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Antithyroid Antibody

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181. Selenium Supplementation in Youths With Autoimmune Thyroiditis

: No Criteria Inclusion Criteria: A positive titer of antithyroid peroxidase (anti-TPO) or antithyroglobulin (anti-Tg) antibodies (TPO and / or Tg> 60 IU / ml) and at least one of: Abnormal thyroid function that requires substitution treatment with L-thyroxine (TSH > 5 micro-units per milliliter (mcU/ml) and decreased or normal levels of fT4 or fT3) Increased volume of thyroid gland (goiter) Morphological changes on ultrasound of the thyroid gland Exclusion Criteria: Presence of another chronic disease (...) Posted : January 1, 2016 Sponsor: Aristotle University Of Thessaloniki Information provided by (Responsible Party): Assimina Galli-Tsinopoulou, Aristotle University Of Thessaloniki Study Details Study Description Go to Brief Summary: To investigate whether the supplementation of organic selenium at the "adult" dose (200 mcg per day in the form of L-selenomethionine) has a favorable impact on thyroid function, including the titer of anti-thyroid antibodies [Anti-thyroid peroxidase (anti-TPO) and Anti

2015 Clinical Trials

182. MKSAP: 21-year-old woman with a rash in the lower extremities

hydralazine, diltiazem, isoniazid, minocycline, and certain tumor necrosis factor α inhibitors (such as infliximab and etanercept). Other agents that possibly cause DILE include specific anticonvulsants, antithyroid agents, and certain antibiotics. The diagnostic laboratory evaluation for DILE is similar to that for patients with suspected idiopathic systemic lupus erythematosus. Antinuclear antibodies are typically positive, whereas anti–double-stranded DNA antibodies are usually negative in DILE (...) as livedo reticularis in the lower extremities beginning at the thighs. The remainder of the examination is normal. Laboratory studies: Antinuclear antibodies Positive (titer: 1:320) Anti–double-stranded DNA antibodies Negative Anti-Smith antibodies Negative Anti-U1-ribonucleoprotein antibodies Negative Anti-Ro/SSA antibodies Negative Anti-La/SSB antibodies Negative Antihistone antibodies Negative ANCA Positive (titer: 1:320) in a perinuclear pattern; negative for myeloperoxidase Urinalysis Normal Chest

2015 KevinMD blog

183. Hyponatremia in a Teenager: A Rare Diagnosis. (PubMed)

adrenal hypoplasia. Findings for antiadrenal and antithyroid antibodies were positive, allowing the diagnosis of autoimmune polyglandular syndrome type II.Adrenal insufficiency is a rare disease, especially in children, and its clinical manifestations are due to glucocorticoid and mineralocorticoid deficiency. In most of the cases, symptoms are nonspecific, requiring a high index of clinical suspicion. If the diagnosis and treatment are delayed, acute adrenal insufficiency carries a high morbidity

2015 Pediatric Emergency Care

184. Coexistence of Hidradenitis Suppurativa with Autoimmune Thyroiditis: Report of Three Cases. (PubMed)

of these two diseases has not previously been described. The coexistence of HS with autoimmune disorders, such as AT, may support the hypothesis on dysregulation of the immune system's function as implicated in the pathogenesis of HS. Based on our findings, we feel that an assessment of thyroid function and antithyroid antibodies should be performed in patients with HS. © 2015 S. Karger AG, Basel.

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2015 Dermatology

185. Lower Serum 25-Hydroxyvitamin D Level is Associated With 3 Types of Autoimmune Thyroid Diseases. (PubMed)

concentration than controls. Serum 25(OH)D levels were associated with neither antithyroid peroxidase antibody nor antithyroglobulin antibody in GD and HT. There was no significant relationship between thyroid-stimulating hormone and 25(OH)D levels. Every 5 nmol/L increase in serum 25(OH)D concentrations was associated with a 1.55-, 1.62-, and 1.51-fold reduction in GD, HT, and PPT risk, respectively. We observed a lower serum vitamin D levels in AITD patients compared with controls. The lower the vitamin D (...) level is, not vitamin D deficiency per se, the higher the risk for developing AITD will be. However, vitamin D does not have strong association with the titers of thyroid antibodies or the levels of thyroid hormones.

