association with thyroid peroxidase antibody levels.Secondary analysis of serum thyroid analytes determined in 17,298 women from a population-based prospective study between 2001 and 2003. Sera were assayed for thyrotropin, free (...) thyroxine, and antithyroid peroxidase antibodies. We analyzed the relationship between thyroid peroxidase antibodies and increasing parity.The incidence of abnormally elevated thyroid peroxidase antibody levels (>50 IU/mL) increased with advancing parity, but was not significant after adjustment for maternal characteristics. However, at higher thyroid peroxidase antibody levels (>500 IU/mL), a significant relationship with advancing parity persisted after adjustments (P = .002).Advancing parity

2011 American Journal of Obstetrics and Gynecology

33. Population Studies of Rheumatic Diseases on a Coastal Island: PART II. ANTINUCLEAR FACTORS AND ANTITHYROID ANTIBODIES (PubMed)

Population Studies of Rheumatic Diseases on a Coastal Island: PART II. ANTINUCLEAR FACTORS AND ANTITHYROID ANTIBODIES 14087254 1996 12 01 2018 12 01 0003-4967 22 1963 Nov Annals of the rheumatic diseases Ann. Rheum. Dis. POPULATION STUDIES OF RHEUMATIC DISEASES ON A COSTAL ISLAND. II. ANTINUCLEAR FACTORS AND ANTITHYROID ANTIBODIES. 431-4 NIENHUIS R L RL MANDEMA E E JANSZ A A eng Journal Article England Ann Rheum Dis 0372355 0003-4967 0 Antibodies 0 Antibodies, Antinuclear 9009-79-4 Rheumatoid (...) Factor OM Adolescent Antibodies Antibodies, Antinuclear Coombs Test Fluorescent Antibody Technique Hemagglutination Inhibition Tests Humans Latex Fixation Tests Netherlands Rheumatic Diseases Rheumatoid Factor Serologic Tests Thyroid Gland ADOLESCENCE ANTIBODIES COOMBS' TEST FLUORESCENT ANTIBODY TECHNIC HEMAGGLUTINATION INHIBITION TESTS LATEX FIXATION TESTS NETHERLANDS RHEUMATISM RHEUMATOID FACTOR SERODIAGNOSIS THYROID GLAND 1963 11 1 1963 11 1 0 1 1963 11 1 0 0 ppublish 14087254 PMC1030884 J Exp Med

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1963 Annals of the Rheumatic Diseases

34. Increased Prevalence of Thyroid Disease in Patients with Antineutrophil Cytoplasmic Antibodies-associated Vasculitis. (PubMed)

Increased Prevalence of Thyroid Disease in Patients with Antineutrophil Cytoplasmic Antibodies-associated Vasculitis. Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) has been linked with thyroid disease as a result of antithyroid medications. We assessed the prevalence of thyroid disease in our patients with AAV.Clinical records of 279 patients with AAV diagnosed between 1991 and 2014 were analyzed.Thyroid disease was identified in 21.5% of patients, but only 2 had (...) previously received propylthiouracil. There was a greater proportion of female patients, patients with antimyeloperoxidase antibodies, and patients with renal disease in the group with thyroid disease.Our data show a higher prevalence of thyroid disease in patients with AAV than the general population. This was not attributable to antithyroid drugs.

2018 Journal of Rheumatology

35. Association Between Thyroid Hormones, Thyroid Antibodies, and Cardiometabolic Factors in Non-Obese Individuals With Normal Thyroid Function (PubMed)

the association of thyroid function, thyroid autoimmunity, and cardiometabolic risk factors in non-obese AIT patients with euthyroidism.A total of 5,608 non-obese individuals including 1,402 AIT patient and 4,206 sex-, age-, and body mass index (BMI)-matched healthy controls were recruited.The AIT patients had significantly lower free T3 and free T4 levels, and higher TSH, antithyroid peroxidase antibodies (TPOAb) and TgAb levels. The elevated levels of high sensitivity C reactive protein (hsCRP (...) Association Between Thyroid Hormones, Thyroid Antibodies, and Cardiometabolic Factors in Non-Obese Individuals With Normal Thyroid Function Hypothyroidism is an important risk factor for cardiovascular diseases, and autoimmune thyroiditis (AIT) is the leading cause of hypothyroidism. Recent studies showed that even AIT patients with euthyroidism still had an increased number of early atherosclerotic lesions. However, the precise mechanism is not yet known. This study aimed to investigate

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2018 Frontiers in endocrinology

36. Association of antithyroglobulin antibodies with the development of thyroid dysfunction induced by nivolumab (PubMed)

