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Antithrombin III deficiency

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1. Strategy for Cardiovascular Surgery in Patients with Antithrombin III Deficiency Full Text available with Trip Pro

Strategy for Cardiovascular Surgery in Patients with Antithrombin III Deficiency Antithrombin III (ATIII) deficiency is a rare disorder in which thrombosis can be induced by stimuli that do not usually lead to thrombus formation, including minor injuries and surgery. Therefore, patients with ATIII deficiency undergoing cardiovascular surgery that involves heparinization require careful perioperative management. We experienced five patients with ATIII deficiency who underwent cardiovascular (...) surgery and were managed with ATIII replacement. By administration of ATIII concentrate, preoperative ATIII activity was maintained at ≥120% and postoperative ATIII activity at ≥80%. All five patients were treated successfully without postoperative complications such as hemorrhage or thrombosis. In patients with ATIII deficiency undergoing cardiac surgery, it is important to perform ATIII replacement to achieve preoperative ATIII activity ≥120% and postoperative ATIII activity ≥80%, while

2018 Annals of Thoracic and Cardiovascular Surgery

2. Successful treatment of a massive pulmonary embolism using rivaroxaban in a patient with antithrombin III deficiency Full Text available with Trip Pro

Successful treatment of a massive pulmonary embolism using rivaroxaban in a patient with antithrombin III deficiency We report a case of acute massive pulmonary embolism in a patient with antithrombin III deficiency. The patient was treated with rivaroxaban. The patient responded well to the therapy, and contrast-enhanced computed tomography showed nearly complete disappearance of the pulmonary embolism. Patients with low antithrombin III activity may have resistance to heparin therapy, leading (...) to insufficient anticoagulation during the acute phase of thromboembolism. This case suggests that direct oral anticoagulants, such as rivaroxaban, may be effective first-line agents for treating venous thromboembolism in patients with antithrombin III deficiency. Antithrombin-III deficiency may lead to insufficient anticoagulation

2017 Journal of cardiology cases

3. Proper diagnosis of antithrombin III deficiency Full Text available with Trip Pro

Proper diagnosis of antithrombin III deficiency 28466833 2018 12 24 2018 12 24 2149-2271 17 4 2017 04 Anatolian journal of cardiology Anatol J Cardiol Proper diagnosis of antithrombin III deficiency. 342 10.14744/AnatolJCardiol.2017.7693 Narlı Özdemir Zehra Z Özcan Muhit M Department of Hematology, Faculty of Medicine, Ankara University, Ankara-Turkey. Muhit.Ozcan@medicine.ankara.edu.tr. eng Letter Comment Turkey Anatol J Cardiol 101652981 2149-2263 IM Anatol J Cardiol. 2016 Dec;16(12):E21-E22 (...) 28005013 Anatol J Cardiol. 2017 Apr;17(4):342-343 28466834 Antithrombin III Deficiency Atrial Fibrillation Echocardiography, Three-Dimensional Humans Pulmonary Embolism Thrombosis 2017 5 4 6 0 2017 5 4 6 0 2018 12 26 6 0 ppublish 28466833 PMC5469120 10.14744/AnatolJCardiol.2017.7693 Circulation. 2008 Oct 14;118(16):1659-67 18824642 Anatol J Cardiol. 2016 Dec;16(12 ):E21-E22 28005013 Haemophilia. 2008 Nov;14(6):1229-39 19141163 Am J Hematol. 1994 Apr;45(4):321-4 8178802 Semin Thromb Hemost. 2007 Sep;33

2017 Anatolian journal of cardiology

4. Antithrombin III deficiency

Antithrombin III deficiency Antithrombin III deficiency Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Antithrombin III deficiency (...) Antithrombin III deficiency Aka: Antithrombin III deficiency From Related Chapters II. Pathophysiology normally inhibits Factor IXa Factor Xa Factor XIa Factor XIIa Thrombin Enhanced by III. Epidemiology s have 25-50% ATIII functional levels First episode of thrombosis occurs ages 10-30 years IV. Complications V. Labs Functional level Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Antithrombin III deficiency." Click on the image