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2015 Medicine

186. Thyroid Autoantibodies in the Cerebrospinal Fluid of Subjects with and without Thyroid Disease: Implications for Hashimoto's Encephalopathy (PubMed)

Thyroid Autoantibodies in the Cerebrospinal Fluid of Subjects with and without Thyroid Disease: Implications for Hashimoto's Encephalopathy Introduction. Plasma antithyroid peroxidase (anti-TPO) and anti-thyroglobulin antibodies (anti-Tg) are widely used in the diagnosis of autoimmune thyroiditis. No research has compared anti-TPO and anti-Tg both in plasma and cerebrospinal fluid (CSF) of healthy individuals vis-à-vis patients with thyroid disease. Methods. We measured anti-TPO and anti-Tg (...) antibodies in plasma and CSF in nine subjects (mean age ± SD: 73 ± 6 years) with hypothyroidism and nine subjects (mean age ± SD: 73 ± 8 years) without thyroid disease. Results. The concentration of anti-TPO autoantibodies in CSF was very low compared to plasma in both subjects with thyroid and without thyroid disease (P = 0.007). CSF anti-Tg autoantibodies titers were very low compared to the plasma in subjects with thyroid disease (P = 0.004), whereas, in subjects without thyroid disease

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2015 Journal of thyroid research

187. Organ-specificity in autoimmune diseases: thyroid and islet autoimmunity in alopecia areata. (PubMed)

and differences in HLA and clinical characteristics of thyroid and islet autoimmunity in patients with AA.A total of 126 patients with AA were newly recruited. Anti-islet and antithyroid autoantibodies were tested, and genotypes of HLA genes were determined.Among the autoimmune diseases associated with AA, autoimmune thyroid disease was most frequent (10.0%), followed by vitiligo (2.7%) and rheumatoid arthritis (0.9%) but not type 1 diabetes (0.0%). The prevalence of thyroid-related autoantibodies in patients (...) with AA was significantly higher than that in controls (TSH receptor antibody [TRAb]: 42.7% vs 1.2%, P = 1.6 × 10(-46); thyroid peroxidase antibody: 29.1% vs 11.6%; P = 1.7 × 10(-6)), whereas the prevalence of islet-related autoantibodies was comparable between patients with AA and control subjects. The frequency of DRB1*15:01-DQB1*06:02, a protective haplotype for type 1 diabetes, was significantly higher in TRAb-positive (12.8%, P = .0028, corrected P value [Pc] = .02) but not TRAb-negative (7.1

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2015 Journal of Clinical Endocrinology and Metabolism

188. Role of the Microbiome in Graves' Orbitopathy

. It is key to properly store placebo at 8°C. Outcome Measures Go to Primary Outcome Measures : Microbiome modification (beneficial modification of the gut microbioma relates to a reduction at the end of treatment of at least 5% of the Firmicutes:Bacteroides ratio and 30% of the anti-TSHr antibody titer and of total IgG and IgA concentrations) [ Time Frame: 6 months ] modification the microbiome in GD patients to reduce pathogenic species and enrich its commensal, symbiotic components. The proportion (...) (%) of each species will be assessed and recorded. Secondary Outcome Measures : Improvement immunological status (antibody responses will be analyzed to identify if microbial or food derived antigens are involved in triggering disease or associated with GO progression) [ Time Frame: 6 months ] To decrease the anti-TSHr antibody titer and the concentration of IgG and IgA in patients with Graves' disease. The concentration of each parameter will be assessed in mg/dl and recorded. Eligibility Criteria Go

2015 Clinical Trials

189. Multicenter,Single-arm Study to Evaluate Efficacy, Safety, & Pharmacokinetics of Denosumab in Children w/ OI

glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 (calculated bythe Schwartz equation at screening) Evidence of any of the following: Current hyperthyroidism (unless well-controlled on stable antithyroid therapy) Current clinical hypothyroidism (unless well-controlled on stable thyroid replacement therapy) History of hyperparathyroidism Current hypoparathyroidism Current, uncontrolled hypercalcemia (albumin-corrected serum Ca >10% ULN) History of osteomalacia or rickets (chart review) Other bone (...) diseases that affect bone metabolism (eg, osteoporosis pseudoglioma syndrome, idiopathic juvenile osteoporosis, osteopetrosis, hypophosphatasia) History of autoimmune disease History of rare hereditary problems of fructose intolerance Positive blood screen for human immunodeficiency virus -1 or -2 antibody Positive blood screen for hepatitis B surface antigen or hepatitis C antibody Received other osteoporosis treatment or bone active treatment with the following guidelines: Prior treatment

2015 Clinical Trials

190. Diagnosis and Management of Subclinical Hypothyroidism in Elderly Adults: A Review of the Literature. (PubMed)

than 10 mIU/L who test positive for antithyroid antibodies or are symptomatic may benefit from levothyroxine treatment to reduce the risk of progression to overt hypothyroidism, decrease the risk of adverse cardiovascular events, and improve their quality of life. After treatment is initiated, careful monitoring is essential. © 2015, The Authors. The Journal of the American Geriatrics Society published by Wiley Periodicals, Inc. on behalf of The American Geriatrics Society.