Association of antithyroglobulin antibodies with the development of thyroid dysfunction induced by nivolumab Thyroid dysfunction (TD) induced by immune checkpoint inhibitors is not sufficiently understood. The purpose of this retrospective observational study was to identify risk factors and the clinical course of TD induced by nivolumab. Patients with advanced solid tumors who were treated with nivolumab from March 2009 through to March 2016 at the National Cancer Center Hospital (Tokyo, Japan (...) ) were included. Thyroid function and antithyroid Abs from serum samples among all patients were evaluated at baseline and during nivolumab treatment. Overt hypothyroidism was defined as low serum-free T4 together with elevated thyroid-stimulating hormone (TSH) >10 μIU/mL. Thyrotoxicosis was defined as low TSH with elevated free T4 and/or free T3. We defined thyroid autoimmunity as the presence of antithyroid Abs at baseline, including antithyroid peroxidase Abs and antithyroglobulin Abs (TgAb

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2018 Cancer science

37. Limbic encephalitis associated with anti-NH2-terminal of α-enolase antibodies: A clinical subtype of Hashimoto encephalopathy. (PubMed)

encephalopathy (HE), who was diagnosed with HE based on the presence of antithyroid antibodies and responsiveness to immunotherapy. This case suggests that LE patients with antibodies to both the thyroid and NAE could be diagnosed with HE and respond to immunotherapy. The aim of this study was to clarify the clinicoimmunological features and efficacy of immunotherapy in LE associated with anti-NAE antibodies to determine whether the LE is a clinical subtype of HE.We examined serum anti-NAE antibodies in 78 (...) LE patients with limbic abnormality on magnetic resonance imaging and suspected HE based on positivity for antithyroid antibodies. Nineteen of the 78 patients had anti-NAE antibodies; however, 5 were excluded because they were double positive for antibodies to the VGKC complex including LGI1. No antibodies against the N-methyl-D-aspartate receptor (NMDAR), contactin-associated protein 2 (Caspr2), γ-aminobutyric acid-B receptor (GABABR), or α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid

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2017 Medicine

38. Total Thyroidectomy for Thyroid Cancer Followed by Thyroid Storm due to Thyrotropin Receptor Antibody Stimulation of Metastatic Thyroid Tissue (PubMed)

Total Thyroidectomy for Thyroid Cancer Followed by Thyroid Storm due to Thyrotropin Receptor Antibody Stimulation of Metastatic Thyroid Tissue Graves disease (GD) is an autoimmune condition characterized by the presence of antibodies against the thyrotropin receptor (TRAB), which stimulate the thyroid gland to produce excess thyroid hormone. Theoretically, TRAB could stimulate highly differentiated thyroid cancer tissue and/or metastases to produce thyroid hormone.A 68-year-old male (...) , with weight loss and palpitations, was diagnosed with thyrotoxicosis. A later MRI, due to persistent shoulder pain, revealed multiple bone metastases. A biopsy was diagnostic for follicular variant of papillary thyroid carcinoma, and total thyroidectomy was performed. One week after thyroidectomy the patient was admitted with severe hyperthyroidism. TRAB was >40 IU/mL (normal <0.7 IU/mL). High-dose antithyroid drug treatment was followed by high-dose radioactive iodine-131 (RAI) and local radiotherapy

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2017 European thyroid journal

39. Thyroid-Stimulating Hormone Receptor Antibodies in Pregnancy: Clinical Relevance (PubMed)

Thyroid-Stimulating Hormone Receptor Antibodies in Pregnancy: Clinical Relevance Graves' disease is the most common cause of thyrotoxicosis in women of childbearing age. Approximately 1% of pregnant women been treated before, or are being treated during pregnancy for Graves' hyperthyroidism. In pregnancy, as in not pregnant state, thyroid-stimulating hormone (TSH) receptor (TSHR) antibodies (TRAbs) are the pathogenetic hallmark of Graves' disease. TRAbs are heterogeneous for molecular (...) of TRAbs in most cases although they persist in women with active disease as well as in women who received definitive therapy (radioiodine or surgery) before pregnancy. Changes of functional properties from stimulating to blocking the TSHR could occur during gestation. Drug therapy is the treatment of choice for hyperthyroidism during gestation. Antithyroid drugs also cross the placenta and therefore decrease both the maternal and the fetal thyroid hormone production. The management of Graves' disease

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2017 Frontiers in endocrinology

40. There is no association between the presence of anti-thyroid antibodies and increased reproductive loss in pregnant women after ART: a systematic review and meta-analysis. (PubMed)

in pregnancies resulting from ART. MEDLINE via PubMed, LILACS and Embase were searched for studies published in peer-reviewed journals from 1999 to 2017. The studies were summarized using the fixed effects model and the Peto's method to calculate RR in order to flesh out the association between TAI and spontaneous abortion. Only four papers were included in this systematic review and meta-analysis. Thirty-one miscarriages were observed in 210 clinical pregnancies of women with antithyroid antibodies; and 158 (...) miscarriages were seen in 1,371 pregnancies without antithyroid antibodies. The meta-analysis failed to find an association between TAI and higher risk of reproductive loss, RR=0.94 95% confidence interval: 0.71-1.24; p=0.879. In conclusion, the presence of antithyroid antibodies was not associated with increased reproductive loss in patients submitted to ART treatments. It is our opinion that the presence of antithyroid antibodies should be considered as a secondary biomarker of autoimmune disease, rather

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2017 JBRA assisted reproduction

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