2018 FP Notebook

5. Overcoming heparin resistance in pregnant women with antithrombin deficiency: a case report and review of the literature Full Text available with Trip Pro

of recurrent miscarriages and a family history of thrombosis. She was managed with adjusted doses of low molecular weight heparin throughout her pregnancy, with regular anti-Xa and antithrombin level monitoring. Prior to delivery and for 4 days after delivery she received human antithrombin III concentrate. She delivered a small for gestational age baby with no other complications. She required an increased dose of heparin due to heparin resistance.Antithrombin deficiency is associated with an increased (...) Overcoming heparin resistance in pregnant women with antithrombin deficiency: a case report and review of the literature The risk of thromboembolic events during pregnancy in patients with antithrombin deficiency is increased. Preventing thromboembolic events during pregnancy in the case of antithrombin deficiency is still a matter of concern.We present a case of a 19-year-old primigravida Greek Pomak woman, who was diagnosed as having congenital antithrombin deficiency. She had a history

2018 Journal of medical case reports

6. Antithrombin III deficiency concomitant with atrial fibrillation causes thrombi in all chambers: 2D and 3D echocardiographic evaluation Full Text available with Trip Pro

Antithrombin III deficiency concomitant with atrial fibrillation causes thrombi in all chambers: 2D and 3D echocardiographic evaluation 28005013 2018 11 12 2018 11 12 2149-2271 16 12 2016 12 Anatolian journal of cardiology Anatol J Cardiol Antithrombin III deficiency concomitant with atrial fibrillation causes thrombi in all chambers: 2D and 3D echocardiographic evaluation. E21-E22 10.14744/AnatolJCardiol.2016.7456 Hayıroğlu Mert İlker Mİ Department of Cardiology, Dr. Siyami Ersek Thoracic (...) Center Training and Research Hospital; İstanbul-Turkey. Ünal Dayı Şennur Ş Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center Training and Research Hospital; İstanbul-Turkey. eng Journal Article Turkey Anatol J Cardiol 101652981 2149-2263 IM Anatol J Cardiol. 2017 Apr;17(4):342 28466833 Antithrombin III Deficiency complications diagnostic imaging Atrial Fibrillation complications diagnostic imaging Echocardiography, Three-Dimensional Echocardiography

2016 Anatolian journal of cardiology

7. Edoxaban Was Effective for the Treatment of Deep Vein Thrombosis and Pulmonary Thromboembolism in a Cancer Patient with Antithrombin III Deficiency Full Text available with Trip Pro

Edoxaban Was Effective for the Treatment of Deep Vein Thrombosis and Pulmonary Thromboembolism in a Cancer Patient with Antithrombin III Deficiency A 57-year-old man with antithrombin III deficiency with deep vein thrombosis and pulmonary thromboembolism after surgery for colon cancer was managed with warfarin and inferior vena cava filtration. After starting chemotherapy for liver metastasis, the control of his prothrombin time-international normalized ratio in response to warfarin began

2016 Internal Medicine

8. SerpinC1/Antithrombin III in kidney-related diseases Full Text available with Trip Pro

SerpinC1/Antithrombin III in kidney-related diseases The gene SerpinC1 encodes a serine protease inhibitor named antithrombin III (ATIII). This protease demonstrates both anticoagulant and anti-inflammatory action. ATIII is the most important coagulation factor inhibitor, and even minor changes in ATIII can significantly alter the risk of thromboembolism. ATIII can also suppress inflammation via a coagulation-dependent or -independent effect. Moreover, apart from ATIII deficiency, ATIII and its

2017 Clinical science (London, England : 1979)

9. Antithrombin III Deficiency (Treatment)

Antithrombin III Deficiency (Treatment) Antithrombin III Deficiency Treatment & Management: Medical Care, Surgical Care, Consultations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvOTU0Njg4LXRyZWF0bWVudA (...) == processing > Antithrombin III Deficiency Treatment & Management Updated: Feb 10, 2018 Author: James L Harper, MD; Chief Editor: Hassan M Yaish, MD Share Email Print Feedback Close Sections Sections Antithrombin III Deficiency Treatment Medical Care Treatment of patients with antithrombin III (ATIII) deficiency depends on the clinical setting. Three congenital conditions are discussed: homozygous antithrombin III deficiency discovered in neonates, heterozygous antithrombin III deficiency in patients