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2015 Journal of the American Geriatrics Society

191. MarginalIodine Status and High Rate of Subclinical Hypothyroidism in Washington DC in Women Planning Conception. (PubMed)

). Median serum TSH concentrations were higher in women with detectable antithyroid antibodies than in women who were antibody negative (2.2 mIU/L vs. 1.7 mIU/L; p=0.005). The median urinary iodine concentration was 100.5 μg (range 19-843 μg/L).The present cohort exhibited the lowest median urinary iodine concentration levels to date reported in the United States for women in their childbearing years. One out of every nine women (11%) had thyroid function tests consistent with subclinical hypothyroidism. (...) MarginalIodine Status and High Rate of Subclinical Hypothyroidism in Washington DC in Women Planning Conception. Subclinical hypothyroidism during pregnancy has been associated with adverse maternal and fetal outcomes. A subset of pregnant women in the United States have been shown to have mild iodine deficiency. No study has evaluated the thyroid and iodine status of women who are planning to become pregnant in the near future.Thyroid function tests, thyroid antibodies, and urine iodine levels

2015 Thyroid

192. Pericarditis as the Presenting Feature of Graves Disease in a Pediatric Patient. (PubMed)

function studies and an elevated thyroid-stimulating hormone receptor antibody level confirmed the diagnosis of Graves thyrotoxicosis. The patient was treated with anti-inflammatory and antithyroid agents and improved in time. We discuss previously reported cases of Graves disease-associated pericarditis in adults, potential etiologies, and management strategies.

2015 Pediatric Emergency Care

193. Autoimmune thyroid disorders. (PubMed)

Autoimmune thyroid disorders. Autoimmune thyroid diseases (AITD) result from a dysregulation of the immune system leading to an immune attack on the thyroid. AITD are T cell-mediated organ-specific autoimmune disorders. The prevalence of AITD is estimated to be 5%; however, the prevalence of antithyroid antibodies may be even higher. The AITD comprise two main clinical presentations: Graves' disease (GD) and Hashimoto's thyroiditis (HT), both characterized by lymphocytic infiltration

2015 Autoimmunity reviews

194. Mechanistic Study of Subclinical Hypothyroidism In the Elderly

Inclusion Criteria: men and women aged 70 and older TSH between 4.5 and 19.9 mU/L as an outpatient ability to provide informed consent Exclusion Criteria: Laboratory Tests: TSH <4.5 mU/L or >20 mU/L on repeat testing at least four weeks later or free T4 level outside the reference range thyroid peroxidase (TPO) antibody positive abnormal liver function tests (LFTs >3 x upper limit of normal) hemoglobin <11 g/dL Surgeries or Procedures: thyroid surgery pituitary surgery bariatric surgery bowel resection (...) % in the past six months celiac sprue, Crohn's disease, ulcerative colitis, Zollinger-Ellison syndrome renal insufficiency with calculated glomerular filtration rate <45 cc/min cognitive impairment with Mini Mental State Exam[30] <24/30 history of any seizures unstable medical or psychological condition in the judgment of the principal investigator Medications: thyroid hormone preparations antithyroid drugs medications that interfere with the absorption or metabolism of thyroid hormone medications

2015 Clinical Trials

195. The Effect of a New Antioxidant Combination (ASTED) on Mild Thyroid Eye Disease (TED)

questionnaire (TED-QOL) before and after treatment in each of the three arms of the study and make a before - after as well as an inter-arm comparison. To determine clinical activity score (CAS Score) before and after treatment in each of the three arms of the study and make a before - after as well as an inter-arm comparison. To determine Serum thyroid auto-antibodies (Anti thyroid peroxidase (TPO), Anti-thyrogluboline) and Thyroid function test (Free T4, T3, and TSH) level before and after treatment (...) Inclusion Criteria: Mild TED of less than 18 months duration (as recorded by the patient). No active state (Clinical activity score of less than 3). No previous specific therapy for TED, except for local measures (artificial tear, head elevation, low salt diet). Euthyroidism as a result of remission after a course of antithyroid drug (ATD) therapy, or euthyroidism for at least 2 months since commencing ATD or after thyroidectomy, or euthyroidism for at least 6 months after radioiodine therapy

2015 Clinical Trials

196. D-vitamin And Graves' Disease; Morbidity And Relapse Reduction

Dietary Supplement: Placebo Not Applicable Detailed Description: In a multicentre trial, 260 patients with newly diagnosed Graves ' disease will be randomized to cholecalciferol 70 mcg/day or placebo in a parallel Group design. Drop outs prior to 31th of December 2017 will be replaced. The intervention will continue during treatment with antithyroid drugs (ATD), and for a period of 12 months after cessation of ATD. Blood samples will be collected at study entry, at 3 and 9 months, and at end of study (...) -terminal propeptide of type 1 procollagen (P1NP). Also C-terminal telopeptide of type 1 collagen (CTX) and N-telopeptide of type 1 collagen (NTX) among others. Level of Thyrotropin receptor antibody (TRAb) [ Time Frame: 3 months, 9 months and 12 months after cessation of ATD treatment, an expected average of 24 months ] Level of TRAb at 3 and 9 months and at end of study period (maximum of 36 months) Level of 25 hydroxy vitamin D [ Time Frame: From randomisation until 12 months after cessation of ATD