2014 eMedicine Pediatrics

10. Antithrombin III Deficiency (Overview)

Antithrombin III Deficiency (Overview) Antithrombin III Deficiency: Practice Essentials, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvOTU0Njg4LW92ZXJ2aWV3 processing > Antithrombin (...) III Deficiency Updated: Feb 10, 2018 Author: James L Harper, MD; Chief Editor: Hassan M Yaish, MD Share Email Print Feedback Close Sections Sections Antithrombin III Deficiency Overview Practice Essentials Antithrombin III (ATIII) is a nonvitamin K-dependent protease that inhibits coagulation by neutralizing the enzymatic activity of thrombin (factors IIa, IXa, Xa). Antithrombin III activity is markedly potentiated by heparin, the principal mechanism by which both heparin and low–molecular-weight

2014 eMedicine Pediatrics

11. Antithrombin III Deficiency (Diagnosis)

Antithrombin III Deficiency (Diagnosis) Antithrombin III Deficiency: Practice Essentials, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvOTU0Njg4LW92ZXJ2aWV3 processing > Antithrombin (...) III Deficiency Updated: Feb 10, 2018 Author: James L Harper, MD; Chief Editor: Hassan M Yaish, MD Share Email Print Feedback Close Sections Sections Antithrombin III Deficiency Overview Practice Essentials Antithrombin III (ATIII) is a nonvitamin K-dependent protease that inhibits coagulation by neutralizing the enzymatic activity of thrombin (factors IIa, IXa, Xa). Antithrombin III activity is markedly potentiated by heparin, the principal mechanism by which both heparin and low–molecular-weight

2014 eMedicine Pediatrics

12. Antithrombin III Deficiency (Follow-up)

Antithrombin III Deficiency (Follow-up) Antithrombin III Deficiency Follow-up: Further Outpatient Care, Complications, Prognosis Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvOTU0Njg4LWZvbGxvd3Vw processing (...) > Antithrombin III Deficiency Follow-up Updated: Feb 10, 2018 Author: James L Harper, MD; Chief Editor: Hassan M Yaish, MD Share Email Print Feedback Close Sections Sections Antithrombin III Deficiency Follow-up Further Outpatient Care Consultation with a coagulation-focused hematologist needs to be done both with the child's parents and the child. Repeat consultation should be undertaken later in adolescence for those children diagnosed early in life. Next: Complications See the list below: Most thrombotic

2014 eMedicine Pediatrics

13. Management of right atrial hemangioma in a patient with antithrombin deficiency. (Abstract)

Management of right atrial hemangioma in a patient with antithrombin deficiency. Hereditary antithrombin (AT) deficiency is an autosomal dominant inheritance disorder. Patients with AT deficiency have a high risk of thromboembolism, and intraoperative cardiopulmonary bypass management is difficult. We present the case of a 53-year-old man who was diagnosed with AT deficiency and who underwent an open heart operation for a right atrial hemangioma. We administered AT-III concentrate (...) perioperatively to maintain his AT-III level up to 80% to establish cardiopulmonary bypass and prevent thromboembolic events postoperatively. The right atrial hemangioma was successfully excised after right atriotomy. The patient had an uneventful postoperative course and was discharged on postoperative day 14. Copyright © 2015 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

2015 Annals of Thoracic Surgery

14. Antithrombin III deficiency

Antithrombin III deficiency Antithrombin III deficiency Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Antithrombin III deficiency (...) Antithrombin III deficiency Aka: Antithrombin III deficiency From Related Chapters II. Pathophysiology normally inhibits Factor IXa Factor Xa Factor XIa Factor XIIa Thrombin Enhanced by III. Epidemiology s have 25-50% ATIII functional levels First episode of thrombosis occurs ages 10-30 years IV. Complications V. Labs Functional level Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Antithrombin III deficiency." Click on the image

2015 FP Notebook

15. Inherited antithrombin-III deficiency causing mesenteric venous infarction: a new clinical entity. Full Text available with Trip Pro

Inherited antithrombin-III deficiency causing mesenteric venous infarction: a new clinical entity. Primary superior mesenteric venous thrombosis is sometimes preceded by peripheral thrombophlebitis. Inherited antithrombin-III deficiency is a recently recognized autosomal dominant trait, which is characterized by thrombophlebitis and pulmonary embolism. This case report illustrates many features of both entities and strongly suggest a causal relationship. While long-term therapy has yet (...) to be established, prophylactic therapy is recommended when asymptomatic individuals with known antithrombin-III deficiency are at increased risk of thrombosis. The efficacy of heparin alone has been unreliable, whereas Coumadin has been encouraging. Antithrombin-III concentrates are being developed and theoretically should be helpful. Patients with thrombophlebitis or pulmonary embolism should be suspected of having antithrombin-III deficiency. Such individuals also represent one mechanism to explain "primary