2015 Clinical Trials

197. DNA Methylation and Autoimmune Thyroid Diseases

Inclusion Criteria: For HT: A positive titers of antithyroid peroxidase (anti-TPO) or antithyroglobulin (anti-Tg) antibodies and at least one of: Abnormal thyroid function that requires substitution treatment with L-thyroxine (TSH > 5 μIU/ml and decreased or normal levels of fT4 or fT3) Increased volume of thyroid gland (goiter) Morphological changes on ultrasound of the thyroid gland For GD: A positive titers of thyroid stimulating antibodies (anti-TSI) and Decreased TSH levels and increased levels (...) Graves Disease Detailed Description: Hashimoto Thyroiditis (HT) and Graves Disease (GD) are known to be caused by abnormal immune response against self cells and tissues. HT involves a cell-mediated autoimmune destruction of the thyroid leading to hypothyroidism. GD is caused by a process in which immune cells make stimulating antibodies against the thyroid stimulating hormone (TSH) receptor on the thyroid gland, thus leading to hyperthyroidism. Although there is substantial evidence that genetic

2014 Clinical Trials

198. Role of oxidative stress and autoimmunity in onset and progression of vitiligo. (PubMed)

and lipid peroxidation (LPO) levels were evaluated in 427 patients and 440 controls; antithyroid peroxidase (TPO) antibody levels were estimated in 102 patients and 72 controls. Patients showed a significant increase in LPO and antimelanocyte antibody levels compared to controls. Antimelanocyte antibody and LPO levels were higher in active vitiligo compared to stable. Only 9.8% of patients showed the presence of anti-TPO antibodies in their circulation. Oxidative stress may be the initial triggering (...) Role of oxidative stress and autoimmunity in onset and progression of vitiligo. Vitiligo is an acquired depigmentation disorder characterized by the loss of functional melanocytes from the epidermis. Two major theories of vitiligo pathogenesis include autoimmunity and oxidative stress-mediated toxicity in melanocytes. The present study aimed to evaluate both the hypotheses in vitiligo patients and to investigate their role in the disease onset and progression. Antimelanocyte antibody levels

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2014 Experimental Dermatology

199. Symptomatic aggravation after corticosteroid pulse therapy in definite sporadic Creutzfeldt-Jakob disease with the feature of Hashimoto¿s encephalopathy. (PubMed)

titers of antithyroid antibodies, corticosteroid pulse therapy is typically performed with expectations of near complete recovery from Hashimoto's encephalopathy. Herein, we provide the first case report that exhibited a negative effect of corticosteroid pulse therapy for a patient with Creutzfeldt-Jakob disease with features of Hashimoto's encephalopathy.We report a case of 59-year-old Asian woman with blurred vision, dysarthria, myoclonus, and rapidly progressive dementia. Cerebrospinal fluid (...) showed 14-3-3 protein positive. Electroencephalogram showed periodic sharp waves (1.5 Hz) at the bilateral frontal or occipital areas. Magnetic resonance imaging showed high signal intensities at the bilateral cerebral cortex, caudate nucleus, and putamen. The patient was diagnosed with probable Creutzfeldt-Jakob disease. However, serum analysis showed a high titer of antithyroid antibodies. We started corticosteroid pulse therapy with subsequent aggravation of seizure activity including generalized

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2014 BMC Neurology

200. Is an Isolated TSH Elevation in Chronic Nonthyroidal Illness "Subclinical Hypothyroidism"? (PubMed)

end-stage renal failure patients, four had isolated TSH elevations. All normalized within 14 months. In 452 systolic heart failure patients, 20 had isolated TSH elevations, five of 20 were persistent, and none progressed to overt hypothyroidism within 6 months. In 207 untreated chronic hepatitis C patients, 12 had isolated TSH elevations and four had increased TSH with reduced free T4; all were female, and 14 had positive antithyroid antibodies. After 1 year, two of 12 developed "clinical (...) hypothyroidism." In 72 chronic hepatitis C patients, nine females had positive antithyroid antibodies. Two antibody-negative patients had TSH 5-6 mU/L with reduced free T4. After 1 year, three of four with positive antithyroid antibodies and baseline TSH < 4 mU/L had elevated TSH with reduced free T4.In chronically ill patients, there is inadequate evidence to determine: 1) that isolated TSH elevations usually persist or progress to overt hypothyroidism; 2) the etiology and clinical significance of isolated

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2014 Journal of Clinical Endocrinology and Metabolism

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