1975 Annals of Surgery

16. Familial thrombosis: inherited deficiency of antithrombin III. Full Text available with Trip Pro

Familial thrombosis: inherited deficiency of antithrombin III. Several members of a family living on the west coast of Scotland and on one of the islands off the coast had serious thrombotic disease. The plasma antithrombin III (ATIII) concentrations were measured by both functional and immunological assay in all available members of the family. Concentrations were 25% to 66% of normal in 12 people, including all seven with thrombotic disease. The inheritance pattern was characteristic (...) of an autosomal dominant disorder. Thrombotic disease generally affected the leg, mesenteric, and axillary veins, although one man who had died before the study began had had severe arterial atheroma. In women the first thrombotic symptoms usually occurred during pregnancy. None of these patients have developed thrombotic symptoms until they were at least 18, so four younger members of the family who have ATIII deficiency but no thrombotic disease may eventually develop symptoms.

1978 British medical journal

17. Antithrombin III deficiency causing postsplenectomy mesenteric venous thrombosis coincident with thrombocytopenia. Full Text available with Trip Pro

Antithrombin III deficiency causing postsplenectomy mesenteric venous thrombosis coincident with thrombocytopenia. The most commonly recognized cause of mesenteric venous thrombosis following splenectomy is hypercoagulation secondary to reactive thrombocytosis. A case is reviewed in which hypercoagulation followed splenectomy for idiopathic thrombocytopenic purpura (ITP) in spite of persistent thrombocytopenia. Episodic mesenteric venous occlusion occurred due to antithrombin III deficiency (...) . This hypercoagulable state may be the cause of primary acute mesenteric venous occlusive disease. Symptoms and signs suggesting thrombosis in the portal circulation demand immediate coagulation studies since even in the thrombocytopenic patient thrombotic proglems can occur. Surgical intervention is the treatment of choice for segmental small bowel ischemia; warfarin therapy is indicated when there is evidence of antithrombin III deficiency.

1977 Annals of Surgery

18. Antithrombin-III deficiency in a Dutch family Full Text available with Trip Pro

Antithrombin-III deficiency in a Dutch family A Dutch family (family A) with inherited antithrombin-III deficiency and an increased incidence of venous thrombosis was investigated. Antithrombin-III levels were measured by means of a coagulation assay in plasma and by single radial immunodiffusion in plasma and serum.THREE GROUPS COULD BE DISTINGUISHED: group I comprised the relations-in-law of family A, group II the members of family A with a plasma antithrombin-III level higher than 90 (...) , the immunoassay appeared to be much less laborious than the coagulation assay. Therefore, the former assay is recommended in any search for similar families. The results of our family investigation confirm the findings of Egeberg (1965) that inherited antithrombin-III deficiency, giving rise to plasma levels between 50 and 60% of normal, causes thrombophilia and that the pattern of inheritance is autosomal dominant.

1973 Journal of Clinical Pathology

19. Familial antithrombin III deficiency. Full Text available with Trip Pro

Familial antithrombin III deficiency. 626859 1978 04 26 2018 11 13 0007-1447 1 6111 1978 Feb 25 British medical journal Br Med J Familial antithrombin III deficiency. 508 eng Letter England Br Med J 0372673 0007-1447 0 Antithrombins 9005-49-6 Heparin AIM IM Adult Antithrombins genetics Child Female Heparin administration & dosage therapeutic use Humans Injections, Subcutaneous Male Thrombosis genetics prevention & control 1978 2 25 1978 2 25 0 1 1978 2 25 0 0 ppublish 626859 PMC1603163 Lancet

1978 British medical journal

20. Antithrombin III deficiency, hypertriglyceridaemia, and venous thromboses. Full Text available with Trip Pro

Antithrombin III deficiency, hypertriglyceridaemia, and venous thromboses. 630261 1978 05 17 2018 11 13 0007-1447 1 6113 1978 Mar 11 British medical journal Br Med J Antithrombin III deficiency, hypertriglyceridaemia, and venous thromboses. 621-2 Gyde O H OH Middleton M D MD Vaughan G R GR Fletcher D J DJ eng Case Reports Journal Article England Br Med J 0372673 0007-1447 0 Antithrombins 0 Triglycerides AIM IM Antithrombins blood genetics Female Humans Middle Aged Pedigree Thrombophlebitis

1978 British medical journal

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